Protein Alignment ds and Cad89D

DIOPT Version :10

• Sequence 1: NP_523446.2
• Gene: ds / 33245
• FlyBaseID: FBgn0284247
• Length: 3556
• Species: Drosophila melanogaster
• Sequence 2: XP_061499378.1
• Gene: Cad89D / 1273990
• VectorBaseID: AGAMI1_002514
• Length: 2001
• Species: Anopheles gambiae
• Alignment Length: 1981
• Identity: 491/1981 - (24%)
• Similarity: 791/1981 - (39%)
• Gaps: 420/1981 - (21%)

  Fly   770 IDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRSNADAVVFLSI------------IDAMQ 822
            |:|.|..:.:    :|:..|:|.....:.:.  .|||:.:|.|.||.:            :.|..
Mosquito     4 INRITAFLLL----LLAGVTKPNQACKLYSK--SNLRTKSDGVQFLRLKEDFPVGGEIVSLYAYP 62

  Fly   823 R-----PPIFEKARYNYYVKEDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGDPDGY--FSIETN 880
            |     |.....:.|.|:..::| ..|||..::..|.|..        :.|.||...  ||:..:
Mosquito    63 RNSILIPRTENSSDYEYFKLKEI-NSTVVSVILNRSLDGL--------VDSDDPQSILKFSVFCS 118

  Fly   881 SGNIRIAKPLDHEAKSQVLLNIQATLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAE 945
            ..:...||. |:::                  ....:.:.:||:|||.|||......:::.||..
Mosquito   119 GTSATSAKQ-DNQS------------------SFFTITVYIEDINDNDPEFINLPYVVTLDESTP 164

  Fly   946 LGAPLY---AAHAHDKDSGSSGQVTYSLV---KESGKGLFAID-ARSGHLILSQHLDYESSQRHT 1003
            :...::   .|...||.:..:..:.|:|.   .:||...|.:: ::...|:|.:.|||::..|..
Mosquito   165 IETVVFNRIKAIDRDKPNTPNSDLEYALAAKHMKSGDFPFRLEGSQRPSLVLQRALDYDAGWRSM 229

  Fly  1004 LI-VTATDGGVPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQ--------VN 1059
            .: :.|:|.|.|..:.|.||.|:::||:|.||:|.:.:|...:.||..:..:.|.        :.
Mosquito   230 SVQIVASDRGNPPRTANATIRVNLRDVDDLPPIFTRAQYRTRIKESFPLTGKPIHIPLYIEPPIM 294

  Fly  1060 ASDLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETR----DRYQ 1120
            |.|.|:.|.. :.|.|| ||.:.           |.|.|.|.:|.::|:..:|.::.    :.:.
Mosquito   295 AFDQDSLNET-LVYGIV-AGNER-----------QLFWISPETGVLFLQKEIDLDSESLPDNTFT 346

  Fly  1121 LTVLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGEN 1185
            |.:.|.....|...|..||.:.|:|.|||.|:|:...|...|.|||.:|..:..|.|.|.|.|||
Mosquito   347 LQIEAQQINDPTKSAFARVDIEVIDLNDNVPEFEVDLYNISIIENLPKGFSILQVNAIDRDQGEN 411

  Fly  1186 AAIRYSLL---PINSSFQVHPVTGEISTREP--LDRELR-------------ELYDLVVEARDQG 1232
            |...|.|:   | ..:|.:...:|.|..|:.  ||:|.|             |.||   .:|:.|
Mosquito   412 AEFYYYLMDEEP-KGAFMIDHGSGWIVVRDETFLDKEQRSSLKMNVHAVERVEQYD---RSRNYG 472

  Fly  1233 TPVRSARVPVRIHVSDVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIV 1297
                  :|.|.|.:.|.|||.||.................|::|.::||:|.|...|..|.|||.
Mosquito   473 ------KVQVEITLLDTNDNTPEFEQGTLYEFKTHCNASIGSKVGQIRALDPDDLGNGKIQYSIK 531

  Fly  1298 KGRDSDGHGL---FSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRET---VRMLRVEVL 1356
            ..|.:    |   |.:||.:|.||....|.:.:.:.:   |.|.|....|.|:   |.::.::::
Mosquito   532 NVRPN----LVIPFLLDPDTGDIRVSEALTYGKIAFF---VEARDQPQNPSESRFNVALVTIDIV 589

  Fly  1357 DLNDNRPTFTSSSLVFRVREDAALGHVVGSISPIERPADVVRNSVEESFEDLRVTYTLNPLTKDL 1421
            ..:.....|..:...|.|..|||:|..||.   |....|:|  |.||.|.||..:|...
Mosquito   590 CQSIEDIEFIGAPYEFWVGADAAIGSSVGQ---IRTTFDMV--SDEEIFFDLLHSYPEG------ 643

