|
Fly 55 LRSSLLILLAIVLLGSSQAASHDQERERKLEVFEGVAVDYQIGYIGDFGGIDSG----PPYIIVA 115
::|...:|..:||||::......|.....|::.|.......||.|. .|:..| |.|.|.|
Rat 14 MKSLGTLLPLLVLLGTTVPGIRGQAGSLDLQIDEEQPAGTLIGDIS--AGLPPGTAPPPMYFISA 76
Fly 116 E--AGVETDLAIDRATGEIRTKVKLDRETRASYSLVAIPLSGRNIRVLVTVKDENDNAPTFPQTS 178
: :||.|||.||..:|.:.|...||||.|..|...|:...|..:.|.|.|.|.||:||.|||..
Rat 77 QEGSGVGTDLDIDEHSGVVCTARVLDRERRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQAR 141
Fly 179 MHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQISGF 243
..::.||:|....:..|.||.|.|.....||.|.:......:.|||.:.....|....:|.|:|.
Rat 142 AALQIPEHTALGTRYPLEPAHDADAGRLGTQGYALSGDGAGETFRLETRPGPGGAPVPELVIAGE 206
Fly 244 LDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVLQV 308
||||....|.|.:||.|||:||.|....:::|:.|:||:.|.||||||.|.|.|:...|:.||||
Rat 207 LDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLAPGSPVLQV 271
Fly 309 YASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPL 373
:|||.||..||.|.|.||||||:.:..|.||..||.:.:.:.||||.:.:|||||.|:|.|..|.
Rat 272 FASDADAGANGAVTYEINRRQSEGDGPFSIDAHTGFLKLERPLDFEQRRVHELVVQARDGGAHPE 336
Fly 374 ETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVTLN 438
..:|||::.|.|.|||||::.|||||.|.||::||:|.||:.||||||.|||. .::|:|||:|.
Rat 337 LGSAFVTVHVRDANDNQPSMTVIFLSADGSPRVSEAAPPGQLVARISVSDPDD-GDFAHVNVSLE 400
Fly 439 GGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDVNDNPPE 503
||:|||||:|:|:.||||.|...||||....|.|.|.|||.|:|||.|..:..|.:||||||.|.
Rat 401 GGEGHFALSTQDSVIYLVCVARRLDREERDVYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPA 465
Fly 504 FEQDLYHANVM-EVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGLITTRS 567
|::.||....: |||.||:.|::|.|.|.|:|.|..:||||| |.||..||.|||.:|:|||.:
Rat 466 FDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLA--PGTHTHWFSIDPTSGIITTAA 528
Fly 568 HIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAENEPVGRCILK 632
.:|.|.||.|||.|||.|||:|||.|:|||.|.:.|||||||.|.::|||.|:.|....|.|.|:
Rat 529 TLDYELEPQPQLIVVATDGGLPPLVSSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQ 593
Fly 633 VSASDPDCGVNAMVNYTIGEGF--KHLTEFEVRSASGEICIAGELDFER-RSSYEFPVLATDRGG 694
|:|:|.|.|...:::|::|.|. .....|.:.:.|||:|....||.:: .||::|.|.|.|.||
Rat 594 VTATDADSGPFGLLSYSLGAGLGASGSPPFRIDAHSGEVCTTRILDRDQGPSSFDFTVTAIDGGG 658
Fly 695 LSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVAVV---ATDPDYGNFGQVS 756
|.:...:|:.:.|.|||.|.||||||..|| .|.|||..||: |.|||.|..|::|
Rat 659 LKSMVYVKVFVADENDNPPQFYPREYAASL--------SAQSTPGTAVLRVHAHDPDQGPHGRLS 715
Fly 757 YRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRSNADAVVFLSIIDAM 821
|.|:|||...:|.:|..:|.:.|..| |..|...:..|.|.|.|||.|::...|.|.:||:...
Rat 716 YHILAGNSPPLFALDAHSGLLTVAWP--LGRRANSVVQLEIGAQDGGGLQAEPIARVNISIVPGT 778
Fly 822 QRPPIFEKARYNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRI 886
..|||||:.:|.:.|.||:..||.|| |:.|........||..::..|||.|.||:::.||.::.
