DRSC/TRiP Functional Genomics Resources

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Protein Alignment ds and Cad99C

DIOPT Version :10

Sequence 1:NP_523446.2 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:NP_733314.1 Gene:Cad99C / 43528 FlyBaseID:FBgn0039709 Length:1706 Species:Drosophila melanogaster


Alignment Length:1870 Identity:434/1870 - (23%)
Similarity:712/1870 - (38%) Gaps:450/1870 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   567 SHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAENEPVGRCIL 631
            |||      |.|::...|..|   ...|..::|.:.|:|||.|.|..:.|.|:|.|:.|||..|.
  Fly   107 SHI------VFQVSCTTRSTG---KKRTIPIIVRVSDINDNAPRFMNTPYEVTVPESTPVGTTIF 162

  Fly   632 K-VSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSA------------SGEICIAGELDFERRSSY 683
            : :.|.|.|.|||.:|.|.|.||..:.|..|..||            .|::.:|..||||:..:|
  Fly   163 RNIQALDKDAGVNGLVEYFIAEGSPNSTNVEKYSADGYGTFAISFPHQGQVTVAKTLDFEKIQTY 227

  Fly   684 EFPVLATDRG-----GLSTTAMIKMQLTDVNDNRPVFYPREYK--VSLRE---SPKASSQASSTP 738
            ...::|:||.     .||:|..:.:.:.|.||..|.|.   |.  |||..   :|:.|:...:..
  Fly   228 YLTIVASDRARNTADRLSSTTTLTVNIADSNDLDPSFI---YSGCVSLDGACINPEYSASVPAGS 289

  Fly   739 IVAVV--------ATDPDYGNFGQVSYRIVA---GNEAGIFRIDRSTGEIFVVRPDMLSVRTQPM 792
            ::.|:        |.|.|..| ..:.|...:   ||.|..|:||.|||    |.....:|.|...
  Fly   290 LLGVLTVLPERIQAVDLDTIN-SPIRYSFASGMPGNYADYFQIDESTG----VLKQTKAVDTSTA 349

  Fly   793 HMLNI-----SATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAA 852
            ...:|     ..:.|....:.|...:|:..:||  .||:...::...||.|:.|.||.|..    
  Fly   350 KKYDIIVKAEEVSPGPQRFTTAKLEIFVKPVDA--NPPVISSSQAEGYVDENSPIGTRVLD---- 408

  Fly   853 SGDVAHRSPVRYSIYSGD-------PDGYFSIETNSGNIR-------IAKPLDHEAKSQVLLNIQ 903
                ||.:|:.:.....|       ||..:.:.|.|.|:.       ..:.||.:..:......|
  Fly   409 ----AHGNPISFMTTDADLSDSDPKPDYIYELTTPSFNVTGDGILVVNEENLDRDPPAPGRFKFQ 469

  Fly   904 ATLGEPPVYGHT---QVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYA-AHAHDKDSGSSG 964
            ....||.....:   .:.:.:.|||||||:. |.:..||:....:..:.|.. ..|.|.|.|.:.
  Fly   470 VVAREPRTNAASAPLSLTVHLRDVNDNAPKL-AMVAPISITAGDQSESRLVTQVTATDNDEGPNA 533

  Fly   965 QVTYSLVKESGKGL--FAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDV- 1026
            .||||:...|..|:  |.|:|.:|.:.....|  .:.:::::.|.|||.|  .||:...:.|.| 
  Fly   534 VVTYSIYHVSNNGIQKFTINATTGEIRTQGRL--LAGEQYSITVQATDIG--GLSSQAIVEVSVT 594

  Fly  1027 QDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVDAGVDNVTNSISSSD 1091
            ...|..||.|:|..|.|.|||...||:.:..|:|.|.:   |..:.|.|           ||.:|
  Fly   595 PGPNTKPPRFQKPIYEVQVSEGAEINSTVTVVHAEDPE---NDAVVYSI-----------ISGND 645

  Fly  1092 VSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKS 1156
            :.| |.:...||.|.:...||||:..||||.:.|.|.|..::.|  .|.::|.|.||.:|:|:.|
  Fly   646 LRQ-FAVGQESGVIIVIRKLDRESLTRYQLILKAEDTGGLSSSA--TVNIKVTDINDKNPEFEAS 707

  Fly  1157 --KYEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLPINSSFQVHPVTGEISTREPLDRELR 1219
              .|.|::||...:.| ||||.|:|.|.|.||.|.|| :|.:..|.::..:|||.|.:.||.|..
  Fly   708 TLPYVFQVEEGKAQAS-VGVVHATDADEGINAEITYS-IPTDIPFTINATSGEILTAKELDYEQL 770

