DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ds and shg

DIOPT Version :9

Sequence 1:NP_001285551.1 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:NP_476722.1 Gene:shg / 37386 FlyBaseID:FBgn0003391 Length:1507 Species:Drosophila melanogaster


Alignment Length:1771 Identity:386/1771 - (21%)
Similarity:629/1771 - (35%) Gaps:544/1771 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   509 YHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGLITTRSHIDCET 573
            |...|.|.....|.||.|.|.|.|.  :..:.||:.::|....::| |:|.||:|.| :|.....
  Fly    93 YAPKVKEEQPENTYVLTVEAVDPDP--DQVIRYSIVQSPFERPKFF-INPSTGVIFT-THTFDRD 153

  Fly   574 EPVPQ----LTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAENEPVGRCILKVS 634
            ||:.:    :||.|.|.|:|||....|..|||.|:|||.|.|:::.|:.|::||......::.:|
  Fly   154 EPIHEKFVFVTVQATDNGLPPLDDVCTFNVTIEDINDNAPAFNKARYDESMSENAQPDAVVMTIS 218

  Fly   635 ASDPDCGVNAMVNYTI--GEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPVLATDRGGLST 697
            |||.|.|.|::|.|.|  ...|::   |::...||.|.:...:|.....||...|          
  Fly   219 ASDFDDGNNSLVEYEILRERDFQY---FKIDKESGIIYLKRPIDKRPGQSYAIIV---------- 270

  Fly   698 TAMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVAVVATDPDYGNFGQVSYRIVAG 762
                                |.|.|.                       ||.....|:..||   
  Fly   271 --------------------RAYNVV-----------------------PDPPQDAQIEVRI--- 289

  Fly   763 NEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIF 827
                  |:..|:     ::|..                             |::.||.    || 
  Fly   290 ------RVVESS-----IKPPS-----------------------------FVNPIDT----PI- 309

  Fly   828 EKARYNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGN--------- 883
                   |:||::...|...:.:.|..::..:..|.:.:.:|..:     :|||.|         
  Fly   310 -------YLKENLKNFTHPIATLRAVSNMPDKPEVIFELNTGRTE-----QTNSKNTFVFNQIGN 362

  Fly   884 ---IRIAKPLDHEAKSQVLLN--IQAT--LGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVP 941
               |.:.|.||:||.:...|.  ::.|  ||.     ..|:.|:|||||||.| :...:...::.
  Fly   363 EVTISLGKTLDYEAITDYTLTMIVRNTHELGT-----EHQIKIQVEDVNDNIP-YYTEVKSGTIL 421

  Fly   942 ESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIV 1006
            |:...|.|:....|.|.| |:|.....|......:..|.||..:|::......|.|....:.:.|
  Fly   422 ENEPPGTPVMQVRAFDMD-GTSANNIVSFELADNREYFTIDPNTGNITALTTFDREERDFYNVKV 485

  Fly  1007 TATDGGVPSLSTN-------LTILVDVQDVNDNPPVFEKDEY-SVNVSESRSINAQIIQVNASDL 1063
            .|:|....||..|       ....:.:.|.||:.|.|::|:| :..:.|..:.|.::|:|.|.|.
  Fly   486 IASDNSPSSLFDNGEPNRGHQVFRISIGDKNDHKPHFQQDKYLAERLLEDANTNTEVIEVKAEDE 550

  Fly  1064 DTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDN 1128
            |  |.::|.|            ||.|.:|...|.|...:|.|.:...||.||...|:|.|.|.|.
  Fly   551 D--NASQILY------------SIESGNVGDAFKIGLKTGKITVNQKLDYETITEYELKVRAFDG 601

  Fly  1129 GTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAA---IRY 1190
               .....|.|::::.|.|||.|.| |..|...|.|.......:..|.|.|.|:.:..|   |.|
  Fly   602 ---IYDDYTTVVIKIEDVNDNPPVF-KQDYSVTILEETTYDDCILTVEAYDPDIKDRNADQHIVY 662

