DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and pcdh2ab6

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_001009593.1	Gene:	pcdh2ab6 / 493592	ZFINID:	ZDB-GENE-041118-5	Length:	939	Species:	Danio rerio

Alignment Length:	692	Identity:	216/692 - (31%)
Similarity:	326/692 - (47%)	Gaps:	65/692 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 IDRATGEIRTKVKLDRE------TRASYSLVAIPLSGRNI-RVLVTVKDENDNAPTFPQTSMHIE 182
            ::..||.::.|.|||||      .:.:..|.||..|..|: |..|.|.|.|||:||||.:.:.:.
Zfish    74 VNMKTGILQVKDKLDREEICGQSLKCALELEAIVNSPLNMYRFEVNVLDVNDNSPTFPSSRLQLN 138

  Fly   183 FPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQISGFLDRE 247
            ..|......:..|..|.|.|:...:.:.|.:   :.|:.|.|.:....:..:..:|.:...||||
Zfish   139 VSEAAFIGERYALPNAFDADVGINSVKSYKL---SANEHFSLDAQSGGEQSVSAELVLQKALDRE 200

  Fly   248 TTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVLQVYASD 312
            ..|...|.:.|:|||.||..|.:.:.:.:.|||||.|:|.:|.|.|.:.|||.|..||:.|.|.|
Zfish   201 KQPVIRLTLTAVDGGKPPRSGTVHIIVNVIDVNDNIPVFTKSLYKARILENAPVEFSVITVNARD 265

  Fly   313 TDADENGLVEYAINRRQSDKE-QMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPLETT 376
            .||..||.:||:..:...||. :.|.|:..||.|.:...||.|:....|:.|.|:|.|..|....
Zfish   266 ADAGLNGEIEYSFIKHGIDKNIESFAINKETGEITVMGKLDHESNNAIEIRVQARDKGSTPRVAH 330

  Fly   377 AFVSIRVTDVNDNQPTINVIFLSD---DASPKISESAQPGEFVARISVHDPDSKTEYANVNVTLN 438
            ..|.:.:.|||||.|.|:|..|.:   :.|||       |..|..|:|.|.||.   .|.:|.|.
Zfish   331 CKVLVEIMDVNDNIPEISVTSLINVVKEGSPK-------GTMVGLITVKDDDSG---ENGSVKLK 385

  Fly   439 GGDG-HFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDVNDNPP 502
            ..|. .|||.....:.|.::|..|||||..|.|.:::.|.|:|:|||.::..|.:.::|||||.|
Zfish   386 ILDSLPFALQNTYKNKYSLVVDGPLDRESASEYNVTISAADEGSPPLSSTSVIAVHVSDVNDNAP 450

  Fly   503 EFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETH--AQWFQIDPQTGLITT 565
            .|.:.:.:..|.|.:..|..:..|.|.|.|.|.|:.:||||.|:.::.  .....|:..||.:.:
Zfish   451 RFPEPVINVYVKENSQIGAVLHTVSAVDPDVGDNARITYSLLESSKSGPVTSMININSDTGDLHS 515

  Fly   566 RSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNV-SV-AENEP--- 625
            ....:.|.....:..|.|.|.|||||||..||.|.:.|.|||.|.....:..: || .||.|
Zfish   516 LQSFNYEEIKTFEFKVQATDSGVPPLSSNVTVNVFVLDENDNSPAILAPYSELGSVNTENIPYSA 580

  Fly   626 -VGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPVLA 689
             .|..:.|:.|.|.|.|.||:::|.|.|. |....|.:.::||||.....:......::...:|.
Zfish   581 EAGYFVAKIRAVDADSGYNALLSYHISEP-KGNNLFRIGTSSGEIRTKRRMSDNDLKTHPLVILV 644

  Fly   690 TDRGGLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESP---KASSQASSTPIVAVVA------- 744
            .|.|..|.:|.:.:....|.....|      |...|.:|   ::.|..:...::|:|:
Zfish   645 CDNGEPSLSATVSIDAVVVESGGDV------KTPFRHAPVKEESFSDLNLYLLIAIVSVSVIFLL 703

  Fly   745 ------------TDPDYGNFGQVSYRIVAGNEAGIFRIDRST 774
                        ||   .:.|:.|..::..:..|.:...:||
Zfish   704 SLISLIAVKCHRTD---SSLGRYSAPMITTHPDGSWSYSKST 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	20/53 (38%)
		Cadherin_repeat	178..282	CDD:206637	26/103 (25%)
		Cadherin_repeat	291..389	CDD:206637	37/98 (38%)
		Cadherin_repeat	406..500	CDD:206637	33/94 (35%)
		Cadherin_repeat	509..607	CDD:206637	33/99 (33%)
		Cadherin_repeat	616..711	CDD:206637	28/100 (28%)
		Cadherin_repeat	719..820	CDD:206637	13/78 (17%)
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdh2ab6	NP_001009593.1	Cadherin_2	28..108	CDD:285466	11/33 (33%)
		Cadherin_repeat	136..235	CDD:206637	26/101 (26%)
		Cadherin_repeat	244..343	CDD:206637	37/98 (38%)
		Cadherin_repeat	356..448	CDD:206637	36/101 (36%)
		Cadherin_repeat	456..557	CDD:206637	33/100 (33%)
		Cadherin_repeat	575..658	CDD:206637	24/83 (29%)
		Cadherin_C_2	685..757	CDD:293101	9/61 (15%)
		Cadherin_tail	793..911	CDD:292596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10294
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910