DRSC/TRiP Functional Genomics Resources

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Protein Alignment ds and hmr-1

DIOPT Version :9

Sequence 1:NP_001285551.1 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:NP_001021650.1 Gene:hmr-1 / 173007 WormBaseID:WBGene00001980 Length:2920 Species:Caenorhabditis elegans


Alignment Length:2804 Identity:665/2804 - (23%)
Similarity:1080/2804 - (38%) Gaps:732/2804 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    78 QERERKLEVFEGVAVDYQIGYIGDFGGIDSGPPYIIVAEAGVETDLAIDRATGEIRTKVKLDRET 142
            ::::.|:.:|.|..       ||:          |.||:..::.|     ..|:|.....|:.| 
 Worm   346 EKKDMKIPLFAGET-------IGE----------INVAKEWLKID-----DDGKIHLLKPLNYE- 387

  Fly   143 RASYSLVAIPLSG------RNIRVLVTVKDENDNAPTFPQTSMHIEFPENTPREVKRTLLPARDL 201
            :.|..:..:|::|      :.||:.|.   :.|..|:|          .|:|       ||.  |
 Worm   388 KTSSIIATVPINGLQSTRTQTIRIHVA---DIDEPPSF----------VNSP-------LPM--L 430

  Fly   202 DLEPYNTQRYNIVSGNVNDAFRLSSHRERD-GVLYLDLQI----------------SGFLDRETT 249
            .:.|.|.....||...|    ....|.:.| .|||..:.:                :|:...|..
 Worm   431 AVVPLNPTIGRIVYQFV----ARDEHGDGDSNVLYKTIDVIPAGSFIVDPKSGVVRTGWSKYERG 491

  Fly   250 PGYSLLIEALDGGTPPLRGFMTVNITIQDV--NDNQPIFNQSRYFATVPENATVGTSVLQV---- 308
            ..|.:..:|:|.............:.|.::  ::..|.|.:..|..||.|:..|..||:.|    
 Worm   492 DTYRISAQAMDLSPSDNTTSQLSEVAILEILADERPPQFAKQEYEVTVSEDNLVDYSVVDVKAQS 556

  Fly   309 YASDTDADENGLVEYAI-NRRQSDKEQMFRIDPRTGAIYINKALDFE---TKELHELVVVAK-DH 368
            :.|..|....|.:.|:: .....|:.:.|||||.||.|::.:.|||:   ..:||:|.|.|: |:
 Worm   557 FRSFEDGRSKGPITYSLEGDTPEDETKWFRIDPSTGIIHLTRLLDFDDPALPKLHKLKVTAREDN 621

  Fly   369 GEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPD----SKTE 429
            .|..::.|    ||:.|||||.||    |.....:.::.|.....:.:.:::..|.|    |:..
 Worm   622 RESHVDLT----IRIDDVNDNVPT----FTRPLYTAQVREDIPLNQTILKVTAVDKDTGDNSRIT 678

  Fly   430 YA--NVNVTLNGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTP-PLHASKSIF 491
            |:  |.|.::| .:|..:...|.::..|      .:|..|  |..:|.|.|.|.| .|.:|..|.
 Worm   679 YSVDNHNFSIN-SNGEISAKVRLDADQL------NERHFV--YRFNVTARDHGEPVSLSSSAMIH 734

  Fly   492 LRITDVNDNPPEF-EQDLYHANVMEVADPGTSVLQVLAH--DRDEGLNSALTYSLAETPETHAQ- 552
            :|..:.||....| ....|.|.|.|.|..||.|:|:.|.  ||||     :|||..:......| 
 Worm   735 IRTENTNDESAVFLPTSQYTAFVAEDAQGGTPVIQIQARDADRDE-----VTYSFMDKNGRSTQK 794

  Fly   553 --WFQIDPQTGLITTRSHID----CETEPVPQLTVVARDGG---VPPL---SSTATVLVTIHDVN 605
              .|.||..|||:..|..:.    .|.|....|||:.:|.|   |.|.   :|.||:|:.|.|||
 Worm   795 MNLFSIDEHTGLVKLRHGVSAADLAEAENPINLTVIVQDDGSCCVYPSKTHTSYATLLIGIEDVN 859

