DRSC/TRiP Functional Genomics Resources

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Protein Alignment ds and LOC1274243

DIOPT Version :10

Sequence 1:NP_523446.2 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:XP_061500834.1 Gene:LOC1274243 / 1274243 VectorBaseID:AGAMI1_002007 Length:2040 Species:Anopheles gambiae


Alignment Length:2206 Identity:530/2206 - (24%)
Similarity:880/2206 - (39%) Gaps:521/2206 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   609 PIFDQSFYNVSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAG 673
            |:|.|...|::::|..|||..:.|:...||:.|       .:..|......|.....||::.:..
Mosquito    27 PVFTQDMNNLALSEQTPVGAVVYKLEGYDPEGG-------NVSFGLIGSDNFIADPISGDVQVIK 84

  Fly   674 ELDFERRSSYEFPVLATDRGGLSTTAM-----------IKMQLTDVNDNRPVFYPREYKVSLRES 727
            |||.|.:.:..|.|...||  :|.|.:           |.:.:.|.|||.|.|....|:..:.| 
Mosquito    85 ELDREAQDTLSFSVSIRDR--VSATGIESENDNIVNVPITIIVLDENDNPPEFQNVPYETEVLE- 146

  Fly   728 PKASSQASSTPIVAVVATDPDYGNFGQVSYRIVAGNEAGI--------------FRI-------D 771
               ::...:|....::.||.|           ..|....:              |.|       |
Mosquito   147 ---NALPGTTIFDGILVTDRD-----------TVGENLDVSCIPQPQNPDACEKFAIEVTDSQQD 197

  Fly   772 RSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRSNADAVVFLSIIDAMQRPPIFEKARYNYYV 836
            |.|..:.:.:|  |....:.::.:.:.|:||   ..||.|.:.:.:.|....||:|: ......:
Mosquito   198 RLTAAVVLKQP--LDYNERMIYQVLLDASDG---LYNASAGLEIHVRDVQNAPPVFQ-GSLAAVI 256

  Fly   837 KEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEA----KSQ 897
            .||.|.||:|..:.|..||......:.|.:.: :|..||.::.::|.:|.|||||.||    ...
Mosquito   257 NEDSPIGTLVMVIQARDGDRGQPRKIVYELVT-NPMDYFLLDKHTGELRTAKPLDKEALPDDTGL 320

  Fly   898 VLLNIQATLGEPPVYGH-------TQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPL-YAAH 954
            ::|.::|......|.|:       ||.:|.:.||||:.|.|..:...:|:.|:...|.|| ....
Mosquito   321 IILTVKAREVVDGVPGNDNLTVASTQASITIRDVNDSPPMFNKTEYFVSLSENTAPGTPLPLEIS 385

  Fly   955 AHDKDSGSSGQVTYSLVKESGKGLFAIDAR----SGHL---ILSQHLDYESSQRHTLIV------ 1006
            ..|.|.|.:.:  ::|.......:|.::.:    |..:   :.:..||||:..:...||      
Mosquito   386 VRDPDVGENAE--FALRLNDVSNVFDVEPKLVTGSSQISIRVANGTLDYENPNQRKFIVLLIAEE 448

  Fly  1007 TATDGGVPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTG----- 1066
            |.|:   |.||:..|:.|.:.|.|||.|.||:|.||..|||:......|..:.|.|||:|     
Mosquito   449 TKTN---PKLSSTATLTVAITDANDNRPTFEQDSYSTTVSETAHPGQLITTITAKDLDSGLYGDQ 510

  Fly  1067 ----------------------------------------------------------------- 1066
                                                                             
Mosquito   511 GIRYSLSGTGSELFSVDAITGAISVADCPGSGVERTAGEMQPVAGQLVRRRRRQIPTRSDLQHEQ 575

  Fly  1067 -NNAR------ITYRIVDAGVDNV---TNSISSSDVSQHFGIFPNS------------------- 1102
             .||.      :|||||::|..|.   .|.|:...:|..:..|..:                   
Mosquito   576 HQNASARGIEYMTYRIVNSGESNEYHDVNVIAPPTISTLYDSFETTTLEQQPQQQLVEELALPTT 640

