DRSC/TRiP Functional Genomics Resources

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Protein Alignment ds and si:dkey-22o22.2

DIOPT Version :10

Sequence 1:NP_523446.2 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:XP_001921123.3 Gene:si:dkey-22o22.2 / 100149950 ZFINID:ZDB-GENE-100922-84 Length:2780 Species:Danio rerio


Alignment Length:2468 Identity:645/2468 - (26%)
Similarity:993/2468 - (40%) Gaps:530/2468 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   270 MTVNITIQDVNDNQPIFNQS-----------------------RYFATVPENATVGTSVLQVYAS 311
            :||.|.:...:|....||:|                       .|..||.|:..||..:..|...
Zfish   120 VTVKIKMLQKDDETRRFNESSVSTGVIGVKSGSRKPRAVSEEVSYTVTVSEDVKVGDLIFTVPDQ 184

  Fly   312 DTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELV----VVAKDHGEQP 372
            ..:.....:|        |:.....:::..:|.:|:          .|.||    |:.|.|.   
Zfish   185 KFEKKWFEVV--------SEGNSPIQMERDSGRVYL----------AHRLVSATEVMVKIHN--- 228

  Fly   373 LETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVTL 437
            :....:...|:|....|...:............:......|..|.::....||.....|:. :.:
Zfish   229 MRGDEWYLCRLTLTLPNMSNLQWAMFPYPYLAAVGPDTGAGSVVYKLVAQSPDGSVGTAHF-LLV 292

  Fly   438 NGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATD-KGTPPLHASKSIFLRITDVNDNP 501
            :||:..|.:......:......|...:|    |||:|.|.| :|....|||..|.     ....|
Zfish   293 DGGEDSFEVDQTTGEVKTTGRPLTPSKE----YTLTVQAVDSQGRRGTHASLFIL-----AGFRP 348

  Fly   502 PEFEQDLYHANVMEVADPG--TSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGLIT 564
            |:|....|..::.|.:..|  .:|:|.::..|     ..|:|.|...|   :..|.|:.::|.::
Zfish   349 PQFTNTTYTIHIPESSAVGQAVAVVQAISFQR-----KTLSYMLLVNP---SNLFSINQESGALS 405

  Fly   565 TRSHIDCET-EPVPQLTVVAR--DGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYN-VSVAENEP 625
            ....:|.|: :.:..|.|.|.  |.|   ||:.|.|:|.|.|.||..|.|..|.|: .:|.|..|
Zfish   406 LTRTVDYESGQHLHHLQVRASEPDTG---LSNMAEVVVHITDENDCTPEFMHSIYSRDNVPETTP 467

  Fly   626 VGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFER-RSSYEFPVLA 689
            .|..:|:|.|.|.|.|:||.::|     |....:|::.| .|.:..:..||:|| ...||..|:|
Zfish   468 TGTSLLQVLARDCDTGLNAELSY-----FIQSVDFDITS-QGVVSPSQRLDYERPNHMYECTVVA 526

  Fly   690 TDRG--GLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVAVV-ATDPDYGN 751
            .|:|  ..:.||.|::::.:|||..|||....||..|      |..|....:||:| |.|||...
Zfish   527 VDKGTPPRTGTASIRIRMANVNDEAPVFSQTIYKTFL------SEDAGPETLVAIVHAKDPDGDG 585

  Fly   752 FGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATD----GGNLRSNADAV 812
               |:|.|..|||...|.:|...|.|.:.|.....:| .|.::||::|||    ||.|..::.|.
Zfish   586 ---VTYAITGGNEDSNFELDNQKGIIKLRRSPPPRLR-GPQYVLNVTATDDNAAGGALPLSSCAQ 646

  Fly   813 VFLSIIDAMQRPPIFEKARYNYYVK----EDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGD--- 870
            |.:.|.|.....|:|::. :||.|.    |:.|.||.|..|.|...|......|:|.|...|   
Zfish   647 VIVGINDINNNKPVFDEC-HNYSVNALVLENQPPGTFVLRVQAHDADTGVNGEVKYGIMQRDGAS 710

  Fly   871 PDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQAT-LGEPPVYGHTQVNIEVEDVNDNAPEFEAS 934
            |.  |:|..::|.|..|...|.|.:.:..|::.|| ..:.|:.|..|:.:.:.|.|||.|:||.|
Zfish   711 PG--FTINPDTGVISTAVSFDREKQREYTLSVTATDQAQEPLIGICQITVLIADQNDNDPKFENS 773

