DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ds and celsr2

DIOPT Version :10

Sequence 1:NP_523446.2 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:NP_001074046.2 Gene:celsr2 / 560426 ZFINID:ZDB-GENE-070122-2 Length:2940 Species:Danio rerio


Alignment Length:1339 Identity:369/1339 - (27%)
Similarity:598/1339 - (44%) Gaps:195/1339 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   507 DLYHANVMEVADPGTSVLQVLAHDRDE-GLNSALTYSLAETPETHAQWFQIDPQTGLITTRSHID 570
            |.:..:|.|.|.|||::.::   .|.. .|:..|....|||        .:.|..|::|..:..:
Zfish    20 DCFSVHVSEDAGPGTAIAEL---QRGSCALDQLLLPRFAET--------FLRPDAGVLTLSNAPN 73

  Fly   571 CE---TEPVPQLTVV-ARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAENEPVGRC-- 629
            |:   :.|.....|| .:|........|:...|.:|..|.......::..:|.:........|  
Zfish    74 CDSVLSNPFSVYAVVDCKDASGFRHLVTSRYDVHVHGKNCASTRKRENKLDVEIISLTESSECRE 138

  Fly   630 -------ILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPV 687
                   :..|...:|     |..|.|....|        ..:.|.:..:..|.|.|.|..||.:
Zfish   139 AHSAVFRVFDVLPGNP-----ARCNVTRTSAF--------YMSDGSLFTSARLCFTRDSLLEFQM 190

  Fly   688 LATDRGGL--------------------------STTAMIKMQLTDVNDNRPVFYPREYKVSLRE 726
            ....|.|.                          |.:.::..:..:||:| |.|:|..|:||:.|
Zfish   191 RCGGRAGAAHAHWRVGRGPFTQTHLSKVLRLAARSNSGLLSRRRRNVNNN-PQFHPPMYQVSVPE 254

  Fly   727 SPKASSQASSTPIVAVVATDPDYGNFGQVSYRIVA---GNEAGIFRIDRSTGEIFVVRPDMLSVR 788
                 :|.:.|.:|.:.|.|||.|..|::.|.:.|   .....:|.:|.::|.:..|  ::|...
Zfish   255 -----NQPAGTFVVVLKAVDPDEGEAGRLEYVLEALFDSRSNNLFAVDPASGVVSTV--EILDRE 312

  Fly   789 TQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAAS 853
            |:..|:..::|.|.|..|..|.|.:.:::.|.....|.||:..|...|:|::..|..|.:|.|..
Zfish   313 TKDTHVFRVTAVDHGTPRRTAMATLTVTVSDTNDHDPAFEQQDYKESVRENLEIGYEVLTVRATD 377

  Fly   854 GDVAHRSPVRYSIY-SGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQAT---LGEPPVYGH 914
            ||......:.|.:. |...:..|.|::.||.||....:|.|.....:|.::|.   ....|....
Zfish   378 GDAPINGNILYHLLNSNGTNDVFEIDSRSGVIRTRGLVDRETVDSYMLMVEANDQGRDPGPRSAT 442

  Fly   915 TQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLF 979
            ..|:|.|||.|||||:|......:.|||.......:....|.|:|.|::..|.:|::..:.:|.|
Zfish   443 ATVHIVVEDDNDNAPQFSEKRYIVQVPEDLTPNTEILQVTATDQDRGNNAVVHFSIMSGNTRGQF 507

  Fly   980 AIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQ--DVNDNPPVFEKDEYS 1042
            .|||::|.|.|...||||.::.:||.:.|.|||.|.|| |::.||.||  |:|||.|:|....:.
Zfish   508 YIDAQTGKLDLVSQLDYEMNKEYTLRIRAQDGGRPPLS-NISGLVTVQVLDINDNAPIFVSTPFQ 571

  Fly  1043 VNVSESRSINAQIIQVNASDLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPNSGWIYL 1107
            ..|.|:..:...:|.:.|.|.|.|:|:|:.||:.:. ..|...:|::|           :|||.:
Zfish   572 ATVLENVPVGYSVIHIQAVDADAGDNSRLEYRLTET-TANFPFTINNS-----------TGWIVV 624

  Fly  1108 RAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVV 1172
            .|.|||||.|.|...|.|.|:|.||..:...:.:.:||.|||:|:|.:..|..|:.|:...|:.|
Zfish   625 AAELDRETVDFYNFGVEARDHGAPAMSSSASISMTILDVNDNNPEFTQKAYYMRLNEDAAVGTSV 689

  Fly  1173 GVVTASDLDLGENAAIRYSLLPIN--SSFQVHPVTGE--ISTREPLDRELRELYDLVVEARDQGT 1233
            ..|:|.|.|:  |:.:.|.:...|  :.|.:...:|.  |:...|||.:|...|.|.|.|.| ||
Zfish   690 VTVSAVDQDI--NSVVTYQISSGNTRNRFSITSQSGGGLITLALPLDYKLERQYVLTVTASD-GT 751

