DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ds and PCDH11Y

DIOPT Version :10

Sequence 1:NP_523446.2 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:NP_116755.1 Gene:PCDH11Y / 83259 HGNCID:15813 Length:1340 Species:Homo sapiens


Alignment Length:1368 Identity:344/1368 - (25%)
Similarity:568/1368 - (41%) Gaps:242/1368 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 ILLAIVLLGSSQAASHDQERERKLEVFEGVAV-----DYQIGYIGDFGGIDSGPPYIIVAEAGVE 120
            :||..|:..|.....:...||   |:.|.|.:     |..:..|.: ..:.:...:.:|.:.|..
Human    44 VLLVCVVFHSGAQEKNYTIRE---EIPENVLIGNLLKDLNLSLIPN-KSLTTTMQFKLVYKTGDV 104

  Fly   121 TDLAIDRATGEI-RTKVKLDRE------TRASYSLVAIPLS------GRNIRVLVTVKDENDNAP 172
            ..:.|:..|||| .|..::|||      .|..:....:.::      .|.:::...::|.|||||
Human   105 PLIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAP 169

  Fly   173 TFPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIV-SGNVNDAFRLSSHRERDGVLYL 236
            .||.|.::|..|||:....|.||..|.|.|:.....|.|.:: |.|:   |.|......:|....
Human   170 LFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYELIKSQNI---FGLDVIETPEGDKMP 231

  Fly   237 DLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATV 301
            .|.:...||||....|.:.::..|||.|.......:.:::.|.|||.|:|.::....::||||.|
Human   232 QLIVQKELDREEKDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPV 296

  Fly   302 GTSVLQVYASDTDADENGLVEYAINRRQSD-KEQMFRIDPRTGAIYINKALDFETKELHELVVVA 365
            ||||.|::|:|.|..||..:.::.:...|: ..::|.::..||.|.|.:.||.|....|:|:|:|
Human   297 GTSVTQLHATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA 361

  Fly   366 KDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKI--SESAQPGEFVARISVHDPDSKT 428
            .|.|..|  ..|.|.:.|||||||.|:|::.::.:..:..:  ||:......:|.|:|.|.|:. 
Human   362 SDGGLMP--ARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDAD- 423

  Fly   429 EYANVNVT-LNGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFL 492
              .|..|| ....:..|.|....::.:|:.....||.|....|.:.::|.|.|.|||:.|..:|:
Human   424 --HNGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFI 486

  Fly   493 RITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQID 557
            ::.|.|||.|.|.|.....::.|...||..:::|.|.|.|.|.|:.:.|.|.  |:...: |.:|
Human   487 KVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLG--PDAPPE-FSLD 548

  Fly   558 PQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAE 622
            .:||::|....:|.|.|.....|::|:|.|||||:|..||.|:|.|.|||.|:|..:.|...|.|
Human   549 RRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPE 613

  Fly   623 NEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPV 687
            |.|....:..::.:|||.|.|:.|..:|   .....:|.:.|.:|.|......|.|::.||.|.|
Human   614 NLPRHGTVGLITVTDPDYGDNSAVTLSI---LDENDDFTIDSQTGVIRPNISFDREKQESYTFYV 675

  Fly   688 LATDRGGL--STTAMIKMQLTDVNDNRPVF----YPREYKVSLRESPKASSQASSTPIVAVVATD 746
            .|.|.|.:  |::|.:.:.:.|||||:|||    |...|::.|      .|....|.:..|:|.|
Human   676 KAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVL------PSTNPGTVVFQVIAVD 734

  Fly   747 PDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRSNADA 811
            .|.|...:|.|.||.||...:|.||:.||.|.::  :...|....:|.:.:.|.|.|        
Human   735 NDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLM--EKCDVTDLGLHRVLVKANDLG-------- 789

  Fly   812 VVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFS 876
                      |...:|.....|.:|.|.:...|::..::..|.:.........:..|.....|..
Human   790 ----------QPDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPVTPNTEIADVSSPTSDYVK 844

  Fly   877 I--ETNSGNIRIAKPLDHEAKSQVLLNIQATL--GEPPVYGHTQVNIEVEDVNDNAPEFEASMVR 937
            |  ...:|.|.:.          |::.|.|.:  .:.|.....|.|::..:.....|| ...|:.
Human   845 ILVAAVAGTITVV----------VVIFITAVVRCRQAPHLKAAQKNMQNSEWATPNPE-NRQMIM 898