  Fly  1103 --------------------GWIYLRAP-LDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLDA 1146
                                |    :|| ||.||...|.|:..|||:......:...|.:.:|||
Mosquito   641 VRIEPLLTNDIQHPRQSDGPG----KAPCLDYETHSVYYLSYRATDDEGRGQTSVVSVRISLLDA 701

  Fly  1147 NDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAAIRYSLL---PINSSFQVHPVTGEI 1208
            ||:.|..:...|...::|.........::.|.|.|:  .:.|.|.::   .:...|::...||::
Mosquito   702 NDSPPVCESPLYRASVDEGATAFEPPLIIRARDPDV--VSEINYRIIGNEAVTRHFEIDKRTGQL 764

  Fly  1209 STREPLDRELRELYD----LVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDVVSVREE 1269
            :..:.:..::..|..    ..|||.|   .:.:....|.|.:.|||::||:.| .:..:.|:.|.
Mosquito   765 TISKTVALDVNHLRSENVFFGVEATD---GLYTTLCNVNITIRDVNNHAPQFA-RENYLTSIEEN 825

  Fly  1270 QPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGHGLFSIDPTSGVIRTRVVLDHEERSIYRLG 1334
            .|.||.|.|::|:|.|.|.||.|.|.|.:|...|    |:||..:||:.....||::.|:.|::.
Mosquito   826 FPIGTVVERLQAIDLDTGINAEIRYRIQQGSFDD----FAIDNRTGVVSIARKLDYDRRNTYQME 886

  Fly  1335 VAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSSLVFRVREDAALGHVVGSISPIERPADVVRN 1399
            :.|||.|.|......||.|.:::.||..|.||.::....|.|||.:|.:|.::..::  .||.  
Mosquito   887 IVASDSGTPSLSGTTMLTVSIINSNDKAPYFTPTTQRAEVSEDAPIGTLVHTLVAVD--PDVA-- 947

  Fly  1400 SVEESFEDLRVTYTLNPLT---------------KDLIEAAFDIDRHSGNLVVARLLDREVQSEF 1449
                |.|.|....| .|:|               ||:    |.||| ||.:.|.|.|.|:..:..
Mosquito   948 ----SSESLDYAAT-EPITAVDKNGKEVGEMEDFKDM----FMIDR-SGKVFVNRRLLRDSFAVI 1002

  Fly  1450 RLEIRALDTTASNNPQSSAITVKIEVADVNDN----APEW-PQDP-IDLQVSEATPVGTIIHNFT 1508
            |:.:...||||.:..|...:.: |.:.|||:.    ||.| |::| ...||.|..|:|||:....
Mosquito  1003 RITVLVTDTTAPSIQQGEGLLI-ITITDVNEEPPLFAPPWTPENPHYHYQVVEEQPIGTILTTVQ 1066

  Fly  1509 ATDADTGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLIVQALD 1573
            |||||:..   .:||       :.||     |.|.:.:.||.:...|.:|:||.......|..:|
Mosquito  1067 ATDADSTI---AEYR-------MTES-----SFFEIHNTTGLVRSIARIDYEATPVIKFNVSVID 1116

  Fly  1574 QSSNVTERLQTSVTVRLRILDANDHAPHFVSPNSSGGKTASLFISDATRIGEVVAHIVAVDEDSG 1638
            ..   ..:|.::..:.:.:::.||:.|.|..|.      ..|.:.:.:.:|.:|..:.|.|.|:|
Mosquito  1117 TG---VPQLTSTAQITVEVVNTNDNDPEFEQPE------YMLQVRENSPVGTLVGMVRARDADAG 1172

