DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and Pcdhb4

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_444359.3	Gene:	Pcdhb4 / 93875	MGIID:	2136738	Length:	784	Species:	Mus musculus

Alignment Length:	909	Identity:	231/909 - (25%)
Similarity:	354/909 - (38%)	Gaps:	239/909 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LILLAIVLLGSSQAASHDQERERKLEVFEGVAVDYQIGYIGDFGGIDSGPPYIIVAEA-----GV 119
            |.:|.::.:..|:|..:....|.:        ..|.:..:....||..|.  :...||     |.
Mouse    17 LTMLLLLWVSGSEAIKYSMPEETE--------SGYLVANLAQDLGIRVGE--LAAREARVHHRGN 71

  Fly   120 ETDLAIDRATGEIRTKVKLDRETRASYS---------LVAIPLSGRNIRVLVTVKDENDNAPTFP 175
            :..|.:|..||.:..|.|||||.....:         ::..|:......:.:|  |.||::|.||
Mouse    72 KDLLQLDAETGNLFLKEKLDREGLCGATEPCVLHFQIILKNPVQFFQTELQLT--DINDHSPEFP 134

  Fly   176 QTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQI 240
            .|.|.:..||:........|..|:|.|:.....|.|. ||.|::  |.:.:....||..|.:|.:
Mouse   135 DTEMLLTIPESAQPGTVFPLKAAQDPDMGSNAIQNYT-VSPNLH--FHVVTLSRSDGRKYPELVL 196

  Fly   241 SGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSV 305
            ...||||..|..:|::.|||||.|...|..||:|.|.|:|||.|.|.||.|...||||..:...:
Mouse   197 DRALDREEQPELTLILTALDGGAPRRSGMTTVHIEIMDINDNAPQFVQSLYEVQVPENFPLDALL 261

  Fly   306 LQVYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGE 370
            :.|.|.|.||...|.:.|::.:...| .|.|.||..||.|.::|.||||....:.:.:.|.|.|
Mouse   262 VTVSARDLDAGIYGNIAYSLFQGDGD-SQPFVIDEITGEIRLSKKLDFEVTPYYNVEIAATDGG- 324

  Fly   371 QPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNV 435
             .|.....|:::|.|||||.|.:.|..||   || |.|:: |...||...|.||||
Mouse   325 -GLSGKCTVAVQVLDVNDNAPELTVSTLS---SP-IPENS-PETVVAVFGVFDPDS--------- 374

  Fly   436 TLNGGDGH----------FALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSI 490
               |.:|.          |.|.:...:.|.:....|||||.::.|.:::..:|.|||.|....:|
Mouse   375 ---GDNGRMVCSIQNELPFLLKSTFENYYTLATERPLDRESIAEYNITITVSDMGTPRLTTQHTI 436

  Fly   491 FLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQ 555
            .::::|:|||.|.|.|..|...|.|...|...:..:.|.|.|.|.|:.:||||
Mouse   437 KVQVSDINDNAPAFTQTSYTLFVHENNSPALHIGTISATDSDSGSNAHITYSL------------ 489

  Fly   556 IDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSV 620
                                            :||
Mouse   490 --------------------------------LPP------------------------------ 492

  Fly   621 AENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEF 685
                           .||...::::::              :.:.:|::.....||:|...::||
Mouse   493 ---------------QDPQLALSSLIS--------------INADNGQLFALRALDYEALQAFEF 528

  Fly   686 PVLATDRG--GLSTTAMIKMQLTDVNDNRP-VFYPRE-----YKVSLRESPKASSQASSTPIVAV 742
            .|.|||.|  .||:..::::.:.|.|||.| |.||.:     |...|   |:|:.....  :..|
Mouse   529 HVGATDGGSPALSSQTLVRVVVLDDNDNAPFVLYPLQNASAPYTELL---PRAAEPGYL--VTKV 588

  Fly   743 VATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRS 807
            ||.|.|.|....:|::::...|.|:|.:....||:...|  :||.|..|.|.|.:...|.|....
Mouse   589 VAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTR--LLSERDAPKHRLLLLVKDNGEPLR 651

  Fly   808 NADAVVFLSIIDAMQRP----------PIFEKARYNYYV-------------------------- 836
            :|...:.:.::|...:|          |..|:.....|:
Mouse   652 SASVTMHVLVVDGFSQPYLPLPEVALDPTREEDNLTLYLVISLASVSSLFLLSVLLFMGARLCRR 716

  Fly   837 -KE------DIPRGTVVGSVIAASGDVAHRSPVRYSI-YSGD------------------PDGY 874
             :|      .:|.|...|.::..||........:|.: .|||                  ||.|
Mouse   717 AREASLGGYSVPEGHFPGHLVDVSGAGTLSQSYQYEVCLSGDSGITDFKFLKPSNPNSLIPDNY 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	18/74 (24%)
		Cadherin_repeat	178..282	CDD:206637	36/103 (35%)
		Cadherin_repeat	291..389	CDD:206637	34/97 (35%)
		Cadherin_repeat	406..500	CDD:206637	29/103 (28%)
		Cadherin_repeat	509..607	CDD:206637	15/97 (15%)
		Cadherin_repeat	616..711	CDD:206637	17/96 (18%)
		Cadherin_repeat	719..820	CDD:206637	26/105 (25%)
		Cadherin_repeat	832..927	CDD:206637	14/95 (15%)
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhb4	NP_444359.3	Cadherin_2	31..112	CDD:285466	18/90 (20%)
		Cadherin_repeat	140..238	CDD:206637	35/100 (35%)
		Cadherin_repeat	247..342	CDD:206637	34/97 (35%)
		Cadherin_repeat	355..446	CDD:206637	29/103 (28%)
		Cadherin_repeat	454..556	CDD:206637	32/204 (16%)
		Cadherin_repeat	570..663	CDD:206637	26/99 (26%)
		Cadherin_C_2	685..768	CDD:293101	11/82 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000