DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ds and si:dkey-22o22.2

DIOPT Version :9

Sequence 1:NP_001285551.1 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster
Sequence 2:XP_001921123.3 Gene:si:dkey-22o22.2 / 100149950 ZFINID:ZDB-GENE-100922-84 Length:2780 Species:Danio rerio


Alignment Length:2468 Identity:645/2468 - (26%)
Similarity:993/2468 - (40%) Gaps:530/2468 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   270 MTVNITIQDVNDNQPIFNQS-----------------------RYFATVPENATVGTSVLQVYAS 311
            :||.|.:...:|....||:|                       .|..||.|:..||..:..|...
Zfish   120 VTVKIKMLQKDDETRRFNESSVSTGVIGVKSGSRKPRAVSEEVSYTVTVSEDVKVGDLIFTVPDQ 184

  Fly   312 DTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELV----VVAKDHGEQP 372
            ..:.....:|        |:.....:::..:|.:|:          .|.||    |:.|.|.   
Zfish   185 KFEKKWFEVV--------SEGNSPIQMERDSGRVYL----------AHRLVSATEVMVKIHN--- 228

  Fly   373 LETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVTL 437
            :....:...|:|....|...:............:......|..|.::....||.....|:. :.:
Zfish   229 MRGDEWYLCRLTLTLPNMSNLQWAMFPYPYLAAVGPDTGAGSVVYKLVAQSPDGSVGTAHF-LLV 292

  Fly   438 NGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATD-KGTPPLHASKSIFLRITDVNDNP 501
            :||:..|.:......:......|...:|    |||:|.|.| :|....|||..|.     ....|
Zfish   293 DGGEDSFEVDQTTGEVKTTGRPLTPSKE----YTLTVQAVDSQGRRGTHASLFIL-----AGFRP 348

  Fly   502 PEFEQDLYHANVMEVADPG--TSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGLIT 564
            |:|....|..::.|.:..|  .:|:|.::..|     ..|:|.|...|   :..|.|:.::|.::
Zfish   349 PQFTNTTYTIHIPESSAVGQAVAVVQAISFQR-----KTLSYMLLVNP---SNLFSINQESGALS 405

  Fly   565 TRSHIDCET-EPVPQLTVVAR--DGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYN-VSVAENEP 625
            ....:|.|: :.:..|.|.|.  |.|   ||:.|.|:|.|.|.||..|.|..|.|: .:|.|..|
Zfish   406 LTRTVDYESGQHLHHLQVRASEPDTG---LSNMAEVVVHITDENDCTPEFMHSIYSRDNVPETTP 467

  Fly   626 VGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFER-RSSYEFPVLA 689
            .|..:|:|.|.|.|.|:||.::|     |....:|::.| .|.:..:..||:|| ...||..|:|
Zfish   468 TGTSLLQVLARDCDTGLNAELSY-----FIQSVDFDITS-QGVVSPSQRLDYERPNHMYECTVVA 526

  Fly   690 TDRG--GLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVAVV-ATDPDYGN 751
            .|:|  ..:.||.|::::.:|||..|||....||..|      |..|....:||:| |.|||...
Zfish   527 VDKGTPPRTGTASIRIRMANVNDEAPVFSQTIYKTFL------SEDAGPETLVAIVHAKDPDGDG 585

  Fly   752 FGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATD----GGNLRSNADAV 812
               |:|.|..|||...|.:|...|.|.:.|.....:| .|.::||::|||    ||.|..::.|.
Zfish   586 ---VTYAITGGNEDSNFELDNQKGIIKLRRSPPPRLR-GPQYVLNVTATDDNAAGGALPLSSCAQ 646

  Fly   813 VFLSIIDAMQRPPIFEKARYNYYVK----EDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGD--- 870
            |.:.|.|.....|:|::. :||.|.    |:.|.||.|..|.|...|......|:|.|...|   
Zfish   647 VIVGINDINNNKPVFDEC-HNYSVNALVLENQPPGTFVLRVQAHDADTGVNGEVKYGIMQRDGAS 710

  Fly   871 PDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQAT-LGEPPVYGHTQVNIEVEDVNDNAPEFEAS 934
            |.  |:|..::|.|..|...|.|.:.:..|::.|| ..:.|:.|..|:.:.:.|.|||.|:||.|
Zfish   711 PG--FTINPDTGVISTAVSFDREKQREYTLSVTATDQAQEPLIGICQITVLIADQNDNDPKFENS 773

