DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and Pcdhga6

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_291067.1	Gene:	Pcdhga6 / 93714	MGIID:	1935218	Length:	932	Species:	Mus musculus

Alignment Length:	1127	Identity:	269/1127 - (23%)
Similarity:	424/1127 - (37%)	Gaps:	325/1127 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   932 EASMVRISVPESAELGAPLYAAHAHD-----KDSGSSGQVTYSLVKESGKGLFAIDARSGHLILS 991
            ||..:|.|:||..|.|: ...:.|.|     ::....|   ..::......||:::.|||.|:.:
Mouse    27 EAGQLRYSIPEEVEKGS-FVGSIAKDLGLQPRELAERG---IRIISRGRSQLFSLNQRSGSLVTA 87

  Fly   992 QHLDYES--SQRHTLIVTATDGGVPSLSTNLTI---------LVDVQDVNDNPPVFEKDEYSVNV 1045
            ..:|.|.  :|....:|          |.|:.|         .|::.|:|||.|.|.|:|..:.:
Mouse    88 GRIDREELCAQSAPCLV----------SFNILIEDKLNLYPVEVEIVDINDNAPRFLKEEMELKI 142

  Fly  1046 SESRSINAQIIQVNASDLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAP 1110
            .|:.::::..:.:...|.|.|.|:...:::  :|..:.:..:.|.|   |...:|.   :.|...
Mouse   143 LENAALSSHFLLMGVYDPDVGVNSIQGFKL--SGSSHFSVHVQSQD---HGPKYPE---LVLEHS 199

  Fly  1111 LDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVV 1175
            ||||....:.|.::|.|.|.|......|::|.|:|.|||.|.|.:..|...:.|||..|:.|..|
Mouse   200 LDREEEAVHHLVLVAMDGGDPVRTGMARILVTVVDVNDNAPVFTQPIYRVSVPENLPVGTRVLTV 264

  Fly  1176 TASDLDLGENAAIRYSLL----PINSSFQVHPVTGEISTREPLDRELRELYDLVVEARDQGTPVR 1236
            .|:|.|.|.:|.|.||.:    .|:..|.::|:||||||.|.||.|....|:|.||||||..  .
Mouse   265 NATDQDEGIHAEITYSFVRITEEISQIFCLNPLTGEISTSETLDYEDSRFYELDVEARDQSD--L 327

  Fly  1237 SARVPVRIHVSDVNDNAPEIADPQEDVV-----SVREEQPPGTEVVRVRAVDRDHGQNASITYSI 1296
            ..|..|.|.:.|:||||||:      ||     ::.|..|.||.:...:..|:|..:|..:..||
Mouse   328 QDRAKVLITILDMNDNAPEV------VVTSGSRAIAENSPSGTVIALFQVYDKDSERNGLVICSI 386

  Fly  1297 VKGRDSDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDN 1361

Mouse   387 ----------------------------------------------------------------- 386

  Fly  1362 RPTFTSSSLVFRVREDAALGHVVGSISPIERPADVVRNSVEESFEDLRVTYTLNPLTKDLIEAAF 1426
                 |.||.|::.|                       |::..|
Mouse   387 -----SESLPFKLEE-----------------------SLDNYF--------------------- 402

  Fly  1427 DIDRHSGNLVVARLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIEVADVNDNAPEWPQDPID 1491
                   .||....||||..|.:.:.:.|.|  ....|.|:.|.:.::|||:|||.|.:.:....
Mouse   403 -------RLVTNTELDREQVSSYNITVTATD--RGTPPLSTKIFISLDVADINDNPPVFSRSSYS 458

  Fly  1492 LQVSEATPVGTIIHNFTATDADTGTNGDLQYRLIRYFPQLNESQEQAMSLF-RMDSLTGALSLQA 1555
            :.|||..|.|..|.:..|.|.|:..|.::.|.|.:     ...|...:|.| .::|:||.|....
Mouse   459 VYVSENNPKGVSIFSLNAVDPDSEENAEIIYSLAK-----ETLQGTPLSSFLSINSITGVLYALC 518

