DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and Pcdh18

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_006500852.1	Gene:	Pcdh18 / 73173	MGIID:	1920423	Length:	1135	Species:	Mus musculus

Alignment Length:	1178	Identity:	288/1178 - (24%)
Similarity:	456/1178 - (38%)	Gaps:	297/1178 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   751 NFGQVSYRIVAGNEAGIFRIDRSTGEIFV-----------------VRPDMLSVRTQPMHMLNIS 798
            |...|.:|.:....:.:..::.:||||.:                 :..|:|::.|:.:.:.:|.
Mouse    60 NPSAVRFRAMPRGNSPLLVVNENTGEISIGAKIDREQLCQKNLNCSIEFDVLTLPTEHLQLFHIE 124

  Fly   799 ATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAASGDVAHRSPVR 863
                            :.::|.....|.|.:......:.|....||.:....|...||...|...
Mouse   125 ----------------VDVLDINDNSPQFSRPVIPIEISESAAVGTRIPLDSAFDPDVGENSLHT 173

  Fly   864 YSIYSGDPDGYFSIETNS-------GNIRIAKPLDHEAKSQVLLNIQAT-LGEPPVYGHTQVNIE 920
            ||:.:.|   ||:||..:       ..:.:.|.||.|.|:...|.:.|: :|.|...|.:.:.|.
Mouse   174 YSLSAND---YFNIEVRTRTDGAKYAELIVVKELDRELKASYELQLTASDMGVPQRSGSSILKIS 235

  Fly   921 VEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGL---FAID 982
            :.|.|||:|.||.....|.:.|::.:|..|...:|.|.|.|::|::.||........:   |.||
Mouse   236 ISDSNDNSPAFEQPSYTIQLLENSPVGTLLLDLNATDPDEGANGRIVYSFSSHVSPKIIETFKID 300

  Fly   983 ARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNPPVFEKDEYSVN--- 1044
            :..|||.|.:.:|||.::.:.:.|.|.|.|..|:..:..|::.|.|||||.|     |.|:|
Mouse   301 SEKGHLTLFKPVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKP-----EISINLMS 360

  Fly  1045 --------VSESRSINAQIIQVNASDLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGI--- 1098
                    |.|...|:..:..|...|.|:|.|..|..::...|               ||.:
Mouse   361 PGKEEVSYVFEGDPIDTFVAIVRVQDKDSGLNGEIICKLHGHG---------------HFKLQKT 410

  Fly  1099 FPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIE 1163
            :.|:..|...|.||||.|..|.|||:|.|.|||:..:.....|::.|.|||.|:||:|:|||.|.
Mouse   411 YENNYLILTNATLDREKRSEYSLTVIAEDKGTPSLSSVRHFTVQINDINDNPPRFQRSRYEFVIS 475

  Fly  1164 ENLRRGSVVGVVTASDLDLGENAAIRYSLL-------PINSSFQVHPVTGEISTREPLDRELREL 1221
            ||...|:.:..|||:|.|||||..:.|::|       .|.:...:.|..|.|......|.|....
Mouse   476 ENNSPGAYITTVTATDPDLGENGHVTYTILESFVLGSSITTYVTIDPSNGAIYALRIFDHEEVSQ 540

  Fly  1222 YDLVVEARDQGTPVR-SARVPVRIHVSDVNDNAPEIADP----QEDVVSVREEQPPGTEVVRVRA 1281
            ...||||||.|:..: |:...|.:.:.|.|||.|.:..|    ....:|:.:....|..|.|:|.
Mouse   541 ITFVVEARDGGSQKQLSSNTTVVLTIIDENDNVPVVIGPAMHNNTAEISIPKGAESGFHVTRIRV 605

  Fly  1282 VDRDHGQNASITYSIVKGRDSDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRE 1346
            ||||.|.||..:.|||.|.:.:   :|.:||.|..|.|.|.::....:.:.|.|...|.|:||..
Mouse   606 VDRDSGANAEFSCSIVSGNEEN---IFIMDPRSCDIHTNVSMESIPSAEWALSVIIQDKGSPPLH 667

  Fly  1347 TVRMLRVEVLDLNDNRPTFTSSSLVFRVREDAALGHVV--GSISPIERPADVV------RNSVEE 1403
            |..:||..|.|..:: .|.|:.:.|.|...|.::..::  |:|..:.....|:      |...:.
Mouse   668 TKVLLRCMVFDYAES-VTSTAMTSVSRASLDVSMIIIISLGAICAVLLVIMVLFATRCNREKKDT 731

