DRSC/TRiP Functional Genomics Resources

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Protein Alignment ds and Cdhr2

DIOPT Version :9

Sequence 1:NP_001285551.1 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:NP_001028536.2 Gene:Cdhr2 / 268663 MGIID:2687323 Length:1308 Species:Mus musculus


Alignment Length:1334 Identity:345/1334 - (25%)
Similarity:568/1334 - (42%) Gaps:232/1334 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   266 LRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVLQVYASDTDADENGLVEYAINRRQS 330
            |..|| |::|.    ::.|.|..:....|:||:..||.....:.|:|:|.|.   :.|.|:   .
Mouse    11 LPAFM-VSVTA----NSPPSFGVNMTLVTLPEDLPVGAVAFWLVATDSDNDH---LTYGIS---G 64

  Fly   331 DKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPLE-TTAFVSIRVTDVNDNQPTIN 394
            .....|.::..||.:.:...|||||....::.:...|    .|. .||.:.:.|.|.|||.|   
Mouse    65 PNASYFSVNANTGEVKLASPLDFETVPFFKITISTSD----GLNIRTAEMQVIVEDRNDNIP--- 122

  Fly   395 VIFLSDDASPKISESAQPGEFVARISVHDPDSKT----EYANVNVTLNGGDGHFALTTRDNSIYL 455
             :||:.:.|..|:|:...|..|..:...|.|:.|    :|....|        ...|...|:::.
Mouse   123 -VFLNTEFSTSINETLPVGSVVFSVLAEDKDTGTAGLVQYFIEKV--------IPSTANSNNLFR 178

  Fly   456 VIVH--LPLDREIVSN-----YTLSVVATDKG-----TPPLHASKSIFLRIT--DVNDNPPEFEQ 506
            ::.:  :.|:..:..|     |.|.:.|.|.|     .|....|:.:|:.|:  |..|..|.|.:
Mouse   179 ILENGSIVLNDTLSYNNKSAFYQLELKACDSGGILDNKPKTQCSQPVFVSISVIDEPDLDPRFIR 243

  Fly   507 DLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGLITTRSHID- 570
            :.|.|:|.|.|..|||||.|.|.|.|:|:|..:|||::.:  |...||.| .:.|:|.....:| 
Mouse   244 EFYSASVAEDATLGTSVLTVEAVDSDKGINDIVTYSVSNS--TRPGWFDI-REDGVIFVNGSLDR 305

  Fly   571 ----CETEPVP-QLTVVARDGGVPPLSSTATVLVTIH--DVNDNEPIFDQSFYNVS--------- 619
                .|.|.|. |:|...::..:....:.|::.|||.  ||||::|    .|||.|         
Mouse   306 EQLLLENEEVQIQVTATEKNLNIYGQEAKASMWVTIRVTDVNDHKP----EFYNCSLPGCSFSPQ 366

  Fly   620 ---------VAENEPVGRCI--LKVSASDPDCGVNA----MVNYTIGEGFKHLTEFEVRSASGEI 669
                     |.|:......|  |.:.|.|||.|.|.    .:|....|.|....|....|.|.::
Mouse   367 EAQVNFIGYVDEHASARISIDGLTMVAYDPDQGDNGTFLLSLNGQDAEAFNVSPERAAGSVSVQV 431

  Fly   670 CIAGE--LDFERRSSYEFPVLATDR-GGLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKAS 731
            .:...  :|:|:.:.....|:|||. ....:.|.:.:.|.::||:||||....|::::.|.....
Mouse   432 VVRNSEMVDYEKETVMVVEVVATDSVSNNYSVATVTIHLRNINDHRPVFSQSLYELTVPEHCPTG 496

  Fly   732 SQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLN 796
            ...:.    .:.|||.|...:|.::|.::.||.|.:|.::.::|.:.|....:|....|.::.|.
Mouse   497 YLVTD----KIQATDLDGDEWGPITYSLLPGNGADLFEVEPNSGNLTVKNGTLLDREKQAVYYLT 557

  Fly   797 ISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAASGDV--AHR 859
            :.||||||  .:....:.::::|....||:. :..||.:|.|:  .|.|..::.|...|.  .:.
Mouse   558 LQATDGGN--QSTTTALEITLLDINDNPPVV-RGSYNVFVPEE--NGNVSVTIQAYDDDQPDTNN 617

  Fly   860 SPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEA-----KSQVLLN-IQATLGEPPVYGHTQVN 918
            |.:.:|:..|.....||::.|:|.:|...|||.||     :.:::|. |.|..|||.:..:..|.
Mouse   618 SLLVFSLLPGPYSSNFSLDPNTGLLRNLGPLDREAIDPALEGRIVLTVIVADCGEPSLSTNVNVT 682

  Fly   919 IEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDKD-SGSSGQVTYSLVKESGKGL--FA 980
            |.|||:|||.|.|..| ...||.|... ||.:....|.|.| :.::.::::||   ||.|.  |.
Mouse   683 ITVEDINDNLPVFNQS-YEFSVWERVP-GAWVGTVKAWDADQTAANNRISFSL---SGTGANNFI 742

  Fly   981 IDAR---------SGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNPPVF 1036
            :...         |..|:....||||:.:...|.|:|.:.|...|.:...:.|.|.||||.||..
Mouse   743 LQGNVLEQGWAEGSLWLLPDVRLDYETQKFFHLTVSAENPGPQGLDSTANVTVTVMDVNDEPPTL 807

