DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and pcdh1a3

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_001019268.1	Gene:	pcdh1a3 / 497126	ZFINID:	ZDB-GENE-050202-3	Length:	939	Species:	Danio rerio

Alignment Length:	866	Identity:	246/866 - (28%)
Similarity:	383/866 - (44%)	Gaps:	147/866 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 TGEIRTKVKLDRE------TRASYSLVAIPLSGRNI-RVLVTVKDENDNAPTFPQTSMHIEFPEN 186
            ||.:..|.::|||      .:.:.:|.|:..:...: |:.:.:.|.|||||.||:::..:...|
Zfish    75 TGSLFVKDRIDREELCGVNQKCALNLEALAQNPHRLYRLEIVIVDVNDNAPFFPESTYPLNVTE- 138

  Fly   187 TPREVKRTLLP-ARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQISGFLDRETTP 250
            ...|..|..|| |:|||:...:.:.|.:.|   |:.|.|..|.|:. ::..:|.:...||||...
Zfish   139 IANEGDRFPLPFAKDLDVGSNSLKDYKLSS---NEYFSLDVHSEQQ-IVSAELVLQKTLDREKQA 199

  Fly   251 GYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVLQVYASDTDA 315
            ...|::.|:|||.||..|.:::.:.:.|||||:|||::|.|...|.||:..|..::.:.|||.|.
Zfish   200 VIHLILTAVDGGKPPKSGTLSIIVEVMDVNDNKPIFSKSLYKVKVKENSQFGAKIITISASDLDE 264

  Fly   316 DENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPLETTAFVS 380
            ..||.::|:. ...:|::.:|.|:..:|.|.:...:|:|.....:|.|.|||.|..|..|...|.
Zfish   265 GTNGQIQYSF-LGNTDEQNLFTINSNSGVIVVQGQIDYEENPAIQLRVQAKDKGSPPKSTHCKVL 328

  Fly   381 IRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVTLNG------ 439
            |.|.|.|||.|.|    ::......:.|.|:||..||.::|.|.|...         ||
Zfish   329 IEVVDENDNAPEI----VTTPLIESVKEDAKPGTAVALVTVSDKDGGK---------NGIVQCAL 380

  Fly   440 -GDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDVNDNPPE 503
             |...|.|.|..|:.|.::|..|||||.||.|.:::.|.|:|||||.:|..|.:.::|||||.|.
Zfish   381 KGLFPFKLETSYNNHYSLVVDGPLDRESVSQYNITITAADEGTPPLSSSTVITVHVSDVNDNAPH 445

  Fly   504 FEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETH---AQWFQIDPQTGLITT 565
            |...:.:|.:.|.:..|..|.:|.|.|.|.|.|:.|:|||.::..:.   .....|:..:|.|.:
Zfish   446 FPAPVINAFLSENSQAGGLVTKVTADDSDTGENAELSYSLLDSSSSSIPVTTLININSLSGEIFS 510

  Fly   566 RSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNV-SV-AENEP--- 625
            ....:.|.....|..|.|.|.|||||||.|||.|.|.|.|||.|:....:... || .||.|
Zfish   511 LQSFNHEETKRFQFQVTATDSGVPPLSSNATVNVFILDENDNSPVILAPYSEPGSVNTENIPYSA 575

  Fly   626 -VGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTE------FEVRSASGEICIAGELDFERRSSY 683
             .|..:.|:.:.|.|.|.||:::|       ||||      |.:.|::|||.....:......::
Zfish   576 EAGYFVAKIRSVDADSGYNALLSY-------HLTEPKGTNLFRIGSSTGEIRTKRRMSDNDLKTH 633

  Fly   684 EFPVLATDRGGLS---TTAMIKMQLTDVNDNRPVFYPREYKVSLRESP---KASSQASSTPIVAV 742
            ...:..:|.|..|   ||:|..:.|..::|         .|.|.||.|   ::.|..:...::|:
Zfish   634 PLIITVSDNGEPSLSATTSMDVVVLESLDD---------IKTSFREVPVKEESFSDLNLYLLIAI 689

  Fly   743 VA-------------------TDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFV------VRP 782
            |:                   ||..:..:|.   .::..:..|.:...:||.:..|      ::.
Zfish   690 VSVSVIFLLSLVGLIAAKCYRTDSSFSRYGA---PVINTHPDGSWSFSKSTQQYDVCFSSDTIKS 751

  Fly   783 DMLSVRTQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKA-------RYNYYVKEDI 840
            |:: |...|     ....|...:..|:|     ......|..|..||.       ||:..::..:
Zfish   752 DVV-VFPSP-----FPPADAELISINSD-----DTFTRTQTLPTNEKPKGPNADWRYSASLRAGV 805

  Fly   841 PRGTVVGSVIA----ASGDVAHRSPVRYSIYSGDPDGYFS------IETNSGNIRIAKPLDHEAK 895
            .....:....|    |.|.:....|...|...|:.:|..|      |.:||.:.|
Zfish   806 QSSVHMEEASAVMQGAQGMLVQNWPTVSSAADGEGEGQLSPPVGAGINSNSWSFR---------- 860

  Fly   896 SQVLLNIQATLGEPPVYGHTQ 916
                      .|..|.||..|
Zfish   861 ----------YGAGPGYGPPQ 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	13/49 (27%)
		Cadherin_repeat	178..282	CDD:206637	32/104 (31%)
		Cadherin_repeat	291..389	CDD:206637	32/97 (33%)
		Cadherin_repeat	406..500	CDD:206637	38/100 (38%)
		Cadherin_repeat	509..607	CDD:206637	36/100 (36%)
		Cadherin_repeat	616..711	CDD:206637	29/109 (27%)
		Cadherin_repeat	719..820	CDD:206637	21/128 (16%)
		Cadherin_repeat	832..927	CDD:206637	18/95 (19%)
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdh1a3	NP_001019268.1	Cadherin_2	24..106	CDD:285466	8/30 (27%)
		Cadherin_repeat	131..231	CDD:206637	32/104 (31%)
		Cadherin_repeat	240..337	CDD:206637	32/97 (33%)
		Cadherin_repeat	349..442	CDD:206637	38/101 (38%)
		Cadherin_repeat	450..552	CDD:206637	36/101 (36%)
		Cadherin_repeat	570..658	CDD:206637	25/94 (27%)
		Cadherin_C_2	680..752	CDD:293101	9/74 (12%)
		Cadherin_tail	788..910	CDD:292596	19/104 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10294
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000