Protein Alignment ds and Cad89D

DIOPT Version :10

• Sequence 1: NP_523446.2
• Gene: ds / 33245
• FlyBaseID: FBgn0284247
• Length: 3556
• Species: Drosophila melanogaster
• Sequence 2: NP_650554.3
• Gene: Cad89D / 42006
• FlyBaseID: FBgn0038439
• Length: 2240
• Species: Drosophila melanogaster
• Alignment Length: 2798
• Identity: 609/2798 - (21%)
• Similarity: 1007/2798 - (35%)
• Gaps: 844/2798 - (30%)

  Fly   932 EASMVR-ISVPESAELGAPLYAAHAHD------KDSGSSGQVTY-SLVKESGKGLFAIDARSGHL 988
            |:..|| |.:.|.|::|..:....|:.      |.:.:||...| :|.:.:...|....|||...
  Fly    69 ESEGVRFIRLREDAQVGKEILRLQAYPRSTAALKGADASGDHKYFNLTEHNATTLVVSLARSLER 133

  Fly   989 ILSQHLDYESSQRHTL---IVTATDGGVPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRS 1050
            ::.:.:     .|:.|   |:.|.........:.|:|.|.::|||||.|.|....|.|:|.|:.|
  Fly   134 LVDRDV-----PRNLLKFRILCAGKQEKLEEGSYLSITVYIEDVNDNAPEFLNVPYVVDVDENTS 193

  Fly  1051 INAQIIQ-VNASDLDTGN--NARITYRIVDAGVDNVTNSISSSDVSQHFGI-FPNSGWIYLRAPL 1111
            |.:.|.: |.|.|.|..|  |:.:.:     .:..|...: |:|.|.:|.: .|:...:.|:..|
  Fly   194 IESIIFEGVQAFDRDKPNTPNSEVHF-----SMSTVPEQL-SADGSPYFALKSPHRPLLILKREL 252

  Fly  1112 DRETRDR-YQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGV- 1174
            |.:...| ::|.:.|.|.||||..|.|.:.:.|.|.:|..|||.:..|..||.|..   .:.||
  Fly   253 DFDNGIRQFKLPIFAWDRGTPANQANTTITINVRDVDDLPPKFTEGVYRTRINEFY---PMTGVP 314

  Fly  1175 ----------VTASDLDLGENAAIRYSLLPINSS--FQVHPVTGEISTREPLDRELREL----YD 1223
                      :.|.|.| ..||::.|.::..|..  |:|:|..|.:..::.:|.|...|    :.
  Fly   315 IRIPLYFAPPIMAFDQD-SLNASLVYDIISGNERQLFRVNPHNGVMYLQKEIDLEEESLPGNTFV 378

  Fly  1224 LVVEARDQGTPVRSARVPVRIHVSDVNDNAPEI-ADPQEDVVSVREEQPPGTEVVRVRAVDRDHG 1287
            |.:|||.:..|::.|...:.:.|.|:|||.||. ||...  :|:.|..|.|..|::|.|||||.|
  Fly   379 LQLEARQKDNPLKKALARIEVEVLDLNDNVPEFEADYYN--ISIVENLPTGFSVLQVNAVDRDQG 441

  Fly  1288 QNASITYSIVKGRDSDGHGLFSIDPTSG--VIRTRVVLDHEERSIYRLGVAASDGGNP------- 1343
            :|:...|::|:.:|:  .|.|.||..:|  .:|...:||.|:|...:|.|.|.: .||
  Fly   442 ENSEFLYNLVETKDA--AGAFRIDSRTGWITVRDDRLLDREQRRSIQLNVEALE-RNPSYLDDKH 503

  Fly  1344 ---PRETVRMLRVEVLDLNDNRPTFTSSSLV-FRVREDAALGHVVGSI---SPIERPADVVRNSV 1401
               |..:...:.:.:||.|||.|.|...:|. |:|..:|..|:|:|.:   .|.|.|
  Fly   504 LKKPGPSKVQVEITLLDTNDNTPKFEHGNLYEFKVPINAPTGYVIGQVVAHDPDEGP-------- 560

