DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and pcdha8

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_002935957.3	Gene:	pcdha8 / 100490196	XenbaseID:	XB-GENE-6037559	Length:	802	Species:	Xenopus tropicalis

Alignment Length:	692	Identity:	203/692 - (29%)
Similarity:	331/692 - (47%)	Gaps:	67/692 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   833 NYYVKEDIPRGTVVGSVIAASG-DVAHRSPVRYSIYSGDPDGYFSIETNSGNIRIAKPLDHE--- 893
            :|.:.|:...||.||.:....| :::..:.....|.|.|...||.:...:|.:.:...:|.|
Frog    34 HYIIPEESKHGTFVGRIAQDLGLEISEINSRVLRIVSRDEKEYFQVNLQNGILFVNNIIDREEIC 98

  Fly   894 -AKSQVLLNIQATLGEPPVYGHTQVNIEVEDVNDNAPEFEASMVRISVPESAELGAPLYAAHAHD 957
             ..:..:::::..:.:|....|  |::|:||:|||.|.|.|....|.:.||..:.:......|.|
Frog    99 PETTVCIIHLEIIVDKPVHIYH--VDVEIEDINDNYPVFSAKEYSIVIAESRVVESKFPLEGAVD 161

  Fly   958 KDSGSSGQVTYSLVKESGKGLFAID-------ARSGHLILSQHLDYESSQRHTLIVTATDGGVPS 1015
            :|.|::....|.|   |..|:|||:       :.|..|:|.:.||.|:...:.|.:||.|||.|.
Frog   162 EDVGTNSIRAYEL---SSNGVFAIEIKKDKHQSESVELVLKKPLDRENQPFYNLTLTAFDGGKPK 223

  Fly  1016 LSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNARITYRIVDAGV 1080
            ||....:|:.|||.|||.|.|::..|.|.:.|:......:.:|.|:|.|.|:|.::||..
Frog   224 LSGTTQLLITVQDSNDNAPAFQESAYEVTLLENAMKGTLVAKVIATDPDEGDNGKVTYEF----- 283

  Fly  1081 DNVTNSISSSDVSQHFGIFPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAHAKTRVIVRVLD 1145
                :|...|.|...|.|...:|.|.:...:|.|..:.|.:.:.|||.|........:::|.|:|
Frog   284 ----SSQVPSQVRSTFTIDQETGEIRVIGEVDFEKNNYYNIRIDATDKGQNPMTGHCKILVSVID 344

  Fly  1146 ANDNDPKFQKSKYEFRIEENLRRGSVVGVVTA--SDLDLGENAAIRYSL---LPINSSFQVHPVT 1205
            .|||.|:...:.....:.|:...|:.|.::..  .|.|.|.|..:...:   :|    |:::|..
Frog   345 INDNPPEMTVTSLSVPVPEDSPMGTTVAIIRIQDKDKDSGANGKVTCFIAGKVP----FKLNPTL 405

  Fly  1206 GE---ISTREPLDRELRELYDLVVEARDQGTPVRSARVPVRIHVSDVNDNAPEIADPQEDVVSVR 1267
            .|   ::...|||||:..:|::.:.|||.|:||.|....:.:.:||||||||..|. ..|.:.:.
Frog   406 REYYALTVDGPLDREIASVYEVEIIARDGGSPVLSVAQTINVEISDVNDNAPSFAQ-LSDTIFIT 469

  Fly  1268 EEQPPGTEVVRVRAVDRDHGQNASITYSIVKG--RDSDGHGLFSIDPTSGVIRTRVVLDHEERSI 1330
            |..|||:.|..|.|.|.|..||:.||||:.:|  .........||:|.||.|...:..|.|:...
Frog   470 ENNPPGSHVHTVSATDSDINQNSFITYSLTEGFIEGIPVSSYLSINPESGKIFALLSFDQEQIHF 534

  Fly  1331 YRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTF--TSSSLVFRVRE----DAALGHVVGSISP 1389
            ::..|.|.|.|..|.....:|.|.::|:|||.||.  ..|:|.|.|.|    .|.:||.|..|..
Frog   535 FQCSVKACDAGLAPLSGNLILNVFIVDVNDNAPTLFPPFSNLDFPVTEIVSRSAKIGHPVTKIRA 599

  Fly  1390 IERPADVVRNSVEESFEDLRVTYTL-NPLTKDLIEAAFDIDRHSGNLVVARLLDREVQSEFRLEI 1453
            ::  ||...|:.        ::|.| :|:.|    ..|.:.:|:|.:|::|.:....:.|::|.|
Frog   600 VD--ADSGYNAF--------LSYGLKDPMEK----TPFGVGQHTGEIVISRPVLESDRDEYKLFI 650

  Fly  1454 RALDTTASNNP-QSSAITVKIEVAD-VNDNAPEWPQDPIDLQ 1493
            ...|   ..:| .||.:|:.|.:.: :.|...|..|..|:.:
Frog   651 VVKD---HGDPVLSSTVTITIVLVEKIQDITVEQNQKGIEYE 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637
		Cadherin_repeat	832..927	CDD:206637	22/98 (22%)
		Cadherin_repeat	937..1032	CDD:206637	34/101 (34%)
		Cadherin_repeat	1040..1149	CDD:206637	29/108 (27%)
		Cadherin_repeat	1158..1252	CDD:206637	28/101 (28%)
		Cadherin_repeat	1263..1361	CDD:206637	33/99 (33%)
		Cadherin_repeat	1369..1481	CDD:206637	30/118 (25%)
		Cadherin_repeat	1489..1598	CDD:206637	1/5 (20%)
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdha8	XP_002935957.3	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10813
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000