DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and Cdhr1

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_446024.1	Gene:	Cdhr1 / 93662	RGDID:	620420	Length:	859	Species:	Rattus norvegicus

Alignment Length:	699	Identity:	210/699 - (30%)
Similarity:	319/699 - (45%)	Gaps:	124/699 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   840 IPRGTVVGS-VIAASGDVAHRSPVRYSIYSGDPD--GYFSIETNSGNIRIAKPLDHEAKSQVL-- 899
            :|..|.||| |...:|......|:.|.| |.||.  ..||::.|.|||.:.:.||.|.:.::.
  Rat    44 LPEDTPVGSHVYTLNGTDPEGDPISYHI-SFDPSTRSVFSVDPNFGNITLVEELDREREDEIEAI 107

  Fly   900 ------LNIQATLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDK 958
                  ||:.|          .:|.|.|.|.||.||.|......|.|||:...|:.::...|.||
  Rat   108 ISISDGLNLVA----------EKVVIVVTDANDEAPRFLQEPYNILVPENTPAGSSIFKVQAEDK 162

  Fly   959 DSGSSGQVTYSLVK-ESGKGLFAIDARSGHLIL--SQHLDYESSQRHTLIVTATDGG-------- 1012
            |:||.|.|||.|.. .|.|  |.:|..||.|.|  ...||||.|:.|.:.|.|.|||
  Rat   163 DTGSGGSVTYFLQSLHSSK--FTVDRHSGVLRLQAGATLDYEKSRAHFITVVAKDGGGRLRGADV 225

  Fly  1013 VPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVD 1077
            |.|.:|  |:.::|:||.|..|:|....|...|.|.....::::.|.|.|.|.|....|.||:
  Rat   226 VFSATT--TVTINVEDVQDTAPIFVGTPYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRL-- 286

  Fly  1078 AGVDNVTNSISSSDVSQHFGIF---PNSGWI-YLRAPLDRETRDRYQLTVLATD---NGTPAAHA 1135
                     ::.||     |:|   ..||.| .|::|.... |:.|:|.|..|:   :|:|||.:
  Rat   287 ---------LNESD-----GLFEINETSGAISVLQSPAQLR-REVYELHVQVTEVNSSGSPAAQS 336

  Fly  1136 KTRVIVRVLDANDNDPKF-----QKSKYEFRIEENLRRGSVV-GV-VTASDLDLGENAAIRYSLL 1193
            ...||:|::|.|::.|.|     .::|:|..:.|:..:|.:: |: :|.:|.|.|.||.....|:
  Rat   337 TVPVIIRIVDLNNHPPTFYGESGPQNKFELSMFEHPPQGEILRGLKITVNDSDQGANAKFNLRLV 401

  Fly  1194 PINSSFQVHP--------VTGEISTREPLDRELRELYDLVVEARDQGTPVR-SARVPVRIHVSDV 1249
            .....|:|.|        ||..:.....:|.|..:.....:.|.:..||.: |:...:.|.:.|.
  Rat   402 GPGGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKSLTFKLLAIEVNTPEKFSSTADIVIQLLDT 466

  Fly  1250 NDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGHGLFSIDPTS 1314
            |||.|:... ...:..:.|..|.|:.||.|.|||.|.|....:.|||. |..||   ||.|.|::
  Rat   467 NDNVPKFTS-HYYIARIPENVPGGSNVVAVTAVDPDTGPWGKVQYSIY-GTGSD---LFLIHPST 526

  Fly  1315 GVIRTR--VVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSSLVFRVRED 1377
            |:|.|:  ..||.|..|.|...|.|.|...  |.::..:.|.:||:||:.|.|..|     |:|.
  Rat   527 GLIYTQPWASLDAEGTSRYNFYVKAEDMDG--RYSLAEVFVTLLDVNDHYPQFVQS-----VQEK 584

  Fly  1378 AALGHVVGS---ISPIERPADVVRNSVEESFEDLRVTYTLNPLTKDLIEAAFDIDRHSGNLVVAR 1439
            ..   |:|:   |...::.|:...|.|:.|            :|:......||||.|:|.:.:..
  Rat   585 TM---VLGTPLKIEATDQDAEEPNNLVDYS------------ITRAEPVNVFDIDAHTGEIRLKN 634

  Fly  1440 LLDREVQS----------EFRLEIRALDTTASNNPQ-SSAITVKIEVAD 1477
            .: |.:::          .:.|:::|.|   ..:|. |:...:||::.|
  Rat   635 SI-RSLEALHNITPSGEYSWSLQVQAKD---RGSPSFSTTALLKIDITD 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637
		Cadherin_repeat	832..927	CDD:206637	30/97 (31%)
		Cadherin_repeat	937..1032	CDD:206637	42/105 (40%)
		Cadherin_repeat	1040..1149	CDD:206637	34/115 (30%)
		Cadherin_repeat	1158..1252	CDD:206637	25/104 (24%)
		Cadherin_repeat	1263..1361	CDD:206637	37/99 (37%)
		Cadherin_repeat	1369..1481	CDD:206637	25/123 (20%)
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Cdhr1	NP_446024.1	Cadherin_repeat	42..130	CDD:206637	29/96 (30%)
		Cadherin_repeat	139..242	CDD:206637	42/106 (40%)
		Cadherin_repeat	251..350	CDD:206637	34/115 (30%)
		Cadherin_repeat	364..469	CDD:206637	25/104 (24%)
		Cadherin_repeat	478..573	CDD:206637	37/100 (37%)
		Cadherin_repeat	580..679	CDD:206637	25/122 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..859
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910