DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and pcdh11

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_005173247.2	Gene:	pcdh11 / 100333121	ZFINID:	ZDB-GENE-140106-21	Length:	1224	Species:	Danio rerio

Alignment Length:	1205	Identity:	323/1205 - (26%)
Similarity:	518/1205 - (42%)	Gaps:	211/1205 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 IDRATGEIRTKV-KLDR---------ETRASYSLVAIPLSG---RNIRVLVTVKDENDNAPTFPQ 176
            ::.:||||.|.. ::||         |.|..|.:....|..   |.:::...::|.|||||.|..
Zfish    77 VEASTGEILTTANRIDREKLCSGVFNEKRCYYEIEVAVLPDEIFRLVKIRFLIEDINDNAPLFQS 141

  Fly   177 TSMHIEFPENTPREVKRTLLPARDLDLEPYNTQRYNIVSGNVNDAFRLSSHRERDGVLYLDLQIS 241
            |.::|..||||....:..:..|.|.|:.....|.|.:|. :|:: |.|......:|..:..|.:.
Zfish   142 TVINISIPENTAINSRYPVPSAFDPDIGINGIQHYELVK-SVSE-FGLDIIETPEGDKWPQLIVQ 204

  Fly   242 GFLDRETTPGYSLLIEALDGGTPPLRGFMTVNITIQDVNDNQPIFNQSRYFATVPENATVGTSVL 306
            ..|||||...:.:.|:..|||.||......:.:|:.|||||:|:|..|.....|||||.:||||.
Zfish   205 QSLDRETKDTFVMKIKVEDGGNPPKSSTAILQVTVSDVNDNRPVFKDSEVEVNVPENAPMGTSVT 269

  Fly   307 QVYASDTDADENGLVEYAI-NRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELVVVAKDHGE 370
            .::|:|.|...|..:.::. |:.....::.|.||..||.|.:.:.||.|...:|:|:|:|.|...
Zfish   270 HLHATDADLGSNAQIHFSFSNQISPSTKRHFAIDSTTGLITVKQPLDREVNPVHKLIVLASDGSS 334

  Fly   371 QPLETTAFVSIRVTDVNDNQPTINVIFLSD--DASPKISESAQPGEFVARISVHDPDSKTEYANV 433
            .|...|  |.:.|||:|||.|:|:..::.:  :.:..:||:|.....:|.|:|.|.||
Zfish   335 TPSRAT--VIVNVTDINDNVPSIDTRYIMNLVNGTVLLSENAPLNTKIALITVTDRDS------- 390

  Fly   434 NVTLNG-------GDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATDKGTPPLHASKSIF 491
              .|||       .|..|.|....|..:|:....|||.|....|.:.:||:|.|.|||:.|..:.
Zfish   391 --DLNGKVTCYTDHDVPFRLKPVFNDQFLLETAAPLDYETTREYAIRIVASDSGKPPLNTSAMVL 453

  Fly   492 LRITDVNDNPPEFEQDLYHANVMEVADPGTSVLQVLAHDRDEGLNSALTYSLA-ETPETHAQWFQ 555
            ::|.|.|||.|.|.|.....::.|..||||.::::.|.|.|.|.|:.:.|||. :.|:    .|.
Zfish   454 IKIKDENDNVPVFPQPEIQLSIPENNDPGTQLIKISATDADSGSNALIIYSLGPDAPD----GFN 514

  Fly   556 IDPQTGLITTRSHIDCETEPVPQLTVVARDGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYNVSV 620
            ||.::|:::....:|.|.:.....||:|||.|..||.|..||.:.:.|.|||.|.|....||..|
Zfish   515 IDSRSGILSVVKRLDREKQEKYSFTVIARDNGTTPLQSNVTVKLIVQDQNDNSPAFTHPEYNFYV 579

  Fly   621 AENEPVGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFERRSSYEF 685
            .||.|:...:..::.:|.|.|.||:|..:|..|   ...|.:...:|.|......|.|::|||.|
Zfish   580 PENLPLYGTVGLITVTDADAGDNAVVTLSIING---KDNFIIDPKTGVIKPNITFDREQQSSYTF 641

  Fly   686 PVLATDRGGLSTT--AMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVAVVATDPD 748
            .|.|.|.|.:.||  |.:.:.:.|||||||||.......|....|..:|..|  .:..|.|.|.|
Zfish   642 VVKAVDAGLMQTTSYAKVTINVVDVNDNRPVFVIPSSNYSYDLVPSNTSPGS--VVTRVFAIDND 704

  Fly   749 YGNFGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATDGGNLRS-NADAV 812
            .|...::.|.|:.|:..|:|.||::||.|.:  .:.:....|.:|.|.:...|.|...| :|.|:
Zfish   705 TGMNAELQYSIIGGSLRGLFTIDKTTGNITL--QEKIVAADQGLHRLVVKVKDLGQPESLHAIAL 767