  Fly  1037 EKDE-YSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVD-----AGVD--NVTNSISSSDVS 1093
            :... .:::|:|:.|.:.|:.:|.|.|:||....||  .:||     ||||  :|.:...|.|  
Mouse   808 DAASLQAISVTENGSEHGQVTRVIAQDVDTAALLRI--ELVDVICTKAGVDVGSVCHGWFSVD-- 868

  Fly  1094 QHFGIFPNSGWIYLR--APLDRETRDRYQLTV----LATDNGTPAAHAKTRVIVRVLDANDNDPK 1152
                   .:|.:|:.  ..:|.|......|.|    |.||.|..|..:...:::.:.|.|||.|.
Mouse   869 -------GNGSVYINQSEAIDYEACHLVTLVVRAYDLNTDPGFDAYSSNGSLLINIKDKNDNAPY 926

  Fly  1153 FQKSKYEF-RIEENLRRGSVVGVVTASDLDLGENAAIRYSLLP-----------------INSSF 1199
            |..:...| .|.|.:.....|..|.|.|.|..:|..|.:|:|.                 |..|.
Mouse   927 FLPNNQTFVIIPELVLPNQQVASVQARDEDSEDNGIIMFSILKAEFVRKDGTSNPVQVFRITRSV 991

  Fly  1200 QVHPVTGEISTREPLDRELRELYDLVVEARDQGT--PV-------------RSARVPVRIHVS-- 1247
            :....||.|.....||..::..|.:.|:|:||.|  |.             :|.||.::...|  
Mouse   992 EAGLFTGSIELVTNLDSTIQGTYQVTVQAQDQPTLGPALETQTTLNLFTVDQSYRVRLQFSTSKE 1056

  Fly  1248 DVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDS---DGHGLFS 1309
            ||..|..||.:      ::.:.......||.::.:|           |..:.|.|   |.:.:||
Mouse  1057 DVGANMEEIKE------ALIQATRTSVYVVTIQNID-----------STARARASSYMDAYFVFS 1104

  Fly  1310 IDPTSGVIRTRVVLDHEE---RSIYRLG---VAASDGGNPPRE-------------TVRMLRVEV 1355
            ......:....:::..::   |.:.:||   |::.:...|.::             .|.:|.:.:
Mouse  1105 NGTALTLTELNMMIRKDQDALRQLLQLGLVVVSSQESQEPDQQKLLTSVIIGLVVSLVLVLVILI 1169

  Fly  1356 LDLNDNRPTFTSSSLVFRVREDAALGHVVGSISPIERPADVVRNSVEESFEDLRVTYTLNPLTKD 1420
            ..|...|.::.......:..::|..       :|||..|..........:...|....|:..|||
Mouse  1170 TALVCLRKSYHRKLRAMKAGKEARK-------TPIETTAPTAAIPGTNMYNTDRANPVLDLPTKD 1227

  Fly  1421 L---IEAAFDIDRHSGNLVVARLLDREVQS-EFR 1450
            |   ..::.|:|..|.|.:....:|.::.| ||:
Mouse  1228 LGLECHSSSDLDYDSLNSLDENSVDLDMDSKEFK 1261

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_001285551.1 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637 5/15 (33%)
Cadherin_repeat 291..389 CDD:206637 26/98 (27%)
Cadherin_repeat 406..500 CDD:206637 23/111 (21%)
Cadherin_repeat 509..607 CDD:206637 38/105 (36%)
Cadherin_repeat 616..711 CDD:206637 28/121 (23%)
Cadherin_repeat 719..820 CDD:206637 23/100 (23%)
Cadherin_repeat 832..927 CDD:206637 33/102 (32%)
Cadherin_repeat 937..1032 CDD:206637 30/106 (28%)
Cadherin_repeat 1040..1149 CDD:206637 33/122 (27%)
Cadherin_repeat 1158..1252 CDD:206637 32/128 (25%)
Cadherin_repeat 1263..1361 CDD:206637 17/119 (14%)
Cadherin_repeat 1369..1481 CDD:206637 19/86 (22%)
Cadherin_repeat 1489..1598 CDD:206637
Cadherin_repeat 1614..1710 CDD:206637
Cadherin_repeat 1723..1843 CDD:206637
Cadherin_repeat 1853..1948 CDD:206637
Cadherin_repeat 1957..2053 CDD:206637
Cadherin_repeat 2061..2154 CDD:206637
Cadherin_repeat 2170..2318 CDD:206637
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
Cdhr2NP_001028536.2 Cadherin_repeat 33..120 CDD:206637 26/96 (27%)
Cadherin_repeat 128..236 CDD:206637 24/115 (21%)
Cadherin_repeat 246..349 CDD:206637 38/105 (36%)
Cadherin_repeat 372..476 CDD:206637 25/103 (24%)
Cadherin_repeat 485..582 CDD:206637 24/102 (24%)
Cadherin_repeat 589..691 CDD:206637 33/103 (32%)
Cadherin_repeat 698..802 CDD:206637 30/108 (28%)
Cadherin_repeat 815..923 CDD:206637 33/118 (28%)
Cadherin_repeat 934..1042 CDD:206637 26/107 (24%)
Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organization. /evidence=ECO:0000250|UniProtKB:Q9BYE9 1178..1308 19/91 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1251..1308 4/11 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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