DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and cdh-9

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_510685.2	Gene:	cdh-9 / 186608	WormBaseID:	WBGene00000401	Length:	623	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	135/555 - (24%)
Similarity:	232/555 - (41%)	Gaps:	108/555 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   408 ESAQPGEFVARISVHDPDSKTEYANVNVTLNGGDGHFALTTRDNSIYLVIVHLPLDR-------E 465
            |..:||..:..:......||    ..:|.|....|:..:..:..| :.:|:...|||       |
Worm    37 EDLKPGNVIGTLPFESQTSK----ETDVELRVVKGNELVDVKPGS-HDLILKKTLDRDEGVGKFE 96

  Fly   466 IVSNYTLSVVATDKGTPPLHASKSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVL-QVLAH 529
            .|.....|.:.||..    ..:.|:|:.:.|:|||.|.|:...|..::.|....||.|. ...|.
Worm    97 AVVECRSSNLDTDFS----QLNISVFVTVKDINDNAPVFDSAEYFVDIKEELPTGTIVFTDFEAT 157

  Fly   530 DRDE-GLNSALTYSLAETPETHAQWFQI-DPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLS 592
            |.|: |.||.:.|::...|  |:.:.:| ||...:||.:..|:.|......:.:.|||.|.|.|:
Worm   158 DNDQPGPNSFVQYTIVAGP--HSHFLEIPDPFKPVITIKDRINYEEIKKFSVEIEARDQGEPSLA 220

  Fly   593 STATVLVTIHDVNDNEPIFDQSFYNVSVAEN-----EPVGRCILKVSASDPDCGVNAMVNYTI-G 651
            ||..:.|||.||||..|.|..|.|.....:|     ||..     :||.|.| .:||.:.::: |
Worm   221 STVPLHVTIVDVNDLLPRFKHSHYTAKSQKNGVLVFEPEA-----ISAQDGD-RLNASLIFSLSG 279

  Fly   652 EGFKHL---TEFEVRS--------ASGEICIAGELDFERRSSYEFPVLATDRGGLSTTAMIKMQL 705
            |..:|.   .:..:||        |:..:..:...|.||.|                ||::.::|
Worm   280 ELSEHFAIDNDGSIRSITPNPPQRATFFVTASEREDTERNS----------------TAILSIRL 328

  Fly   706 TDVNDNRPVFYPREYKVSLRESPKASSQASSTPI----VAVVATDPDYGNFGQVSYRIVAGNEAG 766
                         :..::.:.:..:::.:.:|||    :.|||...   |...::|.::|  :..
Worm   329 -------------QSSLAFQHNTYSTTISPTTPIGSTVITVVANSE---NNTPLTYSLLA--DTN 375

  Fly   767 IFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKAR 831
            ...||..:|.:      :|..:.:....||::|:||.|:.|.|..::..:..::.:.|..|||..
Worm   376 TVSIDEVSGNV------VLRKKLEKPETLNVTASDGENVVSTALHLMTANSEESCRSPIKFEKFE 434

  Fly   832 YNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKS 896
            |    |..|.:..|:|.|.|.|   ...:.:.|.:.:.:.|  |.|:||.    :.|.|..
Worm   435 Y----KMTIGKLNVLGVVNATS---RTGTKITYILMNMNND--FEIDTNG----VVKLLPK---- 482

  Fly   897 QVLLNIQATLGEPPVYGHTQVNIEVEDVNDNAPEF 931
               ..:|..:.|..|...:...:.:..:|.:.|.|
Worm   483 ---ARLQCKVCELIVVAKSGTQMAITKINVDNPAF 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637	22/98 (22%)
		Cadherin_repeat	509..607	CDD:206637	35/100 (35%)
		Cadherin_repeat	616..711	CDD:206637	23/111 (21%)
		Cadherin_repeat	719..820	CDD:206637	21/104 (20%)
		Cadherin_repeat	832..927	CDD:206637	20/94 (21%)
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
cdh-9	NP_510685.2	E_set	<80..129	CDD:298831	15/52 (29%)
		Cadherin_repeat	135..234	CDD:206637	34/100 (34%)
		Cadherin_repeat	338..>405	CDD:206637	16/77 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910