  Fly  1639 DNGQLTYEITGGNGEGRFRINSQTGIIEL--VKSLPPATEDVEKGGRFNLIIGAKDHGQPE--PK 1699
            ..|||||.|.|.: .|.|.|:..||.|.:  ..:|...||.     ..:|...|.|.. ||  .:
Mosquito  1173 LYGQLTYTIVGDH-SGNFVIDPDTGAITVHNASALDRETEQ-----EASLTAIATDRA-PEGMRR 1230

  Fly  1700 KSSLNLHLIVQGSHNNPPRFLQAVYRATILENV---PSGSFVLQVTAKSLHGAENANLSYEIPAG 1761
            .:::.:.:.|...::|.|.|.|.:|.||:.||.   |..: :|||.|.........::.|.|.:.
Mosquito  1231 STTVPVQIRVLDENDNGPTFTQQIYHATVAENAALHPPAA-ILQVMATDPDEGAAGDVKYAILSD 1294

  Fly  1762 VANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQSTLSSSAVRKQRSSDSIGDTSNGQ 1826
            ....:|.:|...||:........:| ..|.:.:..||.                      ..:|.
Mosquito  1295 NVGGIFRLDANSGILYPGASLIGKS-GQYRIDIEARDG----------------------LGSGP 1336

  Fly  1827 HFDVATIYITVGDVNDNSPEFRPGSCYG--LSVPEN--SEPGVIHTVVASDLDEGPNADLIYSIT 1887
            |.|.|||.|.:..:|.:.|.|...:.|.  :.:|||  |...::.||.|:|.|.|.|..::|.:.
Mosquito  1337 HNDAATIVIEIQSINQHRPVFIMPALYNATVEIPENLASPDYLVMTVKATDNDSGSNGKVLYYLQ 1401

  Fly  1888 GGNLG----NKFSIDSSSGELS-ARPLDREQHSRYTLQIQASDRGQPKSRQGHCNITIFVEDQND 1947
            ..::.    ::|||:..||||. .|.|||::.|||.|.:.|.|:|.|...:....:|:.:.|.|:
Mosquito  1402 VNSVNVQETDEFSINEMSGELRIRRQLDRKRQSRYELILVARDQGTPAWFETLRFLTVLLVDVNE 1466

  Fly  1948 NAPRF--KLSKYTGSVQEDAPLGTSVVQISAVDA--DLGVNARLVYSLANETQWQFAIDGQSGLI 2008
            |.|.|  ..:.|...:.|:   |...|:|..:.|  |....|...|.|.......|.:|..||.:
Mosquito  1467 NYPEFPDASNPYKFFITEN---GARDVRIGKIQAFLDSPNPAIFYYMLVGNEDGAFYVDKTSGDL 1528

  Fly  2009 TTVGKLDRELQASYNFMVLATDGGRYEV--------------RSATV-PVQINVLDINDNRPIFE 2058
            .|...:|||....|...|||:......|              |:||: .|.::|||:|||.|:|:
Mosquito  1529 YTNRSVDREENDLYVLYVLASKQSDLYVSEHERALLSMDQLERNATIAKVWVHVLDVNDNAPVFK 1593

  Fly  2059 RYPYIGQVPALIQPGQTLLKVQALDADLGANAEIVYSLNAENSAVSAKFRINPSTGALSASQSLA 2123
            |..|...:.:.....:.:..|.|.|.|||.||.:...:   ..:...|:....:||::..|....
Mosquito  1594 RDVYYAGISSKASINELVTIVNATDRDLGVNATLDLFI---RGSYLYKYGATKTTGSIVPSPFAI 1655

  Fly  2124 SESGKLLH-------------LEVVARDKGNPPQSSL-----------GLIELLIGEAPQGTPVL 2164
            |:.|:::.             ||:||::..:|.:.::           .|:.:::...|  :.|.
Mosquito  1656 SKDGRVVTANYMAEYNQDRFVLEIVAKEIESPEREAVTRVHVWIFNPEQLVRMILSRPP--SEVH 1718

