Protein Alignment ds and PCDHB9

DIOPT Version :10

• Sequence 1: NP_523446.2
• Gene: ds / 33245
• FlyBaseID: FBgn0284247
• Length: 3556
• Species: Drosophila melanogaster
• Sequence 2: NP_061992.3
• Gene: PCDHB9 / 56127
• HGNCID: 8694
• Length: 797
• Species: Homo sapiens
• Alignment Length: 742
• Identity: 213/742 - (28%)
• Similarity: 318/742 - (42%)
• Gaps: 173/742 - (23%)

  Fly   123 LAIDRATGEIRTKVKLDRETRAS-------YSLVAIPLSGRNIRVLVTVKDENDNAPTFPQTSMH 180
            |.:|..||.:.|..|||||....       |..:.:....:..|..:.|:|.||::|.|....|.
Human    75 LLLDSHTGNLLTNEKLDREKLCGPKEPCMLYFQILMDDPFQIYRAELRVRDINDHSPVFRHKEMV 139

  Fly   181 IEFPENTPREVKRTLLPARDLDLEPYNT-QRYNIVSGNVNDAFRLSSHRERDGVLYLDLQISGFL 244
            ::..|||.......|..|:|.| |.:|: |.|.|.|   |..|.:......:|::|.:|.:...|
Human   140 LKISENTAEGTAFRLERAQDPD-EGHNSIQNYTISS---NSFFHIKISGSDEGMIYPELVLDKAL 200

  Fly   245 DRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVLQVY 309
            |||.....||.:.|||||:|...|..|:.|.:.|||||.|.|.|:.|....|||:.||:.:::|.
Human   201 DREEQEELSLTLTALDGGSPSRSGTSTIRIVVLDVNDNVPQFAQALYETQAPENSPVGSLIVKVS 265

  Fly   310 ASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPLE 374
            |.|.|:..|..|.|:......|....|:|:|.:|.|::.:.||:|....:::.:.|.|.|  .|.
Human   266 AGDADSGVNAEVSYSFFDASEDILTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGG--GLS 328

  Fly   375 TTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVTLNG 439
            ....|.|:|.|.|||.|.:.:..||:    .::|:: ||..:|...:.|.||            |
Human   329 ARCTVLIKVLDSNDNPPELIISSLSN----SVAENS-PGIVLAVFKIKDRDS------------G 376

  Fly   440 GDGHFALTTRDN----------SIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRI 494
            .:|......:||          :.|:::....||||..:.|.:::..||.|||.|....||.|::
Human   377 ENGKTICYVQDNLPFFLKPSVDNFYILMTEGALDRESKAEYNITITVTDLGTPRLKTEHSITLQV 441

  Fly   495 TDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQ 559
            :|||||.|.|.|..|...|.|...|...:..|.|.|||.|.|:.:||||            :.||
Human   442 SDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRDSGTNAQVTYSL------------LPPQ 494

  Fly   560 TGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAENE 624
            .                |.|          ||:|    ||:|:                  |:|
Human   495 D----------------PHL----------PLAS----LVSIN------------------ADN- 510

  Fly   625 PVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPVLA 689
                                          .||  |.:||          ||:|...:::|.|.|
Human   511 ------------------------------GHL--FALRS----------LDYEALQAFDFRVGA 533

  Fly   690 TDRG--GLSTTAMIKMQLTDVNDNRP-VFYPREYKVSLRESPKASSQASSTPIV----------- 740
            :|||  .||:.|::::.:.|.|||.| |.||.:           :..|..|.:|
Human   534 SDRGSPALSSEALVRVLVLDANDNSPFVLYPLQ-----------NGSAPCTELVPRAAEPGYLVT 587

  Fly   741 AVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNL 805
            .|||.|.|.|....:||:::...|.|:|.:....||:...|  :||.|....|.|.:...|.|..
Human   588 KVVAVDGDSGQNAWLSYQLLKATEPGLFGVWAHNGEVRTAR--LLSERDAAKHRLVVLVKDNGEP 650

  Fly   806 RSNADAVVFLSIIDAMQRP--PIFEKA 830
            ..:|.|.:.:.::|...:|  |:.|.|
Human   651 PRSATATLHVLLVDGFSQPYLPLPEAA 677

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_523446.2	CA	111..172	CDD:214520	16/55 (29%)
		Cadherin_repeat	178..282	CDD:206637	37/104 (36%)
		Cadherin_repeat	291..389	CDD:206637	31/97 (32%)
		Cadherin_repeat	406..500	CDD:206637	29/103 (28%)
		Cadherin_repeat	509..607	CDD:206637	25/97 (26%)
		Cadherin_repeat	616..711	CDD:206637	21/96 (22%)
		Cadherin_repeat	719..820	CDD:206637	26/111 (23%)
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		CA_like	2171..>2232	CDD:481204
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
PCDHB9	NP_061992.3	Cadherin_2	31..112	CDD:462413	11/36 (31%)
		Cadherin_repeat	137..238	CDD:206637	37/104 (36%)
		Cadherin_repeat	247..343	CDD:206637	31/97 (32%)
		CA	372..449	CDD:214520	27/88 (31%)
		Cadherin_repeat	455..557	CDD:206637	46/204 (23%)
		Cadherin_repeat	576..664	CDD:206637	24/89 (27%)
		Cadherin_C_2	686..768	CDD:465139
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	777..797