DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and PCDHB10

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_061753.1	Gene:	PCDHB10 / 56126	HGNCID:	8681	Length:	800	Species:	Homo sapiens

Alignment Length:	888	Identity:	234/888 - (26%)
Similarity:	360/888 - (40%)	Gaps:	179/888 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   834 YYVKEDIPRGTVVGSVI----AASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHE- 893
            |.|.|:..:|:.|.::.    .|.|::|.|..   .:.|.|...|..:::::||:...:.||.|
Human    33 YSVTEETEKGSFVVNLAKDLGLAEGELAARGT---RVVSDDNKQYLLLDSHTGNLLTNEKLDREK 94

  Fly   894 ---AKSQVLLNIQATLGEP-PVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAH 954
               .|...:|..|..:.:| .:|   :..:.|.|:||:||.|:.....:.:.|:...|.......
Human    95 LCGPKEPCMLYFQILMDDPFQIY---RAELRVRDINDHAPVFQDKETVLKISENTAEGTAFRLER 156

  Fly   955 AHDKDSGSSGQVTYSLVKESGKGLFAIDARSG-------HLILSQHLDYESSQRHTLIVTATDGG 1012
            |.|.|.|.:|...|::   |....|.|:...|       .|:|.:.||.|.....:|.:||.|||
Human   157 AQDPDGGLNGIQNYTI---SPNSFFHINISGGDEGMIYPELVLDKALDREEQGELSLTLTALDGG 218

  Fly  1013 VPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVD 1077
            .||.|...|:.:.|.|||||.|.|.:..|.....|:..|...|::|.|.|:|:|.||.::|...|
Human   219 SPSRSGTSTVRIVVLDVNDNAPQFAQALYETQAPENSPIGFLIVKVWAEDVDSGVNAEVSYSFFD 283

  Fly  1078 AGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVR 1142
            |          |.::...|.|.|.||.|:||..||.|..:.|::.:.|.|.|  ...|:.||:|.
Human   284 A----------SENIRTTFQINPFSGEIFLRELLDYELVNSYKINIQAMDGG--GLSARCRVLVE 336

  Fly  1143 VLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAA--------IRYSLLPINSSF 1199
            |||.|||.|:...|.:...:.||... :.:.|...:|.|.|||..        :.:.|.|...:|
Human   337 VLDTNDNPPELIVSSFSNSVAENSPE-TPLAVFKINDRDSGENGKMVCYIQENLPFLLKPSVENF 400

  Fly  1200 QVHPVTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDVV 1264
            .:      :.|...||||:|..|::.:...|.|||.......:.:.|||||||||....... .:
Human   401 YI------LITEGALDREIRAEYNITITVTDLGTPRLKTEHNITVLVSDVNDNAPAFTQTSY-TL 458

  Fly  1265 SVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGH----GLFSIDPTSGVIRTRVVLDH 1325
            .|||...|...:..|.|.|||.|.||.:|||::..:|.  |    .|.||:..:|.:.....||:
Human   459 FVRENNSPALHIGSVSATDRDSGTNAQVTYSLLPPQDP--HLPLASLVSINADNGHLFALRSLDY 521

  Fly  1326 EERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRP---------TFTSSSLVFRVREDAALG 1381
            |....:...|.|:|.|:|......::||.|||.|||.|         :...:.||.|..|.   |
Human   522 EALQAFEFRVGATDRGSPALSREALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEP---G 583

  Fly  1382 HVVGSISPIERPADVVRNSVEESFEDLRVTYTLNPLTKDLIEAAFDIDRHSGNLVVARLLDREVQ 1446
            ::|..:..::          .:|.::..::|.|...|:   ...|.:..|:|.:..||||.....
Human   584 YLVTKVVAVD----------GDSGQNAWLSYQLLKATE---PGLFGVWAHNGEVRTARLLSERDA 635

  Fly  1447 SEFRLEIRALDTTASNNPQSSAITVKIEVADVNDNAPEWPQDPIDLQVSEATPVGTIIHNFTATD 1511
            ::.||.:...|.  ...|:|:..|:.:.:.| ..:.|..|       :.||.|
Human   636 AKHRLVVLVKDN--GEPPRSATATLHLLLVD-GFSQPYLP-------LPEAAP------------ 678

  Fly  1512 ADTGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLIVQALDQSS 1576
            |......||                  ::::.:.:|....||           :||.|...
Human   679 AQAQAEADL------------------LTVYLVVALASVSSL-----------FLLSVLLF---- 710

  Fly  1577 NVTERLQTSVTVRLRILDANDHAPHFVSPNSSGGKTASLFISDATRIGEVVAHIVAVDEDSGDNG 1641
                     |.|||             ...|.........:.:    |....|:|.|......:.
Human   711 ---------VAVRL-------------CRRSRAASVGRCSVPE----GPFPGHLVDVRGAETLSQ 749

  Fly  1642 QLTYEI--TGGNGEGRFRINSQTGIIELVKSLPPATEDVEKGG 1682
            ...||:  |||.|...|            |.|.|...|::..|
Human   750 SYQYEVCLTGGPGTSEF------------KFLKPVISDIQAQG 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637
		Cadherin_repeat	832..927	CDD:206637	25/101 (25%)
		Cadherin_repeat	937..1032	CDD:206637	31/101 (31%)
		Cadherin_repeat	1040..1149	CDD:206637	38/108 (35%)
		Cadherin_repeat	1158..1252	CDD:206637	27/101 (27%)
		Cadherin_repeat	1263..1361	CDD:206637	35/101 (35%)
		Cadherin_repeat	1369..1481	CDD:206637	24/111 (22%)
		Cadherin_repeat	1489..1598	CDD:206637	16/108 (15%)
		Cadherin_repeat	1614..1710	CDD:206637	16/71 (23%)
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
PCDHB10	NP_061753.1	Cadherin_2	32..112	CDD:285466	20/81 (25%)
		Cadherin_repeat	139..238	CDD:206637	31/101 (31%)
		Cadherin_repeat	247..343	CDD:206637	38/107 (36%)
		Cadherin_repeat	355..447	CDD:206637	27/98 (28%)
		Cadherin_repeat	455..557	CDD:206637	35/104 (34%)
		Cadherin_repeat	576..664	CDD:206637	22/105 (21%)
		Cadherin_C_2	688..770	CDD:293101	23/134 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9422
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000