Rat 779 PTPPIFEQLQYVFSVPEDVAPGTSVG-VVQAHNPPGRLGPVTLTLSGGDPRGLFSLDSASGLLKT 842
Fly 887 AKPLDHEAKSQVL-LNIQATLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPL 950
.:|||.|....|| |.::|..|.|||:...::.:.::|||||:|.|.|....:.:|::...|.|:
Rat 843 LRPLDRELLGPVLELEVRAGSGTPPVFSAARIRVLLDDVNDNSPAFPAPEDTVLLPQNTAPGTPV 907
Fly 951 YAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPS 1015
|...|.|.|||::.:||:||: ..|.|||.:|..:||:.|...|.......|.|.|.|.|||.|.
Rat 908 YTLRALDPDSGANSRVTFSLL-AGGDGLFTVDPTTGHVRLMGPLGPPGGPPHELEVEAQDGGSPP 971
Fly 1016 LSTNLTILVDVQD--VNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVDA 1078
.:::..:.|.:|| ::...|.|:...|.|::....:...||:||.|...| .:.:||.:...
Rat 972 RTSHFRLRVVIQDLGIHGLAPRFDSPTYRVDLPSGTTTGTQILQVQAQAPD---GSPVTYHLAAD 1033
Fly 1079 GVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDN-----GTPAAHAKTR 1138
|..| .||:...|||:::||.||||:::.|.|.|:|... |.....|..|
Rat 1034 GASN------------PFGLESQSGWLWVRAALDRESQELYTLKVMAVSGSKAELGQQTGTATVR 1086
Fly 1139 VIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLLPI---NSSFQ 1200
|: :|:.||:.|:..:......:.||...|:.||.|.|:|.|.|.|..:.|||..: :.:|:
Rat 1087 VV--ILNQNDHSPRLSEEPTFLAVAENQPPGTSVGRVFATDKDSGPNGRLTYSLQQLSEDSKAFR 1149
Fly 1201 VHPVTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDV-- 1263
:||.|||::|.:.||||.:..:.|:|:.:|.|:|.|||...|.:.|.|:|||:|.........
Rat 1150 IHPQTGEVTTLQTLDREQQSSFQLLVQVQDAGSPPRSATGTVHVAVLDLNDNSPTFLQASGAAGG 1214
Fly 1264 ---VSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGHGLFSIDPTSGVIRTRVVLDH 1325
:.|.:..||||.|..::|.|.|.|:|.:|.|::. ..|..|||:.|.:|.:.|...|..
Rat 1215 GLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLT----GSGSELFSLHPHTGELHTAASLIR 1275
Fly 1326 EERSIYRLGVAASDGGNPPRETVRMLRVEVL---------DL--NDNRPTFTSSSLVFRVREDAA 1379
.||..|.|.::|.|.|:|||.....|.|:|| || .|:..| ....|.....|...
Rat 1276 AERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSTRMVESPDLVEADSAAT-VPVVLTVTAAEGLR 1339
Fly 1380 LGHVVGSISPIERPADVVRNSVEESFEDLRVTYTL----NPLTKDLIEAAFDIDRHSGNLVVARL 1440
.|.::||::| :.||.: .| :|||| :| |..|.:|..||.|.:||:
Rat 1340 PGSLLGSVAP-QEPASM---GV--------LTYTLVGGADP------EGTFALDSASGRLYLARV 1386
Fly 1441 LDREVQSEFR-LEIRALDTTASNNPQSSAITVKIEVADVNDNAPEWPQDPIDLQVSEATPVGTII 1504
||.|....:| |.:|| .......:..:.|::.|.|.|::||.:.:||:.|.:.|....|..:
Rat 1387 LDFESGPAWRALTVRA---EGPGGAGARLMRVQVRVQDENEHAPAFARDPLALALPENPEPGATL 1448
Fly 1505 HNFTATDAD-TGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLI 1568
:.|.|:||| .|.|.|::|||:| ||..:...|:|:.|||||....||.|.....|||
Rat 1449 YTFRASDADGPGPNSDVRYRLLR--------QEPPVPALRLDARTGALSAPRGLDRETTPALLLI 1505
Fly 1569 VQALDQSSNVTERLQTSVTVRLRILDANDHAPHFVSPNSSGGKTASLFISDATRIGEVVAHIVAV 1633
|:|.|:.:|.:.|..|.|:.|:.:.|.||:||.|.|| :.:.:.:....|....|:||.