  Fly   935 MVRISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYES- 998
            ..:..:.|...:|.....|.|||.|.|::..:|||| .:.....|.|:..:|.:.::|.:...| 
Zfish   774 RYQYFLREDTPVGTSFLRAAAHDDDQGTNSAITYSL-SQQNPAYFHINPSTGWIYVNQPISQTSR 837

  Fly   999 -SQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNA-S 1061
             ||:    :.|||||..|.|.:||::  :.:|::.||.:|:.||.|.:.|:...:.:|:.:.| |
Zfish   838 ISQQ----IIATDGGSRSSSVDLTVI--ITNVHNQPPQWEQAEYWVTIPENTPRDTKIVTIKATS 896

  Fly  1062 DLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPN----SGWIYLRAPLDRETRDRYQLT 1122
            .|   .:.|:||.:.:       ..:..:::...|.|.||    |..|.:...||.||...:.|.
Zfish   897 PL---GDPRVTYNLEE-------GQVPETNMPVRFYIKPNRRDGSASILVAENLDYETTGFFTLR 951

  Fly  1123 VLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAA 1187
            |...:.......:.|.|.|.:.|.|||.|.|..|.||..:.|....|:.|..|:|:|||.|.:..
Zfish   952 VRVQNVAAVPLASFTTVYVNITDVNDNVPFFMSSTYEATVPEGAEIGTSVAQVSATDLDSGLHGM 1016

  Fly  1188 IRYSLLPINSS----FQVHPVTGEISTREPLDRELRELYDLVVEARD---------QGTPVRSAR 1239
            |.|.:|...|.    |.::..||.|.||...|||.:..|.:.|:::|         ||.| .:..
Zfish  1017 INYIILKDQSGDSQFFSINSYTGIIHTRATFDREQKGSYLIEVQSQDSSESARPGQQGQP-NTDT 1080

  Fly  1240 VPVRIHVSDVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDG 1304
            ..||:.|:|||||||..:.|..: :||.|::..|..|:.|.|.|.|.|.||.:.|.|..|...  
Zfish  1081 AYVRVFVTDVNDNAPAFSQPVYE-ISVEEDKEVGFVVITVTANDEDEGANAKLRYQITSGNTM-- 1142

  Fly  1305 HGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSS 1369
             |.|.::|..|.|.....||:|:...|.|.:.||||   ..|...|:.:.|::.||..|.||.:.
Zfish  1143 -GTFDVEPEVGTIFIAQRLDYEQVQRYELRLVASDG---KWENQTMVVINVINQNDEAPLFTQTE 1203

  Fly  1370 LVFRVREDAALGHVVGSISPIERPADVVRNSV---EESFEDLRVTYTLNPLTKDLIEAAFDIDRH 1431
            ....|.|:..           |.|..|:..|.   ::..:...|.|:|:.....   :.|.||..
Zfish  1204 YHASVMEELT-----------ELPVLVLEVSATDPDQEADQRAVRYSLHGQGAG---SEFTIDEI 1254

  Fly  1432 SGNLVVARLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIEVADVNDNAPEW--PQDPIDL-Q 1493
            :|.:...|.|||||:|.::..:.|.|...:.  .:....|.::|.|:|||||.:  ..|...| .
Zfish  1255 NGRIFAQRRLDREVRSAWQFLVLATDENGAG--LTGFADVLVDVQDINDNAPVFLCATDNCFLGH 1317

  Fly  1494 VSEATPVGTIIHNFTATDAD---TGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGAL-SLQ 1554
            |.|.:|..|.|....|||.|   .|.|..|.||:::     |...|..::||.::..||.: ::.
Zfish  1318 VPENSPADTSIMEMRATDLDDPKAGKNAILTYRIVQ-----NVRNEINLNLFSINPTTGTIYTVL 1377

  Fly  1555 APLDFEAVQEYLLIVQALDQSSNVTERLQTSVTVRLRILDANDHAPHFVSPNSSGGKTASLFISD 1619
            ..||.|.|..||::|:|.|...     |..:.|..:.|.|.|||.|.|..      :.....:|:
Zfish  1378 RSLDREVVDRYLVVVEARDGGG-----LSGTGTATIVISDVNDHPPVFTQ------RVYMASMSE 1431

  Fly  1620 ATRIGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRIN----SQTGIIELVKSLPPATEDVEK 1680
            ...|...|..:.|.|.|.|:|..:|:.|.||:.:.:|.|.    ::.||:.|.|.:     |.||
Zfish  1432 NLDINSEVMVVAATDGDEGENSVMTFSIIGGDEDRKFFIETDKVNRRGIVRLKKKI-----DFEK 1491