  Fly  1402 EESFEDLRVTYTL-NPLTKDLIEAAFDIDRHSGNLVVARLLDREVQSEFRLEIRALDTTASNNPQ 1465
                 :..:.|.| .|.....|  .|.:|..:|.:.|...|.|.     |:.:....|....||.
  Fly   561 -----NGHLLYELQRPKGSGYI--PFRLDNKNGTIYVGGPLRRG-----RIAVFVEATDQPTNPS 613

  Fly  1466 S---SAITVKIEV-ADVNDNAPEWPQDPIDLQVSEATPVGTIIHNFTATDADTGTNGD-LQYRLI 1525
            .   |...:.||| |.::|.|.::...|.:..|...||:||.:.....|....|  || :.|.|:
  Fly   614 ERRFSLAVITIEVYATIDDQAIDFVGAPYEFWVGANTPLGTSVGQVRTTLIYEG--GDEIMYDLL 676

  Fly  1526 RYFPQLNESQEQAMSLFRMDSLTGALSLQAPL--------DFEAVQEYLLIVQALDQSSNVTERL 1582
            ..:   :|...     |.::..:|.:::...|        .||||..||.   |....|.|..|.
  Fly   677 HTY---SEGVP-----FAIEERSGIITVIRELSEFKRKVYQFEAVANYLF---ANSSQSLVMSRS 730

  Fly  1583 QTSVTVRLRILDANDHAP-------HFVSPNSSGGKTASLFISDATRIGEVVAHIVAVDED--SG 1638
            .:.:|......:.:|...       |.|  |....|.....:.:...:..:..|   |:|:  .|
  Fly   731 SSPLTTIASPAELSDEGVLITNLTIHIV--NKPEQKVPLRPVIEEINMNVIHFH---VEENVVGG 790

  Fly  1639 DNGQLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKGGRFNLIIGAKDHGQPEPKKSSL 1703
            ..|||.|:      .|...:|::.|....:.| .|.:.::..|.||      :...:....||..
  Fly   791 IIGQLLYK------NGINLVNNELGTYREMPS-EPTSRNITMGSRF------RSRNRSRSSKSKR 842

  Fly  1704 NLHLIVQGSHNNPPRFL-----QAVYRATILENVPSGSFVLQVTAKSLHGAENANLSYEIPAGVA 1763
            .|...:.|..|...|::     :.|.:.:|.|:
  Fly   843 RLPRRLVGDANIKLRYIIANQQEVVNKISITED-------------------------------- 875

  Fly  1764 NDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQST-LSSSAVRKQRSSDSIGDTSNGQH 1827
                      |.:.|....|||.|.||.|.|.|    ..|| |.|.|
  Fly   876 ----------GTLLTLTGLDREQQPSYELTVIV----EYSTGLVSGA------------------ 908

  Fly  1828 FDVATIYITVGDVNDNSPEFRPGSCYGLSVPEN----SEPGVIHTVVASDLDEGPNADLIYSITG 1888
             .:..:.|.|.|||||:|:|...:..|| :.||    :|..:.|.::..|.||||||:....:.
  Fly   909 -GIYQVNIKVDDVNDNAPKFNALTYVGL-INENCVVGTELSMNHAILIQDADEGPNAEFRVQLQ- 970

  Fly  1889 GNLGNKFSIDSSSGELSARPLDREQHSRYTLQIQASDRGQPKSRQGHCNITIFVEDQNDNAPRFK 1953
            |:..::|||:..:|..|                :.|...:..|..|..||....:..||   .||
  Fly   971 GDYSDEFSIEYVNGTSS----------------ENSTHHKMPSTTGAFNIFNLTDQWND---EFK 1016

  Fly  1954 LSKYTGSVQEDAPLGTSVVQISAVDADLGVNARLVYSLANETQWQFAIDGQSGLITTVGKLDREL 2018
            ..:          |.|:.:|.:             :.|::...::.:..|:.|       ||||.
  Fly  1017 YQE----------LHTTFMQTN-------------FKLSSGPYFRISYTGKRG-------LDREK 1051

  Fly  2019 QASYNFMVLATDGGRYEVRSATVPVQINVLDINDNRPIFERYPYIGQVPALIQPGQTLLKVQALD 2083
            |..||..::|.|.|..   |....:.:.|.|:|||.|:|||..........|:...|.:::..::
  Fly  1052 QQLYNLKIIAADTGGL---SGYAHLTVLVADVNDNAPMFERISVFKDSRLEIREYTTDMEIYFVE 1113

