DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ds and pcdhb

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_002664314.3	Gene:	pcdhb / 100333352	ZFINID:	ZDB-GENE-020731-3	Length:	728	Species:	Danio rerio

Alignment Length:	609	Identity:	195/609 - (32%)
Similarity:	295/609 - (48%)	Gaps:	38/609 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 LDRETRASYS----------LVAIPLSGRNIRVLVTVKDENDNAPTFPQTSMHIEFPEN-TPREV 191
            :||||.....          ::..||...||.:.:|  |.|||||.|.:..:.::..|: :|.|
Zfish     1 MDRETLCPAKTTTCFLKLDLIIESPLRMFNIELGIT--DINDNAPHFRRDKIELDVSESASPGE- 62

  Fly   192 KRTLLP-ARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQISGFLDRETTPGYSLL 255
             |..|| |.|.|:.....:.|.:   :.|:.|.:..|...||..|:||.:...||||....::|:
Zfish    63 -RFSLPNAFDPDVGANTVKTYKL---SENEHFTVDIHSGSDGTKYVDLVLMKALDREDKAVHNLI 123

  Fly   256 IEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVLQVYASDTDADENGL 320
            :.|:|||.|...|..::.:.:||.|||.|.|:|:.|...:.||:..||.|:::.|:|.|...|..
Zfish   124 LTAIDGGVPARSGTASIIVRVQDTNDNAPQFDQALYSLNISENSPAGTVVVKLNATDADEGPNAD 188

  Fly   321 VEYAINRRQSDK-EQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGEQPLETTAFVSIRVT 384
            :.|:.....|:| ::||.:|..||.|.:...:|:|..::.|:.|.|||:|..||...:.||:.||
Zfish   189 LTYSFTLYTSEKTQEMFSLDSNTGEIAVKGTIDYEDMKIFEMFVEAKDNGPVPLSGQSRVSVYVT 253

  Fly   385 DVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVTLNGGDGHFALTTR 449
            |:|||.|.|.:..|.:    .:.|:...|..:|.:.|.|.|: .:...||:|:|.. ..|.|...
Zfish   254 DMNDNYPEITIKSLKN----TVDENIPVGSVIALVGVSDRDT-GDNGKVNLTMNRA-LPFLLNQS 312

  Fly   450 DNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIFLRITDVNDNPPEFEQDLYHANVM 514
            .:.:|.::|..|||||:|..|.:::|.||||.|||..:::|.:.:.|||||.|:|.|..|...|.
Zfish   313 SDHLYELLVSKPLDREVVPEYEITLVVTDKGNPPLSDNETITVHLLDVNDNAPQFPQTFYTIPVK 377

  Fly   515 EVADPGTSVLQVLAHDRDEGLNSALTYSLAE---TPETHAQWFQIDPQTGLITTRSHIDCETEPV 576
            |...||..:..:.|.|.|...|..|.|.:.|   ...:.:..|.|:|:.|.:......|.|.|..
Zfish   378 ENNAPGALLGSITAIDPDLNENQYLVYFIIEREIANTSMSMLFSINPENGNLYALKTFDYEIEKD 442

  Fly   577 PQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIF------DQSFYNVSVAENEPVGRCILKVSA 635
            ....:.|||.|||||||..||.:.|.|.|||.|:.      ..|....::..:...|..|.||.|
Zfish   443 FLFHIEARDSGVPPLSSNVTVHIIIMDQNDNTPLIVSPWRAQGSEVKETIPRSTDKGTLIAKVIA 507

  Fly   636 SDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEFPVLATDRG--GLSTT 698
            .|.|...|:.:.|...:. ...|.|.:...:|||.......:.........|:|.|.|  .||.|
Zfish   508 IDSDSVHNSRITYQFLQN-TDATLFSLDQYNGEIRTMRMFSYRDSRDQRLVVIAKDNGEPALSAT 571

  Fly   699 AMIKMQLTDVNDNRPVFYPREYKV 722
            ..||:...:.........|.||.:
Zfish   572 VTIKLSTVETALKTYTEVPLEYDI 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	13/43 (30%)
		Cadherin_repeat	178..282	CDD:206637	32/105 (30%)
		Cadherin_repeat	291..389	CDD:206637	35/98 (36%)
		Cadherin_repeat	406..500	CDD:206637	33/93 (35%)
		Cadherin_repeat	509..607	CDD:206637	34/100 (34%)
		Cadherin_repeat	616..711	CDD:206637	23/96 (24%)
		Cadherin_repeat	719..820	CDD:206637	2/4 (50%)
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdhb	XP_002664314.3	Cadherin_repeat	50..150	CDD:206637	32/104 (31%)
		Cadherin_repeat	159..258	CDD:206637	35/98 (36%)
		Cadherin_repeat	270..363	CDD:206637	33/94 (35%)
		Cadherin_repeat	372..473	CDD:206637	34/100 (34%)
		Cadherin_repeat	491..576	CDD:206637	22/85 (26%)
		Cadherin_C_2	598..>640	CDD:318652
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10294
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000