  Fly  1681 GGR--FNLIIGAKDHGQPEPKKSSLNLHLI-VQGSHNNPPRFLQAVYRA-TILENVPSGSFVLQV 1741
            ...  |||.:..:|     ....||...:| |:.|:::.|.|....|.| ::.|:||.|:.|.||
Zfish  1492 PHERTFNLTVKVED-----ADFFSLAYCIIQVEDSNDHTPVFFPQFYEAGSMFEDVPVGTIVAQV 1551

  Fly  1742 TAKSLHGAENANLSYEI-PAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQSTL 1805
            ||..|...:|...:|.| |.......|.|| :.|.:......|||..|.:.|.:...|.. ...|
Zfish  1552 TAMDLDSGQNGRFTYSIAPESDPFQQFLVD-KSGWVVVADSLDREKVAQHRLMILATDMG-SPAL 1614

  Fly  1806 SSSAVRKQRSSDSIGDTSNGQHFDVATIYITVGDVNDNSPEFRPGSCYGLSVPENS-EPGVIH-- 1867
            :.||:                      :.:||.|||||.|||.  :.|...|.||: .|.|||  
Zfish  1615 TGSAI----------------------VLVTVQDVNDNGPEFE--APYRPIVWENTIAPQVIHMN 1655

  Fly  1868 ---TVV-ASDLDEGPNAD--------LIYSITGGNLGNKFSIDSSSGELSA-RPLDREQHSRYTL 1919
               |:: |.|.|...|..        |...:|..||.:   :.:.|..::| |..||||..:|.|
Zfish  1656 DTSTLLHAIDRDTSSNGGPFSIRLLMLTSDVTNFNLTD---MRNGSAMITALRSFDREQQKQYLL 1717

  Fly  1920 QIQASDRGQPKSRQGHCNITIFVEDQND--NAP---RFKLSKYTGSVQEDAPLGTSVV-QISAVD 1978
            .|...|.|.| .......:|:.:.|:||  :||   .|.:....|:      |.|:|: |:.:.|
Zfish  1718 PILMIDSGSP-PMSSTSTLTVIIGDKNDHPHAPGHSEFIVYNIQGT------LPTTVLGQVQSPD 1775

  Fly  1979 ADLGVNARLVYSLANETQWQFAIDGQSGLIT------------------------------TVGK 2013
            .|..  :..||....:...||.::..:|.::                              ||.:
Zfish  1776 LDDW--SEKVYKFEGKPPRQFILNQNNGQLSVREGTAAGLYSLQVRVADKSWPDVTSSAEVTVME 1838

  Fly  2014 LDRE------------LQASYNFMVLATDGGRY---------------------EVRSATVPVQ- 2044
            |..|            |.|:..|...|.:..||                     .:.|...|.| 
Zfish  1839 LQEEALRNAASIRLANLTANEFFRASANEESRYMRLRRLLSELFQTDVENVDVFSLASGRQPAQH 1903

  Fly  2045 -INVLDINDNRPIF---ERYPYIGQVPALIQP--GQTLLKV-------QALDADLGANAEIVYS- 2095
             ::|.......|.:   :.:.||....|.::.  |.|:|:|       .|.....|.::::.:| 
Zfish  1904 HLSVWFAAHGSPYYKPEKLHGYIAMHKAKLESALGVTILQVGVDECVYAACGQTGGCSSKVTFSD 1968

  Fly  2096 ----LNAEN-SAVSAKFRINPSTGAL----------SASQSLASESGKLLHLEVVARDKGNP--- 2142
                ||..| |.||...:.:...|.|          |.|||.....|..:..|:..|.|..|   
Zfish  1969 TPTTLNNGNISLVSVSAKASVQCGCLGRESVHLHCSSYSQSPCLNGGTCVDSELGYRCKCPPMFD 2033

  Fly  2143 -PQ------SSLG---------------------LIE----LLIGEAPQGTPVLRFQNETYRVML 2175
             |:      |.||                     :.|    ||....|.|.|..|.:.:...:.|
Zfish  2034 GPECQQTKHSFLGNGYAWFHPIKPCFQSHISLEFITEAANGLLFYNGPMGAPQPREKEDFIALEL 2098

  Fly  2176 KENSP-------SGTRLLQVVA-------------LRSDGRRQKVQFSFGAGNEDGILSLDSLSG 2220
            |...|       |||..||:.|             :.|||:  .||           :.||..||
Zfish  2099 KNGVPVLSVNHGSGTLTLQLSARATVTDRRWHHLDIISDGK--SVQ-----------MILDHCSG 2150

  Fly  2221 EIRVNKPHLLDYDRFSTPSMSALSRGRALHYEEEIDESSEEDPNNSTRSQRAL----------TS 2275
            .: ||:...|..:.|.|              ::.:.::|.|.|.    |:|.|          ..
Zfish  2151 AV-VNEVEGLGVEMFET--------------DQSVCKASGETPG----SERFLDVYQPLQLGGVK 2196