  Fly   606 DNEPIFDQSFYNVSVA-------ENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVR 663
            :|:|.|........:|       :.:|  ..|:||.|:|.|...|..:.|::     :.|:.|.|
 Worm   860 NNKPEFPDCAKYSDIAKIMEGTYKTDP--PTIVKVEATDDDSSANGDIVYSL-----YYTQSESR 917

  Fly   664 SA------SGEICIAGELDFER--RSSYEFPVLATDRGG--LSTTAMIKMQLTDVNDNRPVFYPR 718
            .|      :|.:..:..:.|:|  |...:..|.|||||.  |.......:::.|:|||.|.|...
 Worm   918 KAFVIDRQTGVLTPSPHVVFDRETRPREDVTVKATDRGDRPLIGFCQFSVEVVDINDNSPQFERP 982

  Fly   719 EYKVSLRESPKASSQASSTPIVAVVATDPDYGNFGQVSYRI----VAG----NEAGIFR-IDRST 774
            .|:.|:     :..:|..|.::.|.|.|.|..:..:::|.:    .||    |:...|. ::|.:
 Worm   983 SYETSV-----SRFEAVGTSVITVFAFDNDAAHNAEITYSLEIDTTAGEEHQNDLDFFELVNRRS 1042

  Fly   775 GEIFVVRPDMLSVRTQPMHMLNISATDGG---NLRSNADAVVFLSIIDAMQRPPIFEKA---RYN 833
            |||.:::|  :.::||.. :.|:.|.|.|   .|:|:|.  |.|:::|..|:.|.::.:   :..
 Worm  1043 GEITLIKP--IPMKTQKF-IFNVIADDNGIPEALQSSAQ--VTLNVLDKQQKAPKWQTSPDCKPG 1102

  Fly   834 YYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSI-YSGDPDG-------YFSIETNSGN----IRI 886
            ..|.|::....|:....|.|...:..|.|.|.: .||.|..       .|: :..:||    :.|
 Worm  1103 ITVDENVELNKVILRCRAVSSGDSRNSDVIYKLTASGGPGNKAESKFRQFN-KFENGNEWVEVVI 1166

  Fly   887 AKPLDHEAKSQVLLNIQATLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAEL----- 946
            .:.||:|..:...|.:.||.....|.......:||.||||..|:|...:...::.|  |:     
 Worm  1167 MEGLDYEQVNNYTLTLTATDMTSRVASTKTFVVEVRDVNDVVPQFTVDLFTGTIDE--EMTPNEH 1229

  Fly   947 -----GAPLYAAHAHDKDS-GSSGQVTYSLVKE-SGKGL--FAIDARSGHLILSQHLDYESSQRH 1002
                 |.|:....|.|.|| |...:|.|.:|.| :|:..  |.||..:|.:..::..|.|....:
 Worm  1230 LEKTNGKPIVTVKAIDTDSDGPQNEVHYRIVGEANGEETKHFRIDELTGEIFPNEKFDREKIDMY 1294

  Fly  1003 TLIVTATDGGVPSL-------STNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNA 1060
            .|.|.|:|..|.:|       ..|:.:.:.:.|||||.|.||:.:|...|.||......:|.:.|
 Worm  1295 ILTVEASDRSVSALPGANGPNKDNVKVQIVINDVNDNAPSFEEQKYIGRVKESEGEGHDVITIKA 1359

  Fly  1061 SDLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLA 1125
            .|||..:|.|  |.::.||...:.           ||:..:||.|:::.|||.|..|:|.|.::|
 Worm  1360 HDLDKHSNLR--YHLIGAGGGRIP-----------FGVRTDSGTIFVKEPLDFEASDQYHLVLIA 1411

  Fly  1126 TDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFR-IEENLRRGSVVGVVTASDLDLGENAA-I 1188
            :|.   ..:|.|.|.:.:.|.|||.|:|::.||... |||::....|:..|.|:|.|..|.:: |
 Worm  1412 SDG---RHNATTNVYIHIEDVNDNAPQFEQQKYATTVIEEDVDIPKVLFNVHATDADQDEKSSRI 1473

  Fly  1189 RYSL--LPINSSFQVHPVTGEISTREPLDRELR---ELYDLVVEARDQGTPVRSARVPVRIHVSD 1248
            .|.|  ...:..|::...:|.|...:.|||:..   ..::.||:|.|...........|:::|.|
 Worm  1474 VYRLEGQGADEVFRIGKYSGTIELVKALDRDPPAGVPSWNFVVQAIDDDGNGLVGYADVQVNVRD 1538

