|
Fly 53 HMLRSSLLILLAIVLLGSSQAASHDQERERKLEVFEGVAVDYQIGYIGDFGGIDSGPP----YII 113
|:|...||:|| :|||:....:..|.....|::.|.......||.|. .|:.:|.. |.|
Human 20 HLLLPLLLLLL--LLLGAGVPGAWGQAGSLDLQIDEEQPAGTLIGDIS--AGLPAGTAAPLMYFI 80
Fly 114 VAE--AGVETDLAIDRATGEIRTKVKLDRETRASYSLVAIPLSGRNIRVLVTVKDENDNAPTFPQ 176
.|: :||.||||||..:|.:||...||||.|..|...|:...|..:.|.|.|.|.||:||.|||
Human 81 SAQEGSGVGTDLAIDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQ 145
Fly 177 TSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQIS 241
....::.||:|....:..|.||||.|.....||.|.:......:.|||.:....||....:|.::
Human 146 ARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVT 210
Fly 242 GFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVL 306
|.||||....|.|.:||.|||:||.|....:::|:.|:||:.|.||||||.|.|.|:...|:.||
Human 211 GELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVL 275
Fly 307 QVYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQ 371
||:|||.||..||.|.|.||||||:.:..|.||..||.:.:.:.||||.:.:|||||.|:|.|..
Human 276 QVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAH 340
Fly 372 PLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVT 436
|...:|||::.|.|.|||||::.|||||.|.||::||:|.||:.||||||.|||. .::|:|||:
Human 341 PELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARISVSDPDD-GDFAHVNVS 404
Fly 437 LNGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDVNDNP 501
|.||:|||||:|:|:.||||.|...||||....|.|.|.|||.|:|||.|..:..|.:||||||.
Human 405 LEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNA 469
Fly 502 PEFEQDLYHANVM-EVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGLITT 565
|.|::.||....: |||.||:.|::|.|.|.|:|.|..:||||| |..|..||.|||.:|:|||
Human 470 PAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLA--PGAHTHWFSIDPTSGIITT 532
Fly 566 RSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAENEPVGRCI 630
.:.:|.|.||.|||.|||.|||:|||:|:|||.|.:.|||||||.|.::|||.|:.|....|.|.
Human 533 AASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCF 597
Fly 631 LKVSASDPDCGVNAMVNYTIGEGF--KHLTEFEVRSASGEICIAGELDFER-RSSYEFPVLATDR 692
|:|:|:|.|.|...:::|::|.|. .....|.:.:.||::|....||.:: .||::|.|.|.|.
Human 598 LQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDG 662
Fly 693 GGLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVAVV---ATDPDYGNFGQ 754
|||.:...:|:.|:|.|||.|.|||||| .||..|.|.|..||: |.|||.|:.|:
Human 663 GGLKSMVYVKVFLSDENDNPPQFYPREY--------AASISAQSPPGTAVLRLRAHDPDQGSHGR 719
Fly 755 VSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRSNADAVVFLSIID 819
:||.|:|||...:|.:|..:|.:.|..| |:.|...:..|.|.|.|||.|::...|.|.:||:.
Human 720 LSYHILAGNSPPLFTLDEQSGLLTVAWP--LARRANSVVQLEIGAEDGGGLQAEPSARVDISIVP 782
Fly 820 AMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNI 884
....|||||:.:|.:.|.||:..||.|| ::.|.......:||..|:..|||.|.||::..||.:
Human 783 GTPTPPIFEQLQYVFSVPEDVAPGTSVG-IVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLL 846
Fly 885 RIAKPLDHEAKSQVL-LNIQATLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGA 948
:..:|||.|....|| |.::|..|.||.:...:|.:.::|||||:|.|.|....:.:|.:...|.
Human 847 QTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGT 911
Fly 949 PLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGV 1013
|:|...|.|.|||.:.:||::|: ..|.|.|.:|..:||:.|.:.|.......|.|.:.|.|||.
Human 912 PIYTLRALDPDSGVNSRVTFTLL-AGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGS 975
Fly 1014 PSLSTNLTILVDVQDVNDN--PPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIV 1076
|..:::..:.|.||||... .|.|....|.|::....:...|::||.|...|.| .|||.:.
Human 976 PPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGG---PITYHLA 1037
Fly 1077 DAGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKT---R 1138
..| .|..||:.|.|||:::||.||||.::.|.|.|:|..........:| .
Human 1038 AEG------------ASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTGTAT 1090
Fly 1139 VIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLPI---NSSFQ 1200
|.|.:|:.|::.|:..:......:.||...|:.||.|.|:|.|.|.|..:.|||..: :.:|:
Human 1091 VRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSLQQLSEDSKAFR 1155
Fly 1201 VHPVTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDV-- 1263
:||.|||::|.:.||||.:..|.|:|:.:|.|:|.||....|.:.|.|:|||:|.........
