DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and pcdh2ab3

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_001008484.1	Gene:	pcdh2ab3 / 493590	ZFINID:	ZDB-GENE-041118-3	Length:	939	Species:	Danio rerio

Alignment Length:	962	Identity:	257/962 - (26%)
Similarity:	406/962 - (42%)	Gaps:	200/962 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  1041 YSVN--VSESRSIN--AQIIQVNASDLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPN 1101
            |||:  ||...::.  |:.:.:|..:|::.     .::||            :....::|.:...
Zfish    32 YSVSEEVSPGTTVGNLAKDLNLNVQELESR-----MFQIV------------TGAKKKYFEVNLK 79

  Fly  1102 SGWIYLRAPLDRE----TRDRYQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRI 1162
            :|::|:...:|||    ...:..::|.|..|.....:   ::.:.::|.|||.|.|.:......|
Zfish    80 TGFLYVNERIDREELCAKAPKCTVSVEAVINNPLKLY---QIEINIVDVNDNSPSFSEKSQTIDI 141

  Fly  1163 EENLRRGSVVGVVTASDLDLGENAAIRYSLLPINSSFQ--VH---PVTGEISTREPLDRELRELY 1222
            .|:...|....:..|:|.|:|:||...|. |..|..|.  ||   .|:.|:..::.||||.:.:.
Zfish   142 AESTLPGVRFSLHHATDADVGKNAINDYK-LSSNEHFSLAVHRGEGVSAELVLQKALDREKKPVI 205

  Fly  1223 DLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHG 1287
            .|.:...|.|||.::....:.:.|.|:|||.|..:.|... .||.|....||.:..:.|.|.|.|
Zfish   206 QLTLTTVDGGTPSKTGTSIIMVKVLDINDNTPVFSKPLYK-TSVFENAAIGTTIAVLNATDFDEG 269

  Fly  1288 QNASITYSIVKGRDSDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLR 1352
            .|:.|.|||||...:....:|.||..:|||..:..:|.||.:.:.:...|||.|.||..|...:.
Zfish   270 SNSEIIYSIVKRDQNKVLQMFDIDQNTGVIIVKGNIDFEENNAFEIRAQASDKGQPPMSTHCKVL 334

  Fly  1353 VEVLDLNDNRPTFTSSSLVFRVREDAALGHVVGSISPIERPADVVRNSVEESFEDLRVTYTLNPL 1417
            |||||:|||.|..|.:||:..|:|||::|..|..:|.|:|  |..||.|........|.:.|...
Zfish   335 VEVLDINDNEPEITVTSLLSTVKEDASIGTAVALVSVIDR--DGGRNGVVNCAVSNNVPFKLQTN 397

  Fly  1418 TKDLIEAAFDIDRHSGNLVVARLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIEVADVNDNA 1482
            .|:..           :|||...||||..||:.:.|.|.|  ..:.|.||...:.:.|:||||||
Zfish   398 YKNYY-----------SLVVDGPLDRERASEYNVTISAAD--EGSPPLSSTSVIAVHVSDVNDNA 449

  Fly  1483 PEWPQDPIDLQVSEATPVGTIIHNFTATDADTGTNGDLQYRLIRYFPQLNESQE--QAMSLFRMD 1545
            |.:|:..|::.|.|.:.:|.::|..:|.|.|.|.|..:.|.|:       ||.:  ...|:..::
Zfish   450 PRFPEPVINVYVKENSQIGAVLHTVSAVDPDVGDNARVTYSLL-------ESSKGGPVTSMININ 507

  Fly  1546 SLTGAL-SLQAPLDFEAVQEYLLIVQALDQSSNVTERLQTSVTVRLRILDANDHAPHFVSPNSSG 1609
            |.||.| |||: .::|.::.:...|||.|..   ...|.::|||.:.:||.||::|..::|.|..
Zfish   508 SDTGDLHSLQS-FNYEEIKTFEFKVQATDSG---VPPLSSNVTVNVFVLDENDNSPAILAPYSEL 568

  Fly  1610 GKTASLFISDATRIGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLPPA 1674
            |...:..|..:...|..||.|.|||.|||.|..|:|.|:...|...|||.:.:|.|...:.:  :
Zfish   569 GSVNTENIPYSAEAGYFVAKIRAVDADSGYNALLSYHISEPKGNNLFRIGTSSGEIRTKRRM--S 631

  Fly  1675 TEDVEKGGRFNLIIGAKDHGQP-----------------------------EPKKSSLNLHLIVQ 1710
            ..|::   ...|:|...|:|:|                             |...|.|||:|::
Zfish   632 DNDLK---THPLVILVCDNGEPSLSATVSIDAVVVESGGDVKTPFRHAPVKEESFSDLNLYLLI- 692

  Fly  1711 GSHNNPPRFLQAVYRATILENVPSGSFVL---QVTAKSLHGAENANLSYEIPAGVANDLFHVDWQ 1772
                       |:...:::       |:|   .:.|...|..:::...|..|....    |.|..
Zfish   693 -----------AIVSVSVI-------FLLSLISLIAVKCHRTDSSLGRYSAPMITT----HPDGS 735

  Fly  1773 RGIITTRGQFD--------RESQASYVLPVYVRDA-----------NRQSTLSS----------- 1807
            .....:..|:|        :.....:..|....||           .|..||.:
Zfish   736 WSYSKSTQQYDVCFSSDTLKSDVVVFPAPFPPADAELISINGGDTFTRTQTLPNKEKPKVPSSDW 800

  Fly  1808 -----------SAVRKQRSS----------------DSIGDTSNGQHFDVATIYITVG-DVNDNS 1844
                       |:||.:.||                .|..|...|:      :...|| .|:.||
Zfish   801 RYSASLRAGMQSSVRMEESSVMQGAQGVLVQNWPTVSSAPDNEGGE------VSPPVGAGVDSNS 859

  Fly  1845 PEFRPGSCYGLSVPENSEPGVIHT---VVASDLDEGPNADLIYSITGGNLGN 1893
            ..||.|.  |...|.:.:||.:..   ::       |.:..|.||..|..|:
Zfish   860 WHFRYGP--GPGGPPHLKPGEVPPEAFII-------PGSPAIISIRQGQDGD 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637	21/115 (18%)
		Cadherin_repeat	1158..1252	CDD:206637	29/98 (30%)
		Cadherin_repeat	1263..1361	CDD:206637	38/97 (39%)
		Cadherin_repeat	1369..1481	CDD:206637	37/111 (33%)
		Cadherin_repeat	1489..1598	CDD:206637	34/111 (31%)
		Cadherin_repeat	1614..1710	CDD:206637	33/124 (27%)
		Cadherin_repeat	1723..1843	CDD:206637	27/180 (15%)
		Cadherin_repeat	1853..1948	CDD:206637	10/44 (23%)
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdh2ab3	NP_001008484.1	Cadherin_2	29..111	CDD:285466	18/95 (19%)
		Cadherin_repeat	136..235	CDD:206637	29/99 (29%)
		Cadherin_repeat	244..343	CDD:206637	38/99 (38%)
		Cadherin_repeat	355..448	CDD:206637	35/107 (33%)
		Cadherin_repeat	456..557	CDD:206637	34/111 (31%)
		Cadherin_repeat	575..658	CDD:206637	27/87 (31%)
		Cadherin_C_2	685..757	CDD:293101	15/94 (16%)
		Cadherin_tail	793..911	CDD:292596	26/125 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10294
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000