DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and Pcdh17

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_006518968.1	Gene:	Pcdh17 / 219228	MGIID:	2684924	Length:	1185	Species:	Mus musculus

Alignment Length:	1274	Identity:	318/1274 - (24%)
Similarity:	499/1274 - (39%)	Gaps:	265/1274 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 GDFGGIDSGPPYIIVAEAGVETDLAIDRATGEIRTKVKLDRET------RASYSLVAIPLSGRNI 158
            |.:..:::..|::          |.:|..:|.:.||.::|||:      :...||..........
Mouse    63 GSYRVLENSAPHL----------LDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEIC 117

  Fly   159 RVLVTVKDENDNAPTFPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFR 223
            .:.|.::|.|||||:||...:.::..||.....:..|..|.|.|......:.| :::.:.:..|.
Mouse   118 MIKVEIQDINDNAPSFPSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTY-LLTRDDHGLFA 181

  Fly   224 LSSHRERDGVLYLDLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQ 288
            |......||..:.:|.|...||||....::|::.|||||.||....:.:|:.:.|.|||.|:|..
Mouse   182 LDVKSRGDGTKFPELVIQKALDRELQNHHTLVLTALDGGEPPRSATVQINVKVIDSNDNSPVFEA 246

  Fly   289 SRYFATVPENATVGTSVLQVYASDTDADENGLVEYAINRRQSDK-EQMFRIDPRTGAIYINKALD 352
            ..|...:||||.:||.|:.:.|:|.|...||.|.|:.:....|: .::|.|||:||.|.:...||
Mouse   247 PSYLVELPENAPLGTVVIDLNATDADEGPNGEVLYSFSSYVPDRVRELFSIDPKTGLIRVKGNLD 311

  Fly   353 FETKELHELVVVAKDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVA 417
            :|...:.|:.|.|:|.|..|:.....|::::.|.|||.|:|..:.:...|   :||:|.||..:|
Mouse   312 YEENGMLEIDVQARDLGPNPIPAHCKVTVKLIDRNDNAPSIGFVSVRQGA---LSEAAPPGTVIA 373

  Fly   418 RISVHDPDS-KTEYANVNVTLNGGDG---------HFALTTRDNSIYLVIVHLPLDREIVSNYTL 472
            .:.|.|.|| |.......|...||.|         .|.|....::.|.|:...|||||....|.:
Mouse   374 LVRVTDRDSGKNGQLQCRVLGGGGTGGGLGGPGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNV 438

  Fly   473 SVVATDKGTPPLHASKSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNS 537
            ::||.|.|:|||:::||..::|.|.|||||.|.:.||...|.|...||..:..|||.|.|.|.|.
Mouse   439 TIVARDGGSPPLNSTKSFAVKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNG 503

  Fly   538 ALTYSLAETPETHA------QWFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPP-LSSTA 595
            .::||:.   .:|.      .:..::|..|.|......:.|.....:..|:|:|.|.|. |.|.|
Mouse   504 TVSYSIL---PSHIGDVSIYTYVSVNPTNGAIYALRSFNYEQTKAFEFKVLAKDSGAPAHLESNA 565

  Fly   596 TVLVTIHDVNDNEPI-----FDQSFYNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEG-F 654
            ||.||:.|||||.|:     .......:.|..|..:|..:..|.|.|.|.|.:..:.|.|.:| .
Mouse   566 TVRVTVLDVNDNAPVIVLPTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVDGND 630

  Fly   655 KHLTEFEVRSASGEICIAGELDFERRSSYEF-----PVL-----ATDRGGLSTTAMIKMQLTDVN 709
            .||  ||:..:||||          |:.:.|     ||:     .||.|..:.:|:.|:.:..|:
Mouse   631 DHL--FEIDPSSGEI----------RTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLIIRSVS 683

  Fly   710 DNRPVFYPR------EYKVSLRESPKASSQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGIF 768
            .:.|...||      .:.:||             |::..::|         :|..::|.......
Mouse   684 GSLPEGVPRVNGEQHHWDMSL-------------PLIVTLST---------ISIILLAAMITIAV 726

