DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and Pcdhb2

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_001102593.2	Gene:	Pcdhb2 / 498843	RGDID:	1563132	Length:	793	Species:	Rattus norvegicus

Alignment Length:	812	Identity:	211/812 - (25%)
Similarity:	336/812 - (41%)	Gaps:	188/812 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ILLAIVLLGSSQAASHDQERERKLEVFEGVAVDYQIGYIGDFG-----GIDSGPPYIIVAEAGVE 120
            :||..||||.:||.|..:....:.|...|..|   ...:.|.|     ..:.||.   |...|.:
  Rat    10 VLLFFVLLGIAQAGSTIRRYSVEEEAENGFFV---ANLLKDLGLEVEELAERGPR---VISKGKK 68

  Fly   121 TDLAIDRATGEIRTKVKLDRETRAS-YSLVAIP---LSGRNIRVL---VTVKDENDNAPTFPQTS 178
            .:|..:|.||::..:.|||||.... .....:|   |.|..:.:.   :.::|.||::|.|....
  Rat    69 LNLEFNRQTGDLLLREKLDREELCGPAEPCVVPFQVLLGNPLEIFQAELQIRDINDHSPVFLDKK 133

  Fly   179 MHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQISGF 243
            :.::..|.|.......:..|:|||:...:.|.|:|   :.|..|.|:.....||.:...|.:...
  Rat   134 IILKISEITAPGTTFLIERAQDLDVGSNSLQTYSI---SPNFHFHLNLQDSPDGTVLPQLVLDKV 195

  Fly   244 LDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVLQV 308
            ||||......|::.|||||.||..|.:.:.|.:.|:|||.|.|::.||...||||:.||:.|..|
  Rat   196 LDREERSEIRLILTALDGGNPPRSGTVHILIEVLDINDNAPAFSKLRYEVQVPENSPVGSQVATV 260

  Fly   309 YASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPL 373
            .|.|.|..:||.:.||.::...|..:.||::..:|.|.:.|.||||:.:.:.:.|.|.|.|  .|
  Rat   261 SAKDLDIGDNGQITYAFSQASEDIRKTFRMNATSGEILLVKTLDFESIQAYTVYVQATDGG--GL 323

  Fly   374 ETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVTLN 438
            ..::.|.::|.|:|||.|.:.:...::    .|.|:| |...:|..||.||||
  Rat   324 SGSSVVFVQVKDLNDNPPELTMSTFTN----HIPENA-PETVIAVFSVADPDS------------ 371

  Fly   439 GGDGH----------FALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLR 493
            |.:|.          |.|.....::|.::.:..||||..:.|.:::..:|.|||.|....:|.:.
  Rat   372 GDNGKMVCSIQEDLPFVLKPSVENLYTLMTNTALDRETRTQYNITITVSDMGTPRLTTQHTIAVY 436

  Fly   494 ITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDP 558
            ::|:|||.|.|.|..|...|.|...|...:..:.|.|.|.|.|:.:||||
  Rat   437 VSDINDNAPAFTQTSYTIFVRENNSPALHIGTISATDSDSGSNAHITYSL--------------- 486

  Fly   559 QTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAEN 623
                                         :||
  Rat   487 -----------------------------LPP--------------------------------- 489

  Fly   624 EPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPVL 688
                        .||...:|::::              :.:.:|::.....||:|...::||.|.
  Rat   490 ------------QDPQLALNSLIS--------------INADNGQLFALRALDYEALQAFEFHVS 528

  Fly   689 ATDRG--GLSTTAMIKMQLTDVNDNRP-VFYPREYKVSLRESPKASSQASSTP------------ 738
            |.|.|  .||:.|.:::.:.|.|||.| |.||              .|.:|.|
  Rat   529 AVDGGLPALSSQAPVRLVVLDDNDNAPFVLYP--------------LQNASAPCTELLPRAAEPG 579

  Fly   739 --IVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATD 801
              :..|||.|.|.|....:|::::...|.|:|.:....||:...|  :|..|....|.|.:...|
  Rat   580 YLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTR--LLGERDVLKHRLLLLVKD 642

  Fly   802 GGNLRSNADAVVFLSIIDAMQRP--PIFEKAR 831
            .|:...:|...:.:.::|...:|  |:.|.||
  Rat   643 NGDPPRSASVTLHVLLVDGFSQPYLPLPEVAR 674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	17/67 (25%)
		Cadherin_repeat	178..282	CDD:206637	31/103 (30%)
		Cadherin_repeat	291..389	CDD:206637	35/97 (36%)
		Cadherin_repeat	406..500	CDD:206637	29/103 (28%)
		Cadherin_repeat	509..607	CDD:206637	15/97 (15%)
		Cadherin_repeat	616..711	CDD:206637	18/96 (19%)
		Cadherin_repeat	719..820	CDD:206637	23/114 (20%)
		Cadherin_repeat	832..927	CDD:206637	211/812 (26%)
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhb2	NP_001102593.2	Cadherin_2	27..108	CDD:311943	20/86 (23%)
		Cadherin_repeat	136..234	CDD:206637	31/100 (31%)
		Cadherin_repeat	243..339	CDD:206637	35/97 (36%)
		Cadherin_repeat	351..443	CDD:206637	29/104 (28%)
		Cadherin_repeat	451..553	CDD:206637	33/204 (16%)
		Cadherin_repeat	572..660	CDD:206637	20/89 (22%)
		Cadherin_C_2	683..765	CDD:318652
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9194
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000