  Fly  1249 VNDNAPEIADPQEDVVSVREEQPP----GTEVVRVRAVDRDH--GQNASITYSIVKGRDSDGHGL 1307
            :|||:|..  |:.....:.|.:.|    |...:.|:|.|.|.  .:||:|.|.||:.:..:|..:
 Worm  1539 INDNSPIF--PERLFGYIEENREPIHSDGVYFMDVQARDFDDPTTENANIEYGIVRNKLINGESV 1601

  Fly  1308 FSIDPTSGVIRTRVVLDHE---ERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSS 1369
            |.||..:|.|.....||.|   ||. :.:.|.|:|.|.|.||....:.::|.|:|||.|.|..:.
 Worm  1602 FRIDQNTGKIFAMRSLDREISSERE-FIIEVRANDRGVPSREGFANVTIKVTDMNDNAPFFEKTR 1665

  Fly  1370 LVFRVREDAALGHVVGSISPIERPADVVRNSVEESFEDLRVTYTLNPLTKDLIEAAFDIDRHSGN 1434
            ....|.|.|.:|..|.|.|..:         .:|..:|...||.|:. ..|......|.|....:
 Worm  1666 YEGSVEETAPIGAAVMSFSAFD---------ADEEAKDNVFTYQLSE-ESDYFYVTTDKDSKQSS 1720

  Fly  1435 LVVARL---LDREVQSE---FRLEIRALDTTASNNPQSSAITVKIEVADVNDNAPEWPQDPIDLQ 1493
            :.|.|:   ||.|..::   |.|.||     .|:....:...|.:.:.|.||:||. .....:.:
 Worm  1721 VGVLRVKQPLDYEDVTQRDGFHLGIR-----VSDGRHDAEAAVHVALVDRNDHAPH-IHGATEHR 1779

  Fly  1494 VSEATPVGTIIHNFTATDADTGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGALSLQAPLD 1558
            |.|..|.||.|..:||||.|.|...  ::|:.|        |......|.:|. .|.|.:...||
 Worm  1780 VREDVPRGTSIGRYTATDRDAGDTA--RFRINR--------QSDPKRQFTIDQ-DGTLRVAHTLD 1833

  Fly  1559 FEAVQEYLLIVQALDQSSNVTERLQTSVTVRLRILDANDHAPH-FVSPNSSGGKTASLFISDATR 1622
            .|.:..|.||::|.|.|:|:..::     |.:.:.|.||:.|. :..|.       .....:.|.
 Worm  1834 REDIAVYNLIIEAYDNSNNIGRQM-----VAVYLQDVNDNGPEPYTVPR-------PCIFRENTP 1886

  Fly  1623 IGEV-VAHIVAVDEDSGDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKGGRFNL 1686
            :.:: ...|.|.|.|:.:.|                              ||.|.:|....::: 
 Worm  1887 VNQLGTCEIRATDRDTAEFG------------------------------PPFTMEVSPSFKYS- 1920

  Fly  1687 IIGAKDHGQPEPKKSSLNLHLIVQGSHNNPPRFLQAVYRATILENVPSGSFVLQVTAKSLHGAEN 1751
                                           ::|..::.|    |...|               |
 Worm  1921 -------------------------------QYLNVIFNA----NGDGG---------------N 1935

  Fly  1752 ANLSYEIPAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQSTLSSSAVRKQRSS 1816
            .:::                    ||...:||||:      ||..:.......|:..|.|:..  
 Worm  1936 GSMT--------------------ITPLQEFDREA------PVPGKILEIPLILADRAGRRNE-- 1972

  Fly  1817 DSIGDTSNGQHFDVATIYITVGDVNDNSPEFRPGSCYGLSVPENSEPG-----VIHTVVASDLDE 1876
                          |::::.:||:|||:  ...|.   :::..||..|     ||..|...|.|:
 Worm  1973 --------------ASVHVIIGDLNDNT--MHDGR---MTIHVNSYLGRLKETVIGRVYVDDADD 2018

