DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and pcdh2aa1

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_001009585.2	Gene:	pcdh2aa1 / 493596	ZFINID:	ZDB-GENE-041118-13	Length:	931	Species:	Danio rerio

Alignment Length:	981	Identity:	257/981 - (26%)
Similarity:	418/981 - (42%)	Gaps:	185/981 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   830 ARYNYYVKEDIPRGTVVGSVIAASG-DVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHE 893
            |:.||.::|:...|..||::....| |........:.|..|.....|.:....|.:.:::.:|.|
Zfish    28 AQINYSLQEESKIGVNVGNIAKDLGIDPTSLENRNFRIVVGTKQELFRVNHEDGALFVSQRIDRE 92

  Fly   894 ---AK-SQVLLNIQATLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAH 954
               || :..|:|::|.: |.|:..| |:::::.|||||.|.|.....::.:.|||..||......
Zfish    93 ELCAKINPCLINLKAVI-ENPLEMH-QISVDIIDVNDNPPSFLDENYKLEILESAMTGARFQVET 155

  Fly   955 AHDKDSGSSGQVTYSLVKESGKGLFAIDAR----SGH---LILSQHLDYESSQRHTLIVTATDGG 1012
            |||.|.||:...:|.|   |....|.::..    .|.   |||.:.||.|.|.||.||:||||||
Zfish   156 AHDPDIGSNDLQSYKL---SQNHYFRLETEDMGDEGKIPVLILQKPLDREKSARHNLILTATDGG 217

  Fly  1013 VPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVD 1077
            .|..|....|.:.|.|||||.||.:|.:|:|.|.|.......:::|||||.|.|.|..|.|
Zfish   218 KPHKSAAANITIVVSDVNDNTPVCDKQKYTVTVKEDAPEGTFLLRVNASDSDEGVNGEIEY---- 278

  Fly  1078 AGVDNVTNSI--SSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTRVI 1140
                ::.|..  .:|||   |.:...:|.:.::..|:.|.|..|:|.:||.|.|..:...:..|:
Zfish   279 ----SLRNKFRKGASDV---FDLDNITGELKIKGGLNFEERQVYELKILAADKGAVSLSTQCNVL 336

  Fly  1141 VRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLPINSSFQVHPVT 1205
            |.|.|.|||.|:...:.....|.|:...|:||.::..:|||.|.|..|..| ||.|..|.:.|..
Zfish   337 VNVEDVNDNRPEIDVTSLSSHIPEDAAPGTVVALIGVTDLDSGMNGKIICS-LPKNIPFDLKPSP 400

  Fly  1206 G----EISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDVVSV 1266
            .    .:.|:|.:|:|.:..||:.:.|:|.|:|..|:...:.:.|:|||||:|:.|. ......|
Zfish   401 DGNFYSLVTKENIDKEAKSSYDITITAKDLGSPSLSSTRSIHVEVTDVNDNSPKFAQ-SPYTFYV 464

  Fly  1267 REEQPPGTEVVRVRAVDRDHGQNASITYSIVK-GRDSDGHGLFSIDPTSGVIRTRVVLDHEERSI 1330
            .|...||..|..:.|.|.|.|:||.::|:|.: ..|.......||:..:|.:.:....|.|....
Zfish   465 TENNKPGIAVFSLSASDLDEGENARVSYTIDRINSDQSMTSFLSINEANGTVYSLKSFDFESLKT 529

  Fly  1331 YRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSSLVFRVREDAALGHVVGSISPIERPAD 1395
            :...|.|.|.|:|...:...:.|.:||.|||.|.     :::.|..:       ||...:|   :
Zfish   530 FHFFVVAKDSGSPSLSSNVTVNVFILDQNDNVPV-----ILYPVSAN-------GSAEGVE---E 579

  Fly  1396 VVRNSVEESFEDLRVTYTLNPLTKDLIEAAFDIDRHSGNLVVARLLDREVQSEFRLEIRALDTTA 1460
            :.||.                              ::|:||.              ::||.|
Zfish   580 IPRNV------------------------------NAGHLVT--------------KVRAYD--- 597

  Fly  1461 SNNPQSSAITVKIEVADVNDNAPEWPQDPIDLQVSEATPVGTIIHNFTATDADTGTNGDLQYRLI 1525
                           ||:..|.  |....:. :|||        |:..|.|..||     |.|.:
Zfish   598 ---------------ADIGYNG--WLLFSLQ-EVSE--------HSLFALDRYTG-----QIRTL 631

  Fly  1526 RYFPQLNESQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLIVQALDQSSNVTERLQTSVTVRL 1590
            |.|.:.:|:|.:.:.|.: |:...:||..|.:..:.|:...... |.|..:.|.::.:.:||..|
Zfish   632 RSFTETDEAQHKLVILVK-DNGNVSLSATATVIVKVVEPKEAFA-ASDVKNAVKDKEENNVTFYL 694

  Fly  1591 RILDANDHAPHFVSPNSSGGKTASLFISDATRIGEVVAHIVAVD----------EDSGDNGQLTY 1645
            .|               :.|..:.||:     |..:|..::...          :|:..:|.|.:
Zfish   695 II---------------TLGSVSVLFV-----ISIIVLIVMQCSKSTDYSSKYLQDTNYDGTLCH 739

  Fly  1646 EITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKGGRFNLII---GAKDHGQPEPKKS----SL 1703
            .|...:|:.|:.:....  :.:..::.|.:      .|..|:|   ..:|.|:|:...|    |.
Zfish   740 SIQYRSGDKRYMLVGPR--MSIGSTIAPGS------NRNTLVIPDRRRRDSGEPKVPSSDWRYSA 796

  Fly  1704 NLHLIVQGSHNNPPRFLQAVYRATILENVPSGSFVLQVTAKSLHGAENANLSYEIPAGVANDLFH 1768
            :|...:|.|.......:....:..:::|.|        |..|....|...:|..:.|||.::.:|
Zfish   797 SLRAGMQSSVRMEESSVMQGAQGVLVQNWP--------TVSSAPDNEGGEVSPPVGAGVDSNSWH 853

  Fly  1769 VDWQRG 1774
            ..:..|
Zfish   854 FRYGPG 859

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637
		Cadherin_repeat	832..927	CDD:206637	26/99 (26%)
		Cadherin_repeat	937..1032	CDD:206637	40/101 (40%)
		Cadherin_repeat	1040..1149	CDD:206637	34/110 (31%)
		Cadherin_repeat	1158..1252	CDD:206637	32/97 (33%)
		Cadherin_repeat	1263..1361	CDD:206637	28/98 (29%)
		Cadherin_repeat	1369..1481	CDD:206637	14/111 (13%)
		Cadherin_repeat	1489..1598	CDD:206637	27/108 (25%)
		Cadherin_repeat	1614..1710	CDD:206637	20/112 (18%)
		Cadherin_repeat	1723..1843	CDD:206637	11/52 (21%)
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdh2aa1	NP_001009585.2	E_set	29..111	CDD:324323	19/82 (23%)
		Cadherin_repeat	137..237	CDD:206637	40/102 (39%)
		Cadherin_repeat	246..345	CDD:206637	34/109 (31%)
		Cadherin_repeat	357..451	CDD:206637	32/94 (34%)
		Cadherin_repeat	459..560	CDD:206637	28/100 (28%)
		Cadherin_repeat	579..667	CDD:206637	31/166 (19%)
		Cadherin_C_2	689..>743	CDD:318652	13/73 (18%)
		Cadherin_tail	786..903	CDD:318236	16/82 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9353
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000