DRSC/TRiP Functional Genomics Resources

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Protein Alignment ds and Pcdh15

DIOPT Version :10

Sequence 1:NP_523446.2 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:NP_075604.2 Gene:Pcdh15 / 11994 MGIID:1891428 Length:1943 Species:Mus musculus


Alignment Length:2348 Identity:527/2348 - (22%)
Similarity:840/2348 - (35%) Gaps:752/2348 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1400 SVEESFEDLRVTY--TLNPLTKDLIEAAFDIDRHSGNLVVARLLDREVQSEFRLEIRALDTTASN 1462
            ::|.|.:| .|.|  .|:|:.:.|...:           ..|:|||:  ....:....:.....|
Mouse    77 TIELSLKD-NVDYWVLLDPVKQMLFLNS-----------TGRVLDRD--PPMNIHSIVVQVQCVN 127

  Fly  1463 NPQSSAI--TVKIEVADVNDNAPEWPQDPIDLQVSEATPVGTIIHNFT-------ATDADTGTNG 1518
            ....:.|  .|:|.|.|.|||:|.:..:.....|:|.|||||.|  ||       |||.|.|.||
Mouse   128 KKVGTVIYHEVRIVVRDR
NDNSPTFKHESYYATVNELTPVGTTI--FTGFSGDNGATDIDDGPNG 190

  Fly  1519 DLQYRLIRYFPQ---LNESQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLIVQALDQSSNVTE 1580
            .::| :|:|.|:   .|::.|..:      .|||.:.|:..|::|....|.:|:||.|::.|:.|
Mouse   191 QIEY-VIQYNPEDPTSNDTFEIPL------MLTGNVVLRKRLNYEDKTRYYVIIQANDRAQNLNE 248

  Fly  1581 RLQTSVTVRLRILDANDHAPHFVS----PNSSGGKTASLFISDATRIGEVVAHIVAVDEDSGDNG 1641
            |..|:.|:.:.:||.:|..|.|:.    ||              ||                |..
Mouse   249 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPN--------------TR----------------DCR 283

  Fly  1642 QLTYEITGGNGEGRFRINSQTGIIELVKSLPPATEDVEKGGRFNLIIGAKDHGQPEPKKSSLNLH 1706
            .|||               |..|.||                          ..||    .||..
Mouse   284 PLTY---------------QAAIPEL--------------------------RTPE----ELNPI 303

  Fly  1707 LIVQGSHNNPPRFLQAVYRATILENVPSGSFVLQVTAKSLHGAENANLSYEIPAGVANDLFHVDW 1771
            |:      .||  :||:.:                                              
Mouse   304 LV------TPP--IQAIDQ---------------------------------------------- 314

  Fly  1772 QRGIITTRGQFDRESQASYVLPVYVRDANRQSTLSSSAVRKQRSSDSIGDTSNGQHFDVATIYIT 1836
                       ||..|                                                 
Mouse   315 -----------DRNIQ------------------------------------------------- 319

  Fly  1837 VGDVNDNSPEFRPGSCYGLSVPENSEPGVIHTVVASDLDEGPNADLIYSITGGNLGNKFSIDSSS 1901
                                 |.:..||::::::....::.|..              |.:...:
Mouse   320 ---------------------PPSDRPGILYSILVGTPEDYPRF--------------FHMHPRT 349

  Fly  1902 GELS-ARPLDREQHSRYTLQIQA-SDRGQPKSRQGHCNITIFVEDQNDNAPRFKLSKYTGSVQED 1964
            .||: ..|::|:.|.::.|.|:| .|.|.|.......:|.|.  |:|:.:|.|.:..|.|.:.|.
Mouse   350 AELTLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFASLHIEIL--DENNQSPYFTMPSYQGYILES 412

  Fly  1965 APLG---------TSVVQISAVDADL-GVNARLVYSLANETQWQFAI--DGQSGLITTVGKLDRE 2017
            ||:|         |:.::|.|:|.|: ......::...|:....|.:  .|.:..:|.:..:|||
Mouse   413 APVGATISESLNLTTPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTPTGITRYLTLLQPVDRE 477

  Fly  2018 LQASYNFMVLATDGGRYEVRSATVPVQINVLDINDNRPIFERYPYIGQVPALIQPGQTLLKVQAL 2082
            .|.:|.|::.|.||.:   .|..|.|.|.|:|.|||.|.|....|...|...:.||.:::::.|:
Mouse   478 EQQTYTFLITAFDGVQ---ESEPVVVNIRVMDANDNTPTFPEISYDVYVYTDMSPGDSVIQLTAV 539