  Fly  1877 GPNADLIY----SITGGNLGNKFSIDSSSGELSARPLDREQHSRYTLQIQASDRGQPKSRQGHCN 1937
            ....|..:    |..|..|.:|.|| :.:||::|        ..||:.....|..:.:...|:  
 Worm  2019 WDLGDKTFSWKDSRPGFELSDKGSI-TMAGEMAA--------GTYTMSANVHDNARDEDAVGY-- 2072

  Fly  1938 ITIFVEDQNDNA-PRFKLSKYTGSVQEDAPLGTSVVQISAVDADLGVNARLVYSLANETQWQFAI 2001
            :|:.|     || |:..... .||||                          ..:|.||..|...
 Worm  2073 VTVIV-----NAVPQIAFDN-QGSVQ--------------------------LLIAEETPLQLPD 2105

  Fly  2002 D-------GQSGLITTVGKLDRELQASYNFMVLATDGGRYEVRSATVPV---------------- 2043
            |       |||.:.|...::...:.......|.:...|...:::..|||                
 Worm  2106 DFIRADSNGQSLMDTFKQEMTAYMGGDVTVDVFSVQVGIATLQTRDVPVLNVRFNARGSTYRDTA 2170

  Fly  2044 QINVLDINDNRPIFERYPYIGQVPALIQPGQTLLKVQALDAD-------------LGANAEIVYS 2095
            |:|.| |..:|...:|...:    .::..|..:.|....||.             :.||:.::..
 Worm  2171 QLNGL-IAAHRADLQRKLNV----EIVGVGIDMCKFTQCDAGCQTLNSADYDGIVVSANSTVIVG 2230

  Fly  2096 LNA--ENSAVSAKFRINPSTGALSASQSLASESGKLLHLEVVARDKGNPPQSSLGLI-----ELL 2153
            :||  .:......:|..|     :...||....| :.|       ..||     |..     :.|
 Worm  2231 VNATSRDDCTCPVWRAPP-----ACQHSLCHNDG-VCH-------NTNP-----GFFCECRNDGL 2277

  Fly  2154 IGEAPQGTPVLRFQN--ETYRVMLKENSPSGTRLLQVVALRSDGRRQKVQFSFGAGNEDGILSLD 2216
            .|...|||......|  ..|:.|     |:.|.|             .:.|||.....|.:|..:
 Worm  2278 KGARCQGTTRSFGGNGFAWYKPM-----PACTSL-------------NISFSFMTTQSDALLFYN 2324

  Fly  2217 SLSGEIRVNKPHLLDYDRFSTPSMSALSRGRALHYEEEIDESSEEDPNNSTRSQRALTSSSFALT 2281
            .....:| |..|:    .:|......|..||.         |.|...|..:||  :|..:|.||.
 Worm  2325 GPLETLR-NDTHI----EYSDYIFIQLRGGRI---------SLEVSMNGQSRS--SLEVASTALN 2373

  Fly  2282 NSQPNEIRVVLVARTADAPFLASYAELVIELEDENDNSPKFSQKQFVATVSEGNNKGTFVAQVHA 2346
            :...::|.|....:.         .|||:      ||. :|        :..|.:..:..|:::.
 Worm  2374 DGTWHDISVNQEGKR---------VELVV------DNC-RF--------LGAGADDSSCRAELYT 2414

  Fly  2347 FDSDAGSNARLRYHIVDGNHDNAFVIEPAFSGIVRTNIVLDREIRDIYKLKIIATDEGVPQMTGT 2411
            .|.|.                             |.|||...:|..:..|    :.:..||....
 Worm  2415 PDDDE-----------------------------RLNIVTPVQIGGLAPL----SGQDYPQTIPR 2446

  Fly  2412 ATIR--VQIVDVNDNQ-----PTFPPNNLVTVSEATELGAVI--TSISANDVDTYPALTYRLGAE 2467
            |.:.  |:.::||.:|     |.|..|        :|.|..:  .:..:|.||   :|.:.:..:
 Worm  2447 AGLNGCVRNLNVNGDQYDLATPAFEQN--------SEKGCRLWGATCDSNSVD---SLNHCIHGD 2500

  Fly  2468 STVDIENMSIFALDRYSGKLVLK-------------RRLDYELQQEYELDVIASDAAHEARTVLT 2519
            ...|::.         ||.:|.|             ||:::                        
 Worm  2501 CFADVQG---------SGAMVAKCVCDPGWGGARCERRMEW------------------------ 2532

