DRSC/TRiP Functional Genomics Resources

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Protein Alignment ds and pcdh11

DIOPT Version :10

Sequence 1:NP_523446.2 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:XP_073777978.1 Gene:pcdh11 / 100333121 ZFINID:ZDB-GENE-140106-21 Length:1238 Species:Danio rerio


Alignment Length:1205 Identity:323/1205 - (26%)
Similarity:518/1205 - (42%) Gaps:211/1205 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   125 IDRATGEIRTKV-KLDR---------ETRASYSLVAIPLSG---RNIRVLVTVKDENDNAPTFPQ 176
            ::.:||||.|.. ::||         |.|..|.:....|..   |.:::...::|.|||||.|..
Zfish    91 VEASTGEILTTANRIDREKLCSGVFNEKRCYYEIEVAVLPDEIFRLVKIRFLIEDINDNAPLFQS 155

  Fly   177 TSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQIS 241
            |.::|..||||....:..:..|.|.|:.....|.|.:|. :|:: |.|......:|..:..|.:.
Zfish   156 TVINISIPENTAINSRYPVPSAFDPDIGINGIQHYELVK-SVSE-FGLDIIETPEGDKWPQLIVQ 218

  Fly   242 GFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVL 306
            ..|||||...:.:.|:..|||.||......:.:|:.|||||:|:|..|.....|||||.:||||.
Zfish   219 QSLDRETKDTFVMKIKVEDGGNPPKSSTAILQVTVSDVNDNRPVFKDSEVEVNVPENAPMGTSVT 283

  Fly   307 QVYASDTDADENGLVEYAI-NRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGE 370
            .::|:|.|...|..:.::. |:.....::.|.||..||.|.:.:.||.|...:|:|:|:|.|...
Zfish   284 HLHATDADLGSNAQIHFSFSNQISPSTKRHFAIDSTTGLITVKQPLDREVNPVHKLIVLASDGSS 348

  Fly   371 QPLETTAFVSIRVTDVNDNQPTINVIFLSD--DASPKISESAQPGEFVARISVHDPDSKTEYANV 433
            .|...|  |.:.|||:|||.|:|:..::.:  :.:..:||:|.....:|.|:|.|.||       
Zfish   349 TPSRAT--VIVNVTDINDNVPSIDTRYIMNLVNGTVLLSENAPLNTKIALITVTDRDS------- 404

  Fly   434 NVTLNG-------GDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIF 491
              .|||       .|..|.|....|..:|:....|||.|....|.:.:||:|.|.|||:.|..:.
Zfish   405 --DLNGKVTCYTDHDVPFRLKPVFNDQFLLETAAPLDYETTREYAIRIVASDSGKPPLNTSAMVL 467

  Fly   492 LRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLA-ETPETHAQWFQ 555
            ::|.|.|||.|.|.|.....::.|..||||.::::.|.|.|.|.|:.:.|||. :.|:    .|.
Zfish   468 IKIKDENDNVPVFPQPEIQLSIPENNDPGTQLIKISATDADSGSNALIIYSLGPDAPD----GFN 528

  Fly   556 IDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSV 620
            ||.::|:::....:|.|.:.....||:|||.|..||.|..||.:.:.|.|||.|.|....||..|
Zfish   529 IDSRSGILSVVKRLDREKQEKYSFTVIARDNGTTPLQSNVTVKLIVQDQNDNSPAFTHPEYNFYV 593

  Fly   621 AENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEF 685
            .||.|:...:..::.:|.|.|.||:|..:|..|   ...|.:...:|.|......|.|::|||.|
Zfish   594 PENLPLYGTVGLITVTDADAGDNAVVTLSIING---KDNFIIDPKTGVIKPNITFDREQQSSYTF 655

  Fly   686 PVLATDRGGLSTT--AMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVAVVATDPD 748
            .|.|.|.|.:.||  |.:.:.:.|||||||||.......|....|..:|..|  .:..|.|.|.|
Zfish   656 VVKAVDAGLMQTTSYAKVTINVVDVNDNRPVFVIPSSNYSYDLVPSNTSPGS--VVTRVFAIDND 718

  Fly   749 YGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRS-NADAV 812
            .|...::.|.|:.|:..|:|.||::||.|.:  .:.:....|.:|.|.:...|.|...| :|.|:
Zfish   719 TGMNAELQYSIIGGSLRGLFTIDKTTGNITL--QEKIVAADQGLHRLVVKVKDLGQPESLHAIAL 781

