DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and celsr2

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_001074046.1	Gene:	celsr2 / 560426	ZFINID:	ZDB-GENE-070122-2	Length:	2941	Species:	Danio rerio

Alignment Length:	1339	Identity:	368/1339 - (27%)
Similarity:	598/1339 - (44%)	Gaps:	195/1339 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   507 DLYHANVMEVADPGTSVLQVLAHDRDE-GLNSALTYSLAETPETHAQWFQIDPQTGLITTRSHID 570
            |.:..:|.|.|.|||::.::   .|.. .|:..|....|||        .:.|..|::|..:..:
Zfish    20 DCFSVHVSEDAGPGTAIAEL---QRGSCALDQLLLPRFAET--------FLRPDAGVLTLSNAPN 73

  Fly   571 CE---TEPVPQLTVV-ARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAENEPVGRC-- 629
            |:   :.|.....|| .:|........|:...|.:|..|.......::..:|.:........|
Zfish    74 CDSVLSNPFSVYAVVDCKDASGFRHLVTSRYDVHVHGKNCASTRKRENKLDVEIISLTESSECRE 138

  Fly   630 -------ILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPV 687
                   :..|...:|     |..|.|....|        ..:.|.:..:..|.|.|.|..||.:
Zfish   139 AHSAVFRVFDVLPGNP-----ARCNVTRTSAF--------YMSDGSLFTSARLCFTRDSLLEFQM 190

  Fly   688 LATDRGGL--------------------------STTAMIKMQLTDVNDNRPVFYPREYKVSLRE 726
            ....|.|.                          |.:.::..:..:||:| |.|:|..|:||:.|
Zfish   191 RCGGRAGAAHAHWRVGRGPFTQTHLSKVLRLAARSNSGLLSRRRRNVNNN-PQFHPPMYQVSVPE 254

  Fly   727 SPKASSQASSTPIVAVVATDPDYGNFGQVSYRIVA---GNEAGIFRIDRSTGEIFVVRPDMLSVR 788
                 :|.:.|.:|.:.|.|||.|..|::.|.:.|   .....:|.:|.::|.:..|  ::|...
Zfish   255 -----NQPAGTFVVVLKAVDPDEGEAGRLEYVLEALFDSRSNNLFAVDPASGVVSTV--EILDRE 312

  Fly   789 TQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAAS 853
            |:..|:..::|.|.|..|..|.|.:.:::.|.....|.||:..|...::|::..|..|.:|.|..
Zfish   313 TKDTHVFRVTAVDHGTPRRTAMATLTVTVSDTNDHDPAFEQQDYKESIRENLEIGYEVLTVRATD 377

  Fly   854 GDVAHRSPVRYSIY-SGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQAT---LGEPPVYGH 914
            ||......:.|.:. |...:..|.|::.||.||....:|.|.....:|.::|.   ....|....
Zfish   378 GDAPINGNILYHLLNSNGTNDVFEIDSRSGVIRTRGLVDRETVDSYMLMVEANDQGRDPGPRSAT 442

  Fly   915 TQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLF 979
            ..|:|.|||.|||||:|......:.|||.......:....|.|:|.|::..|.:|::..:.:|.|
Zfish   443 ATVHIVVEDDNDNAPQFSEKRYIVQVPEDLTPNTEILQVTATDQDRGNNAVVHFSIMSGNTRGQF 507

  Fly   980 AIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQ--DVNDNPPVFEKDEYS 1042
            .|||::|.|.|...||||.::.:||.:.|.|||.|.|| |::.||.||  |:|||.|:|....:.
Zfish   508 YIDAQTGKLDLVSQLDYEMNKEYTLRIRAQDGGRPPLS-NISGLVTVQVLDINDNAPIFVSTPFQ 571

  Fly  1043 VNVSESRSINAQIIQVNASDLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPNSGWIYL 1107
            ..|.|:..:...:|.:.|.|.|.|:|:|:.||:.:. ..|...:|::|           :|||.:
Zfish   572 ATVLENVPVGYSVIHIQAVDADAGDNSRLEYRLTET-TANFPFTINNS-----------TGWIVV 624

  Fly  1108 RAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVV 1172
            .|.|||||.|.|...|.|.|:|.||..:...:.:.:||.|||:|:|.:..|..|:.|:...|:.|
Zfish   625 AAELDRETVDFYNFGVEARDHGAPAMSSSASISMTILDVNDNNPEFTQKAYYMRLNEDAAVGTSV 689

  Fly  1173 GVVTASDLDLGENAAIRYSLLPIN--SSFQVHPVTGE--ISTREPLDRELRELYDLVVEARDQGT 1233
            ..|:|.|.|:  |:.:.|.:...|  :.|.:...:|.  |:...|||.:|...|.|.|.|.| ||
Zfish   690 VTVSAVDQDI--NSVVTYQISSGNTRNRFSITSQSGGGLITLALPLDYKLERQYVLTVTASD-GT 751

  Fly  1234 PVRSARVPVRIHVSDVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVK 1298
            ...:|:  |.::|:|.|.:.| :.......|::.|::|.||.||.:.|.|.|.|:||.|||.:
Zfish   752 RFDTAK--VYVNVTDANTHRP-VFQSSHYTVNINEDRPVGTTVVMISATDEDTGENARITYIM-- 811