  Fly  1556 PLDFEAVQEYLLIVQALDQSSNVTERLQTSVTVRLRILDANDHAPHFVSP-NSSGGKTASLFISD 1619
            ..|:|..:|..|:|.|.|:..   ..|.::|::.|.:||.||:.|..:.| ..:.|.|.......
Mouse   519 SFDYEQFRELNLLVTASDRGK---PPLSSNVSLNLFVLDQNDNVPEILYPVLPTDGSTGVELAPR 580

  Fly  1620 ATRIGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKGGRF 1684
            :...|.:|..:||||:|||.|..|:|.:...:..|.|.:...||.|...:.|  ...|..|.
Mouse   581 SAEPGYLVTKVVAVDKDSGQNAWLSYRLIKASEPGLFSVGLHTGEIRTARVL--LDRDALKQ--- 640

  Fly  1685 NLIIGAKDHGQPEPKKSSLNLHLIVQGSHNNPPRFLQAVYRATILENVPS-----GSFVLQVTAK 1744
            :|::..:||||| |..:::.|.:.|..|                   :|.     ||..|.
Mouse   641 SLVVAVQDHGQP-PLSATVTLTVAVASS-------------------IPDILADLGSLDLP---- 681

  Fly  1745 SLHGAENANLSYEIPAGVAN---------------DLFHVDWQRGIITTRGQFDRESQASYV--- 1791
              |.:|:::|:..:...||.               .|:|....|.:..||......|.:.:|
Mouse   682 --HKSEDSSLTIYLVVAVATVSCIFFAFVMGLLVLRLWHWHKSRLLKATRKGVSNMSTSHFVGID 744

  Fly  1792 -LPVYVRDANRQSTLSSSAVRKQRSSDSIGDTSNGQHFDVATIYITVGDVNDNSPEFRPGSCYGL 1855
             :..:::..:.:.:|::.:    |.|..|....|..|    |:....|             |
Mouse   745 GVQAFLQTYSHEVSLTADS----RKSHLIFPQPNYAH----TLISQEG-------------C--- 785

  Fly  1856 SVPENSEPGVIHTVVA-----SDLDE--GPNADLIYS------ITGGNLG--------NKF---- 1895
               |.:||.:|....|     ..||:  .||.|..:|      .:|...|        |:|
Mouse   786 ---EKNEPLLIQEDSAFCKEEDSLDQQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFDTEM 847

  Fly  1896 -----------SIDSSS---GELSARPLDREQHSRYTLQIQASDRGQPKSRQGHCNITIFVEDQN 1946
                       :.|.||   |......|......::|||      ..|..||     .:::...|
Mouse   848 LQAMILASASEAADGSSTLGGGAGTMGLSARYGPQFTLQ------HVPDYRQ-----NVYIPGSN 901

  Fly  1947 DNAPRFKLSKYTGSVQEDAPLG 1968
            ..     |:...|.....||.|
Mouse   902 AT-----LTNAAGKRDGKAPAG 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637	25/110 (23%)
		Cadherin_repeat	1040..1149	CDD:206637	26/108 (24%)
		Cadherin_repeat	1158..1252	CDD:206637	41/97 (42%)
		Cadherin_repeat	1263..1361	CDD:206637	11/102 (11%)
		Cadherin_repeat	1369..1481	CDD:206637	22/111 (20%)
		Cadherin_repeat	1489..1598	CDD:206637	32/109 (29%)
		Cadherin_repeat	1614..1710	CDD:206637	28/95 (29%)
		Cadherin_repeat	1723..1843	CDD:206637	24/143 (17%)
		Cadherin_repeat	1853..1948	CDD:206637	27/133 (20%)
		Cadherin_repeat	1957..2053	CDD:206637	4/12 (33%)
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhga6	NP_291067.1	Cadherin_2	30..112	CDD:285466	22/95 (23%)
		Cadherin_repeat	137..238	CDD:206637	26/108 (24%)
		Cadherin_repeat	246..343	CDD:206637	41/98 (42%)
		Cadherin_repeat	356..448	CDD:206637	32/214 (15%)
		Cadherin_repeat	463..558	CDD:206637	30/102 (29%)
		Cadherin_repeat	579..664	CDD:206637	28/90 (31%)
		Cadherin_C_2	688..772	CDD:293101	14/87 (16%)
		Cadherin_tail	809..>905	CDD:292596	20/111 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000