  Fly  1220 ELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDR 1284
            ..|..||.|:|.....|.....|.:.|.|:.|..|:.:|.:.||.....|:  ...|..|:|.|.
  Fly   771 NEYKFVVTAKDGAPDARLGTASVTVMVLDLPDEVPKFSDARIDVHIPENEE--NFLVATVQAFDP 833

  Fly  1285 DHGQNASITYSIVKGRDSDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAA-SDGGNPPRETV 1348
            |  ....|||.:.||...    ||.:...||.:||...||:|.:..::|.:.. .:.||.|.:|:
  Fly   834 D--SMPEITYVLRKGNAE----LFKVSEKSGEVRTIKGLDYESQKQHQLTIGTIENDGNGPGDTI 892

  Fly  1349 RMLRVEVLDLNDNRPTFTSSSLVFRVREDAALGHVVGSISPIE----RPADVVRNSVEESFEDLR 1409
             :|.|:|.|.||..|.|.:......|.:|..:|.::.::..|:    .|.:|||..:        
  Fly   893 -LLVVDVEDRNDLPPRFITVPDPVTVNDDQGIGTIIATLPAIDGDGTSPGNVVRYEI-------- 948

  Fly  1410 VTYTLNPLTKDLIEAAFDIDRHSGNLVVARLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIE 1474
                   :.:......|.:|..:|.:.:...|.:|..:|::::|||.|.   ..||.|::     
  Fly   949 -------VGRGKAPKYFQVDPDTGAVRIRDELRKEEDTEYQVDIRAYDL---GEPQLSSV----- 998

  Fly  1475 VADVNDNAPEWPQDPIDLQVSEATPVGTIIHNFTAT-----------DADTGTNGD---LQYRLI 1525
                                   .|:...:|:..::           ::.||.:.:   |.:...
  Fly   999 -----------------------APLRVDVHHLLSSGNNEIKLDNKLESGTGMSSESIGLAFSDD 1040

  Fly  1526 RYFPQLNESQEQAMSL-----------------FRMDSLTG---------------ALSLQAPLD 1558
            .|...:.||.|...:|                 ||.:.::|               .|.|..|||
  Fly  1041 SYTTSVPESMEANSTLKLIQIVNSKTSGDGPPAFRCEFVSGNGGGIFNLSSADHGCNLLLIQPLD 1105

  Fly  1559 FEAVQEYLLIVQALDQSSNVTERLQTSVTVRLRILDANDHAPHFVSPNSSGGK-TASLFISDATR 1622
            ||....|.|.:: |.........|:.:.:|.:.:.|.||:||.|......|.: |....:::...
  Fly  1106 FENKSSYSLQLR-LTSHRYFVNPLKDTTSVEIIVQDENDNAPEFEFNRLRGQQDTFYTVVTEEMD 1169

  Fly  1623 IGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGR-------FRINSQTGIIELVKSLPPATEDVEK 1680
            :...:..:.|.|.|||..|.:.|.:. .:.|.|       |.::..||::...|....     |.
  Fly  1170 VDTTILQVRATDRDSGKFGTVRYTLY-DDDENRVNMPTSFFMMSEDTGVLRTAKHFKN-----EN 1228

  Fly  1681 GGRFNLIIGAKDHGQPEPKKSSLNLHLIVQGSHNNPPRFLQAVYRATILENVPSGSFVLQVTAKS 1745
            ......::.|:|....|            ||||..         ||.|:.|             .
  Fly  1229 DFPLTFLVEARDSDGQE------------QGSHRT---------RARIVVN-------------K 1259

  Fly  1746 LHGAENANLSYEIPAGVANDLFH--------VDWQRGIITTRGQFDRESQASYVLPVYVRDANRQ 1802
            |.......||:  |....:||.:        :|.:.|:::   ..:|.|...|:           
  Fly  1260 LADINRMALSF--PNAAPSDLRNYYTELEELLDKKTGLVS---GIERMSSQKYL----------- 1308

  Fly  1803 STLSSSAVRKQRSSDSIGDTSNGQHFDVATIYITVGDVNDNSPEFRPGSCYGLSVPENSEPGVIH 1867
             ..:.|.:....::|               |:..:.|........|..|             ::.
  Fly  1309 -AKNGSVIENPAATD---------------IWFYLIDPKTEQLVSRKDS-------------IVE 1344

  Fly  1868 TVVASDLDEGPNADLIYSITGGNLGNKFSIDSSSGELSARPLDREQHSRYTLQIQASDRGQPKSR 1932
            |.:   |:....::|           ..::..::.|..:.||:|::|........|.|.......
  Fly  1345 TTL---LEPAARSEL-----------NIALPRATAENISFPLERKEHVHKVKAAVAIDNEVFPFT 1395