  Fly   935 MVRISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYES- 998
            ..:..:.|...:|.....|.|||.|.|::..:|||| .:.....|.|:..:|.:.::|.:...| 
Zfish   774 RYQYFLREDTPVGTSFLRAAAHDDDQGTNSAITYSL-SQQNPAYFHINPSTGWIYVNQPISQTSR 837

  Fly   999 -SQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNA-S 1061
             ||:    :.|||||..|.|.:||::  :.:|::.||.:|:.||.|.:.|:...:.:|:.:.| |
Zfish   838 ISQQ----IIATDGGSRSSSVDLTVI--ITNVHNQPPQWEQAEYWVTIPENTPRDTKIVTIKATS 896

  Fly  1062 DLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPN----SGWIYLRAPLDRETRDRYQLT 1122
            .|   .:.|:||.:.:       ..:..:::...|.|.||    |..|.:...||.||...:.|.
Zfish   897 PL---GDPRVTYNLEE-------GQVPETNMPVRFYIKPNRRDGSASILVAENLDYETTGFFTLR 951

  Fly  1123 VLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAA 1187
            |...:.......:.|.|.|.:.|.|||.|.|..|.||..:.|....|:.|..|:|:|||.|.:..
Zfish   952 VRVQNVAAVPLASFTTVYVNITDVNDNVPFFMSSTYEATVPEGAEIGTSVAQVSATDLDSGLHGM 1016

  Fly  1188 IRYSLLPINSS----FQVHPVTGEISTREPLDRELRELYDLVVEARD---------QGTPVRSAR 1239
            |.|.:|...|.    |.::..||.|.||...|||.:..|.:.|:::|         ||.| .:..
Zfish  1017 INYIILKDQSGDSQFFSINSYTGIIHTRATFDREQKGSYLIEVQSQDSSESARPGQQGQP-NTDT 1080

  Fly  1240 VPVRIHVSDVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDG 1304
            ..||:.|:|||||||..:.|..: :||.|::..|..|:.|.|.|.|.|.||.:.|.|..|...  
Zfish  1081 AYVRVFVTDVNDNAPAFSQPVYE-ISVEEDKEVGFVVITVTANDEDEGANAKLRYQITSGNTM-- 1142

  Fly  1305 HGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSS 1369
             |.|.::|..|.|.....||:|:...|.|.:.||||   ..|...|:.:.|::.||..|.||.:.
Zfish  1143 -GTFDVEPEVGTIFIAQRLDYEQVQRYELRLVASDG---KWENQTMVVINVINQNDEAPLFTQTE 1203

  Fly  1370 LVFRVREDAALGHVVGSISPIERPADVVRNSV---EESFEDLRVTYTLNPLTKDLIEAAFDIDRH 1431
            ....|.|:..           |.|..|:..|.   ::..:...|.|:|:.....   :.|.||..
Zfish  1204 YHASVMEELT-----------ELPVLVLEVSATDPDQEADQRAVRYSLHGQGAG---SEFTIDEI 1254

  Fly  1432 SGNLVVARLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIEVADVNDNAPEW--PQDPIDL-Q 1493
            :|.:...|.|||||:|.::..:.|.|...:.  .:....|.::|.|:|||||.:  ..|...| .
Zfish  1255 NGRIFAQRRLDREVRSAWQFLVLATDENGAG--LTGFADVLVDVQDINDNAPVFLCATDNCFLGH 1317

  Fly  1494 VSEATPVGTIIHNFTATDAD---TGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGAL-SLQ 1554
            |.|.:|..|.|....|||.|   .|.|..|.||:::     |...|..::||.::..||.: ::.
Zfish  1318 VPENSPADTSIMEMRATDLDDPKAGKNAILTYRIVQ-----NVRNEINLNLFSINPTTGTIYTVL 1377

  Fly  1555 APLDFEAVQEYLLIVQALDQSSNVTERLQTSVTVRLRILDANDHAPHFVSPNSSGGKTASLFISD 1619
            ..||.|.|..||::|:|.|...     |..:.|..:.|.|.|||.|.|..      :.....:|:
Zfish  1378 RSLDREVVDRYLVVVEARDGGG-----LSGTGTATIVISDVNDHPPVFTQ------RVYMASMSE 1431

  Fly  1620 ATRIGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRIN----SQTGIIELVKSLPPATEDVEK 1680
            ...|...|..:.|.|.|.|:|..:|:.|.||:.:.:|.|.    ::.||:.|.|.:     |.||
Zfish  1432 NLDINSEVMVVAATDGDEGENSVMTFSIIGGDEDRKFFIETDKVNRRGIVRLKKKI-----DFEK 1491