  Fly  1422 IEAAFDIDRHSGNLVVARLL---DREVQSEFRLEIRALDTTASNN-----PQSSAITVKIEVADV 1478
              ..|.|:..||.:.|...:   ||... ||...:..|..:|..|     |::.....||.|.:|
Mosquito   644 --VPFAIEERSGIVTVIESMEKFDRRCY-EFETVVSYLPDSAGKNVEQLTPEAYNSLEKIIVTNV 705

  Fly  1479 -------------NDNAPEWPQDPIDLQVSEATP---VGTI-IHNF-TATDAD-------TGTNG 1518
                         ..||     .||:.:|.|..|   :|.: ..:| ...|||       ....|
Mosquito   706 TIHVIKHNFMLLRGTNA-----TPIEFRVKENKPNTMIGQLKFQDFQEQCDADEKGLPPLISVRG 765

  Fly  1519 DLQYRLIRYFPQLNESQEQAMSLFRMD----------------------SLTG-----ALSLQAP 1556
            | :.|..|...|||..:.:.....|..                      |.||     |.:.:.|
Mosquito   766 D-KNRADRQVFQLNGGKNRTRYARRFSRDVSRQSNFIRLYPLVAFDAVFSSTGNGTRKARNSRNP 829

  Fly  1557 ---LDFEAVQEY-------------LLIVQALDQSSN-------VTERLQTSVT------VRLRI 1592
               :.:..|..|             |:.::.||:...       :.|......|      |.:.:
Mosquito   830 TSGVQYSLVNSYDVADTVRLTNDGKLMTIKGLDREKQDVIRVTIIAEYFYKQRTFAGIYQVVIVV 894

  Fly  1593 LDANDHAPHFVSPNSSGGKTASLFISDATRIG-EVVAH--IVAVDED-SGDNGQLTYEITGGNGE 1653
            .|.||:.|.|..|...|      .|::.:.|| |:|.:  |:..|.| :|.|.:....::|.:..
Mosquito   895 EDENDNPPTFNQPFFLG------VIAENSPIGTEIVLNNPIIISDMDAAGPNSEYELLLSGESNS 953

  Fly  1654 GRFRINSQT------GIIELVKSLPPATEDVEKGGRFNLIIGAKDHGQPEPKKSSLNLHLIVQGS 1712
            ...:.::.|      .:..:.::|..|..|   .|...|....:.:.|.||..:|...:.|:...
Mosquito   954 FVAQFSNSTLSNYNKTVAHIFRNLQIANID---PGESRLRPDYRPNKQLEPGNASTPHYNILFMG 1015

  Fly  1713 HNNPPR--------FLQAVYRATILENVPSGSFVLQVT----------------AKSLHGAENAN 1753
            .|...|        .:.|..|..::..|.....:|.|.                .:.:....:..
Mosquito  1016 PNKLDREEIESLTLKMMATDRDNLMSEVELKILILDVNDCAPVFERIAIFRKSRCEMIENTSDLE 1080

  Fly  1754 LSY--EIPAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQSTLSSSAVRKQRSS 1816
            |.|  ||...|.......          |..:..|:.||.:     |:..:...|:..|...|..
Mosquito  1081 LMYLDEIETEVLPKFLDA----------GLMEMNSRVSYGV-----DSLFEMVQSAPYVGMPRLY 1130

  Fly  1817 DS----IGDTSNGQHFDV-ATIY-ITVGDVNDNSPEFRPGSCYGLSVPENSEPG-VIHTVVASDL 1874
            ||    :..|::.:|..: ..:| ..|.....|:......|....::|||.|.| ||..:.|:|.
Mosquito  1131 DSQSVMVNRTADREHLTMRRKLYKQKVRQRGRNTRAVAKKSQLKFALPENVEVGKVIFKLTANDD 1195

  Fly  1875 DEGPNADLIYSITGG---NLGNK---FSIDSSSGELS-ARPLDREQHSRYTLQIQASDRGQPKSR 1932
            |...|:.:.|.:.|.   |.|.:   |.||.::|||. |..|..|...:  |.|.|.|.|   ..
Mosquito  1196 DFEKNSKVFYEVVGQTELNSGERVSYFRIDRNNGELRVANRLPPETDVK--LNITAKDVG---GL 1255

  Fly  1933 QGHCNITIFVEDQNDNAPRFKLSKYTGSVQEDA-PL-GTSVVQISAVDADLGVNARLVYSLANET 1995
            .....:...|.|.|||||.|:...||.:|.|.: |: |..:.|:.|.|.|.|:|..:.|.|..:.
Mosquito  1256 SDMLQVQFRVYDVNDNAPVFEKQWYTFNVDEGSYPITGKKIGQVRANDEDTGMNGNVTYMLITDG 1320

  Fly  1996 QWQ--FAIDGQSGLITTVGKLDRELQASYNFMVLATDGGRYEVR-SATVPVQINVLDINDNRPIF 2057
            ..:  |:|....|.|...|::|||:.|||.|.|||:| ..:::: ||.|.|::.|:|.|||.|.|
Mosquito  1321 DQKIPFSISPLDGTIRVSGEIDREMIASYRFRVLASD-NNFDLKLSAMVDVEVIVMDRNDNNPEF 1384