  Fly  1191 SLLPINSSFQVHPVTGEISTREPLDREL---RELYDLVVEARDQ---GTPVRSARVPVRIHVSDV 1249
            |:...:.:......:|.:...:.|||:.   .:.:.::::|.|:   ||.|.:.: .|.:.:.|:
  Fly   663 SIHQNDGNRWTIDNSGCLRLVKTLDRDPPNGHKNWQVLIKANDEDGVGTTVSTVK-EVTVTLKDI 726

  Fly  1250 NDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNA-SITYSIVKGRDSDGHGLFSIDPT 1313
            |||||.:.:  |..|..:|.:.|| .||:::|.|.|....| :.|:.|......|....||:|  
  Fly   727 NDNAPFLIN--EMPVYWQENRNPG-HVVQLQANDYDDTPGAGNFTFGIDSEATPDIKTKFSMD-- 786

  Fly  1314 SGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSSL-VFRVRED 1377
            ...:...|..|.|.:..|.:.:..||.|.|.:..|.:|.:.:.|:|||..:..||.: ::..:.:
  Fly   787 GDYLHANVQFDREAQKEYFIPIRISDSGVPRQSAVSILHLVIGDVNDNAMSEGSSRIFIYNYKGE 851

  Fly  1378 AALGHVVGSISPIERPADVVRNSVEE----SFEDLRVTYTLNPLTKDLIEAAFDIDRHSGNLVVA 1438
            |.             ..|:.|..|::    ..||....:      |||                 
  Fly   852 AP-------------ETDIGRVFVDDLDDWDLEDKYFEW------KDL----------------- 880

  Fly  1439 RLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIEVAD--------VNDNAPEWPQDPIDLQVS 1495
                  ...:|||           ||.:..||:.:..|:        |.:::...|:..:|..|:
  Fly   881 ------PHDQFRL-----------NPSTGMITMLVHTAEGEYDLSFVVTEDSMFVPRHSVDAYVT 928

  Fly  1496 EATPVGTIIHNFTATDADTGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGALSLQAPLDFE 1560
                  .::........|  .:|.:::        :|.::|:.:|:.|......||||:..|...
  Fly   929 ------VVVRELPEEAVD--KSGSIRF--------INVTKEEFISVPRDFQSPDALSLKDRLQLS 977

  Fly  1561 AVQEYLLIVQALD-----QSSNVTERLQTSVTVRLRILDANDHAPHFVSPNSSGGKTASLFISDA 1620
            ..:.:...|..:|     |:.|.|..::.|.           |...:.:|....|          
  Fly   978 LAKLFNTSVSNVDVFTVLQNENHTLDVRFSA-----------HGSPYYAPEKLNG---------- 1021

  Fly  1621 TRIGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKGGRFN 1685
                     |||.::...:| :|..::        ..:|....:||..|.....|.::.|.....
  Fly  1022 ---------IVAQNQQRLEN-ELDLQM--------LMVNIDECLIEKFKCEESCTNELHKSSVPY 1068

  Fly  1686 LIIGAKDHGQPEPKKSSLNLHLIVQGSHNNPPRFLQAVYRATILENVPSG--------------- 1735
            :|.        ....|.:.::..||.         |.|..|.::....:|               
  Fly  1069 MIY--------SNTTSFVGVNAFVQA---------QCVCEAPLMRRCLNGGSPRYGENDVCDCID 1116

  Fly  1736 SFV---LQVTAKSLHGA-----------ENANLSYEIPAGVANDL-------------------- 1766
            .|.   .::.:.:.:|:           .|..:|.||...:...|                    
  Fly  1117 GFTGPHCELVSVAFYGSGYAFYEPIAACNNTKISLEITPQIDQGLIMYLGPLNFNPLLAISDFLA 1181

  Fly  1767 ---------FHVDWQRGIITTRGQF-----DRESQASYVLPVYVRDANRQSTLSSSAVRKQRSSD 1817
                     ..||:..|.|..|.|.     ||..|...:|                    ||:| 
  Fly  1182 LELDNGYPVLTVDYGSGAIRIRHQHIKMVADRTYQLDIIL--------------------QRTS- 1225