  Fly  1681 GGR--FNLIIGAKDHGQPEPKKSSLNLHLI-VQGSHNNPPRFLQAVYRA-TILENVPSGSFVLQV 1741
            ...  |||.:..:|     ....||...:| |:.|:::.|.|....|.| ::.|:||.|:.|.||
Zfish  1492 PHERTFNLTVKVED-----ADFFSLAYCIIQVEDSNDHTPVFFPQFYEAGSMFEDVPVGTIVAQV 1551

  Fly  1742 TAKSLHGAENANLSYEI-PAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQSTL 1805
            ||..|...:|...:|.| |.......|.|| :.|.:......|||..|.:.|.:...|.. ...|
Zfish  1552 TAMDLDSGQNGRFTYSIAPESDPFQQFLVD-KSGWVVVADSLDREKVAQHRLMILATDMG-SPAL 1614

  Fly  1806 SSSAVRKQRSSDSIGDTSNGQHFDVATIYITVGDVNDNSPEFRPGSCYGLSVPENS-EPGVIH-- 1867
            :.||:                      :.:||.|||||.|||.  :.|...|.||: .|.|||  
Zfish  1615 TGSAI----------------------VLVTVQDVNDNGPEFE--APYRPIVWENTIAPQVIHMN 1655

  Fly  1868 ---TVV-ASDLDEGPNAD--------LIYSITGGNLGNKFSIDSSSGELSA-RPLDREQHSRYTL 1919
               |:: |.|.|...|..        |...:|..||.:   :.:.|..::| |..||||..:|.|
Zfish  1656 DTSTLLHAIDRDTSSNGGPFSIRLLMLTSDVTNFNLTD---MRNGSAMITALRSFDREQQKQYLL 1717

  Fly  1920 QIQASDRGQPKSRQGHCNITIFVEDQND--NAP---RFKLSKYTGSVQEDAPLGTSVV-QISAVD 1978
            .|...|.|.| .......:|:.:.|:||  :||   .|.:....|:      |.|:|: |:.:.|
Zfish  1718 PILMIDSGSP-PMSSTSTLTVIIGDKNDHPHAPGHSEFIVYNIQGT------LPTTVLGQVQSPD 1775

  Fly  1979 ADLGVNARLVYSLANETQWQFAIDGQSGLIT------------------------------TVGK 2013
            .|..  :..||....:...||.::..:|.::                              ||.:
Zfish  1776 LDDW--SEKVYKFEGKPPRQFILNQNNGQLSVREGTAAGLYSLQVRVADKSWPDVTSSAEVTVME 1838

  Fly  2014 LDRE------------LQASYNFMVLATDGGRY---------------------EVRSATVPVQ- 2044
            |..|            |.|:..|...|.:..||                     .:.|...|.| 
Zfish  1839 LQEEALRNAASIRLANLTANEFFRASANEESRYMRLRRLLSELFQTDVENVDVFSLASGRQPAQH 1903

  Fly  2045 -INVLDINDNRPIF---ERYPYIGQVPALIQP--GQTLLKV-------QALDADLGANAEIVYS- 2095
             ::|.......|.:   :.:.||....|.::.  |.|:|:|       .|.....|.::::.:| 
Zfish  1904 HLSVWFAAHGSPYYKPEKLHGYIAMHKAKLESALGVTILQVGVDECVYAACGQTGGCSSKVTFSD 1968

  Fly  2096 ----LNAEN-SAVSAKFRINPSTGAL----------SASQSLASESGKLLHLEVVARDKGNP--- 2142
                ||..| |.||...:.:...|.|          |.|||.....|..:..|:..|.|..|   
Zfish  1969 TPTTLNNGNISLVSVSAKASVQCGCLGRESVHLHCSSYSQSPCLNGGTCVDSELGYRCKCPPMFD 2033

  Fly  2143 -PQ------SSLG---------------------LIE----LLIGEAPQGTPVLRFQNETYRVML 2175
             |:      |.||                     :.|    ||....|.|.|..|.:.:...:.|
Zfish  2034 GPECQQTKHSFLGNGYAWFHPIKPCFQSHISLEFITEAANGLLFYNGPMGAPQPREKEDFIALEL 2098

  Fly  2176 KENSP-------SGTRLLQVVA-------------LRSDGRRQKVQFSFGAGNEDGILSLDSLSG 2220
            |...|       |||..||:.|             :.|||:  .||           :.||..||
Zfish  2099 KNGVPVLSVNHGSGTLTLQLSARATVTDRRWHHLDIISDGK--SVQ-----------MILDHCSG 2150

