Protein Alignment ds and LOC1281582

DIOPT Version :10

• Sequence 1: NP_523446.2
• Gene: ds / 33245
• FlyBaseID: FBgn0284247
• Length: 3556
• Species: Drosophila melanogaster
• Sequence 2: XP_061500640.1
• Gene: LOC1281582 / 1281582
• VectorBaseID: AGAMI1_012303
• Length: 1886
• Species: Anopheles gambiae
• Alignment Length: 1899
• Identity: 471/1899 - (24%)
• Similarity: 733/1899 - (38%)
• Gaps: 492/1899 - (25%)

  Fly   279 VNDNQPIFNQSRYFATVPENATVGTSVLQVYASDTDAD------ENGLVEYAINRRQSDKEQMFR 337
            ::|:..|..:.|.|...|    |||.:.::...|.|.|      :.....:.|..:|:...:.|
Mosquito    51 IDDHAEIVIRLREFPETP----VGTLIYRLRGYDADGDPLTFGVQKSADSHIIRLKQNTSSEAF- 110

  Fly   338 IDPRTGAIYINKALDFETKELHELVVVAKDH--GEQPLETTAFVSIRVTDVNDNQPTINVIFLSD 400
                   :|:|..||.|.:|.:.|::...|.  ||....|.:|: :.|.|:|||:|    ||...
Mosquito   111 -------VYLNHELDREAREEYTLILTLTDGRLGEGNFVTQSFL-LLVEDINDNEP----IFKPF 163

  Fly   401 DASPKISESAQPGEFVARISVHDPDSKTEYANVNVTLNGGDGHFALTTRDNSIYLV-------IV 458
            .:..:::|.:.|| .:..:...|.| :..|..|...:.|       .:.:|:::.:       :|
Mosquito   164 ASVLEVAEDSPPG-ILTTLEAVDKD-EGAYGQVVYYIQG-------LSEENNVFSISTSNGKGVV 219

  Fly   459 HL--PLDREIVSNYTLSVVATDK--------GTPPLHASKSIFLRITDVNDNPPEFEQDLYHANV 513
            .|  .||.|....|.::|:|.|:        ||      .::.:|:.||.|.||||........:
Mosquito   220 RLARALDYERQHFYHINVLAVDRAIQGRINTGT------AALLVRVKDVEDQPPEFLVTQPVVRI 278

  Fly   514 MEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGLITTRSHIDCETEPVP- 577
            .|.|..||.|::|.|.|.|.|:|:.:.|.::   ...::.|:||...|.:.|:..:|.|....|
Mosquito   279 SEDAPIGTEVMRVKAVDGDRGINNRIIYGIS---NNGSELFEIDRLKGSLRTKQKLDREDSKNPI 340

  Fly   578 ----QLTVVARDGG--VPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSVAEN---EPVGRCILKV 633
                .|.|||.:..  .|..|||..:.|.:.||||..|.|....|...:.||   ..:.|.|
Mosquito   341 NGAFILEVVAIEESKLQPAPSSTMEITVIVTDVNDEIPRFRSDGYECEIGENAQENTLARFI--- 402

  Fly   634 SASDPDCGVNAMVNYTIGEG-------------FKHLTEFEVRSASGEICI--AGELDFERRSSY 683
                 |..:|.:.:|..|:.             |:.:.:..:..|:..:.:  ...||:||....
Mosquito   403 -----DGSINEVFDYDQGKNGTFRLSLHPPSDIFEVIPKRAINEATFGLRVKDPSMLDYERVREL 462

  Fly   684 EFPVLAT--DRGGLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVAVVATD 746
            ...|:|:  :..|.::||.|::.:.|.|||.|.|....|::.:.|:..|     .|.:|.:.|||
Mosquito   463 SLTVVASEVESAGRTSTAQIRVVVLDQNDNFPEFSQPVYEIDVPENVTA-----GTVLVQLQATD 522

  Fly   747 PDYGNFGQ--VSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPM--------HMLNISATD 801
            .|.|.||.  |.|..:.|:.:....:|...|.:      .|.....|:        |.|::.|.|
Mosquito   523 SDSGLFGTEGVRYTNLTGSISSFLHLDPHAGTV------TLMASESPVFDREIIQKHYLSVEARD 581

  Fly   802 GGNLRSNADAV-VFLSIIDAMQRPPIFEKARYNYYVKEDIPRGTVVGSVIAASGDV--AHRSPVR 863
            .|. |.|.:.| :.|:::|.....|:|.:.||...:||:.........|.|...|:  :..|.|.
Mosquito   582 NGG-RGNRNTVPLILNVLDVNDNAPVFVQKRYEVRLKENAFEFESPIVVEARDSDLEGSPNSAVE 645