  Fly  2084 ADLG-----ANAEIVYSLNAENSAVSAKFRIN--PSTGALSASQSLASESGKLLHLEVVARDKGN 2141
            :..|     |.|.::.:....:...|.:|.::  .|.||               .|.||||.|
  Fly  1114 SSSGMTAPQATAAMMLAPPPYHIPGSPRFNVDRERSVGA---------------GLGVVARAK-- 1161

  Fly  2142 PPQSSLGLIELLIGEAPQGTPVLRFQNETYRVMLKENSPSGTRLLQVVALRSD-GRRQKVQFSFG 2205
               |...::..|..:.|             ...:.|::|.||::||:.|...| |:...:.:...
  Fly  1162 ---SRRRMVRALTTKCP-------------LFAIYEDTPVGTKVLQLSASDEDFGKNALLHYELQ 1210

  Fly  2206 AGNED-----------GI--LSLDSLSGEIRVNKPHLLDYDRFSTPSMSALSRGRALHYEEEIDE 2257
            ....:           |:  .::|.||||:.||.|            :||
  Fly  1211 GEQVERTPGMPMLRVHGVKYFAIDKLSGELSVNYP------------LSA--------------- 1248

  Fly  2258 SSEEDPNNSTRSQRALTSSSFALTNSQPNEIRVVLVARTADAPFLASYAELVIELEDENDNSPKF 2322
                                         .|.::|.....|...|.....|...:.|.|:::|.|
  Fly  1249 -----------------------------NIEIMLNLTVTDIDGLKDSTCLRFTVMDVNNHAPTF 1284

  Fly  2323 SQKQFVATVSEGNNKGTFVAQVHAFDSDAGSNARLRYHIVDGNHDNAFVIEPAFSGIVRTNIVLD 2387
            .:..:.....||..|.:.:.|:.|.|.|.|.||.:.|.:.|.:  ..|.|:|| ||:::....||
  Fly  1285 KKSWYSFDTPEGEYKDSVLGQLTAIDMDFGENANITYTLSDSH--LPFTIKPA-SGVLKIGGQLD 1346

  Fly  2388 REIRDIYKLKIIATDEG--VPQMTGTATIRVQIVDVNDNQPTFPPNNLVTVSEATELGAVITSIS 2450
            ||::|.|..::||||..  :.:|:.:..:.|.::|:|||:|.|     :...:.|:....|.|::
  Fly  1347 RELKDKYSFQVIATDNAPVMQRMSSSVDVEVNVLDINDNRPEF-----IGYDDQTKAVKFIPSVA 1406

  Fly  2451 ANDVDTYPALTYRLGAESTVDIENMSIFALDRYSGKLVLKRRLDYELQQEYELDVIASDAAHEAR 2515
                                          ||.....|.|..||
  Fly  1407 ------------------------------DRTLMLPVYKAYLD--------------------- 1420

  Fly  2516 TVLTVRVNDENDNAPVFLAQQPPAYFAILPAISEISESLSVDFDLLTVNATDADSEGN-NSKVIY 2579
                             .:.||..:...|.||                   |.|:.|| |..|:|
  Fly  1421 -----------------RSTQPGTFVRQLTAI-------------------DKDNVGNGNGLVLY 1449

  Fly  2580 II---EPAQEGFSVHPSNGVVSVNMSRLQPAVSSSGDY---FVRIIAKDAGKPALKSSTLLRVQA 2638
            .|   |.....|.:...:|.:| .:||    ::...||   .|.:||.|.|.|||.::.::.|..
  Fly  1450 SIRHQEMQAPLFQIDSRDGTIS-TISR----INGYNDYEHLNVSVIASDVGSPALSATAIVIVNL 1509

  Fly  2639 NDNG--------------SGRSQFLQNQYRAQISE--AAPLGSVVLQLG--------------QD 2673
            ....              :..:.|....|..:::|  .||:..:.|.|.              ::
  Fly  1510 QGQAVTDPPKSTPKPEPPANVTVFQHAYYEVKLTENNEAPIEVMRLNLSAGLNPENYRWSLWLEE 1574

