DRSC/TRiP Functional Genomics Resources

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Protein Alignment ds and PCDHB6

DIOPT Version :10

Sequence 1:NP_523446.2 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:NP_061762.2 Gene:PCDHB6 / 56130 HGNCID:8691 Length:794 Species:Homo sapiens


Alignment Length:754 Identity:226/754 - (29%)
Similarity:314/754 - (41%) Gaps:188/754 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 GVETDLAIDRATGEIRTKVKLDRETRASYS---------LVAIPLSGRNIRVLVTVKDENDNAPT 173
            |....|..|..|.::....|||||.....:         |:..||  :..:..:.|:|.||:||.
Human    69 GNRQHLQFDPQTHDLLLNEKLDREELCGSTEPCVLPFQVLLENPL--QFFQASLRVRDINDHAPE 131

  Fly   174 FPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDL 238
            ||...|.::..|.|.......|..|.|||......|||.|.|   |..|.:.:....:|..:.:|
Human   132 FPAREMLLKISEITMPGKIFPLKMAHDLDTGSNGLQRYTISS---NPHFHVLTRNRSEGRKFPEL 193

  Fly   239 QISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGT 303
            .:...||||..|...|.:.|||||:||..|...:.|.:.|:|||.|.|.|..|.|.||||..:|:
Human   194 VLDKPLDREEQPQLRLTLIALDGGSPPRSGTSEIQIQVLDINDNVPEFAQELYEAQVPENNPLGS 258

  Fly   304 SVLQVYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDH 368
            .|:.|.|.|.||...|.|.||: .:..|..|.|.|:..||.|.:.||||||..:.:::.|.|.|.
Human   259 LVITVSARDLDAGSFGKVSYAL-FQVDDVNQPFEINAITGEIRLRKALDFEEIQSYDVDVEATDG 322

  Fly   369 GEQPLETTAFVSIRVTDVNDNQPTINVIF---LSDDASPKISESAQPGEFVARISVHDPDSKTEY 430
            |  .|.....:.:||.|||||.|.:.:.|   |..:..|:|:        ||..||.|.||    
Human   323 G--GLSGKCSLVVRVLDVNDNAPELTMSFFISLIPENLPEIT--------VAVFSVSDADS---- 373

  Fly   431 ANVNVTLNGGDGH-------------FALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTP 482
                       ||             |.|.....:.|.::....||||..:.|.:::..||.|||
Human   374 -----------GHNQQVICSIENNLPFLLRPSVENFYTLVTEGALDRESRAEYNITITVTDLGTP 427

  Fly   483 PLHASKSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETP 547
            .|...:||.::::|||||.|.|.|..|...|.|...|...:..|.|.|||.|:|:.:||||    
Human   428 RLKTQQSITVQVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGINAQVTYSL---- 488

  Fly   548 ETHAQWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFD 612
                    :.||.                |.|          ||||    ||:|:          
Human   489 --------LPPQD----------------PHL----------PLSS----LVSIN---------- 505

  Fly   613 QSFYNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDF 677
                    |:|                               .||  |.:||          ||:
Human   506 --------ADN-------------------------------GHL--FALRS----------LDY 519

  Fly   678 ERRSSYEFPVLATDRG--GLSTTAMIKMQLTDVNDNRP-VFYPREYKVSLRESPKASSQASSTPI 739
            |...|:||.|.|||||  .||:.|::::.:.|.|||.| |.||.:           :..|..|.:
Human   520 EALQSFEFRVGATDRGSPALSSEALVRLLVLDANDNSPFVLYPLQ-----------NGSAPCTEL 573

  Fly   740 V-----------AVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMH 793
            |           .|||.|.|.|....:||:::...|.|:|.:....||:...|  :||.|....|
Human   574 VPRAAEPGYLVTKVVAVDGDSGQNAWLSYQLLKATELGLFGVWAHNGEVRTAR--LLSERDAAKH 636

  Fly   794 MLNISATDGGNLRSNADAVVFLSIIDAMQRP--PIFEKA 830
            .|.:...|.|....:|.|.:.:.::|...:|  |:.|.|
Human   637 RLVVLVKDNGEPPRSATATLHVLLVDGFSQPYLPLPEAA 675

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_523446.2 CA 111..172 CDD:214520 16/62 (26%)
Cadherin_repeat 178..282 CDD:206637 34/103 (33%)
Cadherin_repeat 291..389 CDD:206637 40/97 (41%)
Cadherin_repeat 406..500 CDD:206637 29/106 (27%)
Cadherin_repeat 509..607 CDD:206637 26/97 (27%)
Cadherin_repeat 616..711 CDD:206637 24/96 (25%)
Cadherin_repeat 719..820 CDD:206637 26/111 (23%)
Cadherin_repeat 832..927 CDD:206637
Cadherin_repeat 937..1032 CDD:206637
Cadherin_repeat 1040..1149 CDD:206637
Cadherin_repeat 1158..1252 CDD:206637
Cadherin_repeat 1263..1361 CDD:206637
Cadherin_repeat 1369..1481 CDD:206637
Cadherin_repeat 1489..1598 CDD:206637
Cadherin_repeat 1614..1710 CDD:206637
Cadherin_repeat 1723..1843 CDD:206637
Cadherin_repeat 1853..1948 CDD:206637
Cadherin_repeat 1957..2053 CDD:206637
Cadherin_repeat 2061..2154 CDD:206637
CA_like 2171..>2232 CDD:481204
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
PCDHB6NP_061762.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 773..794
Cadherin_2 29..111 CDD:462413 10/41 (24%)
Cadherin_repeat 139..237 CDD:206637 33/100 (33%)
Cadherin_repeat 246..341 CDD:206637 40/97 (41%)
Cadherin_repeat 354..445 CDD:206637 30/113 (27%)
Cadherin_repeat 453..555 CDD:206637 50/204 (25%)
Cadherin_repeat 574..662 CDD:206637 24/89 (27%)
Cadherin_C_2 683..766 CDD:465139
Blue background indicates that the domain is not in the aligned region.

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