DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and Pcdhb11

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_017456585.1	Gene:	Pcdhb11 / 291648	RGDID:	1309608	Length:	797	Species:	Rattus norvegicus

Alignment Length:	717	Identity:	212/717 - (29%)
Similarity:	327/717 - (45%)	Gaps:	88/717 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   812 VVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSV----------IAASGDVAHRSPVRYSI 866
            ||||:|:..:.:.. .|..||:  :.|:...|.:|.::          :|..|...|
  Rat    14 VVFLTILLLLWKSG-SEAIRYS--IPEETESGYLVANLAKDLGLKVGKLATRGAQIH-------- 67

  Fly   867 YSGDPDGYFSIETNSGNIRIAKPLDHEAKSQV----LLNIQATLGEPPVYGHTQVNIEVEDVNDN 927
            |.|:.: ...::..:||:.:...||.|....|    :|:.|..|..|..:..|:  :::.|:||:
  Rat    68 YKGNKE-LLQLDAETGNLLLKVKLDREVLCGVTEPCVLHFQIILENPVQFFQTE--LQLTDINDH 129

  Fly   928 APEFEASMVRISVPESAELGA--PLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSG---- 986
            :|||..:.:.:.:||||:.|.  ||.|  |.|.|.||:....|::.......:.......|
  Rat   130 SPEFPDTEMLLKIPESAQTGTVFPLKA--AQDSDIGSNAIQNYTVSPNLHFHVLTHSRTDGRKYP 192

  Fly   987 HLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSI 1051
            .|:|.:.||.|.....||.:||.|||.|..|...|:.::|.|:|||.|.|.:..|.|.:.|:..:
  Rat   193 ELVLDRALDREEQPELTLTLTALDGGAPRRSGTTTVRIEVVDINDNAPQFIRTLYKVQILENSPL 257

  Fly  1052 NAQIIQVNASDLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETR 1116
            :..|:.|:|:|||.|...::.|.:...|.|           ||.|.|...:|.|.|...||.|..
  Rat   258 DTLIVTVSATDLDAGIYGKVAYSLFQGGGD-----------SQPFVIDEITGEIRLSKELDFEEI 311

  Fly  1117 DRYQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLD 1181
            ..|.:.:.|||.|.  ...|..|.::|||.|||.|:....|....:.||... :.|.|.:.||.|
  Rat   312 SHYNIEIAATDGGD--LSGKCTVAIQVLDVNDNAPELTIRKLTVLVPENSAE-TAVAVFSVSDSD 373

  Fly  1182 LGENAAIRYSLLPINSSFQVHPVTGE----ISTREPLDRELRELYDLVVEARDQGTPVRSARVPV 1242
            .|:|..:..| :|.|..|.:.| |.|    :.|..|||||.|..|::.:...|.|||..:.:..:
  Rat   374 SGDNGRMMCS-IPNNIPFLLKP-TFENYYMLVTEGPLDRENRAEYNITITVSDLGTPRLTTQHTI 436

  Fly  1243 RIHVSDVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSD--GH 1305
            .:.|||:|||||.......::. |:|...|...:..:.|.|.|.|.||.||||:::.:|..  ..
  Rat   437 TVQVSDINDNAPAFTQTSYNLF-VQENNSPALHIGTISATDSDSGSNAHITYSLLQLQDQQLALS 500

  Fly  1306 GLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTF----- 1365
            .|.||:|.||.:.....||:|....:...|.|:|||.|...:..::.|.|||.|||.|..
  Rat   501 SLISINPDSGQLFALRALDYESLQAFDFQVGATDGGYPALSSQVLVHVVVLDDNDNDPIVLYPLQ 565

  Fly  1366 -TSSSLVFRVREDAALGHVVGSISPIERPADVVRNSVEESFEDLRVTYTLNPLTKDLIEAAFDID 1429
             ||:.....:..:|..|::|..:..::..:.   .:...||:.|:.|   .|       ..|.:.
  Rat   566 NTSAPCTELLPREAESGYLVTKVVAVDHDSG---QNAWLSFQLLKAT---EP-------GLFSVW 617

  Fly  1430 RHSGNLVVARLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIEVADVNDNA------PEWPQD 1488
            .|:|.:...|||......:.||.:...|   :..||.|. :|.:.|..||..:      ||...|
  Rat   618 AHNGEVRTTRLLSERDVPKHRLLLLVKD---NGEPQRST-SVTLHVLLVNSFSQPYLPLPEVEHD 678

  Fly  1489 PI 1490
            ||
  Rat   679 PI 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637	5/7 (71%)
		Cadherin_repeat	832..927	CDD:206637	22/108 (20%)
		Cadherin_repeat	937..1032	CDD:206637	33/100 (33%)
		Cadherin_repeat	1040..1149	CDD:206637	34/108 (31%)
		Cadherin_repeat	1158..1252	CDD:206637	32/97 (33%)
		Cadherin_repeat	1263..1361	CDD:206637	34/99 (34%)
		Cadherin_repeat	1369..1481	CDD:206637	24/111 (22%)
		Cadherin_repeat	1489..1598	CDD:206637	2/2 (100%)
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdhb11	XP_017456585.1	Cadherin_2	31..112	CDD:285466	19/91 (21%)
		Cadherin_repeat	140..238	CDD:206637	33/99 (33%)
		Cadherin_repeat	247..342	CDD:206637	34/107 (32%)
		Cadherin_repeat	352..446	CDD:206637	32/96 (33%)
		Cadherin_repeat	454..556	CDD:206637	34/102 (33%)
		Cadherin_repeat	575..662	CDD:206637	22/103 (21%)
		Cadherin_C_2	687..769	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910