DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and pcdh11x

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_017952262.1	Gene:	pcdh11x / 100493938	XenbaseID:	XB-GENE-6085670	Length:	1227	Species:	Xenopus tropicalis

Alignment Length:	1283	Identity:	336/1283 - (26%)
Similarity:	544/1283 - (42%)	Gaps:	219/1283 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 LLILLAIVLLGSSQAASHDQERERKLEVFEGVAV-----DYQIGYIGDFGGIDSGP-PYIIVAEA 117
            |.:|:|.::..|.....:...||   |:.|.|.:     |..:....|.    |.| .:.:|.:.
Frog    10 LAVLIACIVFESGAQEKNYIVRE---ELPENVLIGNLLKDLNLTLDPDL----STPLQFKLVYKT 67

  Fly   118 GVETDLAIDRATGEI-RTKVKLDRETRAS---------YSLVAIPLSG---RNIRVLVTVKDEND 169
            |....:.::..|||| .|..::|||...|         |.:....|..   |.:::...::|.||
Frog    68 GDVPLIRVEENTGEIFTTSNRIDREKLCSGIFTENKCFYEVEVAVLPDEVFRLVKIRFLIEDIND 132

  Fly   170 NAPTFPQTSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVL 234
            |:|.||.|.::|..||||....:.::..|.|.|:.....|.|.::.|  .:.|.|......:|..
Frog   133 NSPLFPSTVINISIPENTAVNSRYSVPSAIDPDVGVNGIQHYELLKG--QNVFGLDVIETPEGDK 195

  Fly   235 YLDLQISGFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENA 299
            :..|.:...||||....|.:.|:..|||.|.......:.:|:.|||||:|:|.:......:||:|
Frog   196 WPQLIVQQSLDREQKDTYVMKIKVEDGGNPARSSTAILQVTVTDVNDNRPVFKEKDIEVNIPEDA 260

  Fly   300 TVGTSVLQVYASDTDADENGLVE-YAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVV 363
            .|||||.|::|:|.|...|..:. |..|:..:..::.|.||..||.|.:.:.||.|....|:|.|
Frog   261 AVGTSVTQLHATDADLGSNAKIHFYFGNQITNLAKRHFAIDNNTGLITVKEPLDREESPYHKLTV 325

  Fly   364 VAKDHGEQPLETTAFVSIRVTDVNDNQPTINVIFLSD--DASPKISESAQPGEFVARISVHDPDS 426
            :|.|....|...|  |:|.:||:|||.|:|:..::.:  :.:.::||.|.....:|.|:|.|.|:
Frog   326 LASDGSSTPSRAT--VTINITDINDNIPSIDTRYIINPVNGTVQLSEKAPLNTKIALITVTDKDA 388

  Fly   427 KTEYANVNVT-LNGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSI 490
            .   .|..|| ....|..|.|....::.:|:....|||.|....|.:.:||:|.|.|||:.|..:
Frog   389 D---LNGKVTCFTDHDVPFRLKPVFDNQFLLETAAPLDYESTREYAIKIVASDSGKPPLNQSAML 450

  Fly   491 FLRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQ 555
            .::|.|.|||.|.|...:...:.:|...|||.:.::.|.|.|.|.|:.|:|.|.....|   .|.
Frog   451 LIKIKDENDNAPVFTLPMIGLSFVENNPPGTELTKISATDADSGRNAELSYMLGPNAPT---IFN 512

  Fly   556 IDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSV 620
            :|.:||::|....:|.|.:.....||:|:|.|.|.|.:..||.:::.|.|||.|.|..:.||..|
Frog   513 LDRRTGILTAVRKLDREKQDRYTFTVIAKDNGNPSLQTNTTVTLSVLDQNDNSPSFTHNEYNFYV 577

  Fly   621 AENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEF 685
            .||.|:...:..::.:|.|.|.||:|..::   ......|.:...:|.|......|.|::.||.|
Frog   578 PENLPMYGTVGLITVTDADSGENAVVTLSL---VNARDNFIIDPLTGVIRPNITFDREQQGSYTF 639

  Fly   686 PVLATDRGG--LSTTAMIKMQLTDVNDNRPVFY--PREYKVSLRESPKASSQASSTP---IVAVV 743
            .|.|.|:|.  .|:|..:.:.:.|||||:|||.  ...|...|       .|.|::|   :..|.
Frog   640 QVKALDKGSPQKSSTVKVTIFVEDVNDNKPVFVIPSNNYSYDL-------VQTSTSPGSVVARVY 697