  Fly  2083 DADLGANAEIVYSLNAENSAVSAK--FRINPSTGALSASQSLASESGKLLHLEVVARDKGNPPQS 2145
            |||.|:|.||.|.:     .|..|  |.||.:||.:|.:..:....|:...|.|.|.|...|.:.
Mouse   540 DADEGSNGEISYEI-----LVGGKGDFVINKTTGLVSIAPGVELIVGQTYALTVQASDNAPPAER 599

  Fly  2146 SLGLIELLIGEAP---QGTPVLRFQNETYRVMLKENSPSGTRLLQVVALRSDGRRQKVQFSFGAG 2207
            ...:..:.|...|   |..|  ||....|.:.:.|....|..||.:.|...:|  ..:.::...|
Mouse   600 RHSICTVYIEVLPPNNQSPP--RFPQLMYSLEVSEAMRIGAILLNLQATDREG--DPITYAIENG 660

  Fly  2208 NEDGILSLDSLSGEIRVNKPHLLDYDRFSTPSMSALSRGRALHYEEEIDESSEEDPNNSTRSQRA 2272
            :...:.:|...:|                     .||.|:||      |..|.:           
Mouse   661 DPQRVFNLSETTG---------------------ILSLGKAL------DRESTD----------- 687

  Fly  2273 LTSSSFALTNSQPNEIRVVLVARTADA-PFLASYAELVIELEDENDNSPKFSQ--KQFVATVSEG 2334
                            |.:|:...:|. |...|.|.:.|.:.|.|||:|.|..  .:.::.|.|.
Mouse   688 ----------------RYILIVTASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 736

  Fly  2335 NNKGTFVAQVHAFDSDAGSNARLRYHIVDGNHDNAFVIEPAFSGIVRTNIVLDREIRDIYKLKII 2399
            .|  .||.||.|.|.|||.|.::.|.:  ||.:|.|.|  ..:|.:.|.:.|:||.||.|:|.::
Mouse   737 AN--AFVGQVRATDPDAGINGQVHYSL--GNFNNLFRI--TSNGSIYTAVKLNREARDHYELVVV 795

  Fly  2400 ATDEGVPQMTGTATIRVQIVDVNDNQPTFPPNN-LVTVSEATELGAVITSISANDVDTYPALTYR 2463
            |||..|.....|.|:.::::|::||.|.|..:. .|.|.|....|.....|.|.|||....::||
Mouse   796 ATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLPAGTSFLQIEAKDVDLGANVSYR 860

  Fly  2464 LGAESTVDIENMSIFALDRYSGKLVLKRRLDYELQQEYELDVIASDAAHE-------ARTVLTVR 2521
            :.:.     |...:|||..::|:|.|.|.||||...:.|..:.....|.:       ....:||.
Mouse   861 IRSP-----EVKHLFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 920

  Fly  2522 VNDENDNAPVFLAQQPPAYFAILPAISEISESLSVDFDLLTVNATDADSEGNNSKVIYIIEPAQE 2586
            |.|.||..|||                                          ||.||       
Mouse   921 VKDMNDYPPVF------------------------------------------SKRIY------- 936

  Fly  2587 GFSVHPSNGVVSVNMSRLQPAVSSSGDYFVRIIAKDAGKPALKSSTLLRVQANDNGSGRSQFLQN 2651
                   .|:|:.:..:..|..:        :.|:||..|.:.:|. :|.:.:|        :|.
Mouse   937 -------KGMVAPDAVKGTPITT--------VYAEDADPPGMPASR-VRYRVDD--------VQF 977

  Fly  2652 QYRAQISEAAPLGSVVLQLGQDALDQSLAIIAGNEESAFELLQSKAIVLVKPLDRERNDLYKLRL 2716
            .|.|.|.:.                         ||      .|..:|....|:.|...::|| :
Mouse   978 PYPASIFDV-------------------------EE------DSGRVVTRVNLNEEPTTIFKL-V 1010

  Fly  2717 VLSHPHGPPLISSLNSSSGISVIITILDANDNFPIFDRSAKYEAEISELAPLRYSIAQLQAIDAD 2781
            |::...|.|::     ||..:|.|.:|...: .|.|.:.......:||||.....:..:.|.   
Mouse  1011 VVAFDDGEPVM-----SSSATVRILVLHPGE-IPRFTQEEYRPPPVSELAARGTVVGVISAA--- 1066

