DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ds and rptor

DIOPT Version :9

Sequence 1:	NP_001285551.1	Gene:	ds / 33245	FlyBaseID:	FBgn0284247	Length:	3556	Species:	Drosophila melanogaster
Sequence 2:	XP_012827007.1	Gene:	rptor / 100170605	XenbaseID:	XB-GENE-1012818	Length:	1353	Species:	Xenopus tropicalis

Alignment Length:	941	Identity:	187/941 - (19%)
Similarity:	300/941 - (31%)	Gaps:	299/941 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  2063 IGQVPALIQPGQTLLKVQALDADLGANAEIVYSLNAENSAVSAKFRINPSTGALSASQSLASESG 2127
            :.|:|.:|:.| |..:.....|:.....::..::..||.        ||........|.|.|:..
Frog   388 LSQLPTIIEEG-TAFRHSPFFAEQLTAFQVWLTMGVENR--------NPPEQLPIVLQVLLSQVH 443

  Fly  2128 KLLHLEVVAR--DKGNPPQSSLGL--------IELLIGEAPQGTPVLRF--------QNETYRVM 2174
            :|..|:::.|  |.| |...||.|        ::||...|.:..|:|.|        .:.....:
Frog   444 RLRALDLLGRFLDLG-PWAVSLALSVGIFPYVLKLLQSSARELRPLLVFIWAKILAVDSSCQADL 507

  Fly  2175 LKENSPSGTRLLQVVA---LRSDGRRQK------VQFSFGAGNEDGILSLDSLSGEI------RV 2224
            :|:|...  ..|.|:|   :.::.|...      :..::..|.|      ..|.|.:      ::
Frog   508 VKDNGHK--YFLSVLADPYMPAEHRTMTSFILAVIVNNYNTGQE------ACLQGNLIAICLEQL 564

  Fly  2225 NKPHLLDYDRFSTPSMSALSRGR------ALHYEEEIDESSEE------DPNNSTRSQRALTSSS 2277
            |.||.|      .....|:..||      |..:....|.:.|:      ||....||     |:.
Frog   565 NDPHPL------LRQWVAICLGRIWQNFDAARWCGVRDSAHEKLYSLLSDPMPEVRS-----SAV 618

  Fly  2278 FALTNSQPNEIRVVLVARTADAPFLASYAELVIELEDENDNSPKFSQKQFVATVSEGNNKGTFVA 2342
            |||.....|.......:.|.|.......|:|:      ||.|| ..:|:.|..:|
Frog   619 FALGTFVGNSAERTDHSTTIDHNVAMMLAQLI------NDGSP-MVRKELVVALS---------- 666

  Fly  2343 QVHAFDSDAGSNARLRYHIVDGNHDNAFVIEPAFSGIVRTNIVLDREIRDIYKLKIIATDEG--- 2404
                             |:|.....|...:...|           .|....|.|...|:.||
Frog   667 -----------------HLVVQYESNFCTVALQF-----------MEEEKNYPLPSPASTEGGSL 703

  Fly  2405 --VPQMTGTATIR--------------------VQIVDVNDNQP------TFPPNNLVTVSEATE 2441
              :....||..:|                    :|.:.:::...      ||.|.||.|.|.|:.
Frog   704 TPIRDSPGTPRLRSVSSYGNIRAVTTPRNLNKSLQNLSLSEESKTAGSAITFSPGNLSTSSSASS 768

  Fly  2442 -LGA-----VITSISAND----VDTYPALTYRLGAESTVDIENMSIF----------ALDRYS-- 2484
             ||:     .|.|....|    |.:|.:|      .|.:.:...|::          |.|.|.
Frog   769 TLGSPDNEEYILSFETIDKMRRVSSYSSL------NSLIGVSFNSVYTQIWRVLLHLAADPYPEV 827

  Fly  2485 GKLVLKRRLDYELQQEYELDVIASDAAHEARTVLTVRVNDENDNAPVF----------LAQQPPA 2539
            ..|.:|           .|:.||..|...||....:..:....:||..          :...||.
Frog   828 SDLAMK-----------VLNSIAHKATVNARPQRILDASSLTQSAPASPTNKGMHIHQVGGSPPT 881

  Fly  2540 YFAILPAISEISESLSVDFDLLTVNATDAD-------SEGNNSKVIYI----------------- 2580
                 |:.|  |.||:.|   :|......|       :.|.|..|.|.
Frog   882 -----PSAS--SSSLTND---VTKPPVSRDIPSNRPANAGGNVGVQYTPHSHQFPRTRKMFDKGP 936

