Protein Alignment ds and pcdh18b

DIOPT Version :10

• Sequence 1: NP_523446.2
• Gene: ds / 33245
• FlyBaseID: FBgn0284247
• Length: 3556
• Species: Drosophila melanogaster
• Sequence 2: XP_005157386.2
• Gene: pcdh18b / 562031
• ZFINID: ZDB-GENE-080804-1
• Length: 1161
• Species: Danio rerio
• Alignment Length: 1113
• Identity: 289/1113 - (25%)
• Similarity: 441/1113 - (39%)
• Gaps: 247/1113 - (22%)

  Fly    62 LLAIVLLGSSQAASHD-QERERKLEVFEGVAVDYQIGYI-----GDFGGI-----DSGPPYIIVA 115
            ||.::||.   |.:|: ..:..|.:|.|    :.::|.:     .|..|:     .|..|.....
Zfish    18 LLKLMLLA---AVAHNVSGKTLKYKVLE----EQRVGTVIARLKEDVAGLLAKLPSSVSPRFRAM 75

  Fly   116 EAGVETDLAIDRATGEIRTKVKLDRE--------TRASYSLVAIPLSGRNI-RVLVTVKDENDNA 171
            :.|....|::....|||....|:|||        ....:.::.||.....: .:.|.|.|.||||
Zfish    76 QRGSTPLLSVREEDGEISIATKIDREKLCEKNLNCTIEFDVITIPTEYLQLFHIQVEVLDINDNA 140

  Fly   172 PTFPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYL 236
            |.|.:..:.||..|:.....:..|..|.|.|:.......|::..   |:.|::......||..|.
Zfish   141 PQFSRAIIPIEISESASVGTRFPLDSAVDPDVGENALHTYSLTR---NNFFKIDIRTRTDGAKYA 202

  Fly   237 DLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATV 301
            ||.:...|||||...|.|.:.|.|.|.||..|...:.|:|.|.|||.|.|::..|...:.||:::
Zfish   203 DLVVMRELDRETQSSYQLQLTASDSGVPPKSGSTLLKISISDSNDNSPAFDEQAYVVNLLENSSL 267

  Fly   302 GTSVLQVYASDTDADENGLVEYAINRRQSDK-EQMFRIDPRTGAIYINKALDFETKELHELVVVA 365
            ||.::.:.|:|.|...||.:.|:.:.....| .:.|:|:|..|.|.:.|.:|:||...:|:.|.|
Zfish   268 GTLLVDLNATDPDEGNNGKIVYSFSSHVPPKILETFKINPDNGHITLIKKVDYETTSSYEIDVQA 332

  Fly   366 KDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSD--DASPKISESAQPGEFVARISVHDPDSKT 428
            :|.|...:.....:.|:|.|||||:|.||:..::.  :....|||::....|:|.:.|.|.||
Zfish   333 QDMGPNSIPGHCKIIIKVVDVNDNKPKININLMTQGKEEVAYISEASPVDTFIALVRVDDSDS-- 395

  Fly   429 EYANVNVTLNG-------GDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHA 486
                   .:||       |.|||.|.....:.|:::.::.||||..|.|:|:|:|.|:|||.|..
Zfish   396 -------GINGEVVCRLHGHGHFRLQKTYENNYMILTNVSLDREKRSEYSLTVIAEDRGTPSLST 453

  Fly   487 SKSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETP---E 548
            .|...:::.|.|||||.||:..|.....|...||..:..|:|.|.|.|.|..:|||:.|:.   .
Zfish   454 IKHFTVQVQDENDNPPRFEKSRYEIFKSENNSPGAYLTSVVATDPDLGPNGQVTYSIVESQVQGS 518

  Fly   549 THAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPP-LSSTATVLVTIHDVNDNEPIFD 612
            :.:.:..|||..|.:......|.|.......||.|||||.|. |||..|||:||.|.|||.||..
Zfish   519 SISTYVTIDPSNGAVYALRSFDREEVGRLSFTVQARDGGSPAFLSSNTTVLLTILDENDNPPIIV 583