Human 1156 IHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLNDNSPTFLQASGAAGG 1220
Fly 1264 ---VSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGHGLFSIDPTSGVIRTRVVLDH 1325
:.|.:..||||.|..::|.|.|.|:|.:|.|::. ..|..|||:.|.||.:.|...|..
Human 1221 GLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT----GPGSELFSLHPHSGELLTAAPLIR 1281
Fly 1326 EERSIYRLGVAASDGGNPPRETVRMLRVEVL----------DLNDNRP--------TFTSSSLVF 1372
.||..|.|.::|.|.|:|||.....|.|:|| ||.:..| |.|::
Human 1282 AERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAA---- 1342
Fly 1373 RVREDAALGHVVGSISPIERPADVVRNSVEESFEDLRVTYTL----NPLTKDLIEAAFDIDRHSG 1433
|....|.::||::..| ||.|. .:|||| :| |..|.:|..||
Human 1343 ---EGLRPGSLLGSVAAPE-PAGVG-----------ALTYTLVGGADP------EGTFALDAASG 1386
Fly 1434 NLVVARLLDREVQSEFR-LEIRALDTTASNNPQSSAITVKIEVADVNDNAPEWPQDPIDLQVSEA 1497
.|.:||.||.|....:| |.:|| .......:..:.|:::|.|.|::||.:.:||:.|.:.|.
Human 1387 RLYLARPLDFEAGPPWRALTVRA---EGPGGAGARLLRVQVQVQDENEHAPAFARDPLALALPEN 1448
Fly 1498 TPVGTIIHNFTATDAD-TGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGALSLQAPLDFEA 1561
...|..::.|.|:||| .|.|.|::|||:| ||..:...|:|:.|||||....||.|.
Human 1449 PEPGAALYTFRASDADGPGPNSDVRYRLLR--------QEPPVPALRLDARTGALSAPRGLDRET 1505
Fly 1562 VQEYLLIVQALDQSSNVTERLQTSVTVRLRILDANDHAPHFVSPNSSGGKTASLFISDATRIGEV 1626
....||:|:|.|:.:|.:.|....|:.|:.:.|.||:||.|.|| :.:.:.:....|..
Human 1506 TPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASP-------SRVRLPEDQPPGPA 1563
Fly 1627 VAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKGGRFNLIIGAK 1691
..|:||.|.|.|:..:::|.:..| |:|.||::|.||.:.:|:.| |.|:.....|.:.|.
Human 1564 ALHVVARDPDLGEAARVSYRLASG-GDGHFRLHSSTGALSVVRPL-----DREQRAEHVLTVVAS 1622
Fly 1692 DHGQPEPKKSSLNLHLIVQGSHNNPPRFLQAVYRATILENVPSGSFVLQVTAKSLHGAENANLSY 1756
|||.| |:.::..|.:.|...::..|.|.|..|...:.||.|.|:.:|.:.|.......|..::|
Human 1623 DHGSP-PRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTY 1686
Fly 1757 EIPAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQSTLSSSAVRKQRSSDSIGD 1821
.||:::.|.:|...|::||....|||.|....|.||.:|......|:...||
Human 1687 ---GGVSSESFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVR---------- 1738
Fly 1822 TSNGQHFDVATIYITVGDVNDNSPEFRPGSCY-GLSVPENSEPGVIHTVVASDLDEGPNADLIYS 1885
:.|.|.||::|.| ||.: .|.|||..:|..:..:.|||.|.|.|..|.|.
Human 1739 -------------VAVEDENDHAPTF--GSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYR 1788
Fly 1886 ITGGNLGNKFSIDSSSGEL-SARPLDREQHSRYTLQIQASDRGQPKSRQGHCNITIFVEDQNDNA 1949
|..|:....|.:|.:|||. :.||||||....:.|:|:|.|.||| :......:|:.|.|.||:|
Human 1789 ILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQP-ALSATLLLTVTVLDANDHA 1852
Fly 1950 PRFKLSKYTGSVQEDAPLGTSVVQISAVDADLGVNARLVYSLANETQWQFAIDGQSGLITTVGKL 2014
|.|.:..|:..|.||.|.||.::|:.|.|.|.|.|..:.|.|...|...|.::..||.:.|...|
Human 1853 PAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTAAAL 1917
Fly 2015 DRELQASYNFMVLATDGGRYEVRSATVPVQINVLDINDNRPIFE------RYPYIGQVPALIQPG 2073
|||...||.|.|.|.||......|.||.|.|.|.|:||:.|.|. |.|..| |:...|.