  Fly  1404 SFEDLRV---TYTLNPL--TKDLIEAAFDIDRHSGNLVVARLLD--REVQSEFR--------LEI 1453
            ...:.||   ||..:|.  ::.:         |.|::.:...::  ..::|..|        ||.
Mouse   732 RSYNCRVAESTYQHHPKRPSRQI---------HKGDITLVPTINGTLPIRSHHRSSPSSSPTLER 787

  Fly  1454 RALDTTASNNPQ---SSAITVKIEVADVNDNAPEWPQDPIDLQVSEATP-------VGTIIH--- 1505
            ..:.:..|:|..   :|.:|:.      :::.||    ...|:::.|||       :.:::|
Mouse   788 GQMGSRQSHNSHQSLNSLVTIS------SNHVPE----NFSLELTHATPAVEQVSQLLSMLHQGQ 842

  Fly  1506 ------------------------NFTATDADTGTN--GDLQYRLIRYFPQLNESQEQAMSLFRM 1544
                                    .|:..|:..|.:  ||..|.|.|..|......|....||..
Mouse   843 YQPRPSFRGNKYSRSYRYALQDMDKFSLKDSGRGDSEAGDSDYDLGRDSPIDRLLGEGFSDLFLT 907

  Fly  1545 DS-LTGALSL---------------QAPL----------------DFEAVQEYLLIVQALDQSSN 1577
            |. :..|:.|               ..||                :|.|..:.....|.||..|.
Mouse   908 DGRIPAAMRLCTEECRVLGHSDQCWMPPLPSPSSDYRSNMFIPGEEFPAQPQQQHSHQGLDDDSQ 972

  Fly  1578 VTERLQTSVTVRLRILDANDHAPHFVSPNSSGGKTASLFISDATRIGEVVAHIVAVDEDSGDN-- 1640
            ..|                         |....|:.|.|..|:..           ||||||:
Mouse   973 PAE-------------------------NGEKKKSFSTFGKDSPS-----------DEDSGDSST 1001

  Fly  1641 GQLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDV----EKGGRFNLIIGAKDHGQPEPKKS 1701
            ..|..|::                 .:.:.|.||:.|.    .:|.|.|.:         |.:|.
Mouse  1002 SSLLSEMS-----------------SVFQRLLPASLDTFSECNEGDRSNSL---------ERRKG 1040

  Fly  1702 SLNLHLIVQGSHNNPPRFLQAVYRATILENVPSGSFV-------LQVTAKSLHGAENANLSYEIP 1759
            .      .||.....|:.:.|...:|..:|..|.|..       :|.::|.|...|      |||
Mouse  1041 P------AQGKTGGYPQGVAAWAASTHFQNPTSSSGTPLGTHSSVQPSSKWLPAME------EIP 1093

  Fly  1760 AGVANDLF 1767
            .....|.|
Mouse  1094 ENYEEDDF 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637	11/85 (13%)
		Cadherin_repeat	832..927	CDD:206637	27/102 (26%)
		Cadherin_repeat	937..1032	CDD:206637	31/97 (32%)
		Cadherin_repeat	1040..1149	CDD:206637	35/122 (29%)
		Cadherin_repeat	1158..1252	CDD:206637	35/101 (35%)
		Cadherin_repeat	1263..1361	CDD:206637	34/97 (35%)
		Cadherin_repeat	1369..1481	CDD:206637	22/137 (16%)
		Cadherin_repeat	1489..1598	CDD:206637	29/176 (16%)
		Cadherin_repeat	1614..1710	CDD:206637	20/101 (20%)
		Cadherin_repeat	1723..1843	CDD:206637	13/52 (25%)
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdh18	XP_006500852.1	Cadherin_2	32..111	CDD:369785	8/50 (16%)
		Cadherin_repeat	141..242	CDD:206637	27/103 (26%)
		Cadherin_repeat	250..350	CDD:206637	31/99 (31%)
		Cadherin_repeat	368..461	CDD:206637	32/107 (30%)
		Cadherin_repeat	470..572	CDD:206637	35/101 (35%)
		Cadherin_repeat	587..678	CDD:206637	33/93 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10386
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000