DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and Pcdhb7

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_444362.3	Gene:	Pcdhb7 / 93878	MGIID:	2136741	Length:	829	Species:	Mus musculus

Alignment Length:	809	Identity:	216/809 - (26%)
Similarity:	335/809 - (41%)	Gaps:	176/809 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LHPSHMLRSSLLILLAIVLLGSSQAASHDQERERKLEVFEGVAVDYQIGYIGDFGGIDSGPPYII 113
            |..:|..|..:..:..:||:   |..|....:...||..|..:.   :.::....|:  |...:.
Mouse    35 LEKAHPKRQVIAFIFMMVLV---QVCSEPTTQYSILEETESGSF---VAHLAKDLGL--GARELA 91

  Fly   114 VAEAGVETD-----LAIDRATGEIRTKVKLDRETRAS-------YSLVAIPLSGRNIRVLVTVKD 166
            ...|.|.:|     |.:|..||::..:.|:|||...|       :..|.:....:..:..:.::|
Mouse    92 ARSARVVSDDYKQRLLLDPETGDLLLREKVDREEVCSTVDPCVLHFQVTLEKPVQYFQGELLIQD 156

  Fly   167 ENDNAPTFPQTSMHIEFPENTPREVKRTLLP---ARDLDLEPYNTQRYNIVSGNVNDAFRLSSHR 228
            .||:||.||:..|.:..|||:.   ..||||   |:|||:.....|:|.:   :.|..|.:.:..
Mouse   157 INDHAPEFPEGEMLLNIPENSQ---PGTLLPLNLAQDLDVGSNGLQQYTV---SPNSHFHVLTRN 215

  Fly   229 ERDGVLYLDLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFA 293
            ..:|..|.:|.....||||.....||.:.|||||:||..|...|.|.|.|:|||.|.|..|.|..
Mouse   216 NSEGKKYPELVQDRALDREEQAELSLTLIALDGGSPPRSGTALVRILIMDINDNAPEFVNSPYEV 280

  Fly   294 TVPENATVGTSVLQVYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKEL 358
            .|.|::...:.||.|:|.|.||...|.|.|...:...:.::.|.|:..||.|.:.|.||||..:.
Mouse   281 QVLESSLPDSPVLTVFAQDADAGNFGRVSYGFFQASDEIQRTFSINKVTGEIQLKKELDFEKIKF 345

  Fly   359 HELVVVAKDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHD 423
            :.:.:.|.|.|  .|.....|.:.|.|||||.|.:.:..|:.    .:.|:| |...::...|.|
Mouse   346 YHVKIEATDGG--GLSGKGLVIVEVLDVNDNAPELTISSLTS----SVPENA-PETIISIFRVGD 403

  Fly   424 PDSKTEYANVNVTLNGGDG-HFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHAS 487
            .||.   .|..|..:..:. .|.|.:...:.|.::...|||||..:.|.::::.:|.|||.|...
Mouse   404 RDSG---ENAKVVCSIPENLPFILKSTFKNFYTLVTESPLDRESRAEYNITIMVSDLGTPRLTTW 465

  Fly   488 KSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQ 552
            .:|.::::|||||.|.|.:..|...|.|...|...:..:.|.|.|.|.|:.:||||. .|.
Mouse   466 HTITVQVSDVNDNAPAFTRTSYTMFVRENNSPALHIGTISATDSDSGSNAHITYSLL-LPH---- 525

  Fly   553 WFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYN 617
                ||:.                             ||||    |::|:
Mouse   526 ----DPEL-----------------------------PLSS----LISIN--------------- 538

  Fly   618 VSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSS 682
               |:|                                           |::.....||:|...:
Mouse   539 ---ADN-------------------------------------------GQLFALRALDYEVLQA 557

  Fly   683 YEFPVLATDRG--GLSTTAMIKMQLTDVNDNRP-VFYPREYKVSLRESPKASSQASSTP------ 738
            :||.|.|||||  .||:.|::::.:.|.|||.| |.||              .|.:|.|
Mouse   558 FEFHVGATDRGSSALSSQALVRVVVLDDNDNAPFVLYP--------------MQNASAPCTELLP 608

  Fly   739 --------IVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHML 795
                    :..|||.|.|.|....:|::::...|.|:|.:....||:...|  :||.|..|.|.|
Mouse   609 RAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTSR--LLSERDAPKHRL 671

  Fly   796 NISATDGGNLRSNADAVVFLSIIDAMQRP 824
            .:...|.|....:|...:.:.::|...:|
Mouse   672 LMLVKDNGEPPRSASVTLHVLLVDGFSQP 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	16/72 (22%)
		Cadherin_repeat	178..282	CDD:206637	38/106 (36%)
		Cadherin_repeat	291..389	CDD:206637	32/97 (33%)
		Cadherin_repeat	406..500	CDD:206637	27/94 (29%)
		Cadherin_repeat	509..607	CDD:206637	22/97 (23%)
		Cadherin_repeat	616..711	CDD:206637	19/96 (20%)
		Cadherin_repeat	719..820	CDD:206637	25/114 (22%)
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhb7	NP_444362.3	Cadherin_2	63..143	CDD:285466	18/84 (21%)
		Cadherin_repeat	171..269	CDD:206637	37/103 (36%)
		Cadherin_repeat	277..374	CDD:206637	32/98 (33%)
		Cadherin_repeat	386..478	CDD:206637	27/95 (28%)
		Cadherin_repeat	486..588	CDD:206637	41/204 (20%)
		Cadherin_repeat	607..695	CDD:206637	22/89 (25%)
		Cadherin_C_2	719..801	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000