Rat 1506 VEATDRPANASRRKATRVSARVFVTDENDNAPVFASP-------SRMRLPEDQPPGPAALHVVAR 1563
Fly 1634 DEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKGGRFNLIIGAKDHGQPEP 1698
|.|.|:..:::|.:..| |:|.||:::.||.:.:|:.| |.|:.....|.:.|.|||.| |
Rat 1564 DPDLGEAARVSYRLAAG-GDGHFRLHATTGALSVVRPL-----DREQRAEHVLTVVASDHGSP-P 1621
Fly 1699 KKSSLNLHLIVQGSHNNPPRFLQAVYRATILENVPSGSFVLQVTAKSLHGAENANLSYEIPAGVA 1763
:.|:..|.:.|...::..|.|.|..|...:.||.|.|:.:|.:.|.......|..::| .||:
Rat 1622 RSSTQLLTVSVVDVNDEAPAFPQQEYNVILRENSPPGTSLLTLKATDPDLGANGQVTY---GGVS 1683
Fly 1764 NDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQSTLSSSAVRKQRSSDSIGDTSNGQHF 1828
.:.|.:|...|::||....|||.|....|.||.||......|:...||
Rat 1684 GESFSLDPNSGVLTTLRALDREEQEEINLTVYARDRGLPPLLTHITVR----------------- 1731
Fly 1829 DVATIYITVGDVNDNSPEFRPGSCY-GLSVPENSEPGVIHTVVASDLDEGPNADLIYSITGGNLG 1892
:||.|.||:||.| |:.: .|.|||..:|..:.|:.|||.|.|.|..|.|.|.||:..
Rat 1732 ------VTVEDENDHSPTF--GNTHLSLEVPEGQDPQTLTTLRASDPDGGLNGQLQYRILGGDPS 1788
Fly 1893 NKFSIDSSSGEL-SARPLDREQHSRYTLQIQASDRGQPKSRQGHCNITIFVEDQNDNAPRFKLSK 1956
..|::|.:|||. :.||||||....:.|||:|.|.||| :......:|:.|.|.||:||.|.:..
Rat 1789 GAFALDLTSGEFGTTRPLDREVEPAFQLQIEARDGGQP-ALSATLLVTVTVLDANDHAPAFPVPS 1852
Fly 1957 YTGSVQEDAPLGTSVVQISAVDADLGVNARLVYSLANETQWQFAIDGQSGLITTVGKLDRELQAS 2021
|:..|.||||:||.::|:.|.|.|.|.|.|::|.|...|...|.::..||.::|...||||..||
Rat 1853 YSVEVPEDAPVGTLLLQLQAHDPDEGDNGRVMYYLGAGTAGAFLLEPTSGELSTATALDREHCAS 1917
Fly 2022 YNFMVLATDGGRYEVRSATVPVQINVLDINDNRPIFE------RYPYIGQVPALIQPGQTLLKVQ 2080
|.|.|.|.||......|.|||:.:.|.|:||:.|.|. |.|..| |:|.:|...|..::
Rat 1918 YAFSVTAVDGAAAGPLSTTVPITVTVRDVNDHAPAFPTSPLRLRLPRPG--PSLNKPTLALATLR 1980
Fly 2081 ALDADLGANAEIVYSLNAENSAVSAKFRINPSTGALSASQSLASESGKLLHLEVVARDKGNPPQS 2145
|.|.|.||||.|:|.|.......:. ::..||.:..::|.|:...:...|.:||.|.|.|.:|
Rat 1981 AEDRDAGANASILYRLAGTPPPGTT---VDSYTGEIRVARSPAALGPRDRVLFIVATDLGRPARS 2042
Fly 2146 SLGLIELLIGEAPQGTPVLRFQNETYRVMLKENSPSGTRLLQVVALRSDGRRQKVQFSFGAGNED 2210
:.|::.:.|...|:..| ||.......:|:||:|.||.::...|:.|.|....:.:|..:|||.
Rat 2043 ATGVVIVGIQGEPERGP--RFPRANNEAVLRENAPPGTPVISPKAVHSGGSNGPITYSILSGNER 2105
Fly 2211 GILSLDSLSGEIRVNKPHLLDYDRFSTPSMSALSRGRALHYEEEIDESSEEDPNNSTRSQRALTS 2275
||.|:...:|.|.|.....||::
Rat 2106 GIFSIQPSTGTITVQSAEGLDFE------------------------------------------ 2128
Fly 2276 SSFALTNSQPNEIRVVLVARTADAPFLASYAELVIELEDENDNSPKFSQKQFVATVSEGNNKGTF 2340
||.: :|:||.|.:..| .:::.|.:.|:|.|||:|:|.|..:||.:.|.......