  Fly  1818 SIGDTSNGQHFDVATIYITVGDVNDNSPEFRPGSCYGLSVPENSEPGVIHTVVASDLDEGPNADL 1882
                           |.:||    ||.   |..:|..|..|                 .||    
  Fly  1226 ---------------IEMTV----DNC---RLSTCQTLGAP-----------------IGP---- 1247

  Fly  1883 IYSITGGNLGNKFSIDSSSGELSARPLDREQHSRYTLQIQASDRGQPKSRQGHC--NITIFVEDQ 1945
                      |:|...::..:|...|:|.||..|   |:..:.....|...| |  |:||..:..
  Fly  1248 ----------NEFLNVNAPLQLGGTPVDLEQLGR---QLNWTHVPNQKGFFG-CIRNLTINEQTY 1298

  Fly  1946 NDNAPRFKLSKYTGSVQEDAPLGTSVVQISAVDADLGVNARLVYSL------------------A 1992
            |...|         ||..:...|..  |..||....|::...:.::                  .
  Fly  1299 NLGMP---------SVFRNIDSGCQ--QSVAVAFSFGIDRNFIIAIIVCLALLLIILLAVVVQKK 1352

  Fly  1993 NETQW-QFAIDG-QSGLITTVGKLDRELQASYNFMVLATDGGRYEVRSATVP--VQINVLDINDN 2053
            .:..| :..||. :..:|....:...|....|:..||.|. ..||.:....|  :|.|:.|.||.
  Fly  1353 QKNGWHEKDIDDIRETIINYEDEGGGERDTDYDLNVLRTQ-PFYEEKLYKDPHALQGNMRDPNDI 1416

  Fly  2054 RPIFERYPYIGQVPALIQPGQTLLKVQALDADLGA-NAEIV--YSLNAENSAVSAKFRINPSTGA 2115
            ..|.:   ::|.            |.:..|.|:|| ..:.|  |:...:.:          |.|:
  Fly  1417 PDIAD---FLGD------------KKENCDRDVGATTVDDVRHYAYEGDGN----------SDGS 1456

  Fly  2116 LSASQSLAS--ESGKL 2129
            ||   ||||  :.|.|
  Fly  1457 LS---SLASCTDDGDL 1469

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_001285551.1 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637
Cadherin_repeat 291..389 CDD:206637
Cadherin_repeat 406..500 CDD:206637
Cadherin_repeat 509..607 CDD:206637 37/101 (37%)
Cadherin_repeat 616..711 CDD:206637 23/96 (24%)
Cadherin_repeat 719..820 CDD:206637 12/100 (12%)
Cadherin_repeat 832..927 CDD:206637 28/110 (25%)
Cadherin_repeat 937..1032 CDD:206637 23/101 (23%)
Cadherin_repeat 1040..1149 CDD:206637 32/109 (29%)
Cadherin_repeat 1158..1252 CDD:206637 23/102 (23%)
Cadherin_repeat 1263..1361 CDD:206637 28/98 (29%)
Cadherin_repeat 1369..1481 CDD:206637 18/124 (15%)
Cadherin_repeat 1489..1598 CDD:206637 19/113 (17%)
Cadherin_repeat 1614..1710 CDD:206637 13/95 (14%)
Cadherin_repeat 1723..1843 CDD:206637 26/182 (14%)
Cadherin_repeat 1853..1948 CDD:206637 20/96 (21%)
Cadherin_repeat 1957..2053 CDD:206637 23/117 (20%)
Cadherin_repeat 2061..2154 CDD:206637 18/74 (24%)
Cadherin_repeat 2170..2318 CDD:206637
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
shgNP_476722.1 Cadherin_repeat 93..191 CDD:206637 37/101 (37%)
Cadherin_repeat 200..292 CDD:206637 32/156 (21%)
CA 332..410 CDD:214520 25/87 (29%)
Cadherin_repeat 417..518 CDD:206637 23/101 (23%)
Cadherin_repeat 531..619 CDD:206637 31/104 (30%)
Cadherin_repeat 627..729 CDD:206637 23/102 (23%)
Cadherin_repeat 736..834 CDD:206637 29/100 (29%)
LamG 1127..1294 CDD:238058 44/244 (18%)
Cadherin_C 1358..1489 CDD:279398 35/141 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45464693
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR24026
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.030

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