  Fly   613 QSFYNVSVAE-----NEPVGRCILKVSASDPDCGVNAMVNYTI----GEGFKHLTEFEVRSASGE 668
            ....:...||     :...|..:..:.|:|.|.|.|:.:..:|    .||.     |.:.....|
Zfish   584 APLLSNHTAEVPLWRHAESGHLVTIIKATDRDAGANSELTCSIVGGNDEGL-----FVIDPRRCE 643

  Fly   669 ICIAGELDFERRSSYEFPVLATDRGG---LSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKA 730
            :...|.::...|..::..:|..|||.   ||..|::.:.|.|        ||..|  ||..|...
Zfish   644 LRTNGSVEASGREGFDLAILVQDRGASIRLSARAVLHISLRD--------YPESY--SLNPSDIN 698

  Fly   731 SSQASSTPIVAVVA-----------------------TDPDYGNFGQVSYRIVAGNEAGIFRIDR 772
            :.......::.:::                       .||.:      ||..         |:..
Zfish   699 NQSPLDVSMIIIISLGAICGVLLIVMVMFATRCSREQKDPRH------SYNC---------RVAE 748

  Fly   773 ST--------------GEIFVVRPDM---LSVRTQPMHMLNISATD---GGNLRSNADAVVFLS- 816
            ||              |:|.:| |.:   |.||..|.......|.:   ..:.|.:.:::|.:|
Zfish   749 STYQNHPKKPARQIHKGDITLV-PTINGTLPVRAHPRSPSASPAPESRQSHHSRQSLNSLVTISS 812

  Fly   817 --------IIDAMQRPP---------IFEKARYNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRY 864
                    :..|...||         |..:.:|.       ||.:..|:....|...|.....::
Zfish   813 NHVPENFALELAHATPPVEQVSQLLSILHQGQYQ-------PRPSFRGNKYTRSYRYALNEMDKF 870

  Fly   865 SI--------YSGDPD------------GYFSIETNSGNIRI---------------------AK 888
            |:        .:||.|            |:..:.|..|:.|:                     ..
Zfish   871 SLKDSGRGDSEAGDSDCEMGRESPLLGEGFSELFTPDGHHRLHPTMKLCTEECRVLGHSDQCWMP 935

  Fly   889 PLDHEAKSQVLLNIQATLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAE--LGAPLY 951
            ||...|.|....|:... ||.|....|             ||         ||:|.|  |....:
Zfish   936 PLPSPASSDYRSNLYIP-GEDPQQKAT-------------PE---------VPQSGESTLRKKSF 977

  Fly   952 AAHAHDKDSGSSGQV--------TYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTA 1008
            :....:.:.| .|:.        |.||:.|. ..:|       ..:|...||..|....|...||
Zfish   978 STFGKESEEG-EGEADDGEDLCGTTSLLSEM-NSVF-------QRLLPSSLDNYSETNETEKATA 1033

  Fly  1009 TDGGVPSL 1016
            ...||.||
Zfish  1034 CAAGVGSL 1041

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_523446.2	CA	111..172	CDD:214520	17/69 (25%)
		Cadherin_repeat	178..282	CDD:206637	32/103 (31%)
		Cadherin_repeat	291..389	CDD:206637	31/98 (32%)
		Cadherin_repeat	406..500	CDD:206637	34/100 (34%)
		Cadherin_repeat	509..607	CDD:206637	38/101 (38%)
		Cadherin_repeat	616..711	CDD:206637	24/106 (23%)
		Cadherin_repeat	719..820	CDD:206637	23/152 (15%)
		Cadherin_repeat	832..927	CDD:206637	23/135 (17%)
		Cadherin_repeat	937..1032	CDD:206637	23/90 (26%)
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		CA_like	2171..>2232	CDD:481204
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdh18b	XP_005157386.2	None