DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and Pcdhgb5

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_291055.1	Gene:	Pcdhgb5 / 93702	MGIID:	1935196	Length:	926	Species:	Mus musculus

Alignment Length:	1001	Identity:	250/1001 - (24%)
Similarity:	395/1001 - (39%)	Gaps:	247/1001 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 IDSGPPYIIVAEAGVETDLAIDRATGEIRTKVKLDRETRASYSLV------AIPLSGRNI-RVLV 162
            |.|..||           .::...:||:....:||||......||      |:..:..|. .|.|
Mouse    68 ISSEKPY-----------FSVSSESGELLVSSRLDREQICGKKLVCALEFEAVAENPLNFYHVSV 121

  Fly   163 TVKDENDNAPTFPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSH 227
            .::|.||:.|.|..|...::..|:.....:..|..|.|.|:...:.|.|.:   :.:..|.|.:.
Mouse   122 ELEDINDHTPNFTHTFSELQISESAQPGTRFILEVAEDADIALNSLQNYKL---SPSPGFSLVNK 183

  Fly   228 RERDGVLYLDLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYF 292
            .::||..|.:|.:...||||....|.|::.|||||.|||.|...:.|.:.|.|||.|:|||..|.
Mouse   184 EKQDGRKYPELVLEKTLDREQQNYYRLVLTALDGGDPPLSGTTELRIQVTDANDNPPVFNQEVYK 248

  Fly   293 ATVPENATVGTSVLQVYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKE 357
            ..:|||...||:||:|.|:|.|...|..:.|:.:|    ..|:|.::.::|.|...|.||||..:
Mouse   249 VRLPENVPPGTTVLRVTATDKDEGVNSEISYSFHR----AGQVFGLNSKSGEIITQKTLDFEEIK 309

  Fly   358 LHELVVVAKDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVH 422
            .:.:||.|:|.|....:.|  |.|.:.|.|||:|.|.|..|.:    .|.|:|.||..:|.|.:|
Mouse   310 EYSIVVEARDGGGLVAQCT--VEINIQDENDNRPEITVRSLLE----MIPENAPPGTLIALIKIH 368

  Fly   423 DPDSKTEYANVNVTLNGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHAS 487
            |.|| .|...||..|: .:..|.:.:...:.|.::....||||:...|.:::.|||:|.|||.:|
Mouse   369 DGDS-GENGEVNCRLD-DEVPFKIISSSKNSYKLVTDRALDRELTPEYNVTITATDRGKPPLSSS 431

  Fly   488 KSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAET---PET 549
            ..:.|.:.|||||.|.|.|..|...:.|...||.|:.||.|.|.|.|.|..::||:..:   |::
Mouse   432 TKVTLHVGDVNDNAPLFHQASYLVYIAENNPPGASIAQVSASDPDLGSNGHVSYSIIASDLEPKS 496

  Fly   550 HAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQS 614
            ...:..::.|:|::..:...|.|.....|||:.|||.|.|.||:..::.|.:.|.|||.|
Mouse   497 LWSYVTVNAQSGVVFAQRAFDHEQLRSFQLTLQARDHGSPTLSANVSMRVLVGDRNDNAP----- 556

  Fly   615 FYNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFER 679
                         |.:
Mouse   557 -------------RVL------------------------------------------------- 559

  Fly   680 RSSYEFPVLATDRGGLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVAVVA 744
                 :|.|..|  |.:...|:                          |:|:.....  :..|||
Mouse   560 -----YPALEPD--GSALFDMV--------------------------PRAAQPGYL--VTKVVA 589

  Fly   745 TDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRSNA 809
            .|.|.|:...:||.::..::.|:|.:...|||:...|  .|..:......|.:...|||....:|
Mouse   590 VDADSGHNAWLSYHVLQASDPGLFSLGLRTGEVRTAR--ALGEKDAARQRLLVGVRDGGQPPLSA 652

  Fly   810 DAVVFLSIIDAMQR----------PPIFEKARYNYYVKEDIPRGTV---VGSVIAASGDVAHRS- 860
            .|.:.|...|::|.          || ..:|...:|:...:...:|   :..::|.:..:.|.|
Mouse   653 TATLLLVFADSLQEALPDLSDHSLPP-DPQAELQFYLVVALALVSVLFLLAVILAIALRLRHSSS 716

  Fly   861 ----------------------------PVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQ 897
                                        |..|::|     |..:.:|....::.::||   :..|
Mouse   717 PSVWNCFQPGFCSESKPVVFPNYSEGTLPYSYNLY-----GAHAGKTECNFLKCSEPL---SSGQ 773

  Fly   898 VLLNIQATLGEPPVYGHTQVNIEVEDVNDNAP------------------------------EFE 932
            .||..:::....|:...::.....|.:...||                              :|:
Mouse   774 GLLCPESSGALFPLCDSSEPTSHPEPLTPQAPPNTDWRFSQAQRPGTSGSQNGDETGTWPNNQFD 838

  Fly   933 ASMVRISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHL-DY 996
            ..|::..:..|        |:.|.|..|...|          |.|...:.||.|.....||: ||
Mouse   839 TEMLQAMILAS--------ASEAADGSSTLGG----------GAGTMGLSARYGPQFTLQHVPDY 885

  Fly   997 ESS-----QRHTLIVTA--TDGGVPS 1015
            ..:     ...||...|  .||..|:
Mouse   886 RQNVYIPGSNATLTNAAGKRDGKAPA 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	16/67 (24%)
		Cadherin_repeat	178..282	CDD:206637	31/103 (30%)
		Cadherin_repeat	291..389	CDD:206637	34/97 (35%)
		Cadherin_repeat	406..500	CDD:206637	34/93 (37%)
		Cadherin_repeat	509..607	CDD:206637	32/100 (32%)
		Cadherin_repeat	616..711	CDD:206637	6/94 (6%)
		Cadherin_repeat	719..820	CDD:206637	24/100 (24%)
		Cadherin_repeat	832..927	CDD:206637	17/126 (13%)
		Cadherin_repeat	937..1032	CDD:206637	21/87 (24%)
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhgb5	NP_291055.1	Cadherin_2	32..112	CDD:285466	13/54 (24%)
		Cadherin_repeat	139..238	CDD:206637	31/101 (31%)
		Cadherin_repeat	246..339	CDD:206637	34/98 (35%)
		Cadherin_repeat	352..444	CDD:206637	34/93 (37%)
		Cadherin_repeat	452..554	CDD:206637	32/101 (32%)
		Cadherin_repeat	574..658	CDD:206637	23/113 (20%)
		Cadherin_C_2	683..764	CDD:293101	10/85 (12%)
		Cadherin_tail	803..>899	CDD:292596	20/113 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9496
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910