  Fly   813 VFLSIIDAMQRPPIFEK--------------------ARYNYYVKEDIPRGTVVGSVIAASGDV- 856
            |.|.:.|.:......::                    .:.|.||       .||.::||.:..|
Zfish   768 VHLFVNDTVSNATFIQEQLRKSLETPLERNIGDNDVTPQTNGYV-------IVVIAIIAGTMTVI 825

  Fly   857 ----------AHRSP----VRYSIYSGDPDGYFSIETNSGNIRIAKPLDHEAKSQVLLN---IQA 904
                      ..::|    |:.|..||:   :.|...:...|:..|.....:...:|||   |:.
Zfish   826 LVIFVTALVRCRQTPRHKVVQKSKQSGE---WVSPNQDGRQIKKKKKKKKRSPKSLLLNFVTIEE 887

  Fly   905 TLGEPPVYGHT----QVNIEVEDVNDNAPEFEASMVR---ISVPESAELGAPLYAAHAHDKDSGS 962
            |..:.|.:.|.    .:.:|:|         |.:|.:   .:.|.:.:..:|..|.|.    ..:
Zfish   888 TKSDDPTHEHVNGTLDLPVELE---------EQTMGKYNWATTPTTFKPDSPDLAKHY----KSA 939

  Fly   963 SGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYESSQRHTLIVTATDGGVPSLSTNLTILVDVQ 1027
            |.|.|:.:..|:     .:..:..|:|....||      :|.:|     |..|||...:
Zfish   940 SPQPTFQIKPET-----PVAPKKHHVIQELPLD------NTFVV-----GCDSLSKCSS------ 982

  Fly  1028 DVNDNPPVFEKDEYSVNVSESRSINAQIIQVNASDLDTGNNA---------------RITYRIVD 1077
                    ...|.|||:....:.......|::.....|.:.|               |:|:.:.|
Zfish   983 --------SSSDPYSVSECSCQGGFKAPGQIHTRQNQTPDKAFPVVPTMCPHKQTQRRVTFHLPD 1039

  Fly  1078 AGVDNVTNS-------ISSSDVSQHFGI-FPNSGWIYLRAPLDRETRDRYQLTVLATDNGTPAAH 1134
            ...::.::|       .|::.::|...: ||...:....:|..|...|         .|..|.:.
Zfish  1040 GSQESCSDSGLGEPEPNSAASITQPLPLGFPQDEYYEQTSPNSRTEGD---------GNSDPEST 1095

  Fly  1135 AKTRVIVRVLDAND-----------ND--------PKFQKSKY----EFRIEENLRRG------- 1169
            .:..:...:.:|::           :|        .:||.|..    .|..:::..||
Zfish  1096 IEVNLQKALAEASETCTQECLILGHSDSCWMPPALTQFQTSNATTLPSFGFQQSWARGIKPDGRH 1160

  Fly  1170 SVVGVVTASDLDLGENAAIRYSLLPINSSFQVHPV 1204
            ::...|...|||.|.|....|:.|..:.|.:..||
Zfish  1161 TLGRSVPKDDLDKGSNRPQFYNTLERHCSKKEDPV 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520	16/59 (27%)
		Cadherin_repeat	178..282	CDD:206637	31/103 (30%)
		Cadherin_repeat	291..389	CDD:206637	35/98 (36%)
		Cadherin_repeat	406..500	CDD:206637	33/100 (33%)
		Cadherin_repeat	509..607	CDD:206637	33/98 (34%)
		Cadherin_repeat	616..711	CDD:206637	33/96 (34%)
		Cadherin_repeat	719..820	CDD:206637	29/101 (29%)
		Cadherin_repeat	832..927	CDD:206637	25/116 (22%)
		Cadherin_repeat	937..1032	CDD:206637	18/97 (19%)
		Cadherin_repeat	1040..1149	CDD:206637	20/142 (14%)
		Cadherin_repeat	1158..1252	CDD:206637	14/58 (24%)
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637
		Cadherin_repeat	2170..2318	CDD:206637
		Cadherin_repeat	2326..2424	CDD:206637
		Cadherin_repeat	2434..2528	CDD:206637
		Cadherin_repeat	2549..2641	CDD:206637
		Cadherin_repeat	2652..2748	CDD:206637
		Cadherin_repeat	2758..2858	CDD:206637
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
pcdh11	XP_005173247.2	E_set	28..>97	CDD:298831	7/19 (37%)
		Cadherin_repeat	143..245	CDD:206637	31/103 (30%)
		Cadherin_repeat	253..351	CDD:206637	35/99 (35%)
		Cadherin_repeat	367..462	CDD:206637	33/103 (32%)
		Cadherin_repeat	470..566	CDD:206637	33/99 (33%)
		Cadherin_repeat	574..669	CDD:206637	33/97 (34%)
		Cadherin_repeat	685..774	CDD:206637	28/92 (30%)
		Protocadherin	775..975	CDD:285562	42/238 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910