  Fly   864 YSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQ---------VLLNIQAT-LGEPPVYGHTQVN 918
            |.:.......||.::..:|.:.:.:.:|.|....         :.|.|:|. .||||:....:|.
Mosquito   646 YRLIGAHHSDYFHVDRRTGRLSVREAVDFERLESSGGSGDTRTIALTIEAADGGEPPLTAQVEVT 710

  Fly   919 IEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDKD-SGSSGQVTYSLVKESGKGLFAID 982
            :.|:||||.||.|..|...|.:||....|.|:....|.|.| |..:..|||. :::.|.|.|.|.
Mosquito   711 VYVQDVNDYAPVFLESQYAIVIPEDTPSGLPVLRVTAMDGDGSFPNNHVTYR-IQQGGDGRFVIG 774

  Fly   983 ARSGHLILSQHLDYE----------SSQRHTLIVTATDG--GVPSLSTNLTILVDVQDVNDNPPV 1035
            |.:|.:.::.....:          |...:.|.|.||||  |...|..:..:.|.:.|||:.||.
Mosquito   775 ASTGEISITHGASLDPNLLAPDALGSGSTYVLEVFATDGGNGDQQLQGSCLVNVTITDVNNKPPY 839

  Fly  1036 FEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVDAGVDNVTN-----SISSSDVSQH 1095
            | ....:|.|.|:..:..::.::.|:|.|.|  |.:.|.|..:..:..|.     .:...|.:..
Mosquito   840 F-VGPTAVAVRENTPVGTEVYRLMATDPDEG--AMLRYYIDRSLSEGKTEEGALVKLDDYDFAAA 901

  Fly  1096 FGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAH--AKTRVIVRVLDANDNDPKFQKSKY 1158
            |.:...:|.:.:...||||.....:|..:..|.......  |.|.:.:.|||.|||:|||:|..|
Mosquito   902 FILNETNGLLKIAKLLDREKIAEIKLACVVEDVAAERGDQMANTFLKITVLDENDNNPKFRKPFY 966

  Fly  1159 EFRIEENLRRGSVVGVVTASDLDLGENAAIRYSL---LPINSSFQVHPVTGEISTREPLDRELRE 1220
            :..|.||.:.|..|..|.|.|.|  :|..::|||   ..:.....|...||||..|..:|.|...
Mosquito   967 KHSIAENSQYGVAVCTVVAEDAD--QNKTVKYSLEGEKGVLELLHVDDETGEIVVRNRIDHEEYS 1029

  Fly  1221 LYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRD 1285
            ..:..|.|.|.|||.|::.|.|.:.|.|.|||.|...|...|.. |.|....|.|:..:.|.|.|
Mosquito  1030 WLNFSVRAADTGTPPRASFVEVFVQVLDENDNNPYFVDSVNDYY-VSENASVGAEIAIILAKDLD 1093

  Fly  1286 HGQNASITYSI--VKGRDSDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPP---- 1344
            :|....|||.:  |..::.     |||||..|::|....||.||.:.|.|.|.|.|  |.|
Mosquito  1094 YGDFGRITYILDRVSSKEK-----FSIDPEKGILRVAGALDREETAEYMLAVEAWD--NYPYGYL 1151

  Fly  1345 ----RETVRMLRVEVLDLNDNRPTFTSSSLVFRVREDAALGHVVGSISPIERPADVVRNSVEESF 1405
                |...:.:.:.|||.|||.|.                         |::|
Mosquito  1152 NGESRNAFKHILIHVLDDNDNVPV-------------------------IQKP------------ 1179

  Fly  1406 EDLRVTYTLNPLTKDLIEAAFDIDRHSGNLVVARLLDREVQSEFRLEIRALDTTASNNPQSSAIT 1470
                                      ||                                .|.||
Mosquito  1180 --------------------------SG--------------------------------CSMIT 1186

  Fly  1471 VKIEVADVNDNAPEWPQDPIDLQVSEATPVGTIIHNFTATDADTGTNGDLQYRL-------IRYF 1528
               |..::||.                      |....|||||..|||:.|...       |.|.
Mosquito  1187 ---EYHNINDP----------------------IVKLRATDADDPTNGNGQLSFDIVDPSGIFYI 1226

  Fly  1529 PQLNESQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLIVQALDQSSNVTERLQTSVTVRLRIL 1593
            .|::....:..|...:.:|.|..:|:            |||..|....|....     :|.:.:.
Mosquito  1227 QQVSAQYAEIYSRGPLKNLHGNYTLE------------LIVSDLGGVPNTARE-----SVDICVT 1274

