DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and Cdhr1

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	NP_570948.1	Gene:	Cdhr1 / 170677	MGIID:	2157782	Length:	859	Species:	Mus musculus

Alignment Length:	987	Identity:	268/987 - (27%)
Similarity:	402/987 - (40%)	Gaps:	254/987 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   840 IPRGTVVGS-VIAASGDVAHRSPVRYSIYSGDPD--GYFSIETNSGNIRIAKPLDHEAKSQVL-- 899
            :|..|.||| |...:|......|:.|.| |.||.  ..||::.|.|||.:.:.||.|.:.::.
Mouse    44 LPEDTPVGSHVYTLNGTDPEGDPISYHI-SFDPSTRSVFSVDPNFGNITLVEELDREREDEIEAI 107

  Fly   900 ------LNIQATLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDK 958
                  ||:.|          .:|.|.|.|.||.||.|......|.|||:...|:.::...|.||
Mouse   108 ISISDGLNLVA----------EKVVILVTDANDEAPRFIQEPYIIRVPENIPAGSSIFKVQAEDK 162

  Fly   959 DSGSSGQVTYSLVK-ESGKGLFAIDARSGHLIL--SQHLDYESSQRHTLIVTATDGG-------- 1012
            |:||.|.|||||.. .|.|  |::|..||.|.|  ...||||.|:.|.:.|.|.|||
Mouse   163 DTGSGGSVTYSLQNLHSSK--FSMDRHSGVLRLQAGATLDYEKSRAHYITVIAKDGGGRLRGADM 225

  Fly  1013 VPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVD 1077
            |.|.:|  |:.::|:||.|..|:|....|...|.|.....::::.|.|.|.|.|....|.||:
Mouse   226 VFSATT--TVTINVEDVQDTAPIFVGTPYYGYVYEDTLPGSEVLTVVAIDGDRGKPNHILYRL-- 286

  Fly  1078 AGVDNVTNSISSSDVSQHFGIF---PNSGWI-YLRAP--LDRETRDRYQLTVLATD---NGTPAA 1133
                     ::.||     |||   ..||.| .|::|  |.||.   |:|.|..|:   .|:|||
Mouse   287 ---------LNESD-----GIFEINETSGAISVLQSPALLRREV---YELHVQVTEVNSPGSPAA 334

  Fly  1134 HAKTRVIVRVLDANDNDPKF-----QKSKYEFRIEENLRRGSVV-GV-VTASDLDLGENAAIRYS 1191
            .|...|.:|::|.|::.|.|     .::|:|..:.|:..:|.:: |: :|.:|.|.|.||.....
Mouse   335 QATVPVTIRIVDLNNHPPTFYGESGPQNKFELSMFEHPPQGEILRGLKITVNDSDQGANAKFNLR 399

  Fly  1192 LLPINSSFQVHP--------VTGEISTREPLDRELRELYDLVVEARDQGTPVR-SARVPVRIHVS 1247
            |:.....|:|.|        ||..:.....:|.|..:|....:.|.:..||.: |:...:.|.:.
Mouse   400 LVGPGGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKLLTFKLLAIEVNTPEKFSSTADIVIQLL 464

  Fly  1248 DVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGHGLFSIDP 1312
            |.|||.|:... ...:..:.|..|.|:.||.|.|||.|.|....:.|||. |..||   ||.|.|
Mouse   465 DTNDNVPKFTS-HYYIARIPENAPGGSNVVAVTAVDPDTGPWGKVHYSIY-GTGSD---LFLIHP 524

  Fly  1313 TSGVIRTR--VVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSSLVFRVR 1375
            ::|:|.|:  ..||.|..|.|...|.|.|...  |.::..:.|.:||:||:.|.|..|     |:
Mouse   525 STGLIYTQPWASLDAEGTSRYNFYVKAEDMDG--RYSLAEVFVTLLDVNDHYPQFVQS-----VQ 582

  Fly  1376 EDAALGHVVGS---ISPIERPADVVRNSVEESFEDLRVTYTLNPLTKDLIEAAFDIDRHSGNLVV 1437
            |...   |:|:   |...::.|:...|.|:.|            :|:......||||.|:|
Mouse   583 EKTM---VLGTPLKIEATDQDAEEPNNLVDYS------------ITRAEPVNVFDIDAHTG---- 628

  Fly  1438 ARLLDREVQSEFRLE--IRALDTTASNNPQSSAITVKIEVADVNDNAPEWPQDPIDLQVSEATPV 1500
                      |.||:  ||:|:...:..| |...:..::|...:..:|.:..
Mouse   629 ----------EIRLKNSIRSLEALHNITP-SGDYSWSLQVQAKDRGSPSFST------------- 669

  Fly  1501 GTIIHNFTATDADTGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGALSLQAPLDFEAVQEY 1565
             |.:.....||.:..:.|.:...||    |..::..:|:.:     |.|.:::       .|...
Mouse   670 -TALLKIDITDTERLSRGSMAAFLI----QTKDNPMKAVGV-----LAGVMAI-------VVAIT 717

  Fly  1566 LLIVQAL---DQSSNVTERLQTSVTVRLRILDANDHAPHFVS---PNSSGGKTASLFISDATRIG 1624
            :||..|.   ::.||..      :.||..:......|||.|.   ......|.|:.||
Mouse   718 VLISTATFWRNKKSNKV------LPVRRVLRRRPSPAPHTVRIEWLKFRRAKAATKFI------- 769

  Fly  1625 EVVAHIVAVDEDS-GDNGQLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKGGRFNLII 1688
                    :.||| .:|..                ||:.|::     :||....:
Mouse   770 --------LKEDSPNENCN----------------NSRVGVM-----VPPRAPAL---------- 795

  Fly  1689 GAKDHGQPEPKKSSLNLHLIVQGSHNNPPRFLQAVYRATILENVP--SGSFVLQ-----VTAKSL 1746
                  .|.||.:|   .::.|                   :.||  |||...|     .|.|:|
Mouse   796 ------PPPPKMAS---SMVAQ-------------------QTVPTVSGSLTPQPSPQLPTPKTL 832

  Fly  1747 HGAENANLSYEI 1758
            .|...::|..|:
Mouse   833 GGPVQSSLVSEL 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637
		Cadherin_repeat	832..927	CDD:206637	30/97 (31%)
		Cadherin_repeat	937..1032	CDD:206637	43/105 (41%)
		Cadherin_repeat	1040..1149	CDD:206637	37/117 (32%)
		Cadherin_repeat	1158..1252	CDD:206637	26/104 (25%)
		Cadherin_repeat	1263..1361	CDD:206637	37/99 (37%)
		Cadherin_repeat	1369..1481	CDD:206637	25/116 (22%)
		Cadherin_repeat	1489..1598	CDD:206637	18/111 (16%)
		Cadherin_repeat	1614..1710	CDD:206637	15/96 (16%)
		Cadherin_repeat	1723..1843	CDD:206637	12/43 (28%)
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Cdhr1	NP_570948.1	Cadherin_repeat	42..130	CDD:206637	29/96 (30%)
		Cadherin_repeat	139..242	CDD:206637	43/106 (41%)
		Cadherin_repeat	251..350	CDD:206637	37/117 (32%)
		Cadherin_repeat	364..469	CDD:206637	26/104 (25%)
		Cadherin_repeat	478..573	CDD:206637	37/100 (37%)
		Cadherin_repeat	580..679	CDD:206637	28/147 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..838		15/82 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910