  Fly  1234 PVRSARVPVRIHVSDVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVK 1298
            ...:|:  |.::|:|.|.:.| :.......|::.|::|.||.||.:.|.|.|.|:||.|||.:  
Zfish   752 RFDTAK--VYVNVTDANTHRP-VFQSSHYTVNINEDRPVGTTVVMISATDEDTGENARITYIM-- 811

  Fly  1299 GRDSDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRP 1363
               .|....|:||..||.:.|::.||:|::..|.|.:.|.|.|.|.:.....|.:.|.|:|||.|
Zfish   812 ---DDSIPQFNIDSDSGAVTTQMELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNSP 873

  Fly  1364 TFTSSSLVFRVREDAALGHVVGSISPIERPADVVRNSVEESFEDLRVTYTLNPLTKDLIEAAFDI 1428
            .|.....:..|.||..:...|..:|..:|          :|..:.||.||.......  :..|.|
Zfish   874 VFQRDRYLGSVMEDIPVFTSVLQVSATDR----------DSGLNGRVFYTFQGGEDG--DGDFII 926

  Fly  1429 DRHSGNLVVARLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIEVADVNDNAPEWPQDPIDLQ 1493
            :..||.:...|.||||..:.:.|:..|:|....  ...:|:.:::.:.|||||.|.:.:|..|:.
Zfish   927 ESTSGIVRTLRRLDRENTAIYNLQAFAVDKGVP--ALKTAVDMQVTILDVNDNPPVFEKDEFDIF 989

  Fly  1494 VSEATPVGTIIHNFTATDADTGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGALSLQAPLD 1558
            |.|.:|:|.::.:.:|:|.|.|:|..:.|:::         :.....:|::|..:|.|:....||
Zfish   990 VEENSPIGLVVAHISASDPDEGSNAQIMYQIV---------EGNIPEVFQLDIFSGELTALTDLD 1045

  Fly  1559 FEAVQEYLLIVQALDQSSNVTERLQTSVTVRLRILDANDHAP-----HFVSPNSSGGKTASLFIS 1618
            :|...||:::|||      .:..|.:..||.::::|.||:.|     ..:..|         :::
Zfish  1046 YETRAEYVIVVQA------TSAPLVSRATVHIKLIDKNDNVPVLKNFQIIFNN---------YVT 1095

  Fly  1619 DATRI--GEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKG 1681
            |.|..  ..|:..|.|.|.|..|  ||.|....||......:|..||.|.|.::|     |..:.
Zfish  1096 DKTNSFPSGVIGRIPAQDPDVSD--QLHYSFEAGNELKLVILNQSTGEIRLSRAL-----DNNRP 1153

  Fly  1682 GRFNLIIGAKD--HG------------QPEPKKSSLNLHLIVQGSHNNPPRFLQAVYRATILENV 1732
            ...::.|...|  |.            ..|...:|:.|.|    ::.:..||| ::..|..||.|
Zfish  1154 LEASMKISVSDGVHSVSAQCLLQVTVITDEMLSNSITLRL----ANASQERFL-SLLLAQFLEGV 1213

  Fly  1733 PSGSFVLQVTAKSL------------HGAENANLSYEIP 1759
            .|   ||..:.:.:            .|..|.:||..:|
Zfish  1214 AS---VLSASREDVVVFNIQDDTDVSAGILNVSLSVALP 1249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_523446.2 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637
Cadherin_repeat 291..389 CDD:206637
Cadherin_repeat 406..500 CDD:206637
Cadherin_repeat 509..607 CDD:206637 24/102 (24%)
Cadherin_repeat 616..711 CDD:206637 20/129 (16%)
Cadherin_repeat 719..820 CDD:206637 28/103 (27%)
Cadherin_repeat 832..927 CDD:206637 28/98 (29%)
Cadherin_repeat 937..1032 CDD:206637 37/96 (39%)
Cadherin_repeat 1040..1149 CDD:206637 34/108 (31%)
Cadherin_repeat 1158..1252 CDD:206637 31/97 (32%)
Cadherin_repeat 1263..1361 CDD:206637 36/97 (37%)
Cadherin_repeat 1369..1481 CDD:206637 27/111 (24%)
Cadherin_repeat 1489..1598 CDD:206637 28/108 (26%)
Cadherin_repeat 1614..1710 CDD:206637 27/111 (24%)
Cadherin_repeat 1723..1843 CDD:206637 12/49 (24%)
Cadherin_repeat 1853..1948 CDD:206637
Cadherin_repeat 1957..2053 CDD:206637
Cadherin_repeat 2061..2154 CDD:206637
CA_like 2171..>2232 CDD:481204
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
celsr2NP_001074046.2 None
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.