Human 1918 DREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPG--PSFSTPT 1980
Fly 2074 QTLLKVQALDADLGANAEIVYSLNAENSAVSAKFRINPSTGALSASQSLASESGKLLHLEVVARD 2138
..|..::|.|.|.||||.|:|.|.......:. ::..||.:..::|..:...:...|.:||.|
Human 1981 LALATLRAEDRDAGANASILYRLAGTPPPGTT---VDSYTGEIRVARSPVALGPRDRVLFIVATD 2042
Fly 2139 KGNPPQSSLGLIEL-LIGEAPQGTPVLRFQNETYRVMLKENSPSGTRLLQVVALRSDGRRQKVQF 2202
.|.|.:|:.|:|.: |.|||.:|. ||...:....::||:|.||.::...|:.:.|....:.:
Human 2043 LGRPARSATGVIIVGLQGEAERGP---RFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITY 2104
Fly 2203 SFGAGNEDGILSLDSLSGEIRVNKPHLLDYDRFSTPSMSALSRGRALHYEEEIDESSEEDPNNST 2267
|..:|||.|..|:...:|.|.|.....||: |..|
Human 2105 SILSGNEKGTFSIQPSTGAITVRSAEGLDF---------------------------EVSP---- 2138
Fly 2268 RSQRALTSSSFALTNSQPNEIRVVLVARTADAPFLASYAELVIELEDENDNSPKFSQKQFVATVS 2332
.:|:||.|.:..| .::..|.:.|:|.|||:|:|.:..:||.:.
Human 2139 -------------------RLRLVLQAESGGA---FAFTVLTLTLQDANDNAPRFLRPHYVAFLP 2181
Fly 2333 EGNNKGTFVAQVHAFDSDAGSNARLRYHIVDGNHDNA-FVIEPAFSGIVRTNIVLDREIRDIYKL 2396
|.......:.||.|.|.|.||..::.|.:........ |.::|. :|.:.|..:|||||....:|
Human 2182 ESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPT-TGTITTTAILDREIWAETRL 2245
Fly 2397 KIIATDEGVPQMTGTATIRVQIVDVNDNQPTFPPNNLVTVSEATELGAVITSISANDVDTYPALT 2461
.::|||.|.|.:.|:||:.|.::|.|||:||.|....:.|||...||:.|..::.||||:.|.|.
Human 2246 VLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLW 2310
Fly 2462 YRLGAESTVDIENMSIFALDRYSGKLVLKRRLDYELQQEYELDVIASDAAHEARTVLTVRVNDEN 2526
|.|......| .|::.||.|::.|...||:|....|:|.::|.|..||.|..|||.|.|.|
Human 2311 YVLSPSGPQD-----PFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTVLVEDVN 2370
Fly 2527 DNAPVF---------LAQQPPAYFAILPAISEISESLSVDFDLLTVNATDADSEGNNSKVIYIIE 2582
||||.| |...||. ..:|:|:|||.|| |.|..:.|.:.
Human 2371 DNAPAFSQSLYQVMLLEHTPPG------------------SAILSVSATDRDS-GANGHISYHLA 2416
Fly 2583 PAQEGFSVHPSNGVVSVNMSRLQPAVSSSGDYFVRIIAKDAGKPALKSSTLLRVQANDNGSGRSQ 2647
...:||||.|:||.:...:..:......||...|.:.|:|.|.|...:...:.||..|.......
Human 2417 SPADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPS 2481
Fly 2648 FLQNQYRAQISEAAPLGSVVLQLGQDALDQS-------LAIIAGNEESAFELLQSKA-------- 2697
|..:.||..::|..|.||.:|.|.....|.| .:||:||....|:|....|
Human 2482 FTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGP 2546
Fly 2698 -------IVLVKPLDRERNDLYKLRLVLSHPHGPPLISSLNSSSGISVIITILDANDNFPIFDRS 2755
:||::|||.|....|.|.:..:....|| .||.:.|.:|:||.|||.|:|.|
Human 2547 GPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPP------QSSVVPVTVTVLDVNDNPPVFTR- 2604
Fly 2756 AKYEAEISELAPLRYSIAQLQAIDADQENTPNSEVVYDITSGNDEHMFTIDLVTGVLFVNNRLDY 2820
|.|...:.|..|:...:..::|.|||. .|:..|.:.::||:...:|.:|..:|.|.:.:.||.