  Fly  2520 VRVNDENDNAPVFLAQQPPAYFAILPAISEISESLSVDFDLLTVNATDADSEGNNSKVIYIIEPA 2584
                       :..||  .|:....|.|: ..|.:| |.:||.::     .:.|.:       ||
 Worm  2533 -----------IQFAQ--GAFIEYSPRIA-FPEQVS-DIELLFIS-----GKVNGA-------PA 2570

  Fly  2585 QEGFSVHPSNGVVSVNMSRLQPAVSSSGDYFVRIIAKDAGKPALKSSTLLRVQANDNGSGRSQFL 2649
            :..|........||.|:...|..|:::|.:.:....:.|.:....|..||:    :|.|...||.
 Worm  2571 ELSFGTDSQQSYVSTNLESGQNGVTAAGKFDIGTGGRRARQELRVSEVLLK----ENASYWLQFT 2631

  Fly  2650 QNQYRAQIS 2658
            :|..||.:|
 Worm  2632 RNPTRASLS 2640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_001285551.1 CA 111..172 CDD:214520 15/66 (23%)
Cadherin_repeat 178..282 CDD:206637 21/122 (17%)
Cadherin_repeat 291..389 CDD:206637 37/106 (35%)
Cadherin_repeat 406..500 CDD:206637 24/100 (24%)
Cadherin_repeat 509..607 CDD:206637 42/112 (38%)
Cadherin_repeat 616..711 CDD:206637 27/111 (24%)
Cadherin_repeat 719..820 CDD:206637 29/112 (26%)
Cadherin_repeat 832..927 CDD:206637 27/106 (25%)
Cadherin_repeat 937..1032 CDD:206637 30/115 (26%)
Cadherin_repeat 1040..1149 CDD:206637 33/108 (31%)
Cadherin_repeat 1158..1252 CDD:206637 27/100 (27%)
Cadherin_repeat 1263..1361 CDD:206637 34/106 (32%)
Cadherin_repeat 1369..1481 CDD:206637 28/117 (24%)
Cadherin_repeat 1489..1598 CDD:206637 32/108 (30%)
Cadherin_repeat 1614..1710 CDD:206637 10/96 (10%)
Cadherin_repeat 1723..1843 CDD:206637 19/119 (16%)
Cadherin_repeat 1853..1948 CDD:206637 24/103 (23%)
Cadherin_repeat 1957..2053 CDD:206637 22/118 (19%)
Cadherin_repeat 2061..2154 CDD:206637 17/112 (15%)
Cadherin_repeat 2170..2318 CDD:206637 31/147 (21%)
Cadherin_repeat 2326..2424 CDD:206637 16/99 (16%)
Cadherin_repeat 2434..2528 CDD:206637 13/108 (12%)
Cadherin_repeat 2549..2641 CDD:206637 19/91 (21%)
Cadherin_repeat 2652..2748 CDD:206637 3/7 (43%)
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
hmr-1NP_001021650.1 Cadherin_repeat 431..521 CDD:206637 16/93 (17%)
Cadherin_repeat 534..638 CDD:206637 37/107 (35%)
Cadherin_repeat 647..742 CDD:206637 23/103 (22%)
Cadherin_repeat 752..861 CDD:206637 42/113 (37%)
Cadherin_repeat 875..975 CDD:206637 27/106 (25%)
Cadherin_repeat 983..1085 CDD:206637 29/111 (26%)
Cadherin_repeat 1103..1206 CDD:206637 26/103 (25%)
Cadherin_repeat 1216..1331 CDD:206637 30/116 (26%)
Cadherin_repeat 1340..1432 CDD:206637 33/107 (31%)
Cadherin_repeat 1443..1542 CDD:206637 26/98 (27%)
Cadherin_repeat 1553..1657 CDD:206637 34/104 (33%)
Cadherin_repeat 1666..1768 CDD:206637 28/116 (24%)
Cadherin_repeat 1779..1868 CDD:206637 32/104 (31%)
EGF_CA 2250..2283 CDD:238011 9/45 (20%)
LamG 2286..2459 CDD:238058 49/263 (19%)
LamG 2533..2679 CDD:304605 32/128 (25%)
Cadherin_C 2812..>2919 CDD:279398
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 55 1.000 Domainoid score I7413
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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