Rat 2129 -----TNPR---LRLVLQAESGGA---FAFSVLTLTLQDANDNAPRFLQPHYVAFLPESRPLEGP 2182
Fly 2341 VAQVHAFDSDAGSNARLRYHIVDGNHDNA-FVIEPAFSGIVRTNIVLDREIRDIYKLKIIATDEG 2404
:.||.|.|.|.||..::.|.:........ |.::|| :|.:.|..:|||||....:|.::|||.|
Rat 2183 LLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPA-TGTITTTAILDREIWAETRLVLMATDRG 2246
Fly 2405 VPQMTGTATIRVQIVDVNDNQPTFPPNNLVTVSEATELGAVITSISANDVDTYPALTYRLGAEST 2469
.|.:.|:||:.|.::|.|||:||.|....:.|||...||:.|..::.||||:.|.|.|.|.....
Rat 2247 SPALVGSATLTVMVIDTNDNRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGP 2311
Fly 2470 VDIENMSIFALDRYSGKLVLKRRLDYELQQEYELDVIASDAAHEARTVLTVRVNDENDNAPVF-- 2532
.| .|::.||.|::.|...||:|....|.|.::|.|..||....|||.|.|.|||.|:|
Rat 2312 QD-----PFSIGRYGGRVSLTGPLDFEQCDHYHLQLLAHDGPHEGHANLTVLVEDVNDNVPIFSQ 2371
Fly 2533 -------LAQQPPAYFAILPAISEISESLSVDFDLLTVNATDADSEGNNSKVIYIIEPAQEGFSV 2590
|...||. ..:|:|:|||.|| |.|..:.|.:....|||||
Rat 2372 SLYQVMMLEHTPPG------------------SAILSVSATDRDS-GANGHISYHLASPAEGFSV 2417
Fly 2591 HPSNGVVSVNMSRLQPAVSSSGDYFVRII--AKDAGKPALKSSTLLRVQANDNGSGRSQFLQNQY 2653
..:||.:...:..: |:...|...|.:: |:|.|.|...:...:.||..|.......|....|
Rat 2418 DTNNGTLFTTVGAM--ALGHEGPGVVDVVLEARDHGAPGRSAQATVHVQLKDQNDHAPSFTLPHY 2480
Fly 2654 RAQISEAAPLGSVVLQLGQDALDQ---------SLAIIAGNEESAFELLQSKA------------ 2697
|..:||..|.||.:|.| :|:|. ..:||:||....|:|....|
Rat 2481 RVAVSEDLPPGSTLLTL--EAIDADGSRSHATVDYSIISGNRGRVFQLEPRLAEVGDGVGPGPQA 2543
Fly 2698 ---IVLVKPLDRERNDLYKLRLVLSHPHGPPLISSLNSSSGISVIITILDANDNFPIFDRSAKYE 2759
:||::|||.|....|.|.:..:....|| .||.:.|.:|:||.|||.|:|.| |.|.