  Fly  2674 ALDQSLAIIAGNEESAFELLQSKAIVL--VKPLDRERNDLYKLRLVLSHPHGPPLISSLNSSSGI 2736
            .||::      :....|| ..:|.::|  :||.|||....|:||:
  Fly  1575 GLDET------DAHPPFE-YDAKNMLLYALKPFDREHISRYQLRI-------------------- 1612

  Fly  2737 SVIITILDANDNFPIFDRSAKYEAEISELAPLRYSIAQLQAIDADQENTPNSEVVYDITSGNDEH 2801
                             |:.:...|....|.:.|.:.                         ||.
  Fly  1613 -----------------RADRLSREARNYARVSYPVV-------------------------DER 1635

  Fly  2802 MFTIDLVTGVLFVNNRLDYDSGAKSYELIIRACDSHHQRPLCSLQPFRLELH--DENDNEPKF-- 2862
                  :.|:                                ||...|:.:|  |||||.|||
  Fly  1636 ------IEGL--------------------------------SLNECRILVHIADENDNAPKFRG 1662

  Fly  2863 ---PLTEYVHFLAENEPVGSSVFRAHASDLDKGPFGQLNYSIGPAPSDESSWKMFRVDSESGLVT 2924
               |:   |..|.::...|..|.|..|:|||:|...::.|.:...|:     ::|.:|..||.:
  Fly  1663 NGQPI---VAVLPQSASFGYPVTRVEANDLDEGLNAEIRYRLLNEPA-----RLFGIDELSGNI- 1718

  Fly  2925 SAFVFDYEQRQR-YDMELLASD-MG---GKKASVAVRVEIESRDEFTPQFTERTYRFVLPAAVAL 2984
             ..:.:..:.:. |..::.|:| ||   |:...|.|.|.|.:.        .:..|.|:......
  Fly  1719 -RLLGELSRTEHIYGFDVKATDRMGADDGRSGIVNVFVYIINE--------AKQVRLVVAGMPVE 1774

  Fly  2985 PQGYVVGQVTATDSDSGPDGRVVYQLSAPHSH----------FKVNRSSGAVLIKRKLKLDGDGD 3039
            .:..:.|.:.|.....|.|.||  :|..|:|.          :.|:..:.:::...:|:   |..
  Fly  1775 VERRIEGLMEALSDAIGKDVRV--RLLEPYSGGLEPATNAYIYAVDPHTNSIMEMEQLQ---DAL 1834

  Fly  3040 GNLYMDGRDISLVISASSGRHNSLSSMAVVEIA-LDPLAHPGTNLASAGGSSSGSIG--DWAIGL 3101
            ..|.:|...:... ....|:    ....::|:| ...||.|      |..|:|..:|  ::...:
  Fly  1835 AGLQLDALQLQQQ-KLDGGK----PMPRILELAEFGQLARP------AHASASSFMGGLEFVTVV 1888

  Fly  3102 LVAFLLVLCAAAGIFLFIHMRSRKPRNAVKPHLATDNAGVGNTNSYVDPSAFDTIPIRGSISGGA 3166
            |:| |:.|.|......::.||.::...:.:...|:| ||:..|                 |:|
  Fly  1889 LLA-LISLGALIAACCYVCMRQKRRLWSQRDFSASD-AGLTYT-----------------IAG-- 1932

  Fly  3167 AGAASGQFAPPKYDEIPPFGAHAGSSGAATTSELSGSEQSGSSGRGSAEDDGEDEEIRMINEGPL 3231
            .|:..||....:..:........||:|:...:.....|...||.:..:.....::     .|..|
  Fly  1933 IGSPRGQKQRRQRQQRHTQRCSKGSTGSQRPTSAFMPESVCSSAQTQSTATATEK-----LEQQL 1992

  Fly  3232 HHRNGGAGAGSDDGRISDISVQNTQEYLARLGIVDHDPSGAGGGASSMAGSSHPMHLYHDDDATA 3296
            ||.:......:.         |...:||                              ::.....
  Fly  1993 HHHHQQQAMATQ---------QQHHQYL------------------------------NEQQRQQ 2018

