DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and LOC108348201

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_001055818.2	Gene:	LOC108348201 / 108348201	RGDID:	11368541	Length:	800	Species:	Rattus norvegicus

Alignment Length:	817	Identity:	211/817 - (25%)
Similarity:	331/817 - (40%)	Gaps:	200/817 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ILLAIVLLGSSQAASHD------QERERKLEVFEGVAVDYQIGYIGDFGGIDSGPPYIIVAEAGV 119
            :|...|.||:|.|::..      :|.||. .....:|.|..:| :|:          :...||.:
  Rat    28 VLFLYVFLGASWASAEQLQYSVAEETERG-TFLANLAKDLGLG-LGE----------LSAREARI 80

  Fly   120 ETD-----LAIDRATGEIRTKVKLDRETRASYS---------LVAIPLSGRNIRVLVTVKDENDN 170
            .:|     |.:...|||:....|||||.....:         |:..|.  :..|..:.|||.|||
  Rat    81 VSDQNTRFLLLSPLTGELILNEKLDREELCGPTEPCVLTFQLLLERPF--QIYRAALHVKDINDN 143

  Fly   171 APTFPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLY 235
            :|.|....:|::..|:|.......|..|:|.|:...:...|.|   :.||.|.:..:...:|.::
  Rat   144 SPVFLDKEIHLKISESTTPGATFFLERAQDSDVGTNSLSNYTI---SPNDYFHIHVNDGGEGTIF 205

  Fly   236 LDLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENAT 300
            .:|.:...||||..|.::|.:.|||||:||..|...|.|.:.|:|||.|.|.||.|....||:..
  Rat   206 PELVLDKMLDREEIPEFTLTLTALDGGSPPRSGTALVRILVLDINDNSPQFVQSLYKVQSPEDTP 270

  Fly   301 VGTSVLQVYASDTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVA 365
            ||:.|:.|.|.|.|...||.:.|..:.......|.|:|:..:|.:|:.:.|::|..:.:.:.:.|
  Rat   271 VGSLVVAVSARDLDTGSNGQITYTFSYATERILQTFQINSTSGNLYLKRELNYEAIQTYSITIQA 335

  Fly   366 KDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEY 430
            :|.|  .|.....|.:.|.|||||.|.    ||....:..|.|:: |...||...:.|.||.
  Rat   336 RDGG--GLSGKCTVVVEVMDVNDNPPE----FLLSSLNSPIPENS-PEAVVAVFRIRDRDSG--- 390

  Fly   431 ANVNVTLNGG--------DGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHAS 487
                   |.|        |..|.|.....:.|.::...|||||..:.|.:::..:|.|||.|...
  Rat   391 -------NNGKTMCSVAHDLPFVLKPSVENFYTLVTEKPLDREAYTEYNITITVSDLGTPRLTTQ 448

  Fly   488 KSIFLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQ 552
            .:|.::::|:|||.|.|.|..|...|.|...|...:..:.|.|.|.|.|:.:||||
  Rat   449 HTITVQVSDINDNAPTFTQTSYTMFVRENNSPALHIGTISATDSDSGSNAHITYSL--------- 504

  Fly   553 WFQIDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYN 617
                                               :||
  Rat   505 -----------------------------------LPP--------------------------- 507

  Fly   618 VSVAENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSS 682
                              .||...::::::              :.:.:|::.....||||...:
  Rat   508 ------------------HDPQLALDSLIS--------------INADNGQLFAIRALDFEDLQA 540

  Fly   683 YEFPVLATDRG--GLSTTAMIKMQLTDVNDNRP-VFYPREYKVSLRESPKASSQASSTP------ 738
            :||.|.|.|:|  .||:.|::::.:.|.|||.| |.||              .|.:|||
  Rat   541 FEFHVGAEDQGSPALSSQALVRVVVLDDNDNAPFVLYP--------------LQNASTPCTELLP 591

  Fly   739 --------IVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHML 795
                    :..|||.|.|.|....:|::::...|.|:|.:....||:...|  ||..|..|.|.|
  Rat   592 RAAEPGYLVTKVVAVDRDSGQNAWLSFQLLKATEPGLFSVWSHNGEVRTTR--MLGERDVPKHKL 654

  Fly   796 NISATDGGNLRSNADAVVFLSIIDAMQRP--PIFEKA 830
            .:...|.|....:|...:.:.::|...:|  |:.|.|
  Rat   655 LLVVKDNGEPPRSASVTLHVLLVDGFSQPYLPLPEMA 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	21/74 (28%)
		Cadherin_repeat	178..282	CDD:206637	32/103 (31%)
		Cadherin_repeat	291..389	CDD:206637	29/97 (30%)
		Cadherin_repeat	406..500	CDD:206637	28/101 (28%)
		Cadherin_repeat	509..607	CDD:206637	15/97 (15%)
		Cadherin_repeat	616..711	CDD:206637	18/96 (19%)
		Cadherin_repeat	719..820	CDD:206637	26/114 (23%)
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
LOC108348201	XP_001055818.2	Cadherin_2	44..125	CDD:285466	20/92 (22%)
		Cadherin_repeat	151..252	CDD:206637	32/103 (31%)
		Cadherin_repeat	261..357	CDD:206637	29/97 (30%)
		Cadherin_repeat	370..461	CDD:206637	28/101 (28%)
		Cadherin_repeat	469..571	CDD:206637	33/204 (16%)
		Cadherin_repeat	590..678	CDD:206637	22/89 (25%)
		Cadherin_C_2	701..783	CDD:293101
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9194
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000