DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and pcdh19

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_009289395.1	Gene:	pcdh19 / 555688	ZFINID:	ZDB-GENE-030131-4218	Length:	1094	Species:	Danio rerio

Alignment Length:	1251	Identity:	310/1251 - (24%)
Similarity:	477/1251 - (38%)	Gaps:	356/1251 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 DSGPPYIIVAEAGVETDLAIDRATGEIRTKVKLDRET---RASYSLVAIPLSGRNIRVLV---TV 164
            :|.|.::.::.||:            :.||.|:||:.   :.....:::.:...::.:.|   .:
Zfish    68 NSEPRWVNLSPAGL------------LITKQKIDRDAVCRQTPKCFISLEVMSNSMEICVIKIEI 120

  Fly   165 KDENDNAPTFPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRE 229
            .|.|||||.||...:.||..||.....:..|..|.|.|......|.|.|..   ||.|.|.....
Zfish   121 IDVNDNAPRFPTNHIDIEISENAAPGTRFPLEGASDPDSGSNGIQTYTITP---NDIFGLEIKTR 182

  Fly   230 RDGVLYLDLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFAT 294
            .||....:|.:...|||||...|:..:.|.|||.||..|.:.:||.:.|.|||.|:|::..|...
Zfish   183 GDGSKIAELVVEKTLDRETQSRYTFELTAEDGGDPPKSGTVQLNIKVIDSNDNNPVFDEPVYTVN 247

  Fly   295 VPENATVGTSVLQVYASDTDADENGLVEYA-INRRQSDKEQMFRIDPRTGAIYINKALDFETKEL 358
            |.||:.:.|.|:.:.|:|.|...||.|.|: ||...:..:|||:|||:||.|.:|..||.|...:
Zfish   248 VLENSPINTLVIDLNATDPDEGTNGEVVYSFINFVSNLTKQMFKIDPKTGVITVNGVLDHEELHI 312

  Fly   359 HELVVVAKDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDAS-PKISESAQPGEFVARISVH 422
            ||:.|.|||.|...:.....|.:.|.|:|||.|.|.:  ||:::. .::||:|..|..:|.:.|.
Zfish   313 HEIDVQAKDLGPNSIPAHCKVIVNVIDINDNAPEIKL--LSENSEMVEVSENAPLGYVIALVRVS 375

  Fly   423 DPDSKTEYANVNVTLNGGDGHFALTTRDN---------SIYLVIVHLPLDREIVSNYTLSVVATD 478
            |.||            |.:|......:.|         |...::|...||||....|.|:::|.|
Zfish   376 DNDS------------GANGKVQCRLQGNVPFRLNEFESFSTLLVDGRLDREQRDMYNLTILAED 428

  Fly   479 KGTPPLHASKSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSL 543
            .|.|||.:|||..:::||.|||||.|.:..|.|.|:|...||..:|.|.|.|.|.|:|..::|
Zfish   429 SGYPPLRSSKSFAVKVTDENDNPPYFTKPHYQAMVLENNVPGAFLLAVSARDPDLGMNGTVSY-- 491

  Fly   544 AETPETHAQWFQIDPQTGLITTRS-----------HIDCETEPVPQLTVVARDGGVPPLSSTATV 597
             |..::..:...::   ..:|..|           |.|..|.   :..|.|:|||.|||:|.|||
Zfish   492 -EIIKSEVRGMSVE---SYVTVNSNGEIYGVRAFNHEDTRTF---EFKVSAKDGGDPPLTSNATV 549

  Fly   598 LVTIHDVNDNEPIFD-----QSFYNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHL 657
            .:.:.|||||.|:..     .....||:.:|..||..:.::.|.|.|.|.|..:.|:|.||  .:
Zfish   550 RIVVLDVNDNTPVMTTPPLVNGTAEVSIPKNAGVGYLVTQIKADDYDEGENGRLTYSISEG--DM 612

  Fly   658 TEFEVRSASGEICIAGELDFERRSSYEFPVLATDRG--GLSTTAMIKMQLTDVNDNRPVFYPREY 720
            ..||:...:||:..........:.||:..|:|.|.|  .||.:|.|.:.|
Zfish   613 AYFEIDQINGEVRTTKTFGENAKPSYQITVVAHDHGQTSLSASAYIVIYL--------------- 662

