DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ds and cdh-9

DIOPT Version :9

Sequence 1:NP_001285551.1 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:NP_510685.2 Gene:cdh-9 / 186608 WormBaseID:WBGene00000401 Length:623 Species:Caenorhabditis elegans


Alignment Length:555 Identity:135/555 - (24%)
Similarity:232/555 - (41%) Gaps:108/555 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   408 ESAQPGEFVARISVHDPDSKTEYANVNVTLNGGDGHFALTTRDNSIYLVIVHLPLDR-------E 465
            |..:||..:..:......||    ..:|.|....|:..:..:..| :.:|:...|||       |
 Worm    37 EDLKPGNVIGTLPFESQTSK----ETDVELRVVKGNELVDVKPGS-HDLILKKTLDRDEGVGKFE 96

  Fly   466 IVSNYTLSVVATDKGTPPLHASKSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVL-QVLAH 529
            .|.....|.:.||..    ..:.|:|:.:.|:|||.|.|:...|..::.|....||.|. ...|.
 Worm    97 AVVECRSSNLDTDFS----QLNISVFVTVKDINDNAPVFDSAEYFVDIKEELPTGTIVFTDFEAT 157

  Fly   530 DRDE-GLNSALTYSLAETPETHAQWFQI-DPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLS 592
            |.|: |.||.:.|::...|  |:.:.:| ||...:||.:..|:.|......:.:.|||.|.|.|:
 Worm   158 DNDQPGPNSFVQYTIVAGP--HSHFLEIPDPFKPVITIKDRINYEEIKKFSVEIEARDQGEPSLA 220

  Fly   593 STATVLVTIHDVNDNEPIFDQSFYNVSVAEN-----EPVGRCILKVSASDPDCGVNAMVNYTI-G 651
            ||..:.|||.||||..|.|..|.|.....:|     ||..     :||.|.| .:||.:.::: |
 Worm   221 STVPLHVTIVDVNDLLPRFKHSHYTAKSQKNGVLVFEPEA-----ISAQDGD-RLNASLIFSLSG 279

  Fly   652 EGFKHL---TEFEVRS--------ASGEICIAGELDFERRSSYEFPVLATDRGGLSTTAMIKMQL 705
            |..:|.   .:..:||        |:..:..:...|.||.|                ||::.::|
 Worm   280 ELSEHFAIDNDGSIRSITPNPPQRATFFVTASEREDTERNS----------------TAILSIRL 328

  Fly   706 TDVNDNRPVFYPREYKVSLRESPKASSQASSTPI----VAVVATDPDYGNFGQVSYRIVAGNEAG 766
                         :..::.:.:..:::.:.:|||    :.|||...   |...::|.::|  :..
 Worm   329 -------------QSSLAFQHNTYSTTISPTTPIGSTVITVVANSE---NNTPLTYSLLA--DTN 375

  Fly   767 IFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKAR 831
            ...||..:|.:      :|..:.:....||::|:||.|:.|.|..::..:..::.:.|..|||..
 Worm   376 TVSIDEVSGNV------VLRKKLEKPETLNVTASDGENVVSTALHLMTANSEESCRSPIKFEKFE 434

  Fly   832 YNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKS 896
            |    |..|.:..|:|.|.|.|   ...:.:.|.:.:.:.|  |.|:||.    :.|.|..    
 Worm   435 Y----KMTIGKLNVLGVVNATS---RTGTKITYILMNMNND--FEIDTNG----VVKLLPK---- 482

  Fly   897 QVLLNIQATLGEPPVYGHTQVNIEVEDVNDNAPEF 931
               ..:|..:.|..|...:...:.:..:|.:.|.|
 Worm   483 ---ARLQCKVCELIVVAKSGTQMAITKINVDNPAF 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_001285551.1 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637
Cadherin_repeat 291..389 CDD:206637
Cadherin_repeat 406..500 CDD:206637 22/98 (22%)
Cadherin_repeat 509..607 CDD:206637 35/100 (35%)
Cadherin_repeat 616..711 CDD:206637 23/111 (21%)
Cadherin_repeat 719..820 CDD:206637 21/104 (20%)
Cadherin_repeat 832..927 CDD:206637 20/94 (21%)
Cadherin_repeat 937..1032 CDD:206637
Cadherin_repeat 1040..1149 CDD:206637
Cadherin_repeat 1158..1252 CDD:206637
Cadherin_repeat 1263..1361 CDD:206637
Cadherin_repeat 1369..1481 CDD:206637
Cadherin_repeat 1489..1598 CDD:206637
Cadherin_repeat 1614..1710 CDD:206637
Cadherin_repeat 1723..1843 CDD:206637
Cadherin_repeat 1853..1948 CDD:206637
Cadherin_repeat 1957..2053 CDD:206637
Cadherin_repeat 2061..2154 CDD:206637
Cadherin_repeat 2170..2318 CDD:206637
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
cdh-9NP_510685.2 E_set <80..129 CDD:298831 15/52 (29%)
Cadherin_repeat 135..234 CDD:206637 34/100 (34%)
Cadherin_repeat 338..>405 CDD:206637 16/77 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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