  Fly  2782 QENTPNSEVVYDITSGNDEHMFTIDLVTGVLFVNNRLDYDSGAKSYELIIRACDSHHQRPLCSLQ 2846
               ..|..:||.|.:||:|..|.|:.||||::||:.|||:: ..||.|.::| || .:..|.:|:
Mouse  1067 ---AINQSIVYSIVAGNEEDKFGINNVTGVIYVNSPLDYET-RTSYVLRVQA-DS-LEVVLANLR 1125

  Fly  2847 -PFR-------LELHDENDNEPKFPLTEYVHFLAENEPVGSSVFRAHASDLDKGPFGQLNYSIGP 2903
             |.:       :|:.||||:.|.|....|:..::|:..:.:||.|..|:|.|.|.:..:.|.:..
Mouse  1126 VPSKSNTAKVYIEIQDENDHPPVFQKKFYIGGVSEDARMFASVLRVKATDRDTGNYSAMAYRLII 1190

  Fly  2904 APSDESSWKMFRVDSESGLVTSAFVFDYEQRQRYDMELLASDMGGK----KASVAVRVE------ 2958
            .|..|.. :.|.|::.:||:.:|.:|...:|..:..:::|:|..||    ||.|.|.|.      
Mouse  1191 PPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQ 1254

  Fly  2959 ----------IESRDEFTPQFTERTYRFVLPAAVALPQGYVVGQVTATDSDSGPD----GRVVYQ 3009
                      :|.:.|...:..:|..:..:|.|..:.:.  :|.....|:.|..|    ...||.
Mouse  1255 VIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVES--IGARRHGDAYSLEDYSKCDLTVYA 1317

  Fly  3010 LSAPHSHFKVNRSSGAVLIKRKLKLDGDGDGNLYMDGR--DISLVISASSGRHNSLSSMAVVEIA 3072
            :. |.::..::|:.   |.|             ::||:  ||:.......|....:..:...| |
Mouse  1318 ID-PQTNRAIDRNE---LFK-------------FLDGKLLDINKDFQPYYGEGGRILEIRTPE-A 1364

  Fly  3073 LDPLAHPGTNLASAGGSSSGSIGDWAIGLLVAFLLVLCAAAGIF-LFIHMRSRKPRNAVKPHLAT 3136
            :..:...|.:|    |.:.|::      |.:||:::||....|. :.:..|..|.|.|.    .|
Mouse  1365 VTSIKKRGESL----GYTEGAL------LALAFIIILCCIPAILVVLVSYRQFKVRQAE----CT 1415

  Fly  3137 DNAGVGNTNSYVDPSAFDTIPIRGSISGGAAGAASGQFAPPKYDEIPPFGAH----AGSSGAATT 3197
            ..|.:.:......|:|  .:|           ||.   |||.....||.|||    .|.|.....
Mouse  1416 KTARIQSAMPAAKPAA--PVP-----------AAP---APPPPPPPPPPGAHLYEELGESAMHNL 1464

  Fly  3198 SELSGSEQSGSSGRGSAEDDGEDEEIRMINEGPLHHRNGGAGAGSDDGRISDISVQNTQEYLARL 3262
            ..|...||  |.|..|..:|...            ||:|.|.:.|            |.|     
Mouse  1465 FLLYHFEQ--SRGNNSVPEDRSS------------HRDGMAFSSS------------TTE----- 1498

  Fly  3263 GIVDHDPSGAGGGASSMAG---------------SSH-PMHLYH------DDDATARSDITNLI- 3304
               .|:|:...|.......               |:| |:::..      :.|...|:|...|: 
Mouse  1499 ---SHEPAHVEGPLKESQPNPARTFSFVPDEDNLSTHNPLYMESIGQRSTNSDLQPRTDFEELLA 1560

  Fly  3305 ---YAKLNDVTGAGSEI------------------------------------------------ 3318
               ..|...:.|...:|                                                
Mouse  1561 PRTQVKSQSLRGPREKIQRVWNQSVSFPRRLMWKAPNRPETIDLVEWQITNQRAECESARCHPSQ 1625

