DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and pcdh2ab11

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_001009590.2	Gene:	pcdh2ab11 / 493599	ZFINID:	ZDB-GENE-041118-10	Length:	940	Species:	Danio rerio

Alignment Length:	689	Identity:	215/689 - (31%)
Similarity:	323/689 - (46%)	Gaps:	59/689 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 IDRATGEIRTKVKLDRE------TRASYSLVAIPLSGRNI-RVLVTVKDENDNAPTFPQTSMHIE 182
            :::.||.:..|.::|||      .:.|..|.|:..|..|: |..|.|.|.|||||.|..:..|:.
Zfish    75 VNKKTGILHVKERIDREEICEQNIKCSLPLEAMISSPLNVFRFEVNVVDINDNAPAFRTSVTHLN 139

  Fly   183 FPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQISGFLDRE 247
            ..|.|....:..|..|.|.|:...:.:.|.:   :.|:.|.|......|..:..:|.:...||||
Zfish   140 ISELTFPGERFPLQGAFDADVGSNSLKSYKL---SQNEHFSLDVQGGGDQSVSAELVLQKALDRE 201

  Fly   248 TTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVLQVYASD 312
            ......|.:.|:|||.||..|.:.:.:.:.|:|||.|:|::|.|.:.|.|||..||.|:.|.|.|
Zfish   202 KQAVIQLTLTAVDGGKPPKSGSIEIIVNVLDINDNTPVFSKSLYKSKVTENAARGTHVITVKAVD 266

  Fly   313 TDADENGLVEYAINRRQSDKE-QMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPLETT 376
            .|...||.:.|:|....:||. ..|.|:..||.|.:.|.:|||.:...||.:.|||.|..|....
Zfish   267 LDEGVNGEIIYSIINPNNDKNVDAFSINSVTGEITVQKDVDFEQRNAIELRIQAKDKGYNPKAAH 331

  Fly   377 AFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVTLN-GG 440
            ..|.:.|.|||||.|.|:|..|..    .:.|.|..|..|..|:|.|.|:.   .|..|||| .|
Zfish   332 CKVLVEVVDVNDNIPVISVTSLVS----TVKEDAPIGTMVGMITVTDNDAG---KNGQVTLNIEG 389

  Fly   441 DGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDVNDNPPEFE 505
            ...|.:.....:.|.::|:.|||||..|.|.:::.|.|:|:|||.::..|.:.::|||||.|.|.
Zfish   390 SVPFKVQNSYKNYYTLVVNGPLDRERASEYNVTISAADEGSPPLSSTSVIAVHVSDVNDNAPRFP 454

  Fly   506 QDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETH--AQWFQIDPQTGLITTRSH 568
            :.:.:..|.|.:..|..:..|.|.|.|.|.|:.:||||.|:.::.  .....|:..||.:.:...
Zfish   455 EPVINVYVKENSQIGAVLHTVSAVDPDVGDNARITYSLLESSKSGPVTSMININSDTGDLHSLQS 519

  Fly   569 IDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNV-SV-AENEP----VG 627
            .:.|.....:..|.|.|.|||||||..||.|.:.|.|||.|.....:..: || .||.|    .|
Zfish   520 FNYEEIKTFEFKVQATDSGVPPLSSNVTVNVFVLDENDNSPAILAPYSELGSVNTENIPYSAEAG 584

  Fly   628 RCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPVLATDR 692
            ..:.|:.|.|.|.|.||:::|.|.|. |....|.:.::||||.....:......::...:|..|.
Zfish   585 YFVAKIRAVDADSGYNALLSYHISEP-KGNNLFRIGTSSGEIRTKRRMSDNDLKTHPLVILVCDN 648

  Fly   693 GGLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESP---KASSQASSTPIVAVVA---------- 744
            |..|.:|.:.:....|.....|      |...|.:|   ::.|..:...::|:|:
Zfish   649 GEPSLSATVSIDAVVVESGGDV------KTPFRHAPVKEESFSDLNLYLLIAIVSVSVIFLLSLI 707

  Fly   745 ---------TDPDYGNFGQVSYRIVAGNEAGIFRIDRST 774
                     ||   .:.|:.|..|:..:..|.:...:||
Zfish   708 SLIAVKCHRTD---SSLGRYSAPIITTHPDGSWSYSKST 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	18/53 (34%)
		Cadherin_repeat	178..282	CDD:206637	27/103 (26%)
		Cadherin_repeat	291..389	CDD:206637	39/98 (40%)
		Cadherin_repeat	406..500	CDD:206637	34/94 (36%)
		Cadherin_repeat	509..607	CDD:206637	33/99 (33%)
		Cadherin_repeat	616..711	CDD:206637	28/100 (28%)
		Cadherin_repeat	719..820	CDD:206637	14/78 (18%)
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdh2ab11	NP_001009590.2	Cadherin_2	28..108	CDD:311943	9/32 (28%)
		Cadherin_repeat	137..236	CDD:206637	27/101 (27%)
		Cadherin_repeat	245..344	CDD:206637	39/98 (40%)
		Cadherin_repeat	356..449	CDD:206637	34/95 (36%)
		Cadherin_repeat	457..558	CDD:206637	33/100 (33%)
		Cadherin_repeat	576..659	CDD:206637	24/83 (29%)
		Cadherin_C_2	686..758	CDD:318652	10/61 (16%)
		Cadherin_tail	795..912	CDD:318236
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10294
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000