  Fly  2581 IEPAQEGFSVHPSNGVVSVNMSRLQPAVSSSGDYFVRIIAKDAGKPALKSSTLLRVQANDNGSGR 2645
            .:|..:|     ...:|..|.:     |.|....|....||...:|.:|......:::.......
Frog   937 DQPGDDG-----DEAIVHKNFT-----VGSFQTGFCDWSAKYFAQPVMKMPEEHDMESQVRKERE 991

  Fly  2646 SQFLQN-QYRAQISEAAPLGSVVLQLGQDALDQSLAIIAGNEESA------FELLQSKAIVLVKP 2703
            .:||:| :.|.|...       ::|.|...||..:.|   |....      |....|...|..|.
Frog   992 WRFLRNTRVRKQAQR-------LIQKGISRLDDQIFI---NRNPGVPSVVKFHPFTSSIAVADKD 1046

  Fly  2704 ----LDRERNDLYKLRLVLSHPHGP-----PLISSLNSSSGISVIITILDAN-----DNFPIFDR 2754
                .|.|:.:    :|...|...|     ..:..||... .|:::|..|..     .||...::
Frog  1047 SICFWDWEKGE----KLDYFHNGNPRYTRITAVEYLNGQD-CSLLLTATDDGAIRVWKNFADLEK 1106

  Fly  2755 SAKYEAE---ISELAPLRYSIAQLQAIDADQENTPNSEVVYD--------ITSGNDE--HMFTID 2806
            :.:....   :|::.|....:|:..:|..|:.....:.:|.|        ||||:..  .::..|
Frog  1107 NPEMVTAWQGLSDMLPTTRGLARRVSIYLDRSKQGGAGMVVDWEQETGLLITSGDVRIIRLWDTD 1171

  Fly  2807 LVTGVLFVNNRLDYDSGAKSYELIIRACDSH 2837
            ..|.|      .|..:||.|....: :||||
Frog  1172 RETKV------QDIPTGADSCVTSL-SCDSH 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ds	NP_001285551.1	CA	111..172	CDD:214520
		Cadherin_repeat	178..282	CDD:206637
		Cadherin_repeat	291..389	CDD:206637
		Cadherin_repeat	406..500	CDD:206637
		Cadherin_repeat	509..607	CDD:206637
		Cadherin_repeat	616..711	CDD:206637
		Cadherin_repeat	719..820	CDD:206637
		Cadherin_repeat	832..927	CDD:206637
		Cadherin_repeat	937..1032	CDD:206637
		Cadherin_repeat	1040..1149	CDD:206637
		Cadherin_repeat	1158..1252	CDD:206637
		Cadherin_repeat	1263..1361	CDD:206637
		Cadherin_repeat	1369..1481	CDD:206637
		Cadherin_repeat	1489..1598	CDD:206637
		Cadherin_repeat	1614..1710	CDD:206637
		Cadherin_repeat	1723..1843	CDD:206637
		Cadherin_repeat	1853..1948	CDD:206637
		Cadherin_repeat	1957..2053	CDD:206637
		Cadherin_repeat	2061..2154	CDD:206637	23/100 (23%)
		Cadherin_repeat	2170..2318	CDD:206637	34/174 (20%)
		Cadherin_repeat	2326..2424	CDD:206637	16/122 (13%)
		Cadherin_repeat	2434..2528	CDD:206637	24/115 (21%)
		Cadherin_repeat	2549..2641	CDD:206637	21/115 (18%)
		Cadherin_repeat	2652..2748	CDD:206637	22/115 (19%)
		Cadherin_repeat	2758..2858	CDD:206637	22/93 (24%)
		Cadherin_repeat	2866..2960	CDD:206637
		Cadherin_repeat	2985..3071	CDD:206637
rptor	XP_012827007.1	Raptor_N	53..204	CDD:373119
		COG5096	470..>694	CDD:227427	53/287 (18%)
		HEAT repeat	514..542	CDD:293787	4/29 (14%)
		HEAT repeat	555..585	CDD:293787	7/35 (20%)
		HEAT repeat	597..623	CDD:293787	9/30 (30%)
		HEAT repeat	638..668	CDD:293787	10/63 (16%)
		WD40	<1021..1350	CDD:225201	40/190 (21%)
		WD40 repeat	1029..1067	CDD:293791	8/41 (20%)
		WD40 repeat	1073..1126	CDD:293791	9/53 (17%)
		WD40 repeat	1131..1180	CDD:293791	12/54 (22%)
		WD40 repeat	1188..1225	CDD:293791	4/9 (44%)
		WD40 repeat	1232..1266	CDD:293791
		WD40 repeat	1274..1309	CDD:293791
		WD40 repeat	1322..1346	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	56	1.000	Domainoid score	I10813
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000