DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and CDHR3

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_689963.2	Gene:	CDHR3 / 222256	HGNCID:	26308	Length:	885	Species:	Homo sapiens

Alignment Length:	632	Identity:	167/632 - (26%)
Similarity:	283/632 - (44%)	Gaps:	73/632 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   619 SVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKH------LTE-FEVRSASG---EICIAG 673
            :||||.|.|..:.|.|..     ::|.::..| .||..      ||| |.|...||   |:...|
Human    30 NVAENSPPGTSVHKFSVK-----LSASLSPVI-PGFPQIVNSNPLTEAFRVNWLSGTYFEVVTTG 88

  Fly   674 --ELDFERRSS-YEFPVLATDRGGLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQAS 735
              :||||...: ::..:...|..|::...::.:|:||||:      |.:::.:|.|.........
Human    89 MEQLDFETGPNIFDLQIYVKDEVGVTDLQVLTVQVTDVNE------PPQFQGNLAEGLHLYIVER 147

  Fly   736 STP--IVAVVATDP-DYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNI 797
            :.|  |..|.|.|| |......:||.:::..::  ||:. :.|.:|...........:..|:: :
Human   148 ANPGFIYQVEAFDPEDTSRNIPLSYFLISPPKS--FRMS-ANGTLFSTTELDFEAGHRSFHLI-V 208

  Fly   798 SATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAAS-GDVAHRSP 861
            ...|.|.|:::.:..|  :|::.....|.|......|.|.|::..||:|.::.|.. .|....|.
Human   209 EVRDSGGLKASTELQV--NIVNLNDEVPRFTSPTRVYTVLEELSPGTIVANITAEDPDDEGFPSH 271

  Fly   862 VRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEA---KSQVLLNIQATLGEPPVYG----HTQVNI 919
            :.|||.:  ...||.|...:|.|::|:.:|.:|   :....::::..:.:.| ||    ..|:..
Human   272 LLYSITT--VSKYFMINQLTGTIQVAQRIDRDAGELRQNPTISLEVLVKDRP-YGGQENRIQITF 333

  Fly   920 EVEDVNDNAPEFEASMVRISVPESAELGAPLYAAH--AHDKDS-GSSGQVTYSLVKESGKG-LFA 980
            .|||||||....:.....|.|||....|..|...:  ..|.|| ..:.:..:::....|.| .|.
Human   334 IVEDVNDNPATCQKFTFSIMVPERTAKGTLLLDLNKFCFDDDSEAPNNRFNFTMPSGVGSGSRFL 398

  Fly   981 ID-ARSGHLILSQHLDYE------SSQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNPPVFEK 1038
            .| |.||.::|...||||      :..::|:|:...|...|....|:.:.:.....|:.|.:|::
Human   399 QDPAGSGKIVLIGDLDYENPSNLAAGNKYTVIIQVQDVAPPYYKNNVYVYILTSPENEFPLIFDR 463

  Fly  1039 DEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPNSG 1103
            ..|..:|||.|....::.||.|:|.|...:: :.|.|...|.     |:...:|   |.|.|.:|
Human   464 PSYVFDVSERRPARTRVGQVRATDKDLPQSS-LLYSISTGGA-----SLQYPNV---FWINPKTG 519

  Fly  1104 WIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRR 1168
            .:.|...:|.||...|.|.:.||:|...::   ..|.|.:|:.||..|....:.|...:..:|:.
Human   520 ELQLVTKVDCETTPIYILRIQATNNEDTSS---VTVTVNILEENDEKPICTPNSYFLALPVDLKV 581

  Fly  1169 GSVVG--VVTASDLDLGENAAIRYSLLP--INSSFQVHPVTGEISTR 1211
            |:.:.  .:|.:||| ....:.|||:.|  :|:.|...|..|...||
Human   582 GTNIQNFKLTCTDLD-SSPRSFRYSIGPGNVNNHFTFSPNAGSNVTR 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637	32/104 (31%)
		Cadherin_repeat	719..820	CDD:206637	21/103 (20%)
		Cadherin_repeat	832..927	CDD:206637	29/102 (28%)
		Cadherin_repeat	937..1032	CDD:206637	27/105 (26%)
		Cadherin_repeat	1040..1149	CDD:206637	32/108 (30%)
		Cadherin_repeat	1158..1252	CDD:206637	17/58 (29%)
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
CDHR3	NP_689963.2	Cadherin_repeat	26..128	CDD:206637	31/103 (30%)
		Cadherin_repeat	141..231	CDD:206637	19/95 (20%)
		Cadherin_repeat	242..341	CDD:206637	29/101 (29%)
		Cadherin_repeat	349..456	CDD:206637	26/106 (25%)
		Cadherin_repeat	465..561	CDD:206637	31/107 (29%)
		Cadherin_repeat	570..679	CDD:206637	17/59 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	808..885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910