  Fly  3319 -GSS-----ADDAGTTAGSIGTIGT----------AITHGHGVMSSYGEVPVPVPVVVGGSNVGG 3367
             |||     .:||..:....|...|          :::.|....||:..........:..:...|
Mouse  1626 RGSSNVLLATEDAHESEKEGGHRDTLIVQQTEQLKSLSSGSSFSSSWSHFSFSTLPTISRAVELG 1690

  Fly  3368 SLSSIVHSEEELTGSYNWDYLLDWGPQYQPLAHVFSEIARLKDDTLSEHSGSGASSSAKSKHSSS 3432
            |..::|.|..:.|        |:..|..:|         |:.:...|:......:|..:.|.:|.
Mouse  1691 SEPNVVTSPADCT--------LELSPPLRP---------RILNSLSSKRETPTCASDTEPKRNSF 1738

  Fly  3433 HSSAGAGSV--------VLKPP--------PSAPPTHIPPPLLTNVAPRAINLP----MRLPPHL 3477
            ..:....|:        :.:||        |.:||...||.|:|...|  |:.|    :.|||.|
Mouse  1739 EIAPHPPSISAPLPHPPLPRPPIAFTTFPLPLSPPNPPPPQLVTFSLP--ISTPPTSSLPLPPPL 1801

  Fly  3478 SLAPAHLPRSPIGHEASGSFSTSSAMSPSFSPSLSPLATRSPSISPLGAGPPTHLPHVSLPRHGH 3542
            ||.|.  ||.|.........|||...:.|.|   :|.|..:.|.:.......|..|..|.|:.|.
Mouse  1802 SLPPP--PRPPAPRLFPQPPSTSIPSTDSIS---APAAKCTASATHARETTSTTQPPASNPQWGA 1861

  Fly  3543 APQPSQRG 3550
            .|....:|
Mouse  1862 EPHRHPKG 1869

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_523446.2 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637
Cadherin_repeat 291..389 CDD:206637
Cadherin_repeat 406..500 CDD:206637
Cadherin_repeat 509..607 CDD:206637
Cadherin_repeat 616..711 CDD:206637
Cadherin_repeat 719..820 CDD:206637
Cadherin_repeat 832..927 CDD:206637
Cadherin_repeat 937..1032 CDD:206637
Cadherin_repeat 1040..1149 CDD:206637
Cadherin_repeat 1158..1252 CDD:206637
Cadherin_repeat 1263..1361 CDD:206637
Cadherin_repeat 1369..1481 CDD:206637 19/84 (23%)
Cadherin_repeat 1489..1598 CDD:206637 41/118 (35%)
Cadherin_repeat 1614..1710 CDD:206637 15/95 (16%)
Cadherin_repeat 1723..1843 CDD:206637 3/119 (3%)
Cadherin_repeat 1853..1948 CDD:206637 20/96 (21%)
Cadherin_repeat 1957..2053 CDD:206637 31/107 (29%)
Cadherin_repeat 2061..2154 CDD:206637 27/94 (29%)
CA_like 2171..>2232 CDD:481204 10/60 (17%)
Cadherin_repeat 2326..2424 CDD:206637 35/97 (36%)
Cadherin_repeat 2434..2528 CDD:206637 30/100 (30%)
Cadherin_repeat 2549..2641 CDD:206637 13/91 (14%)
Cadherin_repeat 2652..2748 CDD:206637 19/95 (20%)
Cadherin_repeat 2758..2858 CDD:206637 36/107 (34%)
Cadherin_repeat 2866..2960 CDD:206637 28/113 (25%)
Cadherin_repeat 2985..3071 CDD:206637 15/91 (16%)
Pcdh15NP_075604.2 ECD 36..145 CDD:408229 17/81 (21%)
Cadherin_repeat 156..245 CDD:206637 34/97 (35%)
CA 310..398 CDD:214520 25/230 (11%)
Cadherin_repeat 404..510 CDD:206637 31/108 (29%)
Cadherin_repeat 518..614 CDD:206637 29/100 (29%)
Cadherin_repeat 626..718 CDD:206637 26/147 (18%)
Cadherin_repeat 727..820 CDD:206637 35/98 (36%)
Cadherin_repeat 828..926 CDD:206637 29/102 (28%)
Cadherin_repeat 935..1032 CDD:206637 31/164 (19%)
Cadherin_repeat 1050..1145 CDD:206637 36/103 (35%)
Cadherin_repeat 1154..1248 CDD:206637 27/94 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1425..1453 13/43 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1475..1533 14/89 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1714..1865 41/157 (26%)
Blue background indicates that the domain is not in the aligned region.

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