  Fly  2165 RFQNETYRVMLKENSPSGTRLLQVVALR----SDGRRQ----KVQFSFGAGNEDGILSLDSLSGE 2221
            :.::|    ::.|...:..||:.|..:|    |.||.:    .:.|.........|:.::.:..|
Mosquito  1719 QDRDE----IVSELGNATQRLIIVDEIRYHVDSLGRIRMDWCDMYFHAVDMTTQMIVPVEEILRE 1779

  Fly  2222 IRVNKPHLLDYDR-FS----TPSMS---------ALSRGRAL-------------------HYEE 2253
            |......|.||:. ||    .|:.:         ||:...||                   |:..
Mosquito  1780 IDAKYDFLQDYNAGFSIMNVVPAYATTVQDEFDLALAALIALLIVLFVGAVSFIVLCCCLKHWSI 1844

  Fly  2254 EIDESSEEDPNNSTRSQRALTSSSFALTNSQPNEIRVVLVARTADAPFLASYAELVIELEDEND- 2317
            .|.        :.||.:.||...            :::....|.:.|.   :.|..::|.:|.: 
Mosquito  1845 TIP--------SETRRKDALIKK------------QIIEDLNTTENPL---WIEQKLKLYEEQEL 1886

  Fly  2318 -----NSPKFSQKQFVATVSEGNNKGTFVAQVHAFDSDAGSNARLRYHIVDGNHDNAFVIEPAFS 2377
                 :.|:.||:|.:...:..|:.....:|: :.......:.:|.:|.....|           
Mosquito  1887 TMQVFSEPEMSQQQSMNHSNSTNSSQDPPSQL-SLTLGLDHHHQLHHHQQSAAH----------- 1939

  Fly  2378 GIVRTNIVLDREIRDIYKLKIIATDEGVPQMTGTATIRVQIVDVNDN-QPTFPPNNLVTVSEATE 2441
                      ::.||.|.|.                      ...|| ..|..|.|..|.:.:|.
Mosquito  1940 ----------QQRRDSYDLS----------------------QAGDNTYATIQPRNYGTSNLSTV 1972

  Fly  2442 LGAVIT---SISANDVDTYPALTYRLGAESTVDIENMSIFALDRYSGKLVLKRRLDYELQQ 2499
            ||:.:.   ::|::.| |.|:.|      |:.::.:.:.....|...:|...|...:::||
Mosquito  1973 LGSSLAPPGALSSSGV-TSPSAT------SSSEVADYATLRNSRAPSQLFEFRGSTFQVQQ 2026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_523446.2 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637
Cadherin_repeat 291..389 CDD:206637
Cadherin_repeat 406..500 CDD:206637
Cadherin_repeat 509..607 CDD:206637
Cadherin_repeat 616..711 CDD:206637 26/105 (25%)
Cadherin_repeat 719..820 CDD:206637 20/121 (17%)
Cadherin_repeat 832..927 CDD:206637 32/105 (30%)
Cadherin_repeat 937..1032 CDD:206637 26/108 (24%)
Cadherin_repeat 1040..1149 CDD:206637 41/228 (18%)
Cadherin_repeat 1158..1252 CDD:206637 20/100 (20%)
Cadherin_repeat 1263..1361 CDD:206637 36/97 (37%)
Cadherin_repeat 1369..1481 CDD:206637 36/126 (29%)
Cadherin_repeat 1489..1598 CDD:206637 29/109 (27%)
Cadherin_repeat 1614..1710 CDD:206637 28/99 (28%)
Cadherin_repeat 1723..1843 CDD:206637 28/122 (23%)
Cadherin_repeat 1853..1948 CDD:206637 35/103 (34%)
Cadherin_repeat 1957..2053 CDD:206637 31/112 (28%)
Cadherin_repeat 2061..2154 CDD:206637 21/116 (18%)
CA_like 2171..>2232 CDD:481204 13/68 (19%)
Cadherin_repeat 2326..2424 CDD:206637 10/97 (10%)
Cadherin_repeat 2434..2528 CDD:206637 15/69 (22%)
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
LOC1274243XP_061500834.1 None
Blue background indicates that the domain is not in the aligned region.

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