DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ds and CDHR2

DIOPT Version :9

Sequence 1:NP_001285551.1 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:NP_001165447.1 Gene:CDHR2 / 54825 HGNCID:18231 Length:1310 Species:Homo sapiens


Alignment Length:1386 Identity:346/1386 - (24%)
Similarity:588/1386 - (42%) Gaps:261/1386 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   284 PIFNQSRYFATVPENATVGTSVLQVYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYIN 348
            |.|..:.....:||:..||.....:.|.|.|.|.   :.|.::   ......|.:.|:||.:.:.
Human    24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDNDP---LTYGMS---GPNAYFFAVTPKTGEVKLA 82

  Fly   349 KALDFET---------------KELHELVVVAKDHGEQP--LETTAFVSIRVTDVNDNQPTINVI 396
            .|||:||               :...|::|:.:|..:..  .:.|||    .|.:|:..|..:|:
Human    83 SALDYETLYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAF----STSINETLPVGSVV 143

  Fly   397 F--LSDD-----------ASPKISESAQPGEFVARISVHDPDSKTEYANVNVTLNGGDGHFALTT 448
            |  |:.|           :..|:..|....|.:.||          .||.::.|||     :|:.
Human   144 FSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI----------LANGSIVLNG-----SLSY 193

  Fly   449 RDNSIYLVIVHLPLDREIVSNYTLSVVATDKG-----TPPLHASKSIFLRIT--DVNDNPPEFEQ 506
            .:.|.:               |.|.:.|.|.|     |..:..|..:||.|:  |..|..|:|.:
Human   194 NNKSAF---------------YQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVR 243

  Fly   507 DLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGLITTRSHID- 570
            :.|.|:|.|.|..|||||.|.|.|.|:|:|..:.||::.:  |...||.|... |:|.....:| 
Human   244 EFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYS--TRPGWFDIGAD-GVIRVNGSLDR 305

  Fly   571 ---CETEPVPQLTVVARDGGVPPLSSTAT----VLVTIHDVNDNEPIFDQSFYNVSV-------- 620
               .|.:...||.|.|.:..:......|.    |.|.:.||||::|    .|||.|:        
Human   306 EQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKP----EFYNCSLPACTFTPE 366

  Fly   621 --------------AENEPVGRCILKVSASDPDCGVNAMVNYTIG----EGFKHLTEFEVRSASG 667
                          :...|:..  |.:...|||.|.|.....::|    |.|....|..|.|||.
Human   367 EAQVNFTGYVDEHASPRIPIDD--LTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAVGSASV 429

  Fly   668 EIC--IAGELDFERRSSYEFPVLATDRGGLS-TTAMIKMQLTDVNDNRPVFYPREYKVSLRESPK 729
            ::.  ::..:|:||:::....|:|||....: :.||:.:.|.|:||:||.|....|.:::.|   
Human   430 QVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPE--- 491

  Fly   730 ASSQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHM 794
             .|...|....::.|||||.|.:||::|.::.||.|.:|::|..:|.:.|...::|...:|.::.
Human   492 -HSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYY 555

  Fly   795 LNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAASGDV--A 857
            |.:.|||||||.|:....:.|  :|.....|:. ...||.:|:|:  .|.|..::.|...|.  .
Human   556 LTLQATDGGNLSSSTTLQIHL--LDINDNAPVV-SGSYNIFVQEE--EGNVSVTIQAHDNDEPGT 615

  Fly   858 HRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEA-----KSQVLLNIQAT-LGEPPVYGHTQ 916
            :.|.:.:::..|.....||::.::|.:|...|||.||     :.:::|.:..: .|||.:.....
Human   616 NNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVN 680

  Fly   917 VNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDKD-SGSSGQVTYSLVKESGKGLFA 980
            |.|.|||:|||.|.|..|....:|.|. :.|..:....|.|.| :.::.::::|| ..||...|.
Human   681 VTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRISFSL-SGSGANYFM 743

  Fly   981 IDA-------RSGHLIL--SQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNPPVF 1036
            |..       ..|:|.|  ...||||:.....|.|:|.:.......|.:.:.|:|:|||||||..
Human   744 IRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTL 808

  Fly  1037 EKDEY-SVNVSESRSINAQIIQVNASDLDTGNNARITYRIVD-----AGVDNVTNSISSSDVSQH 1095
            :.... .:.|:|:.|.:.|:..|.|||:||  :|::..::|:     ||||  ..|:...    .
Human   809 DVASLRGIRVAENGSQHGQVAVVVASDVDT--SAQLEIQLVNILCTKAGVD--VGSLCWG----W 865