  Fly   813 VFLSIIDAMQRPPIFEK--------------------ARYNYYVKEDIPRGTVVGSVIAASGDV- 856
            |.|.:.|.:......::                    .:.|.||       .||.::||.:..| 
Zfish   782 VHLFVNDTVSNATFIQEQLRKSLETPLERNIGDNDVTPQTNGYV-------IVVIAIIAGTMTVI 839

  Fly   857 ----------AHRSP----VRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLN---IQA 904
                      ..::|    |:.|..||:   :.|...:...|:..|.....:...:|||   |:.
Zfish   840 LVIFVTALVRCRQTPRHKVVQKSKQSGE---WVSPNQDGRQIKKKKKKKKRSPKSLLLNFVTIEE 901

  Fly   905 TLGEPPVYGHT----QVNIEVEDVNDNAPEFEASMVR---ISVPESAELGAPLYAAHAHDKDSGS 962
            |..:.|.:.|.    .:.:|:|         |.:|.:   .:.|.:.:..:|..|.|.    ..:
Zfish   902 TKSDDPTHEHVNGTLDLPVELE---------EQTMGKYNWATTPTTFKPDSPDLAKHY----KSA 953

  Fly   963 SGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQ 1027
            |.|.|:.:..|:     .:..:..|:|....||      :|.:|     |..|||...:      
Zfish   954 SPQPTFQIKPET-----PVAPKKHHVIQELPLD------NTFVV-----GCDSLSKCSS------ 996

  Fly  1028 DVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNA---------------RITYRIVD 1077
                    ...|.|||:....:.......|::.....|.:.|               |:|:.:.|
Zfish   997 --------SSSDPYSVSECSCQGGFKAPGQIHTRQNQTPDKAFPVVPTMCPHKQTQRRVTFHLPD 1053

  Fly  1078 AGVDNVTNS-------ISSSDVSQHFGI-FPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAH 1134
            ...::.::|       .|::.::|...: ||...:....:|..|...|         .|..|.:.
Zfish  1054 GSQESCSDSGLGEPEPNSAASITQPLPLGFPQDEYYEQTSPNSRTEGD---------GNSDPEST 1109

  Fly  1135 AKTRVIVRVLDAND-----------ND--------PKFQKSKY----EFRIEENLRRG------- 1169
            .:..:...:.:|::           :|        .:||.|..    .|..:::..||       
Zfish  1110 IEVNLQKALAEASETCTQECLILGHSDSCWMPPALTQFQTSNATTLPSFGFQQSWARGIKPDGRH 1174

  Fly  1170 SVVGVVTASDLDLGENAAIRYSLLPINSSFQVHPV 1204
            ::...|...|||.|.|....|:.|..:.|.:..||
Zfish  1175 TLGRSVPKDDLDKGSNRPQFYNTLERHCSKKEDPV 1209

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_523446.2 CA 111..172 CDD:214520 16/59 (27%)
Cadherin_repeat 178..282 CDD:206637 31/103 (30%)
Cadherin_repeat 291..389 CDD:206637 35/98 (36%)
Cadherin_repeat 406..500 CDD:206637 33/100 (33%)
Cadherin_repeat 509..607 CDD:206637 33/98 (34%)
Cadherin_repeat 616..711 CDD:206637 33/96 (34%)
Cadherin_repeat 719..820 CDD:206637 29/101 (29%)
Cadherin_repeat 832..927 CDD:206637 25/116 (22%)
Cadherin_repeat 937..1032 CDD:206637 18/97 (19%)
Cadherin_repeat 1040..1149 CDD:206637 20/142 (14%)
Cadherin_repeat 1158..1252 CDD:206637 14/58 (24%)
Cadherin_repeat 1263..1361 CDD:206637
Cadherin_repeat 1369..1481 CDD:206637
Cadherin_repeat 1489..1598 CDD:206637
Cadherin_repeat 1614..1710 CDD:206637
Cadherin_repeat 1723..1843 CDD:206637
Cadherin_repeat 1853..1948 CDD:206637
Cadherin_repeat 1957..2053 CDD:206637
Cadherin_repeat 2061..2154 CDD:206637
CA_like 2171..>2232 CDD:481204
Cadherin_repeat 2326..2424 CDD:206637
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
pcdh11XP_073777978.1 None
Blue background indicates that the domain is not in the aligned region.

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