  Fly  2058 ERYP--------------YIGQVPALIQPGQTLLKVQALDADL--GANAEIVYSLNAENSAVSAK 2106
            ..|.              |:..:....:.|..:.:|.|.|:|.  ..|..::|||..::..:  :
Mosquito  1385 TAYDDLRSDRNNIKRLPVYVAYLDVNAKVGTFVKQVMARDSDFRENGNGLVIYSLTGQSDVL--Q 1447

  Fly  2107 FRINPSTGAL-SASQSLASESG-----KLLHLEVVARDKGNPPQSSLGLIEL-LIGEAPQGTPVL 2164
            |.|:|..|.: :||:...||:|     :.|::.|||.|.|.||:||:.|:.: |.|:..|..||.
Mosquito  1448 FSIDPKDGVVTTASKFTPSEAGTRKTYEHLNVTVVASDFGTPPRSSMALLIVNLQGDTLQQHPVE 1512

  Fly  2165 R----FQNETYRVMLKENSPSGTRLLQVVALRSDGRRQKVQFSFGAGNEDGILSLDSLSGEIRVN 2225
            .    |..:.|.:.|:||.|: .|::..|.|.........::.......|....:|..:|.:.:.
Mosquito  1513 ERPPLFPYKYYEIELRENDPA-PRIVLNVTLSKRYANDPFRWEIVGDTFDDQFRIDERNGSLWLL 1576

  Fly  2226 KPHLLDYDRFSTPSMSALSRGRALHYEEEIDESSEEDPNNSTRSQRALTSSSFALTNSQPNEIRV 2290
            :|    .||....|.....|.:.:                 .|..|.:.|..:||.|.
Mosquito  1577 RP----LDREERDSYDVRIRVQKI-----------------KRETRNIPSVLYALENP------- 1613

  Fly  2291 VLVARTADAPFLASYAELVIELEDENDNSPKFSQK--QFVATVSEGNNKGTFVAQVHAFDSDAGS 2353
              |.|.:...| .:..|::|::.|.|||:|.|...  ..::.|.:..|.|..|.:|.|.|.||||
Mosquito  1614 --VKRKSHRLF-DNEVEIMIKVVDVNDNAPVFRDNYGPIISVVPDTANYGYAVMKVEATDDDAGS 1675

  Fly  2354 NARLRYHIVDGNHDNAFVIEPA-------FSGIVRTNIVLDREIRDIYKLKIIATD-EGVPQMTG 2410
            |..:||.:::         |||       .:|.:|....|......::...:.||| ||......
Mosquito  1676 NGEVRYSLLN---------EPARLFAIDSLTGQIRLLNSLASFKEKVFGFDVKATDREGADDGKS 1731

  Fly  2411 T-ATIRVQIVDVNDNQPTFPPNNLVTVSEATELGAVITSISANDVDTYPALTYRLGAEST----V 2470
            | |.:.|.::..:...........|.:.:  :||.:.:|:|     |......|:.|..|    .
Mosquito  1732 TIANVFVYVLHAHQEVCLILAGLPVDIEK--QLGMISSSLS-----TATGYDIRIRALETNTKVD 1789

  Fly  2471 DIENMSIFALDRYSGKLV----LKR---RLD 2494
            |..|:.::|:||.:..||    |:|   |||
Mosquito  1790 DATNLYLYAIDRKTNGLVEMTELQRSLSRLD 1820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_523446.2	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637	13/61 (21%)
		Cadherin_repeat	832..927	CDD:206637	19/96 (20%)
		Cadherin_repeat	937..1032	CDD:206637	26/102 (25%)
		Cadherin_repeat	1040..1149	CDD:206637	29/120 (24%)
		Cadherin_repeat	1158..1252	CDD:206637	35/111 (32%)
		Cadherin_repeat	1263..1361	CDD:206637	26/103 (25%)
		Cadherin_repeat	1369..1481	CDD:206637	35/132 (27%)
		Cadherin_repeat	1489..1598	CDD:206637	33/176 (19%)
		Cadherin_repeat	1614..1710	CDD:206637	22/105 (21%)
		Cadherin_repeat	1723..1843	CDD:206637	23/143 (16%)
		Cadherin_repeat	1853..1948	CDD:206637	32/102 (31%)
		Cadherin_repeat	1957..2053	CDD:206637	37/100 (37%)
		Cadherin_repeat	2061..2154	CDD:206637	30/115 (26%)
		CA_like	2171..>2232	CDD:481204	12/60 (20%)
		Cadherin_repeat	2326..2424	CDD:206637	28/106 (26%)
		Cadherin_repeat	2434..2528	CDD:206637	21/72 (29%)
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
Cad89D	XP_061499378.1	None