  Fly   721 KVSLRESPKASSQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVV---RP 782
                  ||..::|....|:           |...: :.|..|:.|.|..:..    |||.   :.
Zfish   663 ------SPDLNAQEQIGPV-----------NLSLI-FIIALGSIAVILFVTM----IFVAVKCKR 705

  Fly   783 DMLSVRTQP---MHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDI---P 841
            |...:||..   :::..::....||.:.::                  :|.:.:   |.||   |
Zfish   706 DNKEIRTYNCSFLYLRRVAEYSYGNQKKSS------------------KKKKLS---KNDIRLVP 749

  Fly   842 RGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNI----RIAKPLDHEAKSQVLLNI 902
            |            ||.                    ||:..|:    .:...|::....|..|.:
Zfish   750 R------------DVE--------------------ETDKMNVVSCSSLTSSLNYFDYHQQTLPL 782

  Fly   903 QATLGEPPVYGHTQVNIEVEDVNDNAPE------FEASMVRISVPESAEL---GAPLYAAHAHDK 958
            .....|     .|.:|:|.::..:.||.      |..     ..|:..:|   |.||.....:..
Zfish   783 GCRRSE-----STFLNVENQNSRNAAPNHGYHHTFTG-----QGPQQPDLIINGMPLPETENYSI 837

  Fly   959 DSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTIL 1023
            ||                                  .|.:|:.|.:..|:|
Zfish   838 DS----------------------------------SYVNSRAHLIKSTST-------------- 854

  Fly  1024 VDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVDAGVDNVTN--- 1085
              .:|:..|.   .||.   ...||...:::      .|:..|:.|       |..|::|.|
Zfish   855 --FKDMEGNS---LKDS---GHEESDQTDSE------HDVQRGHYA-------DTAVNDVLNMTV 898

  Fly  1086 -----SISSSDVSQHF------GIFPNSG--W-----IYLRAPLDRETRDRYQLTVLAT------ 1126
                 .|...|.|:.|      .|..:|.  |     |..||......|:...|::.||
Zfish   899 PSNNSQIPDQDQSEGFHCQDECRILGHSDRCWMPRVPIPARAKSPEHGRNVIALSIEATTVDVPH 963

  Fly  1127 --DNGTP----AAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGEN 1185
              |.||.    |...|        |..|.|          |.|:..||.:....|.:..    .|
Zfish   964 YEDCGTTKRTFATFGK--------DGPDED----------RAEQRGRRQTAEPAVCSPK----TN 1006

  Fly  1186 AAIRYSLLPINSSFQVHPVTGEISTREPLDR--------------------------------EL 1218
            .|:|.:   .|....|.|:|..:..:.|..:                                .:
Zfish  1007 GAVREA---GNGREAVSPITSPVHLKSPQSKASSTYNTLKCRDAERIANHSLLRQPEGKDSEPAM 1068

  Fly  1219 RELYDLVVEARDQGTP 1234
            ||:..|:.:.||:.:|
Zfish  1069 REINTLLQDGRDKESP 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	12/66 (18%)
		Cadherin_repeat	178..282	CDD:206637	35/103 (34%)
		Cadherin_repeat	291..389	CDD:206637	39/98 (40%)
		Cadherin_repeat	406..500	CDD:206637	32/102 (31%)
		Cadherin_repeat	509..607	CDD:206637	35/108 (32%)
		Cadherin_repeat	616..711	CDD:206637	29/96 (30%)
		Cadherin_repeat	719..820	CDD:206637	17/106 (16%)
		Cadherin_repeat	832..927	CDD:206637	17/101 (17%)
		Cadherin_repeat	937..1032	CDD:206637	13/97 (13%)
		Cadherin_repeat	1040..1149	CDD:206637	29/141 (21%)
		Cadherin_repeat	1158..1252	CDD:206637	19/109 (17%)
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdh19	XP_009289395.1	E_set	28..107	CDD:298831	9/50 (18%)
		Cadherin_repeat	137..235	CDD:206637	35/100 (35%)
		Cadherin_repeat	243..343	CDD:206637	39/99 (39%)
		Cadherin_repeat	357..450	CDD:206637	32/104 (31%)
		Cadherin_repeat	458..559	CDD:206637	35/109 (32%)
		Cadherin_repeat	574..667	CDD:206637	31/115 (27%)
		Cadherin_C_2	676..>731	CDD:293101	12/59 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10294
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000