  Fly  2276 SSFALTNSQPNEIRVVLVARTADAPFLASYAELVIE---------LEDENDNSPKFSQKQFVATV 2331
            .:.:|..|.|:.           ..|:.....||::         .|.|| .:|..:....|...
Zfish  2197 ETHSLRRSHPHY-----------KGFVGCMRNLVVDSQVYDLSSAAESEN-TAPGCALTDGVCLT 2249

  Fly  2332 SEG----------NNKGTFVAQVH---------------AFDSDAGSNARLRYHIVDGNHDNA-- 2369
            :.|          ...|:|....|               :|:.|    :.|||.:..|.....  
Zfish  2250 AGGPSCGVHGRCLGEWGSFSCDCHPGYSGHKCDKALPEWSFERD----SVLRYQLRGGGSPRRTQ 2310

  Fly  2370 --FVIEPAFSGIVRTNIVLDREIRDIYKLKIIATDEGVPQM-----TGTATIRVQIVDVNDNQ 2425
              |::....|    |..:|....||..:..|:...:|...:     .||.::::....||..|
Zfish  2311 AHFLLRTRSS----TGTLLSMASRDANEFIILEIVDGYLNVRANLGDGTHSLKLTGQRVNHGQ 2369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_523446.2 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637 3/11 (27%)
Cadherin_repeat 291..389 CDD:206637 19/101 (19%)
Cadherin_repeat 406..500 CDD:206637 21/94 (22%)
Cadherin_repeat 509..607 CDD:206637 28/102 (27%)
Cadherin_repeat 616..711 CDD:206637 33/98 (34%)
Cadherin_repeat 719..820 CDD:206637 36/105 (34%)
Cadherin_repeat 832..927 CDD:206637 31/102 (30%)
Cadherin_repeat 937..1032 CDD:206637 29/96 (30%)
Cadherin_repeat 1040..1149 CDD:206637 28/113 (25%)
Cadherin_repeat 1158..1252 CDD:206637 36/106 (34%)
Cadherin_repeat 1263..1361 CDD:206637 33/97 (34%)
Cadherin_repeat 1369..1481 CDD:206637 26/114 (23%)
Cadherin_repeat 1489..1598 CDD:206637 35/113 (31%)
Cadherin_repeat 1614..1710 CDD:206637 28/102 (27%)
Cadherin_repeat 1723..1843 CDD:206637 34/121 (28%)
Cadherin_repeat 1853..1948 CDD:206637 34/112 (30%)
Cadherin_repeat 1957..2053 CDD:206637 26/161 (16%)
Cadherin_repeat 2061..2154 CDD:206637 33/152 (22%)
CA_like 2171..>2232 CDD:481204 21/80 (26%)
Cadherin_repeat 2326..2424 CDD:206637 23/131 (18%)
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
si:dkey-22o22.2XP_001921123.3 Cadherin_repeat 257..360 CDD:206637 25/112 (22%)
Cadherin_repeat 355..447 CDD:206637 27/102 (26%)
Cadherin_repeat 461..549 CDD:206637 31/93 (33%)
Cadherin_repeat 558..657 CDD:206637 37/108 (34%)
Cadherin_repeat 668..766 CDD:206637 29/99 (29%)
Cadherin_repeat 775..863 CDD:206637 28/94 (30%)
Cadherin_repeat 874..978 CDD:206637 28/113 (25%)
Cadherin_repeat 986..1093 CDD:206637 36/107 (34%)
Cadherin_repeat 1101..1194 CDD:206637 32/99 (32%)
Cadherin_repeat 1203..1302 CDD:206637 26/114 (23%)
Cadherin_repeat 1317..1416 CDD:206637 34/108 (31%)
Cadherin_repeat 1424..1524 CDD:206637 30/109 (28%)
Cadherin_repeat 1533..1630 CDD:206637 34/120 (28%)
Cadherin_repeat 1637..1745 CDD:206637 33/111 (30%)
Cadherin_repeat 1756..1836 CDD:206637 12/87 (14%)
EGF_CA 2003..2038 CDD:238011 10/34 (29%)
LamG 2062..2223 CDD:214598 42/203 (21%)
EGF_CA 2247..2281 CDD:238011 4/33 (12%)
LamG 2312..2438 CDD:214598 13/62 (21%)
EGF_CA 2512..2544 CDD:238011
CADH_Y-type_LIR 2700..2758 CDD:460041
Blue background indicates that the domain is not in the aligned region.

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