  Fly  1096 FGIFPNSGWIYLR--APLDRETRDRYQLTV----LATDNGTPAAHAKTRVIVRVLDANDNDPKF- 1153
            |.:..| |.:|:.  ..:|.|..|...|.|    ||||.|..|......:::.:.|.|||.|.| 
Human   866 FSVAAN-GSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFL 929

  Fly  1154 QKSKYEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLPIN------------------SSFQ 1200
            .::|....|.|.:.....|..|.|.|.|.|.|..|.:|:|.::                  :|.:
Human   930 PENKTFVIIPELVLPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSE 994

  Fly  1201 VHPVTGEISTREPLDRELRELYDLVVEARDQGT--PVRSARVPVRIHVSDVNDNAP-EIADPQED 1262
            .....|.|.....||..|:..|.:.|:|||:.:  |...|...:.:...|.:..:. :.:.|:|:
Human   995 ADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEE 1059

  Fly  1263 VVSVRE------EQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGHGLF------SIDPTSG 1315
            |.:.|:      .|...|.|..|...|.|....|. .:|.:     |.:.:|      ::|..|.
Human  1060 VGANRQAINAALTQATRTTVYIVDIQDIDSAARAR-PHSYL-----DAYFVFPNGSALTLDELSV 1118

  Fly  1316 VIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSSLVFRVREDAAL 1380
            :||      :::.|:.:|               ..|.:.||...:::.:..|..|:..:   ..|
Human  1119 MIR------NDQDSLTQL---------------LQLGLVVLGSQESQESDLSKQLISVI---IGL 1159

  Fly  1381 GHVVGSISPIERPADV-VRNSVEESFEDLRVTYTLNPLTKDLIEAA--------FDIDRHSGNLV 1436
            |..:..:..|...|.| ||.|.....:.::...........::.:|        ::.:|.:..| 
Human  1160 GVALLLVLVIMTMAFVCVRKSYNRKLQAMKAAKEARKTAAGVMPSAPAIPGTNMYNTERANPML- 1223

  Fly  1437 VARLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIEVADVNDN-APEWPQDPIDLQVSEATPV 1500
              .|.::::..|:......||:.:.|:...:::.|.....::.:: .|..|.:|      :..|:
Human  1224 --NLPNKDLGLEYLSPSNDLDSVSVNSLDDNSVDVDKNSQEIKEHRPPHTPPEP------DPEPL 1280

  Fly  1501 GTIIHNFTATDADTGTNGDLQ 1521
            ..::     .....|.:|.|:
Human  1281 SVVL-----LGRQAGASGQLE 1296

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_001285551.1 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637
Cadherin_repeat 291..389 CDD:206637 26/114 (23%)
Cadherin_repeat 406..500 CDD:206637 22/100 (22%)
Cadherin_repeat 509..607 CDD:206637 36/105 (34%)
Cadherin_repeat 616..711 CDD:206637 30/123 (24%)
Cadherin_repeat 719..820 CDD:206637 32/100 (32%)
Cadherin_repeat 832..927 CDD:206637 29/102 (28%)
Cadherin_repeat 937..1032 CDD:206637 28/104 (27%)
Cadherin_repeat 1040..1149 CDD:206637 34/120 (28%)
Cadherin_repeat 1158..1252 CDD:206637 26/113 (23%)
Cadherin_repeat 1263..1361 CDD:206637 21/109 (19%)
Cadherin_repeat 1369..1481 CDD:206637 18/120 (15%)
Cadherin_repeat 1489..1598 CDD:206637 5/33 (15%)
Cadherin_repeat 1614..1710 CDD:206637
Cadherin_repeat 1723..1843 CDD:206637
Cadherin_repeat 1853..1948 CDD:206637
Cadherin_repeat 1957..2053 CDD:206637
Cadherin_repeat 2061..2154 CDD:206637
Cadherin_repeat 2170..2318 CDD:206637
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
CDHR2NP_001165447.1 Cadherin_repeat 32..120 CDD:206637 21/93 (23%)
Cadherin_repeat 129..236 CDD:206637 31/140 (22%)
Cadherin_repeat 246..349 CDD:206637 36/105 (34%)
Cadherin_repeat 372..476 CDD:206637 27/105 (26%)
Cadherin_repeat 485..582 CDD:206637 33/102 (32%)
Cadherin_repeat 589..691 CDD:206637 29/103 (28%)
Cadherin_repeat 699..804 CDD:206637 28/106 (26%)
CA <864..926 CDD:214520 19/66 (29%)
Cadherin_repeat 935..1044 CDD:206637 25/108 (23%)
Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000269|PubMed:24725409 1180..1310 17/131 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1259..1310 7/49 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 58 1.000 Domainoid score I10828
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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