  Fly  2221 EIRVNKPHLLDYDRFSTPSMSALSRGRALHYEEEIDESSEEDPNNSTRSQRAL----------TS 2275
            .: ||:...|..:.|.|              ::.:.::|.|.|.    |:|.|          ..
Zfish  2151 AV-VNEVEGLGVEMFET--------------DQSVCKASGETPG----SERFLDVYQPLQLGGVK 2196

  Fly  2276 SSFALTNSQPNEIRVVLVARTADAPFLASYAELVIE---------LEDENDNSPKFSQKQFVATV 2331
            .:.:|..|.|:.           ..|:.....||::         .|.|| .:|..:....|...
Zfish  2197 ETHSLRRSHPHY-----------KGFVGCMRNLVVDSQVYDLSSAAESEN-TAPGCALTDGVCLT 2249

  Fly  2332 SEG----------NNKGTFVAQVH---------------AFDSDAGSNARLRYHIVDGNHDNA-- 2369
            :.|          ...|:|....|               :|:.|    :.|||.:..|.....  
Zfish  2250 AGGPSCGVHGRCLGEWGSFSCDCHPGYSGHKCDKALPEWSFERD----SVLRYQLRGGGSPRRTQ 2310

  Fly  2370 --FVIEPAFSGIVRTNIVLDREIRDIYKLKIIATDEGVPQM-----TGTATIRVQIVDVNDNQ 2425
              |::....|    |..:|....||..:..|:...:|...:     .||.::::....||..|
Zfish  2311 AHFLLRTRSS----TGTLLSMASRDANEFIILEIVDGYLNVRANLGDGTHSLKLTGQRVNHGQ 2369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dsNP_001285551.1 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637 3/11 (27%)
Cadherin_repeat 291..389 CDD:206637 19/101 (19%)
Cadherin_repeat 406..500 CDD:206637 21/94 (22%)
Cadherin_repeat 509..607 CDD:206637 28/102 (27%)
Cadherin_repeat 616..711 CDD:206637 33/98 (34%)
Cadherin_repeat 719..820 CDD:206637 36/105 (34%)
Cadherin_repeat 832..927 CDD:206637 31/102 (30%)
Cadherin_repeat 937..1032 CDD:206637 29/96 (30%)
Cadherin_repeat 1040..1149 CDD:206637 28/113 (25%)
Cadherin_repeat 1158..1252 CDD:206637 36/106 (34%)
Cadherin_repeat 1263..1361 CDD:206637 33/97 (34%)
Cadherin_repeat 1369..1481 CDD:206637 26/114 (23%)
Cadherin_repeat 1489..1598 CDD:206637 35/113 (31%)
Cadherin_repeat 1614..1710 CDD:206637 28/102 (27%)
Cadherin_repeat 1723..1843 CDD:206637 34/121 (28%)
Cadherin_repeat 1853..1948 CDD:206637 34/112 (30%)
Cadherin_repeat 1957..2053 CDD:206637 26/161 (16%)
Cadherin_repeat 2061..2154 CDD:206637 33/152 (22%)
Cadherin_repeat 2170..2318 CDD:206637 38/186 (20%)
Cadherin_repeat 2326..2424 CDD:206637 23/131 (18%)
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
si:dkey-22o22.2XP_001921123.3 Cadherin_repeat 257..360 CDD:206637 25/112 (22%)
Cadherin_repeat 355..447 CDD:206637 27/102 (26%)
Cadherin_repeat 461..549 CDD:206637 31/93 (33%)
Cadherin_repeat 558..657 CDD:206637 37/108 (34%)
Cadherin_repeat 668..766 CDD:206637 29/99 (29%)
Cadherin_repeat 775..863 CDD:206637 28/94 (30%)
Cadherin_repeat 874..978 CDD:206637 28/113 (25%)
Cadherin_repeat 986..1093 CDD:206637 36/107 (34%)
Cadherin_repeat 1101..1194 CDD:206637 32/99 (32%)
Cadherin_repeat 1203..1302 CDD:206637 26/114 (23%)
Cadherin_repeat 1317..1416 CDD:206637 34/108 (31%)
Cadherin_repeat 1424..1524 CDD:206637 30/109 (28%)
Cadherin_repeat 1533..1630 CDD:206637 34/120 (28%)
Cadherin_repeat 1637..1745 CDD:206637 33/111 (30%)
Cadherin_repeat 1756..1836 CDD:206637 12/87 (14%)
EGF_CA 2003..2038 CDD:238011 10/34 (29%)
LamG 2062..2223 CDD:214598 42/203 (21%)
EGF_CA 2247..2281 CDD:238011 4/33 (12%)
Laminin_G_2 2315..2438 CDD:280389 12/59 (20%)
EGF_CA 2512..2544 CDD:238011
Cadherin_C 2602..2758 CDD:279398
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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