  Fly   938 ISVPESAELGAP---------LYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQH 993
            :...:..:..:|         :....|.|.|| ...:||..|         .||           
Human   899 MKKKKKKKKHSPKNLLLNVVTIEETKADDVDS-DGNRVTLDL---------PID----------- 942

  Fly   994 LDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQDV-----NDNP-PVFE-KDEYSVNVSESRSI 1051
            |:.::..::..:.|.|           |...|..|:     :.:| |.|: :.|..:|:..    
Human   943 LEEQTMGKYNWVTTPT-----------TFKPDSPDLARHYKSASPQPAFQIQPETPLNLKH---- 992

  Fly  1052 NAQIIQVNASDLDTGNNARITYRIVDAGVDNVTN-SISSSD-----------------VSQHFGI 1098
              .|||    :|...|    |:    ...|:::| |.||||                 ||.|  .
Human   993 --HIIQ----ELPLDN----TF----VACDSISNCSSSSSDPYSVSDCGYPVTTFEVPVSVH--T 1041

  Fly  1099 FPNSGWIYLRAP-------LDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLDAN------DND 1150
            .|:...:....|       .|....|....::.:|.:|.|..:.:.....|...:|      ::|
Human  1042 RPSQRRVTFHLPEGSQESSSDGGLGDHDAGSLTSTSHGLPLGYPQEEYFDRATPSNRTEGDGNSD 1106

  Fly  1151 PK---FQKSKYEFRIEENLRRGS--------VVGVVTA----SDLDLGENAAIRYSLL----PIN 1196
            |:   ....|.|..::..:...|        :.|...|    :.||...::..:.|.|    |::
Human  1107 PESTFIPGLKKEITVQPTVEEASDNCTQECLIYGHSDACWMPASLDHSSSSQAQASALCHSPPLS 1171

  Fly  1197 SSFQVH---PVTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIA- 1257
            .:...|   |||..|               ::..:......:.....|..|.||.::.:.|.:. 
Human  1172 QASTQHHSPPVTQTI---------------VLCHSPPVTQTIALCHSPPPIQVSALHHSPPLVQG 1221

  Fly  1258 -----DPQEDVVSVREEQPP---------GTEVVRVRAVDRDHGQNASITYSIVKGRDSDGHGLF 1308
                 .|.....|.....||         .:.:.:|.|:.|...|:   :.|:.:|.....:||.
Human  1222 TALHHSPPSAQASALCYSPPLAQAAAISHSSSLPQVIALHRSQAQS---SVSLQQGWVQGANGLC 1283

  Fly  1309 SID 1311
            |:|
Human  1284 SVD 1286

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_523446.2 CA 111..172 CDD:214520 17/73 (23%)
Cadherin_repeat 178..282 CDD:206637 29/104 (28%)
Cadherin_repeat 291..389 CDD:206637 38/98 (39%)
Cadherin_repeat 406..500 CDD:206637 27/96 (28%)
Cadherin_repeat 509..607 CDD:206637 35/97 (36%)
Cadherin_repeat 616..711 CDD:206637 30/96 (31%)
Cadherin_repeat 719..820 CDD:206637 26/100 (26%)
Cadherin_repeat 832..927 CDD:206637 16/98 (16%)
Cadherin_repeat 937..1032 CDD:206637 16/108 (15%)
Cadherin_repeat 1040..1149 CDD:206637 27/139 (19%)
Cadherin_repeat 1158..1252 CDD:206637 18/112 (16%)
Cadherin_repeat 1263..1361 CDD:206637 13/58 (22%)
Cadherin_repeat 1369..1481 CDD:206637
Cadherin_repeat 1489..1598 CDD:206637
Cadherin_repeat 1614..1710 CDD:206637
Cadherin_repeat 1723..1843 CDD:206637
Cadherin_repeat 1853..1948 CDD:206637
Cadherin_repeat 1957..2053 CDD:206637
Cadherin_repeat 2061..2154 CDD:206637
CA_like 2171..>2232 CDD:481204
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
PCDH11YNP_116755.1 Cadherin_2 60..134 CDD:462413 18/77 (23%)
Cadherin_repeat 175..277 CDD:206637 29/104 (28%)
Cadherin_repeat 285..383 CDD:206637 38/99 (38%)
CA 416..496 CDD:214520 25/82 (30%)
Cadherin_repeat 504..598 CDD:206637 35/96 (36%)
Cadherin_repeat 606..701 CDD:206637 30/97 (31%)
Cadherin_repeat 713..804 CDD:206637 29/116 (25%)
Protocadherin 807..1008 CDD:462451 43/261 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1052..1112 10/59 (17%)
FAM47 <1180..1247 CDD:405345 13/81 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1321..1340
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.