Human 2605 ASYRVTVPEDTPVGAELLHVEASDADP--GPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDC 2667
Fly 2821 DSGAKSYELIIRACD---SHHQRPLCSLQPFRLELHDENDNEPKFPLTEYVHFLAENEPVGSSVF 2882
::.|: ::|:::|.| :|. :|.|..:|:.|.||:.|.|||......:|||:|.|:.|.
Human 2668 ETQAR-HQLVVQAADPAGAHF-----ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVT 2726
Fly 2883 RAHASDLDKGPFGQLNYSI---GPAPSDESSWKMFRVDSESGLVTSAFVFDYEQRQRYDMELLAS 2944
..||.|.|.|.||:|.||: ||.|....: |.::|.:|.:.:...||||..:.:.:.:.|:
Human 2727 TLHAIDGDAGAFGRLRYSLLEAGPGPEGREA---FALNSSTGELRARVPFDYEHTESFRLLVGAA 2788
Fly 2945 DMGGKKASVAVRVEIESRDEFTPQFTERTYRFVLPAAVALPQGYVVGQVTATDSDSGPDGRVVYQ 3009
|.|...|||.|.|.:...||:.|.|....:.|.:|.... :|:.:|.|.|||.|.|.||.|:|.
Human 2789 DAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGAR--RGHSLGHVQATDEDGGADGLVLYS 2851
Fly 3010 LSAPHSHFKVNRSSGAVLIKRKLKLDGDGDGNLYMDG-------RDISLVISASSGRHNSLSSMA 3067
|:....:|.:|:::||:.::...:..|.|.......| |::.|.:.|......|.| |
Human 2852 LATSSPYFGINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIARGPLPGSRS--A 2914
Fly 3068 VVEIALDPLAH------PGTNLASAGGSSSGSIGDWAIGLLVAFLLVLCAAAGIFLFIHMRSRKP 3126
.|.:.:| :.| |..||...| |:...:..::||..||.:...:..||||.
Human 2915 TVPVTVD-ITHTALGLAPDLNLLLVG----------AVAASLGVVVVLALAALVLGLVRARSRKA 2968
Fly 3127 RNAVKPHLATDNAGVGNTNSYVDPSAFDTIPIRGSISGGAAGAASGQFAPPKYDEIPPFGAHA-- 3189
..|..| .|...|.|.|::...|. .||. ||...|.
Human 2969 EAAPGP------------MSQAAPLASDSLQKLGR-------------EPPS----PPPSEHLYH 3004
Fly 3190 ------GSSGAATTSELSGS-EQSGSSGRGSAEDDGEDEEIRMINEGPLHHRNGGAGAGSDDGRI 3247
|..||.......|| :.|.|||||||| ..||:|||||||.| |:
Human 3005 QTLPSYGGPGAGGPYPRGGSLDPSHSSGRGSAE-AAEDDEIRMINEFP---------------RV 3053
Fly 3248 SDISVQNTQEYLARLGIVDHDPSGAGGGASSMAGSSHPMHLYHDDDATARSDITNLIYAKLNDVT 3312
:.: |||:|.......:..|.|..:.:... ....|..
Human 3054 ASV-------------------------ASSLAARGPDSGIQQDADGLSDTSCE----PPAPDTW 3089
Fly 3313 GAGSEIGSSADDAGTT----AGSIGTIGTAITHGHGVM-SSYGEVPVPVPVVVGGSNVGGSLSSI 3372
..|.:.|.....||.| .|...| .||...|.|:. :..|:...|.. |...|.|:|::|
Human 3090 YKGRKAGLLLPGAGATLYREEGPPAT-ATAFLGGCGLSPAPTGDYGFPAD---GKPCVAGALTAI 3150
Fly 3373 VHSEEELTGSYNWDYLLDWGPQYQPLAHVFSEIARLKDDTLSEHSGSGASSSAKSKHSSSHSSAG 3437
|..||||.|||||||||.|.||:||||.||:|||||||:.
Human 3151 VAGEEELRGSYNWDYLLSWCPQFQPLASVFTEIARLKDEA------------------------- 3190
Fly 3438 AGSVVLKPPPSAPPTHIPPPLLTNVA-PRAINLPMRLPPHLSLAPAHLP----RSPIGHEASGSF 3497
:|.|.||... ||||:|.|| |.|.::|.: |.:.:.|.|..| ||||.|| ||.
Human 3191 ------RPCPPAPRID-PPPLITAVAHPGAKSVPPK-PANTAAARAIFPPASHRSPISHE--GSL 3245
Fly 3498 STSSAMSPSFSPSLSPLATRSPSISPLGA--GP 3528
| |:||||||||||||||.|||.:||.|. ||
Human 3246 S-SAAMSPSFSPSLSPLAARSPVVSPFGVAQGP 3277
| 