  Fly   769 RIDRSTGEIFVVRPDMLSVRTQPMHMLNIS--ATDGGN-------------LRSNADAVVFLSII 818
            :..|...||          ||....:...|  ...||.             ::|..:....::::
Mouse   727 KCKRENKEI----------RTYNCRIAEYSHPQLGGGKGKKKKINKNDIMLVQSEVEERNAMNVM 781

  Fly   819 DAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGN 883
            :.:..|.:.....|..| :..:|..             :.||.|.|            ::..|.|
Mouse   782 NVVSSPSLATSPMYFDY-QTRLPLS-------------SPRSEVMY------------LKPASNN 820

  Fly   884 IRIAKPLDHEAKSQVLLNIQATLGEPPVYGHTQVNIEVEDVNDNAP----------EFEASMVRI 938
            :.:  |..|...............|.|.   |:::| ::  .||.|          :|..|....
Mouse   821 LTV--PQGHAGCHTSFTGQGTNSSETPA---TRMSI-IQ--TDNFPAEPNYMGSRQQFVQSSSTF 877

  Fly   939 SVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHT 1003
            ..||.|.|         .|...|.|.|....  :::.||...                :.|.|..
Mouse   878 KDPERASL---------RDSGHGDSDQADSD--QDTNKGSCC----------------DMSVREA 915

  Fly  1004 LIVTAT-------DGGVPSL-----STNLTILVDVQDVNDNPPVFEK-----DEYSVNVSESRSI 1051
            |.:..|       :...|:|     .|..||...:|.|:..||..|:     ||..|.....|..
Mouse   916 LKMKTTSTKSQPLEQAFPTLLSFAILTLHTITTRLQSVDPLPPEPEECINCTDECRVLGHSDRCW 980

  Fly  1052 NAQIIQVN-ASDLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRET 1115
            ..|....| |.:.|...|..:.  .|:|.|:..|....:....:.|..|               .
Mouse   981 MPQFPAANQAENADYRTNLFVP--TVEANVETETYETVNPTGKKTFCTF---------------G 1028

  Fly  1116 RDRYQLTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDL 1180
            :|:.:.|:|.. |..|...|| |.:..:|   ...|....|..:..||.   ..|..|.:...:.
Mouse  1029 KDKREHTILIA-NVKPYLKAK-RALSPLL---QEVPSASSSPTKACIEP---CASTKGSLDGCEA 1085

  Fly  1181 DLGENAAIRYSLLPINSSFQVHPVTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIH 1245
            ..|..|....|.||.:|.:       ...:::|.|....        |.||     .|||...:|
Mouse  1086 KPGPLAEASSSYLPTDSQY-------PSPSKQPRDPSFM--------ASDQ-----MARVFADVH 1130

  Fly  1246 ------VSDVNDNAPEIADPQEDVVSVREEQPPGTEVVR 1278
                  .|::.....::..|..|   :..|.....||||
Mouse  1131 SRARRASSEMGAVLEQLEQPNRD---LGRESVDAEEVVR 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	15/66 (23%)
		Cadherin_repeat	178..282	CDD:206637	28/103 (27%)
		Cadherin_repeat	291..389	CDD:206637	35/98 (36%)
		Cadherin_repeat	406..500	CDD:206637	37/103 (36%)
		Cadherin_repeat	509..607	CDD:206637	34/104 (33%)
		Cadherin_repeat	616..711	CDD:206637	29/105 (28%)
		Cadherin_repeat	719..820	CDD:206637	15/115 (13%)
		Cadherin_repeat	832..927	CDD:206637	15/94 (16%)
		Cadherin_repeat	937..1032	CDD:206637	21/106 (20%)
		Cadherin_repeat	1040..1149	CDD:206637	23/109 (21%)
		Cadherin_repeat	1158..1252	CDD:206637	20/99 (20%)
		Cadherin_repeat	1263..1361	CDD:206637	5/16 (31%)
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Pcdh17	XP_006518968.1	Cadherin_2	21..112	CDD:369785	12/58 (21%)
		Cadherin_repeat	142..240	CDD:206637	28/98 (29%)
		Cadherin_repeat	248..348	CDD:206637	35/99 (35%)
		Cadherin_repeat	362..466	CDD:206637	37/103 (36%)
		Cadherin_repeat	475..577	CDD:206637	34/104 (33%)
		Cadherin_repeat	592..680	CDD:206637	28/99 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I10386
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000