DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and Pcdhgc4

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_291060.1	Gene:	Pcdhgc4 / 93707	MGIID:	1935203	Length:	941	Species:	Mus musculus

Alignment Length:	676	Identity:	217/676 - (32%)
Similarity:	323/676 - (47%)	Gaps:	62/676 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 IDRATGEIRTKVKLDRETRASYSLVAI---------PLSGRNIRVLVTVKDENDNAPTFPQTSMH 180
            :|..:|.:..|..:|||.....|...|         ||  ...|..|.:.|.||:||.||:..:.
Mouse    80 VDLDSGALLIKNPIDREALCGLSASCIVPLEFVTEGPL--EMYRAEVEIVDVNDHAPRFPRQQLD 142

  Fly   181 IEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQISGFLD 245
            :|..|..|...:..|..|:|.|:...:...|.:.|   |:.|.|...:..||.|..:|.:...||
Mouse   143 LEIGEAAPPGQRFPLEKAQDADVGSNSISSYRLSS---NEHFALDVKKRSDGSLVPELLLEKPLD 204

  Fly   246 RETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVLQVYA 310
            ||....|.|::.|:|||.||..|...:.:::.|||||.|.|.||.|..:|.|:|..|..::|:.|
Mouse   205 REKQSDYRLVLTAVDGGNPPRSGTAELRVSVLDVNDNAPAFQQSSYRISVLESAPAGMVLIQLNA 269

  Fly   311 SDTDADENGLVEYAINRRQSDK-EQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPLE 374
            ||.|...:|.|.::.:....|: ..:|.:.|.||.:.:...||||::..:|..|.|:|.|...:|
Mouse   270 SDPDLGPSGNVTFSFSGHTPDRVRNLFSLHPTTGKLTLQGPLDFESENYYEFDVRARDGGSPAME 334

  Fly   375 TTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVTLNG 439
            ....:.:.:.|||||.|.|.|    ......:.|||:||..||.|||.||||.   :|.:|:|..
Mouse   335 QHCSLRVDLLDVNDNAPHITV----TSELGTLPESAEPGTVVALISVQDPDSG---SNGDVSLRI 392

  Fly   440 GDGH--FALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDVNDNPP 502
            .| |  |||.:...:.:.::...|||||..|:|.:.|.|:|.|.|||...::|||.|:|||||||
Mouse   393 PD-HLPFALKSAFRNQFSLVTAGPLDREARSSYDIMVTASDAGNPPLSTHRTIFLNISDVNDNPP 456

  Fly   503 EFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETH----AQWFQIDPQTGLI 563
            .|.|..:...|.|...||..:..:.|.|.|.|||:.::|||.| |...    :.:..::||||.:
Mouse   457 SFFQRSHEVFVPENNRPGDLLCSLAASDPDSGLNALISYSLLE-PRNRDVSASSFISLNPQTGAV 520

  Fly   564 TTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIF------DQSFYNVSVAE 622
            ......|.|.....|..|.|||.|.||||||.||.:.:.|:|||.|..      ..|....::..
Mouse   521 HATRSFDYEQTQTLQFEVQARDRGSPPLSSTVTVRLFVLDLNDNAPAVLRPRARPGSLCPQALPP 585

  Fly   623 NEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFP- 686
            :...|..:.||:|.|.|.|.||.|:|.:.|. ...:.|.|...:||:          |::...|
Mouse   586 SVGAGHLVTKVTAVDLDSGYNAWVSYQLLEA-PDPSLFAVSRYAGEV----------RTAVPIPA 639

  Fly   687 --------VLATDRGG--LSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVA 741
                    ::..|.|.  |||:..:.:.|.:  |..||........:.||.....:...:..:||
Mouse   640 DLPPQKLVIVVKDSGSPPLSTSVTLLVSLEE--DTHPVVPDLRESSAPREGESRLTLYLAVSLVA 702

  Fly   742 VVATDPDYGNFGQVSYRIVAGNEAGI 767
            :...  .:|:|..:..:.:.|...|:
Mouse   703 ICFV--SFGSFVALLSKCLRGAACGV 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	15/55 (27%)
		Cadherin_repeat	178..282	CDD:206637	32/103 (31%)
		Cadherin_repeat	291..389	CDD:206637	30/98 (31%)
		Cadherin_repeat	406..500	CDD:206637	43/95 (45%)
		Cadherin_repeat	509..607	CDD:206637	37/101 (37%)
		Cadherin_repeat	616..711	CDD:206637	24/105 (23%)
		Cadherin_repeat	719..820	CDD:206637	8/49 (16%)
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhgc4	NP_291060.1	Cadherin_2	33..114	CDD:369785	8/33 (24%)
		Cadherin_repeat	143..241	CDD:206637	32/100 (32%)
		Cadherin_repeat	249..349	CDD:206637	30/99 (30%)
		Cadherin_repeat	361..454	CDD:206637	43/96 (45%)
		Cadherin_repeat	464..564	CDD:206637	37/100 (37%)
		Cadherin_repeat	583..669	CDD:206637	23/96 (24%)
		Cadherin_tail	820..>914	CDD:374265
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10386
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000