  Fly   744 ATDPDYGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDML----------------SVRTQPM 792
            |.|.|.|....:.|.|:.||..|:|.|...:|.| .::..:|                |.:.:|.
Frog   698 AIDNDTGINADLRYSIIGGNSRGLFAIGERSGNI-TLKEKLLAGDHGVLYKLVIKVNDSGKPEPF 761

  Fly   793 H-------MLNISATDGGNL----RSNADAVVFLSIIDAMQRPPIFEKARYNYYVKEDIP--RGT 844
            |       .:|.:.|:|..:    |.:.:..|.....|....|      :.|.|||..|.  .||
Frog   762 HTIAFVHLFVNETITNGSYIQELVRKSKETAVGEDFRDGEITP------QTNDYVKIIIAIIAGT 820

  Fly   845 V-VGSVIAASGDVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKS--QVLLN---IQ 903
            : |..||..:..|..|...|:.:..........:..|..|.:|.|....:.:|  .:|||   |:
Frog   821 MTVILVIFVTALVRCRQTPRHKVVQKSKQSGEWVSPNQENRQIKKKKKKKKRSPKNLLLNFVTIE 885

  Fly   904 ATLGEPPVYGH----TQVNIEVEDVNDNAPEFEASMVR---ISVPESAELGAPLYAAHAHDKDSG 961
            .:..|.|.:.|    ..:.:|:|         |.:|.:   .:.|.:.:..:|..|.|.    ..
Frog   886 ESKSEDPAHEHINGTLDIPVELE---------EQTMGKYNWATTPTTFKPDSPDLAKHY----KS 937

  Fly   962 SSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDV 1026
            :|.|.|:.:..|:     .:..:..|:|....||      :|.:|     |..|||...:...|.
Frog   938 ASPQPTFQIKPET-----PVPPKKHHVIQELPLD------NTFVV-----GCDSLSKCSSSSSDP 986

  Fly  1027 QDVND--------NPPVFEKDEYSVNVSESRSINAQIIQVNASDLDT----GNNARITYRIVDAG 1079
            ..|::        .|......:.:...::.:|...:      |:|:|    .:..|:|:.:.|..
Frog   987 YSVSECSCQGGFKAPGPIHTRQNAKEAAKPQSPQKE------SNLETWIQPTSQRRVTFHLPDGS 1045

  Fly  1080 VDNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVL 1144
            .:    |.|.|.:..|... .|:...: ..||.....:.|:.|         :|:::|..
Frog  1046 QE----SCSDSGLGDHEST-GNANTSH-PLPLGFPQEEYYEQT---------SANSRTEG----- 1090

  Fly  1145 DANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASD--LDLG--ENAAIRYSLLPINSS------- 1198
            |.| :||       |..||.||::.......|.:.  |.||  :|..:..||:....|
Frog  1091 DGN-SDP-------ESTIEVNLQKALAEASETCTQECLILGHSDNCWMPPSLMQYQQSNPPLPSF 1147

  Fly  1199 -FQ-----------VHPVTGEISTREPLDRELRELYDLVVEARDQGTP 1234
             ||           ||.:.....|::.:|:               |||
Frog  1148 GFQQGWGRGSRPDGVHTLGRPGKTKDDIDK---------------GTP 1180

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	18/73 (25%)
		Cadherin_repeat	178..282	CDD:206637	29/103 (28%)
		Cadherin_repeat	291..389	CDD:206637	36/98 (37%)
		Cadherin_repeat	406..500	CDD:206637	31/94 (33%)
		Cadherin_repeat	509..607	CDD:206637	31/97 (32%)
		Cadherin_repeat	616..711	CDD:206637	29/96 (30%)
		Cadherin_repeat	719..820	CDD:206637	28/130 (22%)
		Cadherin_repeat	832..927	CDD:206637	27/106 (25%)
		Cadherin_repeat	937..1032	CDD:206637	20/105 (19%)
		Cadherin_repeat	1040..1149	CDD:206637	20/112 (18%)
		Cadherin_repeat	1158..1252	CDD:206637	22/100 (22%)
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdh11x	XP_017952262.1	Cadherin_2	28..97	CDD:400525	19/75 (25%)
		Cadherin_repeat	141..243	CDD:206637	29/103 (28%)
		Cadherin_repeat	252..349	CDD:206637	36/98 (37%)
		Cadherin_repeat	365..460	CDD:206637	31/97 (32%)
		Cadherin_repeat	475..564	CDD:206637	31/91 (34%)
		Cadherin_repeat	572..667	CDD:206637	29/97 (30%)
		Cadherin_repeat	686..771	CDD:206637	20/85 (24%)
		Protocadherin	774..974	CDD:400603	50/234 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9561
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000