DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and pcdh2ab10

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_001009589.2	Gene:	pcdh2ab10 / 493598	ZFINID:	ZDB-GENE-041118-9	Length:	940	Species:	Danio rerio

Alignment Length:	800	Identity:	242/800 - (30%)
Similarity:	367/800 - (45%)	Gaps:	72/800 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 ALHPSHMLRSSLL--ILLAIVLLGSSQAASHDQERERKLEVFEGVAVDYQIGYIGDFGGIDSGPP 110
            ||..:|:|||.:.  :.|...:..:.|......|..........:|.|:.:. :.|.    ....
Zfish     2 ALTRTHVLRSWIFFSVFLCCWIFTNGQIVYSISEEANPGTAVGNLAKDFNLN-VQDI----ERRG 61

  Fly   111 YIIVAEAGVETDLAIDRATGEIRTKVKLDRE------TRASYSLVAIPLSGRNI-RVLVTVKDEN 168
            :.||:|:. :.....:..||.:..|.::|||      .:.|..|.||..|..|: |..:.|.|.|
Zfish    62 FQIVSESN-KRYFDFNFKTGVLHVKERIDREELCEQKIKCSLPLEAIVNSPLNVFRFEINVLDIN 125

  Fly   169 DNAPTF--PQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERD 231
            ||.|.|  |:|:::|.  |:.....:..|..|.|.|:...:.:.|.:   :.|:.|.|......:
Zfish   126 DNPPKFRTPKTTINIS--ESALPGEQFALPSAFDADVGINSVKSYKL---SPNEHFSLDVQSGGE 185

  Fly   232 GVLYLDLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVP 296
            ..:..:|.:...||||..|...|.:.|:|||.|...|.|.:.:.::|||||.|:|::|.|.|.|.
Zfish   186 QSVSAELVLQKALDREKQPLIRLTLTAVDGGKPLRSGTMQITVHVEDVNDNIPVFSKSLYKARVN 250

  Fly   297 ENATVGTSVLQVYASDTDADENGLVEYAINRRQSDKE-QMFRIDPRTGAIYINKALDFETKELHE 360
            |||..|||::.|.|||.|...||.:.||:....:|:. :.|.|:|.||.|.:...:|:|.|...|
Zfish   251 ENAPPGTSIITVQASDPDEGVNGQIVYALVNHDNDRNVESFAINPETGEITVKGDVDYERKNAVE 315

  Fly   361 LVVVAKDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPD 425
            |.|.|||.|.:|......|.:.:.|||||.|.|:|..|.:    .:.|.|.....|..|:|.|.|
Zfish   316 LRVQAKDKGHKPRAALCKVLLEIIDVNDNVPEISVTSLVN----TVKEDALIDTVVGMITVTDND 376

  Fly   426 SKTEYANVNVTLN-GGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKS 489
            :.   .|..|.|| .|...|.:.....:.|.:.|:.|||||..|.|.:::.|.|:|||||.::..
Zfish   377 AG---KNGQVILNIQGSSPFKVQNSYKNYYTLFVNGPLDRERASEYNVTISAADEGTPPLSSTSV 438

  Fly   490 IFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETH--AQ 552
            |.:.::|||||.|.|.:.:.:..|.|.:..|..:..|.|.|.|.|.|:.:||||.|:.::.  ..
Zfish   439 IAVHVSDVNDNAPRFPEPVINVYVKENSQIGAVLHTVSAVDPDVGDNARITYSLLESSKSGPVTS 503

  Fly   553 WFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYN 617
            ...|:..||.:.:....:.|.....:..|.|.|.|||||||..||.|.:.|.|||.|.....:..
Zfish   504 MININSDTGDLHSLQSFNYEEIKTFEFKVQATDSGVPPLSSNVTVNVFVLDENDNSPAILAPYSE 568

  Fly   618 V-SV-AENEP----VGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELD 676
            : || .||.|    .|..:.|:.|.|.|.|.||:::|.|.|. |....|.:.::||||.....:.
Zfish   569 LGSVNTENIPYSAEAGYFVAKIRAVDADSGYNALLSYHISEP-KGNNLFRIGTSSGEIRTKRRMS 632

  Fly   677 FERRSSYEFPVLATDRGGLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESP---KASSQASSTP 738
            .....::...||..|.|..|.:|.:.:....|.....|      |...|.:|   ::.|..:...
Zfish   633 DNDLKTHPLVVLVCDNGEPSLSATVSIDAVVVESGGDV------KTPFRHAPVKEESFSDLNLYL 691

  Fly   739 IVAVVATDPDY--GNFGQVSYRIVAGNEAGIFRIDRSTGE----IFVVRPD---MLSVRTQPMHM 794
            ::|:|:....:  ...|.::.:        ..|.|.|.|.    :....||   ..|..||...:
Zfish   692 LIAIVSVSVIFLLSLIGLIAVK--------CHRTDSSLGRYSAPMITTHPDGSWSYSKSTQQYDV 748

  Fly   795 LNISATDGGNLRSNADAVVF 814
            ...|.|    |:|  |.|||
Zfish   749 CFSSDT----LKS--DVVVF 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	21/67 (31%)
		Cadherin_repeat	178..282	CDD:206637	27/103 (26%)
		Cadherin_repeat	291..389	CDD:206637	40/98 (41%)
		Cadherin_repeat	406..500	CDD:206637	33/94 (35%)
		Cadherin_repeat	509..607	CDD:206637	33/99 (33%)
		Cadherin_repeat	616..711	CDD:206637	29/100 (29%)
		Cadherin_repeat	719..820	CDD:206637	23/107 (21%)
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdh2ab10	NP_001009589.2	Cadherin_2	28..109	CDD:311943	18/86 (21%)
		Cadherin_repeat	137..236	CDD:206637	27/103 (26%)
		Cadherin_repeat	245..344	CDD:206637	40/98 (41%)
		Cadherin_repeat	356..449	CDD:206637	33/95 (35%)
		Cadherin_repeat	457..558	CDD:206637	33/100 (33%)
		Cadherin_repeat	576..659	CDD:206637	25/83 (30%)
		Cadherin_C_2	686..758	CDD:318652	16/85 (19%)
		Cadherin_tail	795..912	CDD:318236
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10294
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000