DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and si:ch73-379j16.2

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_017214536.1	Gene:	si:ch73-379j16.2 / 108179154	ZFINID:	ZDB-GENE-141215-68	Length:	791	Species:	Danio rerio

Alignment Length:	857	Identity:	234/857 - (27%)
Similarity:	378/857 - (44%)	Gaps:	147/857 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   830 ARYNYYVKEDIPRGTVVGSVIAASG-DVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHE 893
            |:..|.:.|::..||:||::....| ||:.....|:.|.||..|..|.:..|:|.:.:.|.:|.|
Zfish    31 AQIRYSIPEEVKEGTIVGNIAKDLGLDVSTLLDRRFRIVSGSNDALFQVNQNNGMLYVGKLIDRE 95

  Fly   894 A----KSQVLLNIQATLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAH 954
            |    .:..|:::: |:.|.|:..| .|.:|:.||||:||.|....|.:.:.||...|.......
Zfish    96 ALCDGNTACLISLK-TVVENPLEIH-YVEVEITDVNDHAPSFANKDVLLEIQESTIPGEDFQLQE 158

  Fly   955 AHDKDSGSSGQVTYSLVKESGKGLFAIDARSGH-------LILSQHLDYESSQRHTLIVTATDGG 1012
            |:|.|||.:....|.|   |....|.|:.|...       |.|.:.||.|....|:|||||.|||
Zfish   159 AYDPDSGVNSVRFYKL---SQTEYFEIELRENGGEKKVPVLKLRKSLDRERQVIHSLIVTAVDGG 220

  Fly  1013 VPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVD 1077
            ....|.:..|.|.|.|.|||.|.|.::.|||::.|:..:...:|::||:|||.|.|..|.|..
Zfish   221 NQPRSGSTVINVTVLDDNDNRPKFSQELYSVSLRENAPLGTLVIKLNATDLDEGQNGEIVYSF-- 283

  Fly  1078 AGVDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVR 1142
              |.|:...|..:     |.: .|:|.|.::..||.|..:.|::.|:|:|.|.|...:..|:|::
Zfish   284 --VKNIEKYIYDT-----FDL-DNTGEIRVKGSLDFEKNNVYRIAVMASDKGQPPKTSNCRIIIK 340

  Fly  1143 VLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAA--------IRYSLLPINSSF 1199
            |:|.|||.|:.:.:.....:.|:.:.|:|:.:|:.:|.|.|.|..        :.:.|.|   ||
Zfish   341 VIDENDNAPEIEVTSLSDVVPEDSKPGAVISLVSITDKDSGVNGKVVCRISDDVPFELKP---SF 402

  Fly  1200 QVHPVTGEISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPE-IADPQEDV 1263
            :.:..:  :.|...|||||...||:.:.|.|.|.|..|:...:::.:||||||||| :.:|.|
Zfish   403 KDNMYS--LVTNAKLDRELTSHYDVTITATDLGQPPLSSIKTLKVQISDVNDNAPEFVHNPLE-- 463

  Fly  1264 VSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDGH--GLFSIDPTSGVIRTRVVLDHE 1326
            :.:.|...||..:..|.|.|||..:||:|||.|::...:..|  ...:::..:|.|......|.|
Zfish   464 LYLMENNAPGASIYSVSAFDRDLNENAAITYQIIREEGTRSHMSSFLNVNADNGHIHALKSFDFE 528

  Fly  1327 ERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFT-------SSSLVFRVREDAALGHVV 1384
            ....::..:.|:|.|:|...:...:.|.:||.|||.|...       |:..|..:..:...||:|
Zfish   529 SVKTFQFHILATDSGSPSLSSNVTVNVFILDQNDNVPVILYPVSANGSAEGVEEIPRNVNAGHLV 593

  Fly  1385 GSISPIERPADVVRN-----SVEESFEDLRVTYTLNPLTKDLIEAAFDIDRHSGNLVVARLLDRE 1444
            ..:...:  ||:..|     |::|..|                .:.|.:||::|.:...|.....
Zfish   594 TKVRAYD--ADIGYNGWLLFSLQEVSE----------------HSLFALDRYTGQIRTLRSFTET 640

  Fly  1445 VQSEFRLEIRALDTTASNNPQSSAITVKIEVADVNDNAPEWPQDPIDLQVSEATPVGTIIHNFTA 1509
            .:::.:|.|...|.  .|...|:..||.::|.:        |::.                 |.|
Zfish   641 DEAQHKLVILVKDN--GNVSLSATATVIVKVVE--------PKEA-----------------FAA 678

  Fly  1510 TDA-----DTGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGALSLQAPLDFEAVQEYLLIV 1569
            :|.     |...|....|.:|..         .::|:..:.|:...:.:|.....:...:||
Zfish   679 SDVKNAEKDEEENNVTFYLIIPL---------GSVSVLFVISIIVLIVMQCSKSTDYSSKYL--- 731

  Fly  1570 QALDQSSNVTERLQTSVTVRLRILDANDHAPHFVSPNSSGGKTA-------SLFISDATRIGEVV 1627
                |.:|....|..|:..|     :.|.....|.|..|.|.|.       :|.|.|..|
Zfish   732 ----QDTNYDGTLCHSIQYR-----SGDKRYMLVGPRMSIGSTIAPGSNRNTLVIPDRRR----- 782

  Fly  1628 AHIVAVDEDSGD 1639
                   .|||:
Zfish   783 -------RDSGE 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637
		Cadherin_repeat	832..927	CDD:206637	31/99 (31%)
		Cadherin_repeat	937..1032	CDD:206637	34/101 (34%)
		Cadherin_repeat	1040..1149	CDD:206637	35/108 (32%)
		Cadherin_repeat	1158..1252	CDD:206637	29/101 (29%)
		Cadherin_repeat	1263..1361	CDD:206637	27/99 (27%)
		Cadherin_repeat	1369..1481	CDD:206637	23/116 (20%)
		Cadherin_repeat	1489..1598	CDD:206637	17/113 (15%)
		Cadherin_repeat	1614..1710	CDD:206637	7/26 (27%)
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
si:ch73-379j16.2	XP_017214536.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9353
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000