DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and Pcdh7

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_038948108.1	Gene:	Pcdh7 / 360942	RGDID:	1303209	Length:	1271	Species:	Rattus norvegicus

Alignment Length:	1023	Identity:	276/1023 - (26%)
Similarity:	411/1023 - (40%)	Gaps:	279/1023 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   516 VADPGTSVLQVLAHDRDEGL---NSALTYSLAETPETHAQWFQIDPQTG-LITTRSHIDCETEPV 576
            :|:.|.:.:::.....|.|:   :..:|:||    |:.:::.:||..|| |.|:...||  .|.:
  Rat    38 LAEEGPADVRIGNVASDLGIVTGSGEVTFSL----ESGSEYLKIDNLTGELSTSERRID--REKL 96

  Fly   577 PQLTVVARDGG---------VPPLSSTATVL---VTIHDVNDNEPIFDQSFYNVSVAENEPVGRC 629
            ||..::..:..         :.|..|...:.   |.:.|:|||.|.|......::|.||.|||..
  Rat    97 PQCQMIFDENECFLDFEVSVIGPSQSWVDLFEGRVIVLDINDNTPTFPSPVLTLTVEENRPVGTL 161

  Fly   630 ILKVSASDPDCGVNAMVNYTI----------GEGFK----------------------------- 655
            .|..:|:|.|.|.|.:..|.:          |||.:
  Rat   162 YLLPTATDRDFGRNGIERYELLQEPGGGGGGGEGRRLGPADSAPYPGGGGNSGSGGGSGGSKRRL 226

  Fly   656 -------------HLTEFEVRSA---SGE----ICIAGELDFERRSSYEFPVLATDRGG--LSTT 698
                         ..:.||::.|   .||    :.:.|.||.|:|.|||..:...|.|.  .|:.
  Rat   227 DAPEGGGGTGPSGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQ 291

  Fly   699 AMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVAVVATDPDYGNFGQVSYRIVAGN 763
            |::::.:||||||.|.|....|:..|     |.:.|..|||:.:.|||.|.|..||:.|...|..
  Rat   292 AILRVLITDVNDNSPRFEKSVYEADL-----AENSAPGTPILQLRATDLDVGVNGQIEYVFGAAT 351

  Fly   764 EAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFE 828
            |                     |||    .:|.:..|.|           :||::
  Rat   352 E---------------------SVR----RLLRLDETSG-----------WLSVL---------- 370

  Fly   829 KARYNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHE 893
                                         ||                              :|.|
  Rat   371 -----------------------------HR------------------------------IDRE 376

  Fly   894 AKSQVLLNIQA-TLGEPPVYGHTQVNIEVEDVNDNAPEFEASMV-RI-------SVPESAELGAP 949
            ..:|:...:.| ..|:||......|.:.::|.|||.|..|...: ||       :|.|...:..|
  Rat   377 EVNQLRFTVMARDRGQPPKTDKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTP 441

  Fly   950 LYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSG----------HLILSQHLDYESSQRHTL 1004
            :......|:|.|.:|.||.::|   |...|.:...|.          .|..|..||||:::...:
  Rat   442 IALVQVSDRDQGENGVVTCTVV---GDVPFQLKPASDTEGDQNKKKYFLHTSAPLDYETTREFNV 503

  Fly  1005 IVTATDGGVPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNA 1069
            ::.|.|.|.||||:|.:::|.|.|.|||||||.:....|...|:.....::..|.|:|.|:|.||
  Rat   504 VIVAVDSGSPSLSSNNSLVVKVGDTNDNPPVFGQSVVEVYFPENNIPGERVATVLATDADSGKNA 568

  Fly  1070 RITYRIVDAGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAH 1134
            .|.|.:             .|.|...|.|.|:||.|.:...||||..|||:..|.|.|.|.|...
  Rat   569 EIAYSL-------------DSSVMGTFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQ 620

  Fly  1135 AKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLPINSSF 1199
            ..|.|||:|.|.|||||||.:..:.|.::|||:..|.||:||..|.|.|.||.:...:...::.|
  Rat   621 GSTTVIVQVADKNDNDPKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENSNIF 685

  Fly  1200 QVHPVTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDVV 1264
            .:...||.|.:....|||.:..|...|:|.|.|.|.|||...|.:.|.|.|||||.:..|:....
  Rat   686 SIENDTGTIYSTMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPRNISY 750

  Fly  1265 SVREEQPPG----TEVVRVRAVDRDHGQNASITYSIVKGRDSDGHGLFSIDPTSGVIRTRVVLDH 1325
            ::   .||.    |.|..|.|.|.|.|.||.:.||||.|   :...||.||.||||:.....|..
  Rat   751 TL---LPPSSNVRTVVATVLATDSDDGINADLNYSIVGG---NPFKLFEIDSTSGVVSLVGKLTQ 809

  Fly  1326 EERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSSLVFRVREDAALGHVVGSISPI 1390
            :...::||.|..:|.|.|.:.|..::.|.|.:...|
  Rat   810 KHYGLHRLVVQVNDSGQPSQSTTTLVHVFVNESVSN----------------------------- 845

  Fly  1391 ERPADVVRNSVEESFEDLRVTYTLNPLTKDLI-EAAFDIDRHSGNLVV 1437
               |.|:.:.:..|..        .|||:|:. :.:::|.:...::|:
  Rat   846 ---ATVIDSQIVRSLH--------TPLTQDIAGDPSYEISKQRLSIVI 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637	24/106 (23%)
		Cadherin_repeat	616..711	CDD:206637	37/155 (24%)
		Cadherin_repeat	719..820	CDD:206637	25/100 (25%)
		Cadherin_repeat	832..927	CDD:206637	12/95 (13%)
		Cadherin_repeat	937..1032	CDD:206637	33/111 (30%)
		Cadherin_repeat	1040..1149	CDD:206637	38/108 (35%)
		Cadherin_repeat	1158..1252	CDD:206637	34/93 (37%)
		Cadherin_repeat	1263..1361	CDD:206637	34/101 (34%)
		Cadherin_repeat	1369..1481	CDD:206637	9/70 (13%)
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdh7	XP_038948108.1	Cadherin_repeat	35..139	CDD:206637	24/106 (23%)
		Cadherin_repeat	147..304	CDD:206637	37/156 (24%)
		Cadherin_repeat	312..411	CDD:206637	37/208 (18%)
		Cadherin_repeat	429..531	CDD:206637	31/104 (30%)
		Cadherin_repeat	541..635	CDD:206637	38/106 (36%)
		Cadherin_repeat	643..738	CDD:206637	34/94 (36%)
		Cadherin_repeat	749..839	CDD:206637	33/95 (35%)
		Protocadherin	842..1053	CDD:400603	10/81 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9374
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910