DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and Pcdhb1

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_444356.1	Gene:	Pcdhb1 / 93872	MGIID:	2136730	Length:	818	Species:	Mus musculus

Alignment Length:	685	Identity:	215/685 - (31%)
Similarity:	312/685 - (45%)	Gaps:	73/685 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 LILLAIVLLGSSQAASHDQERERKLEVF-EGVAVD--YQIGYIGDFGGIDSGPPYIIVAEAGVET 121
            |.||..|.:|.:....:....|.:...| ..||.|  .::|.:.:.|.       .:||| |...
Mouse    17 LFLLWCVSVGGAATIRYSVAEEMESGSFVANVAKDLGLEVGKLAERGA-------RLVAE-GNRL 73

  Fly   122 DLAIDRATGEIRTKVKLDRETRASYS---------LVAIPLSGRNIRVLVTVKDENDNAPTFPQT 177
            ...:.|.||::..|.|||||.....|         ::|.||  ::.||.|.|.|.|||||.|...
Mouse    74 HFRLHRKTGDLFVKEKLDREALCGKSDPCVLHFEIILAEPL--QSFRVEVRVFDINDNAPVFLNK 136

  Fly   178 SMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQISG 242
            ...::.||:||...:..|..|:|||:.....|.|.:   :.|..|.|.:.....|..|.:|.:..
Mouse   137 EPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTL---SANTYFHLHTRFRSHGPKYAELVLDN 198

  Fly   243 FLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVLQ 307
            .||||..|..:|.|.|:|||:||..|...:.:.:.||||:.|.|::..|.|.||||:..|:.|:.
Mouse   199 PLDREAQPEVNLTITAVDGGSPPKSGTANIRVVVLDVNDHVPQFSRLVYRAQVPENSDNGSLVVV 263

  Fly   308 VYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQP 372
            |.|:|.|...|..:.|::........:.|.:||:||.:.:...||||..|.:::.:.|.|.|  .
Mouse   264 VTATDLDEGTNKQITYSLAENPEAVLRTFLVDPQTGEVRLRGPLDFEMIETYDIDIQATDGG--G 326

  Fly   373 LETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVTL 437
            |...:.|.:.|.|||||.|.:.:   |..:||...:||.. ..||..::.|.|.:.
Mouse   327 LSAHSKVLVEVVDVNDNPPEVTI---SSVSSPLPEDSALQ-TVVALFTIRDRDVRV--------- 378

  Fly   438 NGG--------DGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRI 494
             ||        |..|.:.....:.|.::....||||.||:|.:::||.|.|.|.|.....|.:.|
Mouse   379 -GGKITCFLKEDLPFVVKHTFRNSYSLVTDRSLDREDVSSYNITLVAMDTGPPNLSTETVIEVVI 442

  Fly   495 TDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWF---QI 556
            .|||||.|.|::|.|...|.|...|...:.:|.|.|.|.|.|:.:||||..........|   .|
Mouse   443 ADVNDNSPVFQEDSYVLTVRENNSPAVFIGKVHAEDLDLGENAQVTYSLLPPKSGDLSVFAYISI 507

  Fly   557 DPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVA 621
            :...|.:.....:|.|.....|..|.|.|||...|||..||.|.:.|.|||.|:......|.::.
Mouse   508 NSDNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSEVTVRVVVLDDNDNRPMILYPLQNGTLP 572

  Fly   622 ENEPV------GRCILKVSASDPDCGVNAMVNYTIGEGFKHLTE------FEVRSASGEICIAGE 674
            .|:.|      |..:.||.|.|.|.|.|:.::|       ||.:      |.|:..:|||....:
Mouse   573 CNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSY-------HLLKATDLGLFSVQRQNGEIRTLRQ 630

  Fly   675 LDFERRSSYEFPVLATDRG--GLSTTAMIKMQLTD 707
            :........:..:|..|.|  .|||||.:.:.|.|
Mouse   631 ISERDPMMQKLVILVQDHGQPALSTTASLNILLVD 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	25/69 (36%)
		Cadherin_repeat	178..282	CDD:206637	34/103 (33%)
		Cadherin_repeat	291..389	CDD:206637	33/97 (34%)
		Cadherin_repeat	406..500	CDD:206637	29/101 (29%)
		Cadherin_repeat	509..607	CDD:206637	33/100 (33%)
		Cadherin_repeat	616..711	CDD:206637	29/106 (27%)
		Cadherin_repeat	719..820	CDD:206637
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhb1	NP_444356.1	Cadherin_2	30..110	CDD:285466	21/87 (24%)
		Cadherin_repeat	140..238	CDD:206637	34/100 (34%)
		Cadherin_repeat	246..343	CDD:206637	33/98 (34%)
		Cadherin_repeat	356..448	CDD:206637	29/102 (28%)
		Cadherin_repeat	456..558	CDD:206637	33/101 (33%)
		Cadherin_repeat	577..665	CDD:206637	26/94 (28%)
		Cadherin_C_2	688..772	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000