Rat 2544 LGCLVLLEPLDFESLTQYNLTVTAADRGQPP------RSSAVPVTVTVLDVNDNPPVFTR-ASYR 2601
Fly 2760 AEISELAPLRYSIAQLQAIDADQENTPNSEVVYDITSGNDEHMFTIDLVTGVLFVNNRLDYDSGA 2824
..:.|..|:...:..::|.|||. .|:..|.:.::||:...:|.:|..:|.|.:.:.||.::.|
Rat 2602 VTVPEDMPVGAELLHVEASDADP--GPHGLVHFTLSSGDPLGLFELDENSGALRLAHPLDCETQA 2664
Fly 2825 KSYELIIRACD---SHHQRPLCSLQPFRLELHDENDNEPKFPLTEYVHFLAENEPVGSSVFRAHA 2886
: ::|:::|.| :|. :|.|..:|:.|.||:.|.|||:.....||||:|.|:.|...||
Rat 2665 Q-HQLVVQAADPAGTHF-----ALVPVTVEVQDVNDHGPAFPLSLLSTSLAENQPPGTLVTTLHA 2723
Fly 2887 SDLDKGPFGQLNYSIGPAPSDESSWKMFRVDSESGLVTSAFVFDYEQRQRYDMELLASDMGGKKA 2951
.|.|.|.||:|.|::..|.......:.|.::|.:|.:.:...||||....:.:.:.|:|.|...|
Rat 2724 MDGDAGTFGRLRYTLLEAVPGPEGREAFSLNSSTGELRARVPFDYEHTGSFRLLVGAADAGNLSA 2788
Fly 2952 SVAVRVEIESRDEFTPQFTERTYRFVLPAAVALPQGYVVGQVTATDSDSGPDGRVVYQLSAPHSH 3016
||.|.|.|...||:.|.|...::.|.:|... .:|:.:|.|.|||.|.|.||.|:|.|:....:
Rat 2789 SVTVSVLITGEDEYDPVFLAPSFHFQVPEGA--QRGHSLGHVQATDEDGGADGLVLYSLATSSPY 2851
Fly 3017 FKVNRSSGAVLIKRKLKLDGDGDGNLYMDG-------RDISLVISASSGRHNSLSSMAVVEIALD 3074
|.:|:::||:.::...:..|.|.......| |::.|.:.|......|.| |.|.:.:|
Rat 2852 FGINQTTGALYLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVVARGPLPGSRS--ATVPVTVD 2914
Fly 3075 PLAH------PGTNLASAGGSSSGSIGDWAIGLLVAFLLVLCAAAGIFLFIHMRSRKPRNAVKPH 3133
:.| |..||...| |:...:..::||..||.:...:..||||...|..|
Rat 2915 -ITHTALGLAPDLNLLLVG----------AVAASLGVVVVLALAALVLGLVRARSRKAEAAPGP- 2967
Fly 3134 LATDNAGVGNTNSYVDPSAFDTIPIRGSISGGAAGAASGQFAPPKYDEIPPFGAHA--------G 3190
.|...|.|..::...|. .||. ||...|. |
Rat 2968 -----------MSQTAPIASSSLQKLGR-------------EPPS----PPPSEHLYHQTLPSYG 3004
Fly 3191 SSGAATTSELSGS-EQSGSSGRGSAEDDGEDEEIRMINEGPLHHRNGGAGAGSDDGRISDISVQN 3254
..||.......|| :.|.|||||||| ..||:|||||||.| |::.:
Rat 3005 GPGAGGPYPRGGSLDPSHSSGRGSAE-AAEDDEIRMINEFP---------------RVASV---- 3049
Fly 3255 TQEYLARLGIVDHDPSGAGGGASSMAGSSHPMHLYHDDDATARSDITNLIYAKLNDVTGAGSEIG 3319
|||:|.......:..|.|..:.:... ....|....|.:.|
Rat 3050 ---------------------ASSLAARGPDSGIQQDADGLSDTSCE----PPAPDTWYKGRKAG 3089
Fly 3320 SSADDAGTT----AGSIGTIGTAITHGHGVM-SSYGEVPVPVPVVVGGSNVGGSLSSIVHSEEEL 3379
.....||.| .|...| .||...|.|:. :..|:...|.. |...|.|:|::||..||||
Rat 3090 LLLPGAGATLYREEGPPAT-ATAFLGGCGLSPAPTGDYGFPAD---GKPCVAGALTAIVAGEEEL 3150
Fly 3380 TGSYNWDYLLDWGPQYQPLAHVFSEIARLKDDTLSEHSGSGASSSAKSKHSSSHSSAGAGSVVLK 3444
.|||||||||.|.||:||||.||:|||||||:. :
Rat 3151 RGSYNWDYLLSWCPQFQPLASVFTEIARLKDEA-------------------------------R 3184
Fly 3445 PPPSAPPTHIPPPLLTNVA-PRAINLPMRLPPHLSLAPAHLP----RSPIGHEASGSFSTSSAMS 3504
|.|.||... ||||:|.|| |.|.::|.: |...:...|..| ||||.|| ||.| |:|||
Rat 3185 PCPPAPRID-PPPLITAVAHPGAKSVPPK-PASTAATRAIFPPASHRSPISHE--GSLS-SAAMS 3244
Fly 3505 PSFSPSLSPLATRSPSISPLGA--GP 3528
|||||||||||.|||.:||.|. ||
Rat 3245 PSFSPSLSPLAARSPVVSPFGVAQGP 3270
| 