  Fly  1594 DANDHAPHFVSPNSSGGKTASLFISDATRIGEVVAHIVAVDEDSGDNGQLTYEI---TGGNGEGR 1655
            |.|||||.||.|  ||..|..:|  :.|.:|:....:.|.|||.|:|..:.|.:   |.||.. :
Mosquito  1275 DFNDHAPVFVVP--SGNTTVKVF--ENTTLGKPFFQVHAYDEDVGENAIVRYRLKMDTMGNFR-K 1334

  Fly  1656 FRINSQTGIIELVKSLPPATEDVEKGGRFNLIIGAKDHGQPEPKKSSLNLHLIVQGSHNNPPRFL 1720
            |.::.:||.:.|...|     |.|:...::|.|.|.|.|.|.|..|:::
Mosquito  1335 FSLDMETGELSLAAPL-----DREQQMMYDLRIEAYDQGIPTPLSSTVD---------------- 1378

  Fly  1721 QAVYRATILENVPSGSFVLQVTAKSLHGAENANLSYEIPAGVANDLFHVDWQRGIITTRGQFDRE 1785
                                                                             
Mosquito  1379 ----------------------------------------------------------------- 1378

  Fly  1786 SQASYVLPVYVRDANRQSTLSSSAVRKQRSSDSIGDTSNGQHFDVATIYITVGDVNDNSPEFRPG 1850
                  |.||||                                         |||||.|:|...
Mosquito  1379 ------LIVYVR-----------------------------------------DVNDNLPQFLLK 1396

  Fly  1851 SCYGLSVPENSEPG-----VIHTVVASDLD--EGPNADLI-YSITGGNLGNKFSIDSSSGELSA- 1906
            . ..|:..|::.||     :..||....||  :||.|.:: |.|..||....|.:|..:.:|:.
Mosquito  1397 E-ISLNFTEHTTPGTERIRLPDTVDQDYLDPLDGPAASVVCYYIVHGNEDGHFGLDPVTHDLTVE 1460

  Fly  1907 RPLDREQHSRYTLQIQASDR----GQPKSRQGHC-NI---TIFVEDQNDNAPRFKLSKYTGSVQE 1963
            :.||||:.|.|.|.|:|::.    .......||. ||   |:::.|.|||:|.|:...:||.:..
Mosquito  1461 KELDREKKSLYKLHIKATEECTNANLSLDTTGHSGNILKATVYINDINDNSPLFESKIFTGGIST 1525

  Fly  1964 DAPLGTSVVQISAVDADLGVNARLVYSLANETQW------------QFAIDGQSGLITTVGKLDR 2016
            .:..|.:::|:.|.|.|.|:|..:.|....|.:.            .|.::..:|.:.......:
Mosquito  1526 SSLFGATILQLQATDEDDGLNGLVRYYRHGEVRKTLAEGLDDLRSDPFLVEADTGKVLLNFFPQK 1590

  Fly  2017 ELQASYNFMVLATD 2030
            .::..::|.|||.|
Mosquito  1591 SMRGYFDFSVLAND 1604

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_523446.2	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637	0/2 (0%)
		Cadherin_repeat	291..389	CDD:206637	26/105 (25%)
		Cadherin_repeat	406..500	CDD:206637	23/110 (21%)
		Cadherin_repeat	509..607	CDD:206637	32/104 (31%)
		Cadherin_repeat	616..711	CDD:206637	23/114 (20%)
		Cadherin_repeat	719..820	CDD:206637	28/111 (25%)
		Cadherin_repeat	832..927	CDD:206637	26/106 (25%)
		Cadherin_repeat	937..1032	CDD:206637	31/107 (29%)
		Cadherin_repeat	1040..1149	CDD:206637	26/115 (23%)
		Cadherin_repeat	1158..1252	CDD:206637	34/96 (35%)
		Cadherin_repeat	1263..1361	CDD:206637	35/107 (33%)
		Cadherin_repeat	1369..1481	CDD:206637	9/111 (8%)
		Cadherin_repeat	1489..1598	CDD:206637	25/115 (22%)
		Cadherin_repeat	1614..1710	CDD:206637	28/98 (29%)
		Cadherin_repeat	1723..1843	CDD:206637	8/119 (7%)
		Cadherin_repeat	1853..1948	CDD:206637	34/111 (31%)
		Cadherin_repeat	1957..2053	CDD:206637	18/86 (21%)
		Cadherin_repeat	2061..2154	CDD:206637
		CA_like	2171..>2232	CDD:481204
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
LOC1281582	XP_061500640.1	None