  Fly  1933 QGHCNITIFV------------------------EDQNDNAPRF-------KLSKYTGSVQEDAP 1966
            ....::.|.:                        :..:.|.||:       :.|..:.::.....
  Fly  1396 LIAISLVILILGTIGIIYICISWSKYKNFKQRMRQYSSTNPPRYDPVIVNQQASSASETIANMKE 1460

  Fly  1967 LGTSVVQISAVDADLGVNARLVYSLANETQWQFAIDGQSGLI----TTVGKLDRELQASYNFMVL 2027
            ..|.::.: ||..|:..:.:|.:|..|..   |::|..|.:.    |..|.......:......:
  Fly  1461 YETQMLAM-AVPPDVDDDLQLDFSAKNHA---FSLDNVSYITHKENTNGGGQSSPSHSDATTATI 1521

  Fly  2028 ATDGGRYEVRSATVPVQINVLDINDNRPIFERYPYIGQVPALIQPGQTLLKVQALDADLGANAEI 2092
            ||......:.:|::.   |.|.||:.:..|.|               ||                
  Fly  1522 ATLRRHKNLNNASMN---NNLAINNRQNTFNR---------------TL---------------- 1552

  Fly  2093 VYSLNAENSAVSAKFRINPSTGALSASQSLASESGKLLHLEVVARDKGNPPQSSLGLIELLIGEA 2157
              .:|..|:|...   .:|..||||.:.:|    |::.|      ...|..|:....|:      
  Fly  1553 --EMNTRNNANPL---ASPPNGALSGTLTL----GRIKH------QNSNHYQNGAYNID------ 1596

  Fly  2158 PQG-TPVLRFQNETYRVMLKENSPSGTRLLQVVALRSDGRRQKVQFSFGAGNEDGILSLDSLSGE 2221
            |.| ..:...:|..|..|.:..:..|    .|..|..:|.......     ..:|.|:.....||
  Fly  1597 PTGPNNMAHAKNNAYSTMGRRGNTFG----DVGLLNGNGELMNATL-----GRNGQLNNRLYGGE 1652

  Fly  2222 IRVNKPHL----LDYDRFSTPSMSALSRGR------ALHYEEEIDESSEE 2261
            :.:..|..    .|::..|:.:.: :|.|:      ...|..::|.|..|
  Fly  1653 VPITNPLFQRSNSDHNHLSSTNEN-VSFGKRDYGQIGFSYLNDLDRSEVE 1701

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_523446.2 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637
Cadherin_repeat 291..389 CDD:206637
Cadherin_repeat 406..500 CDD:206637
Cadherin_repeat 509..607 CDD:206637 11/39 (28%)
Cadherin_repeat 616..711 CDD:206637 38/112 (34%)
Cadherin_repeat 719..820 CDD:206637 28/121 (23%)
Cadherin_repeat 832..927 CDD:206637 24/111 (22%)
Cadherin_repeat 937..1032 CDD:206637 28/98 (29%)
Cadherin_repeat 1040..1149 CDD:206637 37/108 (34%)
Cadherin_repeat 1158..1252 CDD:206637 36/93 (39%)
Cadherin_repeat 1263..1361 CDD:206637 31/98 (32%)
Cadherin_repeat 1369..1481 CDD:206637 21/115 (18%)
Cadherin_repeat 1489..1598 CDD:206637 27/154 (18%)
Cadherin_repeat 1614..1710 CDD:206637 17/102 (17%)
Cadherin_repeat 1723..1843 CDD:206637 19/127 (15%)
Cadherin_repeat 1853..1948 CDD:206637 11/118 (9%)
Cadherin_repeat 1957..2053 CDD:206637 19/99 (19%)
Cadherin_repeat 2061..2154 CDD:206637 16/92 (17%)
CA_like 2171..>2232 CDD:481204 11/64 (17%)
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
Cad99CNP_733314.1 CA_like 68..140 CDD:481204 13/41 (32%)
Cadherin_repeat 146..259 CDD:206637 37/112 (33%)
Cadherin_repeat 280..383 CDD:206637 25/109 (23%)
Cadherin_repeat 393..496 CDD:206637 24/110 (22%)
Cadherin_repeat 518..594 CDD:206637 24/79 (30%)
Cadherin_repeat 608..699 CDD:206637 36/107 (34%)
Cadherin_repeat 710..802 CDD:206637 36/93 (39%)
Cadherin_repeat 814..903 CDD:206637 30/97 (31%)
Cadherin_repeat 915..1005 CDD:206637 22/135 (16%)
Cadherin_repeat 1041..1144 CDD:206637 22/103 (21%)
Cadherin_repeat 1159..1264 CDD:206637 27/144 (19%)
Blue background indicates that the domain is not in the aligned region.

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