Protein Alignment ds and PCDH15

DIOPT Version :10

• Sequence 1: NP_523446.2
• Gene: ds / 33245
• FlyBaseID: FBgn0284247
• Length: 3556
• Species: Drosophila melanogaster
• Sequence 2: NP_001136235.1
• Gene: PCDH15 / 65217
• HGNCID: 14674
• Length: 1962
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 90/472 - (19%)
• Similarity: 148/472 - (31%)
• Gaps: 207/472 - (43%)

  Fly    63 TLSRLVDALATDDGELEST-FV-NVFLNTFRTFAQPEKVLELLLDRYEK------------LHAE 113
            ||:.|...|..|....|.. |: :||         .||.|..|:..:||            ||:.
Human    13 TLALLTSQLRPDSNHREEMGFLRDVF---------SEKSLSYLMKIHEKLRYYERQSPTPVLHSA 68

  Fly   114 PALLQPESLSDQHKKTLVSVLHVWLDGFPEDWDTDNLQRLLAFTSKRLPKSEIHMKA--LNRFTH 176
            .||.:     |..::...:.:|.         |...|.:||         |..|::|  :...|.
Human    69 MALAE-----DVMEELQAASVHS---------DERELLQLL---------STPHLRAVLMVHDTV 110

  Fly   177 RLDKYSRIPPPLPWSNDYHDFADQFGGLCLTPAFRGPPSHLLNSYRFPNIPVKHFAEQLTRMDME 241
            ....:..:.||||.:.|                                   :.|.|:..:: :.
Human   111 AQKNFDPVLPPLPDNID-----------------------------------EDFEEESVKI-VR 139

  Fly   242 LFKRLIPHQCLGAIWSNRDKHECSSVLATVTQFNAVSFRVISSILIEPRLKPQERALLISTWIDI 306
            |.|...|   |||. ..||:|..:.|:|.:.:..|.                 :|:.|    :.:
Human   140 LVKNKEP---LGAT-IRRDEHSGAVVVARIMRGGAA-----------------DRSGL----VHV 179

  Fly   307 AQELRLLKNFSSLKAIISGLQSNAVYRLSKTWAVLPRDKLELYNELARIFSEDNNAWAQREVLMR 371
            ..|||               :.|.:       |||.:..    :|:::|.::...:.
Human   180 GDELR---------------EVNGI-------AVLHKRP----DEISQILAQSQGSI-------- 210

  Fly   372 EGTAKFADTVGENDRHL-QKVFQKQNTLISHGTIPYLGTFLTDLTMIH------AAIPDTLQDGL 429
              |.|......|.||.. .|||.:                    .:.|      .|||  .|:..
Human   211 --TLKIIPATQEEDRFKDSKVFMR--------------------ALFHYDPREDRAIP--CQEAG 251

  Fly   430 INFDKRRKEFEVLAQIKLLQGAANTYHLPDDPLFDRWFASLLVLD---------------EREAH 479
            :.| :||:..||::|              |||   .|:.:..|.|               .|.::
Human   252 LPF-QRRQVLEVVSQ--------------DDP---TWWQAKRVGDTNLRAGLIPSKQFQERRLSY 298

  Fly   480 TLSCSLEPAPEMTKRPP 496
            ..:....|:|:..|:||
Human   299 RRTTGTLPSPQNFKKPP 315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_523446.2	CA	111..172	CDD:214520	12/62 (19%)
		Cadherin_repeat	178..282	CDD:206637	19/103 (18%)
		Cadherin_repeat	291..389	CDD:206637	16/98 (16%)
		Cadherin_repeat	406..500	CDD:206637	23/112 (21%)
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		CA_like	2171..>2232	CDD:481204
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
PCDH15	NP_001136235.1	ECD	36..145	CDD:408229	31/176 (18%)
		Cadherin_repeat	156..245	CDD:206637	24/165 (15%)
		CA	310..398	CDD:214520	3/6 (50%)
		Cadherin_repeat	404..510	CDD:206637
		Cadherin_repeat	518..614	CDD:206637
		Cadherin_repeat	626..718	CDD:206637
		Cadherin_repeat	727..820	CDD:206637
		Cadherin_repeat	828..926	CDD:206637
		Cadherin_repeat	935..1032	CDD:206637
		Cadherin_repeat	1050..1145	CDD:206637
		Cadherin_repeat	1154..1248	CDD:206637
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1431..1451
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1608..1630
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1752..1773
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1935..1962