  Fly  1299 GRDSDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRP 1363
               .|....|:||..||.:.|::.||:|::..|.|.:.|.|.|.|.:.....|.:.|.|:|||.|
Zfish   812 ---DDSIPQFNIDADSGAVTTQMELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNSP 873

  Fly  1364 TFTSSSLVFRVREDAALGHVVGSISPIERPADVVRNSVEESFEDLRVTYTLNPLTKDLIEAAFDI 1428
            .|.....:..|.||..:...|..:|..:|          :|..:.||.||.......  :..|.|
Zfish   874 VFQRDRYLGSVMEDIPVFTSVLQVSATDR----------DSGLNGRVFYTFQGGEDG--DGDFII 926

  Fly  1429 DRHSGNLVVARLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIEVADVNDNAPEWPQDPIDLQ 1493
            :..||.:...|.||||..:.:.|:..|:|....  ...:|:.:::.:.|||||.|.:.:|..|:.
Zfish   927 ESTSGIVRTLRRLDRENTAIYNLQAFAVDKGVP--ALKTAVDMQVTILDVNDNPPVFEKDEFDIF 989

  Fly  1494 VSEATPVGTIIHNFTATDADTGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGALSLQAPLD 1558
            |.|.:|:|.::.:.:|:|.|.|:|..:.|:::         :.....:|::|..:|.|:....||
Zfish   990 VEENSPIGLVVAHISASDPDEGSNAQIMYQIV---------EGNIPEVFQLDIFSGELTALTDLD 1045

  Fly  1559 FEAVQEYLLIVQALDQSSNVTERLQTSVTVRLRILDANDHAP-----HFVSPNSSGGKTASLFIS 1618
            :|...||:::|||      .:..|.:..||.::::|.||:.|     ..:..|         :::
Zfish  1046 YETRAEYVIVVQA------TSAPLVSRATVHIKLIDKNDNVPVLKNFQIIFNN---------YVT 1095

  Fly  1619 DATRI--GEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKG 1681
            |.|..  ..|:..|.|.|.|..|  ||.|....||......:|..||.|.|.::|     |..:.
Zfish  1096 DKTNSFPSGVIGRIPAQDPDVSD--QLHYSFEAGNELKLVILNQSTGEIRLSRAL-----DNNRP 1153

  Fly  1682 GRFNLIIGAKD--HG------------QPEPKKSSLNLHLIVQGSHNNPPRFLQAVYRATILENV 1732
            ...::.|...|  |.            ..|...:|:.|.|    ::.:..||| ::..|..||.|
Zfish  1154 LEASMKISVSDGVHSVSAQCLLQVTVITDEMLSNSITLRL----ANASQERFL-SLLLAQFLEGV 1213

  Fly  1733 PSGSFVLQVTAKSL------------HGAENANLSYEIP 1759
            .|   ||..:.:.:            .|..|.:||..:|
Zfish  1214 AS---VLSASREDVVVFNIQDDTDVSAGILNVSLSVALP 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637	24/102 (24%)
		Cadherin_repeat	616..711	CDD:206637	20/129 (16%)
		Cadherin_repeat	719..820	CDD:206637	28/103 (27%)
		Cadherin_repeat	832..927	CDD:206637	27/98 (28%)
		Cadherin_repeat	937..1032	CDD:206637	37/96 (39%)
		Cadherin_repeat	1040..1149	CDD:206637	34/108 (31%)
		Cadherin_repeat	1158..1252	CDD:206637	31/97 (32%)
		Cadherin_repeat	1263..1361	CDD:206637	36/97 (37%)
		Cadherin_repeat	1369..1481	CDD:206637	27/111 (24%)
		Cadherin_repeat	1489..1598	CDD:206637	28/108 (26%)
		Cadherin_repeat	1614..1710	CDD:206637	27/111 (24%)
		Cadherin_repeat	1723..1843	CDD:206637	12/49 (24%)
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
celsr2	NP_001074046.1	Cadherin_repeat	248..347	CDD:206637	29/105 (28%)
		Cadherin_repeat	356..455	CDD:206637	27/98 (28%)
		Cadherin_repeat	464..561	CDD:206637	37/97 (38%)
		Cadherin_repeat	569..666	CDD:206637	34/108 (31%)
		Cadherin_repeat	675..768	CDD:206637	31/97 (32%)
		Cadherin_repeat	776..871	CDD:206637	36/99 (36%)
		Cadherin_repeat	880..977	CDD:206637	27/110 (25%)
		Cadherin_repeat	985..1079	CDD:206637	28/108 (26%)
		Cadherin_repeat	1099..1180	CDD:206637	21/87 (24%)
		EGF_CA	1356..1391	CDD:238011
		EGF_CA	1399..1432	CDD:238011
		LamG	1436..>1529	CDD:238058
		EGF_CA	1644..1678	CDD:238011
		Laminin_G_2	1712..1837	CDD:280389
		EGF_CA	1863..1897	CDD:238011
		TNFRSF	1924..1993	CDD:304602
		EGF_Lam	1992..2037	CDD:214543
		HormR	2041..2102	CDD:214468
		GAIN	2120..2358	CDD:293098
		GPS	2386..2439	CDD:197639
		7tm_4	2445..2677	CDD:304433
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910