  Fly  3297 RSDITNLIYAKLNDVTGAGSEIGSSADDAGTTAGSIGTIGTAITHGHGVMSSYGEVPVPV----- 3356
            :.:..::...|            |.|..|..|:|..|.:|.            |..|..:
  Fly  2019 KREYIDVPLPK------------SIAKAAAVTSGGDGAVGV------------GSTPFVLKYNAC 2059

  Fly  3357 -PVVVGGSNVGGSLSSI--VHSEEELTGSYNWDYLLDWGPQYQPLAHVFSEIARLKDDTLSEHSG 3418
             ||    :|:....:|:  :||    ||.       |.|.::..    ..|:.....|:. :|.|
  Fly  2060 QPV----NNLNNYETSLFSLHS----TGQ-------DSGVEFLS----SRELYETSPDSF-QHGG 2104

  Fly  3419 SGASSSAK---SKHSSSHSSAGAGSVVLKPPPSAPPTH-----IPPPLLTNVAPRAINLPMRLPP 3475
            |...::.:   .:|:.:|..      :.:|...:..|:     ...||:.:.. |:.|...|  .
  Fly  2105 SKRGNNTEVLCPRHAKAHLE------LRQPNTDSSDTYEDSLKTDEPLVAHNC-RSANCEHR--Q 2160

  Fly  3476 HLSLAPAHLPRSPIGHEASGSFSTSSAMSPSFSPSLSPLATRSPSISPLGAGPPTHLPHVSLPRH 3540
            | ...|:|.|     |..:..|...|.:..|||.....|..:||.|              ||...
  Fly  2161 H-QQHPSHHP-----HYQNTRFEKRSCVRHSFSGVKDDLMQQSPQI--------------SLRPR 2205

  Fly  3541 GHA 3543
            |||
  Fly  2206 GHA 2208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_523446.2	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637	25/105 (24%)
		Cadherin_repeat	1040..1149	CDD:206637	34/113 (30%)
		Cadherin_repeat	1158..1252	CDD:206637	29/110 (26%)
		Cadherin_repeat	1263..1361	CDD:206637	35/109 (32%)
		Cadherin_repeat	1369..1481	CDD:206637	29/120 (24%)
		Cadherin_repeat	1489..1598	CDD:206637	27/117 (23%)
		Cadherin_repeat	1614..1710	CDD:206637	19/97 (20%)
		Cadherin_repeat	1723..1843	CDD:206637	24/120 (20%)
		Cadherin_repeat	1853..1948	CDD:206637	25/98 (26%)
		Cadherin_repeat	1957..2053	CDD:206637	20/95 (21%)
		Cadherin_repeat	2061..2154	CDD:206637	17/99 (17%)
		CA_like	2171..>2232	CDD:481204	18/74 (24%)
		Cadherin_repeat	2326..2424	CDD:206637	32/99 (32%)
		Cadherin_repeat	2434..2528	CDD:206637	9/93 (10%)
		Cadherin_repeat	2549..2641	CDD:206637	25/98 (26%)
		Cadherin_repeat	2652..2748	CDD:206637	20/113 (18%)
		Cadherin_repeat	2758..2858	CDD:206637	13/101 (13%)
		Cadherin_repeat	2866..2960	CDD:206637	25/98 (26%)
		Cadherin_repeat	2985..3071	CDD:206637	15/95 (16%)
Cad89D	NP_650554.3	Cadherin_repeat	183..290	CDD:206637	34/112 (30%)
		Cadherin_repeat	325..407	CDD:206637	23/82 (28%)
		Cadherin_repeat	416..524	CDD:206637	35/112 (31%)
		Cadherin_repeat	534..626	CDD:206637	25/111 (23%)
		Cadherin_repeat	641..>714	CDD:206637	19/82 (23%)
		CA	851..925	CDD:214520	28/138 (20%)
		CA	1026..1085	CDD:214520	20/81 (25%)
		Cadherin_repeat	1177..1280	CDD:206637	27/158 (17%)
		Cadherin_repeat	1289..1385	CDD:206637	32/98 (33%)
		Cadherin_repeat	1414..1510	CDD:206637	34/157 (22%)
		CA	1576..1658	CDD:214520	30/188 (16%)
		Cadherin_repeat	1666..1760	CDD:206637	27/103 (26%)