DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and cdhr5b

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_017209750.2	Gene:	cdhr5b / 101886483	ZFINID:	ZDB-GENE-110518-2	Length:	722	Species:	Danio rerio

Alignment Length:	563	Identity:	123/563 - (21%)
Similarity:	216/563 - (38%)	Gaps:	148/563 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   618 VSVAENEPVGRCILKVSASDPDCGVNAMVN-------YTIGEGF----KHLTEFEVRSASGEICI 671
            :.:.||..:...:..::|::   ||.|::.       :.|.:.:    |.:.::|
Zfish    37 IFIKENNTIDALVTTINAAE---GVTAVITGQNPPDLFDINDEYQLIAKTVMDYE---------- 88

  Fly   672 AGELDFERRSSYEFPVLATDRGGLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASS 736
                .|::.:.|...:..|..|..||:.::::.|.|:|||.|.|....|.:.::|..|.     .
Zfish    89 ----KFDKDNPYLVNIECTKPGSTSTSLLLRIVLEDINDNPPSFKESWYSLEVKELTKV-----D 144

  Fly   737 TPIVAVVATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRP----DMLSVRTQPMHMLNI 797
            |.:..:.|||||..:  ::.||:  .:..|.|.::.|.....:|:.    |.:...|..::..:.
Zfish   145 TSVGLITATDPDESD--RLYYRL--ESPEGEFDVETSFNPNILVKKLLDYDKVKQVTMTLYAQDT 205

  Fly   798 SATDGGNLRSNADAVVFLSIIDAMQRPP--------IFE------KARYNYYV----KEDIPRGT 844
            .......:...|.|.|.::|||...|||        |||      .:.||..|    :|..|...
Zfish   206 QIGSSAEVSHTATATVVVNIIDIDNRPPWFQPCTEYIFETSTVCINSGYNGVVTLKEQETDPLKL 270

  Fly   845 VVGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQATLGEP 909
            :.|.|....||...:..:.|:...|:.||.|:|.|::|||.:.||:|  .....:|.:.|
Zfish   271 MPGPVYGIDGDAGIKELIGYTFMGGNEDGIFNINTDTGNITMLKPVD--VVGPFVLTVMA----- 328

  Fly   910 PVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKES 974
                       .:.:|.:  :|..:.|.:.|..:|....|.:                   .|||
Zfish   329 -----------FQKLNPD--QFATTTVILKVALTASEFPPKF-------------------TKES 361

  Fly   975 GKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATD-----GGVPSLSTNLTILVDVQDVNDNPP 1034
            .:|..:.||....|:    |:.::|.| .|.|.|||     |..|:|...   :||..|....|.
Zfish   362 YEGFISEDAGVDSLV----LEGKTSNR-ALRVQATDEDFSNGYNPNLRFE---IVDGTDFYITPE 418

  Fly  1035 VFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIV---DAGVDNVT--NSISSSDVSQ 1094
            .|        :..::::....:.:....:||.|:...|..:|   ..||...|  .:|:::|
Zfish   419 GF--------ILMAKAVTPGTVNLEMRVIDTENDESSTASLVVEITPGVPTTTPVTTITTTD--- 472

  Fly  1095 HFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKT 1137
                                ..|..|||.: ||...|:.|..|
Zfish   473 --------------------NTDSTQLTDI-TDTSHPSTHTTT 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637	18/103 (17%)
		Cadherin_repeat	719..820	CDD:206637	22/104 (21%)
		Cadherin_repeat	832..927	CDD:206637	25/98 (26%)
		Cadherin_repeat	937..1032	CDD:206637	24/99 (24%)
		Cadherin_repeat	1040..1149	CDD:206637	19/103 (18%)
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
cdhr5b	XP_017209750.2	Cadherin_repeat	36..124	CDD:206637	18/103 (17%)
		Cadherin_repeat	133..230	CDD:206637	23/105 (22%)
		Cadherin_repeat	<278..346	CDD:206637	20/87 (23%)
		Cadherin_repeat	361..454	CDD:206637	26/108 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910